1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine supplier

Name
1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine
EINECS 616-147-4
CAS No. 74853-08-0
Article Data5
CAS DataBase
Density 1.237 g/cm³
Solubility
Melting Point
Formula C₁₆H₁₉N₃O
Boiling Point 532.786 °C at 760 mmHg
Molecular Weight 269.346
Flash Point 276.02 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 4-[4-(4-Aminophenyl)piperazin-1-yl]phenol;
PSA 52.73000
LogP 3.01220

Synthetic route

: 184177-84-2
4-[4-(4-benzyloxy-phenyl)-piperazin-1-yl]-phenylamine

: 74853-08-0
1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine

Conditions

Conditions	Yield
palladium on activated charcoal In tetrahydrofuran; water at 70℃; under 4137.18 Torr; for 40h;	94%

: 112559-81-6
N-(4-Hydroxyphenyl)-N'-(4'-nitrophenyl)-piperazine

: 74853-08-0
1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine

Conditions

Conditions	Yield
With sodium hypophosphite; 5%-palladium/activated carbon In 2-methoxy-ethanol; water at 70 - 80℃; for 2 - 2.5h;	88%
With ammonium formate; palladium on activated charcoal In ethyl acetate Reduction; Heating;	82%
With hydrogen In methanol; ethyl acetate at 35 - 40℃; under 2250.23 Torr; Large scale;

: 74852-62-3
4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-phenylamine

: 74853-08-0
1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine

Conditions

Conditions	Yield
With Cyclohexyl iodide In N,N-dimethyl-formamide at 82 - 85℃; for 3h;	85.7%
With hydrogen bromide dealkylation; Heating;

: 454479-35-7
1-(4-benzyloxy-phenyl)-4-(4-nitro-phenyl)-piperazine

: 74853-08-0
1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol for 24h; Heating;	81%
Multi-step reaction with 2 steps 1: 99 percent / H2 / Pd/C / H2O; tetrahydrofuran / 20 h / 50 °C / 2585.74 Torr 2: 94 percent / Pd/C / H2O; tetrahydrofuran / 40 h / 70 °C / 4137.18 Torr View Scheme

: acetic acid 4-[4-(4-amino-phenyl)-piperazin-1-yl]-phenyl ester

: 74853-08-0
1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine

Conditions

Conditions	Yield
With water Hydrolysis;

1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine Specification

The CAS registry number of 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine is 74853-08-0. With the molecular formula C₁₆H₁₉N₃O, its IUPAC name is 4-[4-(4-aminophenyl)piperazin-1-yl]phenol. In addition, the molecular weight is 269.34. What's more, it should be stored in sealed container, and put in a cool and dry place.

Physical properties about 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine are: (1)ACD/LogP: 1.84; (2)ACD/LogD (pH 5.5): -1; (3)ACD/LogD (pH 7.4): 1; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 2; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 31; (8)#H bond acceptors: 4; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 4; (11)Polar Surface Area: 52.73 Å²; (12)Index of Refraction: 1.662; (13)Molar Refractivity: 80.586 cm³; (14)Molar Volume: 217.658 cm³; (15)Polarizability: 31.947 ×10^-24cm³; (16)Surface Tension: 59.324 dyne/cm; (17)Density: 1.237 g/cm³; (18)Flash Point: 276.02 °C; (19)Enthalpy of Vaporization: 83.898 kJ/mol; (20)Boiling Point: 532.786 °C at 760 mmHg.

You can still convert the following datas into molecular structure:
(1)SMILES: Oc1ccc(cc1)N3CCN(c2ccc(N)cc2)CC3
(2)Std. InChI: InChI=1S/C16H19N3O/c17-13-1-3-14(4-2-13)18-9-11-19(12-10-18)15-5-7-16(20)8-6-15/h1-8,20H,9-12,17H2
(3)Std. InChIKey: WZIJMPVPOMTRNM-UHFFFAOYSA-N

Product Name

1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine

Synthetic route

1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine Specification

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