Fmoc-cycloleucine

The CAS register number of 1-(Fmoc-amino)cyclopentanecarboxylic acid is 117322-30-2. It also can be called as cyclopentanecarboxylic acid, 1-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]- and the systematic name about this chemical is 1-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}cyclopentanecarboxylic acid. The molecular formula about this chemical is C₂₁H₂₁NO₄ and the molecular weight is 351.40. It belongs to the following product categories which include FMOC; Amino Acids and so on. When you are using it, please do not breathe dust and avoid contact with skin and eyes.

Physical properties about 1-(Fmoc-amino)cyclopentanecarboxylic acid are: (1)ACD/LogP: 4.17; (2)ACD/LogD (pH 5.5): 2.36; (3)ACD/LogD (pH 7.4): 0.74; (4)ACD/BCF (pH 5.5): 13.52; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 68.83; (7)ACD/KOC (pH 7.4): 1.65; (8)#H bond acceptors: 5; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 5; (11)Polar Surface Area: 55.84Ų; (12)Index of Refraction: 1.646; (13)Molar Refractivity: 96.18 cm³; (14)Molar Volume: 264.7 cm³; (15)Polarizability: 38.13x10^-24cm³; (16)Surface Tension: 62.9 dyne/cm; (17)Enthalpy of Vaporization: 91.19 kJ/mol; (18)Boiling Point: 579.4 °C at 760 mmHg; (19)Vapour Pressure: 2.87E-14 mmHg at 25°C.

Preparation: this chemical can be prepared by 1-amino-cyclopentanecarboxylic acid and 9H-fluoren-9-ylmethyl chloroformate. This reaction will need reagent HCl, Zn and solvent acetonitrile, H₂O. The yield is about 70%.

Uses of 1-(Fmoc-amino)cyclopentanecarboxylic acid: it can be used to produce 4'-({[1-(9H-fluoren-9-ylmethoxycarbonylamino)-cyclopentanecarbonyl]-amino}-methyl)-biphenyl-2-carboxylic acid tert-butyl ester with 4'-aminomethyl-biphenyl-2-carboxylic acid tert-butyl ester. This reaction will need reagent <(benzotriazol-1-yl)oxy>tris(dimethylamino)phosphonium hexafluorophosphate (BOP), Et₂NH and solvent dimethylformamide with reaction time of 1 hours. The yield is about 97%.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)C4(NC(=O)OCC3c1ccccc1c2c3cccc2)CCCC4
(2)InChI: InChI=1/C21H21NO4/c23-19(24)21(11-5-6-12-21)22-20(25)26-13-18-16-9-3-1-7-14(16)15-8-2-4-10-17(15)18/h1-4,7-10,18H,5-6,11-13H2,(H,22,25)(H,23,24)
(3)InChIKey: IECZEINPZOFWNU-UHFFFAOYAN
(4)Std. InChI: InChI=1S/C21H21NO4/c23-19(24)21(11-5-6-12-21)22-20(25)26-13-18-16-9-3-1-7-14(16)15-8-2-4-10-17(15)18/h1-4,7-10,18H,5-6,11-13H2,(H,22,25)(H,23,24)
(5)Std. InChIKey: IECZEINPZOFWNU-UHFFFAOYSA-N