1-Phenyl-1,2-Propanedione-2-oxime supplier

Name
1-Phenyl-1,2-propanedione-2-oxime
EINECS 204-329-2
CAS No. 119-51-7
Article Data40
CAS DataBase
Density 1.1 g/cm³
Solubility
Melting Point 113-115 °C(lit.)
Formula C₉H₉NO₂
Boiling Point 292.5 °C at 760 mmHg
Molecular Weight 163.176
Flash Point 130.7 °C
Transport Information
Appearance White to light yellow crystals
Safety 24/25-37/39-26
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms 1-Phenyl-1,2-propanedione2-oxime;1-Phenyl-2-(hydroxyimino)propan-1-one;2-(Hydroxyimino)propiophenone;2-Hydroxyimino-1-phenyl-1-propanone;Isonitrosopropiophenone;NSC 5410;RA 58;a-(Hydroxyimino)propiophenone;α-iso-Nitrosopropiophenone;
PSA 49.66000
LogP 1.71940

Synthetic route

: 93-55-0
1-phenyl-propan-1-one

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

Conditions

Conditions	Yield
With hydrogenchloride; tert-Butyl thionitrate In tetrahydrofuran at 0℃; for 0.3h;	97%
With tert-Butyl thionitrate In tetrahydrofuran for 0.3h;	97%
With chloro-trimethyl-silane; isopentyl nitrite In dichloromethane at -20℃;	96%

: 768-03-6
Phenyl vinyl ketone

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

Conditions

Conditions	Yield
With n-Butyl nitrite; phenylsilane; N,N'-bis(2-ethoxycarbonyl-3-oxobutylidene)ethylenediaminatocobalt(II) complex In tetrahydrofuran for 19h; Ambient temperature;	93%

: 35947-99-0
2-azido-1-phenyl-1-propanone

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; tetrabutyl ammonium fluoride In tetrahydrofuran; dimethyl sulfoxide at 25℃; for 1h; Inert atmosphere;	73%

: 109-95-5
ethyl nitrite

: 93-55-0
1-phenyl-propan-1-one

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

Conditions

Conditions	Yield
With hydrogenchloride In ethanol at 30 - 35℃; for 2h; Solvent; Large scale;	63.8%

: 705-60-2
(2-nitroprop-1-enyl)benzene

: 122-52-1
triethyl phosphite

A: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

B: 1-(diethoxyphosphinyl)-1-phenylpropene

C: 2-(diethoxyphosphinyl)-3-methyl-2-phenyl-2H-azirine

D: α-(diethoxyphosphinyl)-α-ethoxy-α-phenylacetone oxime

Conditions

Conditions	Yield
for 20h; Ambient temperature;	A 10% B 7% C 22% D 60%

...Expand

: 14897-67-7
2-nitropropiophenone

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

Conditions

Conditions	Yield
With tellurium tetrachloride; triethylamine In dichloromethane -78 deg C to RT;	28%

: 93-55-0
1-phenyl-propan-1-one

A: 14897-67-7
2-nitropropiophenone

B: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

Conditions

Conditions	Yield
With tert.-butylnitrite at 80℃;	A 19% B 24%

: 624-91-9
methyl nitrite

: 93-55-0
1-phenyl-propan-1-one

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

Conditions

Conditions	Yield
With hydrogenchloride; diethyl ether

: 544-16-1
n-Butyl nitrite

: 93-55-0
1-phenyl-propan-1-one

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

Conditions

Conditions	Yield
With hydrogenchloride; diethyl ether
With hydrogenchloride In tetrahydrofuran

: 93-55-0
1-phenyl-propan-1-one

: 110-46-3
isopentyl nitrite

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

Conditions

Conditions	Yield
With hydrogenchloride

: 579-07-7
1-Phenylpropane-1,2-dione

A: 4937-86-4
1-phenyl-1,2-propanedione dioxime

B: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

Conditions

Conditions	Yield
With ethanol; hydroxylamine hydrochloride; sodium carbonate

: 50-00-0
formaldehyd

: 63200-78-2
2-bromo-2-nitro-1-phenyl-ethanone

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

Conditions

Conditions	Yield
(i) NaOAc, Et2O, (ii) SnCl2, aq. HCl, MeOH; Multistep reaction;

: 37471-46-8
1-phenyl-1-trimethylsiloxypropene

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

Conditions

Conditions	Yield
With nitrosylchloride In dichloromethane

: 7715-08-4
α--propiophenon

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In 1,4-dioxane

: 25355-34-4
1-phenyl-propane-1,2-dione 1-oxime

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

Conditions

Conditions	Yield
With hydrogenchloride for 5h; Product distribution; Heating; transoximation equilibrium, other isonitroso ketones;	66 % Spectr.
Multi-step reaction with 2 steps 1: sulfuric acid / beim Destillieren 2: natrium carbonate; diluted alcohol; hydroxylamine hydrochloride View Scheme

methyl-benzoyl-acetic acid ester: methyl-benzoyl-acetic acid ester

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: 2813-22-1
2-methanesulfinyl-1-phenyl-ethanone

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: (i) NaH, THF, (ii) /BRN= 969135/ 2: NaNO2, aq. HCl / dioxane View Scheme

: 579-07-7
1-Phenylpropane-1,2-dione

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride
Stage #1: 1-Phenylpropane-1,2-dione With hydroxylamine hydrochloride In water for 0.5h; Reflux; Stage #2: With sodium acetate In water for 0.5h;

: 50-00-0
formaldehyd

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: 60-32-2
6-aminohexanoic acid

: 126263-66-9
6-(4-Methyl-3-oxy-5-phenyl-imidazol-1-yl)-hexanoic acid

Conditions

Conditions	Yield
In ethanol Heating;	98%

...Expand

: 108-24-7
acetic anhydride

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: 16735-28-7
N-(1-methyl-2-oxo-2-phenylethyl)acetamide

Conditions

Conditions	Yield
With indium; acetic acid In tetrahydrofuran for 18h; Reduction; Acetylation; Heating;	96%
With indium; acetic acid In tetrahydrofuran Heating;	96%
With zinc In acetic acid at 0 - 40℃;	86%
With zinc In acetic acid

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: 55253-39-9
(R)-1-hydroxy-1-phenylpropan-2-one oxime

Conditions

Conditions	Yield
With NAD; isopropyl alcohol In aq. phosphate buffer at 20 - 30℃; Solvent; Enzymatic reaction;	95%

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: 579-07-7
1-Phenylpropane-1,2-dione

Conditions

Conditions	Yield
With water; Dess-Martin periodane In dichloromethane for 0.333333h; Ambient temperature;	94%
With 2,6-dicarboxypyridinium chlorochromate In acetonitrile at 20℃; for 0.316667h;	88%
With 2,6-dicarboxypyridinium fluorochromate for 0.5h;	85%

: O-pentyl phenylphosphorohydrazide

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: C20H26N3O3P

Conditions

Conditions	Yield
With silica gel In benzene for 3h; Heating;	94%

: 541-41-3
chloroformic acid ethyl ester

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: 1-phenyl-1,2-propanedione-2-(o-ethoxycarboxy)oxime

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 5 - 10℃; for 2h; Reagent/catalyst; Solvent; Autoclave; Large scale;	93.6%

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: 95-54-5
1,2-diamino-benzene

: 10130-23-1
2-methyl-3-phenylquinoxaline

Conditions

Conditions	Yield
at 140℃; for 0.166667h; Microwave irradiation; neat (no solvent);	93%
In ethanol for 1.5h;	75%

: N,N-dibutylamino(phenyl)phosphonohydrazide

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: C23H33N4O2P

Conditions

Conditions	Yield
With silica gel In benzene for 3h; Heating;	93%

: 24424-99-5
di-tert-butyl dicarbonate

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: 138371-45-6
2-N-(tert-butoxycarbonyl)amino-1-phenyl-1-propanone

Conditions

Conditions	Yield
With indium; acetic acid In tetrahydrofuran for 18h; Heating;	92%

: 1061354-15-1
N,N-dibutylamino(isopropyl)phosphonohydrazide

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: C20H35N4O2P

Conditions

Conditions	Yield
With silica gel In benzene for 4h; Heating;	92%

: nickel(II) perchlorate hexahydrate

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: 108-00-9
N,N-dimethylethylenediamine

: bis[μ-3-[2-(dimethylamino)ethylimino]-3-phenylpropane-2-one oximato]dinickel(II) bis(perchlorate)

Conditions

Conditions	Yield
With triethyl amine In methanol soln. of diamine and monooxime in CH3OH stirred at room temp. for 1 h, Ni salt and Et3N added successively, mixt. stirred at room temp. for 1 h; evapn. in air, solid filtered off, recrystd. from CH3CN/CH2Cl2, dried under vac. over fused CaCl2; elem. anal.;	92%

...Expand

: 50-00-0
formaldehyd

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: 59-51-8
DL-methionine

: 126263-38-5
2-(4-Methyl-3-oxy-5-phenyl-imidazol-1-yl)-4-methylsulfanyl-butyric acid

Conditions

Conditions	Yield
In ethanol Heating;	87%

...Expand

: 98-88-4
benzoyl chloride

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: 28867-82-5
(E)-1-phenyl-2-(O-benzoyloxime)-1,2-propandione

Conditions

Conditions	Yield
	87%

: 59895-97-5
O,O-dipropyl thiophosphorohydrazide

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: O,O-dipropyl 2-(E)-(1-phenyl-2-oxopropylidene)-phosphorohydrazidothioate (E)-oxime

Conditions

Conditions	Yield
With anhydrous silica gel - Na2SO4 In acetonitrile for 2.8h; Reflux;	87%

: 61922-09-6
phosphorohydrazidic acid diisopropyl ester

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: O,O-diisopropyl 2-(E)-(1-phenyl-2-oxopropylidene)-phosphorohydrazide (E)-oxime

Conditions

Conditions	Yield
With anhydrous silica gel - Na2SO4 In acetonitrile for 2.75h; Reflux;	87%

: 61922-08-5
O,O-dipropylhydrazidophosphate

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: O,O-dipropyl 2-(E)-(1-phenyl-2-oxopropylidene)-phosphorohydrazide (E)-oxime

Conditions

Conditions	Yield
With anhydrous silica gel - Na2SO4 In acetonitrile for 2.6h; Reflux;	87%

: 33862-44-1
diphenyl phosphorohydrazidate

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: O,O-diphenyl 2-(E)-(1-phenyl-2-oxopropylidene)-phosphorohydrazide (E)-oxime

Conditions

Conditions	Yield
With anhydrous silica gel - Na2SO4 In acetonitrile for 3.25h; Reflux;	87%

: 50-00-0
formaldehyd

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: 56-40-6
glycine

: 126262-79-1
(4-Methyl-3-oxy-5-phenyl-imidazol-1-yl)-acetic acid

Conditions

Conditions	Yield
In ethanol Heating;	85%

...Expand

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: C19H24N3O3P

Conditions

Conditions	Yield
With silica gel In benzene for 3h; Heating;	85%

: 119300-90-2
O,O-diisopropyl phosphorohydrazidothioate

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: O,O-diisopropyl 2-(E)-(1-phenyl-2-oxopropylidene)-phosphorohydrazidothioate (E)-oxime

Conditions

Conditions	Yield
With anhydrous silica gel - Na2SO4 In acetonitrile for 3h; Reflux;	84%

: 50-00-0
formaldehyd

: 65-49-6
4-Aminosalicylic acid

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: 139325-72-7
2-Hydroxy-4-(4-methyl-3-oxy-5-phenyl-imidazol-1-yl)-benzoic acid

Conditions

Conditions	Yield
In ethanol Heating;	83%

...Expand

: 50-00-0
formaldehyd

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: 2835-06-5
phenylglycin

: 126263-54-5
(4-Methyl-3-oxy-5-phenyl-imidazol-1-yl)-phenyl-acetic acid

Conditions

Conditions	Yield
In ethanol Heating;	83%

...Expand

: 56183-69-8
phosphorohydrazidic acid diethyl ester

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: O,O-diethyl 2-(E)-(1-phenyl-2-oxopropylidene)-phosphorohydrazide (E)-oxime

Conditions

Conditions	Yield
With anhydrous silica gel - Na2SO4 In acetonitrile for 2.5h; Reflux;	83%

: methylidene(adamantyl-1-oxy)amine

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: 1-(adamantyl-1-oxy)-4-methyl-5-phenylimidazole 3-oxide

Conditions

Conditions	Yield
With acetic acid at 20℃;	83%

: 50-00-0
formaldehyd

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: 302-72-7
rac-Ala-OH

: 126262-92-8
2-(4-Methyl-3-oxy-5-phenyl-imidazol-1-yl)-propionic acid

Conditions

Conditions	Yield
In ethanol Heating;	81%

...Expand

: diphenyl(trifluoromethanesulfonato)-λ3-iodane

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: 2-(phenoxyimino)-1-phenylpropan-1-one

Conditions

Conditions	Yield
Stage #1: 1-phenyl-1,2-propanedione 2-oxime With potassium hydroxide In methanol at 25℃; for 0.0833333h; Stage #2: diphenyl(trifluoromethanesulfonato)-λ3-iodane In methanol at 25℃;	81%

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: 41939-99-5
1-phenyl-1,2-propanedione 2-oxime 1-hydrazone

Conditions

Conditions	Yield
With hydrazine hydrate In methanol for 27h;	80%
With hydrazine In ethanol

1-Phenyl-1,2-Propanedione-2-oxime Chemical Properties

Chemistry informtion about 1-Phenyl-1,2-Propanedione-2-oxime (119-51-7) is:
IUPAC Name: (2E)-2-hydroxyimino-1-phenylpropan-1-one , 2-hydroxyimino-1-phenylpropan-1-one
Synonyms: Propiophenone ; Alpha-isonitrosopropiophenone ; 1-phenyl-1,2-propanedione-2-oxime ; 2-isonitrosopropiophenone ; 2-hydroxyiminopropiophenone ; 2-phenyl-1 , 2-propanedione-2-oxime ; Timtec-bb Sbb003926
MF: C₉H₉NO₂
MW: 163.17
EINECS: 204-329-2
Melting Point: 113-115 °C(lit.)
Boiling Point: 292.5 °C at 760 mmHg
Flash Point: 130.7 °F
Density: 1.1 g/cm³
Enthalpy of Vaporization: 56.18 kJ/mol
Vapour Pressure: 0.000835 mmHg at 25°C
Following is the molecular structure of 1-Phenyl-1,2-Propanedione-2-oxime (119-51-7) is:

1-Phenyl-1,2-Propanedione-2-oxime Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	250mg/kg (250mg/kg)		National Technical Information Service. Vol. AD691-490,
rabbit	LD50	skin	> 4gm/kg (4000mg/kg)		Toxicology and Applied Pharmacology. Vol. 28, Pg. 313, 1974.
rat	LD50	oral	4240mg/kg (4240mg/kg)		Toxicology and Applied Pharmacology. Vol. 28, Pg. 313, 1974.

1-Phenyl-1,2-Propanedione-2-oxime Safety Profile

Hazard Codes:
Xn: Harmful
Risk Statements:
R20/21/22: Harmful by inhalation and in contact with skin,also Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements
S24/25: Avoid contact with skin and eyes.
S37/39: Wear suitable gloves and eye / face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 2
RTECS: UH2975000
HS Code: 29280090

1-Phenyl-1,2-Propanedione-2-oxime Specification

Description about 1-Phenyl-1,2-Propanedione-2-oxime (119-51-7) is:
First aid measures:
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Get medical aid. Wash mouth out with water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to physician: Treat symptomatically and supportively.
Handling and Storage:
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Store in a tightly closed container.

Product Name

1-Phenyl-1,2-propanedione-2-oxime

Synthetic route

1-Phenyl-1,2-Propanedione-2-oxime Chemical Properties

1-Phenyl-1,2-Propanedione-2-oxime Toxicity Data With Reference

1-Phenyl-1,2-Propanedione-2-oxime Safety Profile

1-Phenyl-1,2-Propanedione-2-oxime Specification

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