5-AMINO-1,3-DIPHENYLPYRAZOLE

The 1H-Pyrazol-5-amine,1,3-diphenyl-, with the CAS registry number 5356-71-8, is also known as 2,5-Diphenyl-2H-pyrazol-3-ylamine. This chemical's molecular formula is C₁₅H₁₃N₃ and molecular weight is 235.2838. What's more, its systematic name is called 1,3-Diphenyl-1H-pyrazol-5-amine. Its classification code is Drug / Therapeutic Agent.

Physical properties about this chemical are: (1)ACD/LogP: 2.71; (2)#of Rule of 5 Violations: 0; (3)#H bond acceptors: 3; (4)#H bond donors: 2; (5)#Freely Rotating Bonds: 3; (6)Polar Surface Area: 21.06Ų; (7)Index of Refraction: 1.646; (8)Molar Refractivity: 72.95 cm³; (9)Molar Volume: 200.8 cm³; (10)Surface Tension: 48.5 dyne/cm; (11)Density: 1.17 g/cm³; (12)Flash Point: 228.4 °C; (13)Enthalpy of Vaporization: 71.35 kJ/mol; (14)Boiling Point: 454 °C at 760 mmHg; (15)Vapour Pressure: 1.98E-08 mmHg at 25 °C; (16)Melting Point: 129-132 °C.

Preparation of 1H-Pyrazol-5-amine,1,3-diphenyl-: this chemical can be prepared by Phenylpropynenitrile and Phenylhydrazine.

This reaction will occur at temperature of 80 °C for 5 min. The yield is 88%.

Uses of 1H-Pyrazol-5-amine,1,3-diphenyl-: it is used to produce other chemicals. For example, it is used to produce N-(2,5-Diphenyl-2H-pyrazol-3-yl)-acetamide. The yield is 81%.

When you are dealing with this chemical, you should be very careful. This chemical is irritating to eyes, respiratory system and skin. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. And in case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: n1c(cc(n1c2ccccc2)N)c3ccccc3
(2) InChI: InChI=1/C15H13N3/c16-15-11-14(12-7-3-1-4-8-12)17-18(15)13-9-5-2-6-10-13/h1-11H,16H2
(3) InChIKey: SXOFMEWDEKEVJU-UHFFFAOYAW

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LDLo	intraperitoneal	315mg/kg (315mg/kg)		Farmakologiya i Toksikologiya Vol. 27, Pg. 295, 1964. Link to PubMed