triethylene glucol monomethyl ether
2-[2-(2-methoxyethoxy)etoxy]acetic acid
Conditions | Yield |
---|---|
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydrogencarbonate; sodium carbonate at 20℃; Electrochemical reaction; | 99% |
Stage #1: triethylene glucol monomethyl ether With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium carbonate at 20℃; for 2h; aq. buffer; Electroliysis; Stage #2: With Amberlite IR 120 for 0.5h; Mechanism; Solvent; Temperature; aq. buffer; | 99% |
Stage #1: triethylene glucol monomethyl ether With C29H44Cl2N2Ru; sodium hydroxide In water for 24h; Reflux; Stage #2: With hydrogenchloride In water | 88% |
Conditions | Yield |
---|---|
With diethyl ether |
bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]acetoxy}ethoxy)ethoxy]ethyl ester
A
2-[2-(2-methoxyethoxy)etoxy]acetic acid
B
bicyclo[2.2.1]hept-2-ene-5-carbonyl chloride
C
2,2'-[1,2-ethanediylbis(oxy)]bisethanol
Conditions | Yield |
---|---|
With phosphate-buffered saline at 80℃; pH=7.4; Kinetics; Further Variations:; pH-values; Temperatures; |
triethylene glucol monomethyl ether
2-[2-(2-methoxyethoxy)etoxy]acetic acid
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydrogencarbonate In water |
p-nitrophenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate
A
4-nitro-phenol
B
2-[2-(2-methoxyethoxy)etoxy]acetic acid
Conditions | Yield |
---|---|
With 6-{N-[6-(6-deoxy-α-cyclodextrinylthio)acetyl]-L-histidylamino}-6-deoxy-β-cyclodextrin at 25℃; pH=7.4; Kinetics; aq. phosphate buffer; |
m-nitrophenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate
A
2-[2-(2-methoxyethoxy)etoxy]acetic acid
B
meta-nitrophenol
Conditions | Yield |
---|---|
With 6-{N-[6-(6-deoxy-α-cyclodextrinylthio)acetyl]-L-histidylamino}-6-deoxy-β-cyclodextrin at 25℃; pH=7.4; Kinetics; aq. phosphate buffer; |
2-[2-(2-methoxyethoxy)etoxy]acetic acid
Conditions | Yield |
---|---|
With methoxybenzene; trifluoroacetic acid In dichloromethane at 20℃; for 5h; | |
With methoxybenzene; trifluoroacetic acid In dichloromethane at 20℃; for 5h; | |
With trifluoroacetic acid In dichloromethane at 20℃; | 400 mg |
2-(2-methoxyethoxy)ethyl alcohol
2-[2-(2-methoxyethoxy)etoxy]acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium tert-butylate / tert-butyl alcohol / 2 h / 20 °C 1.2: 12 h / 20 °C 2.1: trifluoroacetic acid; methoxybenzene / dichloromethane / 5 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydride / tetrahydrofuran / 3 h / 20 - 25 °C / Cooling with ice 2: trifluoroacetic acid / dichloromethane / 20 °C View Scheme |
2-[2-(2-methoxyethoxy)etoxy]acetic acid
N-(fluoren-9-ylmethoxycarbonyl)glycine
[2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-acetylamino)-acetylamino]-acetic acid
Conditions | Yield |
---|---|
Stage #1: N-(fluoren-9-ylmethoxycarbonyl)glycine With N-ethyl-N,N-diisopropylamine In dichloromethane solid phase reaction; Stage #2: With piperidine In N,N-dimethyl-formamide solid phase reaction; Stage #3: 2-[2-(2-methoxyethoxy)etoxy]acetic acid Further stages; | 100% |
2-[2-(2-methoxyethoxy)etoxy]acetic acid
Conditions | Yield |
---|---|
In toluene | 100% |
2-[2-(2-methoxyethoxy)etoxy]acetic acid
2,3,4,5,6-pentafluorophenol
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 6h; | 99% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 6h; | 50% |
tributylphosphine
2-[2-(2-methoxyethoxy)etoxy]acetic acid
Conditions | Yield |
---|---|
With triethylamine In acetonitrile byproducts: H2; Electrolysis; (Ar); Cu electrodes used; at 4.0 V at 40°C for 1 h and at 2.0 V for 4 h; evapd. (vac.); obtained as an oil; elem. anal.; | 98% |
Conditions | Yield |
---|---|
With dmap In N,N-dimethyl-formamide for 4h; Reflux; | 95% |
2-[2-(2-methoxyethoxy)etoxy]acetic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 60h; | 94.7% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 60h; |
Conditions | Yield |
---|---|
With dmap In N,N-dimethyl-formamide for 4h; Reflux; | 94% |
2-octyldodecan-1-ol
2-[2-(2-methoxyethoxy)etoxy]acetic acid
Conditions | Yield |
---|---|
With p-toluenesulfonic acid monohydrate | 94% |
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 4h; | 94% |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere; | 94% |
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; ethyl cyanoglyoxylate-2-oxime In N,N-dimethyl-formamide | 93% |
Conditions | Yield |
---|---|
92% |
2-[2-(2-methoxyethoxy)etoxy]acetic acid
m-phenylenediamine
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 12h; | 92% |
2-[2-(2-methoxyethoxy)etoxy]acetic acid
benzyl (2α,3β)-2,3-dihydroxy-olean-12-en-28-oate
Conditions | Yield |
---|---|
With dmap In N,N-dimethyl-formamide for 4h; Reflux; | 92% |
(S)-(+)-2-amino-2-methyl-3-hydroxypropanoic acid
2-[2-(2-methoxyethoxy)etoxy]acetic acid
Conditions | Yield |
---|---|
Stage #1: 2-[2-(2-methoxyethoxy)etoxy]acetic acid; 2-((tert-butyldiphenylsilyl)oxy)propanoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.166667h; Stage #2: (S)-(+)-2-amino-2-methyl-3-hydroxypropanoic acid With triethylamine In dichloromethane at 23℃; for 18h; | 92% |
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 4h; | 91% |
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 4h; | 91% |
2-[2-(2-methoxyethoxy)etoxy]acetic acid
2-(2-(2-methoxyethoxy)ethoxy)acetyl chloride
Conditions | Yield |
---|---|
With oxalyl dichloride In toluene at 65℃; for 4h; | 90% |
With thionyl chloride | 80% |
With thionyl chloride; benzene |
1-hydroxy-pyrrolidine-2,5-dione
2-[2-(2-methoxyethoxy)etoxy]acetic acid
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In tetrahydrofuran for 16h; cooling; | 90% |
2-[2-(2-methoxyethoxy)etoxy]acetic acid
Conditions | Yield |
---|---|
With dmap In N,N-dimethyl-formamide for 4h; Reflux; | 90% |
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 4h; | 89% |
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 4h; | 89% |
2-[2-(2-methoxyethoxy)etoxy]acetic acid
methyl 6-amino-2-naphthoate
C19H23NO6
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 1h; | 88% |
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 4h; | 88% |
2-[2-(2-methoxyethoxy)etoxy]acetic acid
[2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-acetylamino)-acetylamino]-acetic acid benzyl ester
Conditions | Yield |
---|---|
Stage #1: 2-[2-(2-methoxyethoxy)etoxy]acetic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h; Stage #2: triglycine benzyl ester toluenesulfonic acid salt With triethylamine In dichloromethane at 20℃; | 86% |
2-[2-(2-methoxyethoxy)etoxy]acetic acid
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide; dmap In dichloromethane at 20℃; for 0.5h; | 86% |
4-nitro-phenol
2-[2-(2-methoxyethoxy)etoxy]acetic acid
p-nitrophenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In tetrahydrofuran at 0℃; | 86% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2h; | 86% |
2-[2-(2-methoxyethoxy)etoxy]acetic acid
C19H19F13N2O6
N-[2-(benzyloxycarbonyl)aminoethyl]-N-(1H,1H,2H,2H,4H,4H-3,6,9,12-tetraoxaperfluorotridecyl)-2-[2-(2-methoxyethoxy)ethoxy]acetamide
Conditions | Yield |
---|---|
With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 0 - 20℃; for 19h; | 84% |
The Acetic acid,2-[2-(2-methoxyethoxy)ethoxy]- is an organic compound with the formula C7H14O5. The IUPAC name of this chemical is 2-[2-(2-Methoxyethoxy)ethoxy]acetic acid. With the CAS registry number 16024-58-1, it is also named as (2-(2-Methoxyethoxy)ethoxy)essigsure. The product's category is Heterocyclic Compounds. Besides, it should be stored in a cool, sealed, dry place.
Physical properties about Acetic acid,2-[2-(2-methoxyethoxy)ethoxy]- are: (1)ACD/LogP: -1.38; (2)ACD/LogD (pH 5.5): -3.48; (3)ACD/LogD (pH 7.4): -4.93; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 5; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 8; (11)Polar Surface Area: 53.99 Å2; (12)Index of Refraction: 1.436; (13)Molar Refractivity: 41.27 cm3; (14)Molar Volume: 157.7 cm3; (15)Polarizability: 16.36×10-24 cm3; (16)Surface Tension: 37.8 dyne/cm; (17)Density: 1.129 g/cm3; (18)Flash Point: 116.7 °C; (19)Enthalpy of Vaporization: 58.84 kJ/mol; (20)Boiling Point: 295.2 °C at 760 mmHg; (21)Vapour Pressure: 0.000376 mmHg at 25 °C.
Preparation: this chemical can be prepared by 2-[2-(2-Methoxy-ethoxy)-ethoxy]-ethanol. This reaction will need reagents Potassium hydroxide; Potassium permanganate, and solvent H2O. The reaction time is 12 hours. The yield is about 75%.
Uses of Acetic acid,2-[2-(2-methoxyethoxy)ethoxy]-: it can be used to produce 2-{2-[2-(2-Methoxy-ethoxy)-ethoxy]-acetylamino}-pentanedioic acid bis-octylamide. It will need reagents Et3N; Benzotriazole-1-yl-oxy-tris(dimethylamino)-phosphoniumhexafluorophosphate and solvent Acetone with reaction time of 12 hours. The yield is about 65%.
When you are using this chemical, please be cautious about it as the following:
It causes burns. When you are using it, wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).
You can still convert the following datas into molecular structure:
(1)InChI: InChI=1/C7H14O5/c1-10-2-3-11-4-5-12-6-7(8)9/h2-6H2,1H3,(H,8,9)
(2)InChIKey: YHBWXWLDOKIVCJ-UHFFFAOYAS
(3)Std. InChI: InChI=1S/C7H14O5/c1-10-2-3-11-4-5-12-6-7(8)9/h2-6H2,1H3,(H,8,9)
(4)Std. InChIKey: YHBWXWLDOKIVCJ-UHFFFAOYSA-N
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