Product Name

  • Name

    2-(2-ETHOXYPHENYL)-5-METHYL-7-PROPYL-3H-IMIDAZOL[5,1-F][1,2,4]-TRIAZIN-4-ONE

  • EINECS 607-089-0
  • CAS No. 224789-21-3
  • Article Data9
  • CAS DataBase
  • Density 1.266 g/cm3
  • Solubility 6.9mg/L at 20℃
  • Melting Point 198-200 °C
  • Formula C17H20N4O2
  • Boiling Point 519.699 °C at 760 mmHg
  • Molecular Weight 312.371
  • Flash Point 268.105 °C
  • Transport Information
  • Appearance Pale yellow solid
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 224789-21-3 (2-(2-ETHOXYPHENYL)-5-METHYL-7-PROPYL-3H-IMIDAZOL[5,1-F][1,2,4]-TRIAZIN-4-ONE)
  • Hazard Symbols
  • Synonyms 2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one;
  • PSA 72.28000
  • LogP 2.74420

Synthetic route

N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}butyroamide
927690-90-2

N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}butyroamide

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
With trichlorophosphate In toluene for 2h; Reflux;78%
With trichlorophosphate
With trichlorophosphate In 1,2-dichloro-ethane for 2h; Reflux;
With trichlorophosphate In 1,2-dichloro-ethane for 2h; Reflux;
3-(2-ethoxy-benzoylamino)-5-methyl-2-propyl-3H-imidazole-4-carboxamide
865444-90-2

3-(2-ethoxy-benzoylamino)-5-methyl-2-propyl-3H-imidazole-4-carboxamide

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol at 160℃; for 30h;72%
With potassium tert-butylate In tert-butyl alcohol at 160℃; for 30h; Sealed tube;72%
5-methyl-2-propyl-3H-imidazole-4-carboxamide
865444-88-8

5-methyl-2-propyl-3H-imidazole-4-carboxamide

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: lithium hexamethyldisilazane / dimethylformamide; tetrahydrofuran / 0.17 h / -10 °C
1.2: 41 percent / Ph2P(O)ONH2 / tetrahydrofuran; dimethylformamide / 20 °C
2.1: 52 percent / pyridine / 2 h / 60 °C
3.1: 72 percent / KOtBu / 2-methyl-propan-2-ol / 30 h / 160 °C
View Scheme
3-amino-5-methyl-2-propyl-3H-imidazole-4-carboxamide
865444-89-9

3-amino-5-methyl-2-propyl-3H-imidazole-4-carboxamide

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 52 percent / pyridine / 2 h / 60 °C
2: 72 percent / KOtBu / 2-methyl-propan-2-ol / 30 h / 160 °C
View Scheme
ethyl 5-methyl-2-propyl-3H-imidazole-4-carboxylate
146650-89-7

ethyl 5-methyl-2-propyl-3H-imidazole-4-carboxylate

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 53 percent / ammonium hydroxide / 24 h / 130 °C
2.1: lithium hexamethyldisilazane / dimethylformamide; tetrahydrofuran / 0.17 h / -10 °C
2.2: 41 percent / Ph2P(O)ONH2 / tetrahydrofuran; dimethylformamide / 20 °C
3.1: 52 percent / pyridine / 2 h / 60 °C
4.1: 72 percent / KOtBu / 2-methyl-propan-2-ol / 30 h / 160 °C
View Scheme
2-butyrylaminopropionic acid
59875-04-6

2-butyrylaminopropionic acid

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Py; DMAP
2: POCl3
View Scheme
Multi-step reaction with 3 steps
1.1: dmap; pyridine / tetrahydrofuran / 4 h / Reflux
2.1: hydrazine hydrate / ethanol / 20 °C
2.2: 3.25 h / Reflux
3.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: dmap; pyridine / tetrahydrofuran / 4 h / Reflux
2: ethanol / 3 h / Reflux
3: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
View Scheme
2-ethoxybenzonitrile
6609-57-0

2-ethoxybenzonitrile

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: AlMeClNH2
2: N2H4
3: POCl3
View Scheme
Multi-step reaction with 3 steps
1.1: trimethylaluminum; ammonium chloride / toluene / 7 h / 0 - 80 °C
2.1: hydrazine hydrate / ethanol / 20 °C
2.2: 3.25 h / Reflux
3.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: amino(methyl)aluminum chloride / toluene / 6 h / 80 °C
2.1: hydrazine hydrate / ethanol / 20 °C
2.2: Reflux
3.1: ethanol / 3 h / Reflux
4.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
View Scheme
2-ethoxy-benzamidine hydrochloride
18637-00-8

2-ethoxy-benzamidine hydrochloride

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N2H4
2: POCl3
View Scheme
ethyl 3-butyramido-2-oxobutyrate
68282-26-8

ethyl 3-butyramido-2-oxobutyrate

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: POCl3
View Scheme
Multi-step reaction with 2 steps
1.1: hydrazine hydrate / ethanol / 20 °C
1.2: 3.25 h / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: ethanol / 3 h / Reflux
2: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
View Scheme
2-ethoxybenzimidohydrazide
889943-46-8

2-ethoxybenzimidohydrazide

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: POCl3
View Scheme
Multi-step reaction with 2 steps
1: ethanol / 3 h / Reflux
2: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
View Scheme
C9H13N3O*ClH

C9H13N3O*ClH

ethyl 3-butyramido-2-oxobutyrate
68282-26-8

ethyl 3-butyramido-2-oxobutyrate

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Stage #1: C9H13N3O*ClH; ethyl 3-butyramido-2-oxobutyrate In ethanol at 70℃; for 4h;
Stage #2: With trichlorophosphate In 1,2-dichloro-ethane for 2h; Heating / reflux;
2-butyrylaminopropionic acid
59875-04-6

2-butyrylaminopropionic acid

2-ethoxy-benzamidine hydrochloride
18637-00-8

2-ethoxy-benzamidine hydrochloride

Ethyl oxalyl chloride
4755-77-5

Ethyl oxalyl chloride

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
With pyridine; sodium hydrogencarbonate; hydrazine hydrate; trichlorophosphate In tetrahydrofuran; ethanol; ethyl acetate; 1,2-dichloro-ethane4.00 g (28%)
...Expand
3-(2-ethoxyphenyl)-6-ethyl-4H-[1,2,4]triazin-5-one
1417529-52-2

3-(2-ethoxyphenyl)-6-ethyl-4H-[1,2,4]triazin-5-one

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 14 h / Reflux; Inert atmosphere
2.1: ammonia / tetrahydrofuran / 20 °C
3.1: tertiary amine / dichloromethane / 0.08 h / Cooling
3.2: 1.17 h / 0 - 20 °C
4.1: trichlorophosphate / toluene / 2 h / Reflux
View Scheme
6-(1-bromoethyl)-3-(2-ethoxyphenyl)-4H-[1,2,4]triazin-5-one
1417529-54-4

6-(1-bromoethyl)-3-(2-ethoxyphenyl)-4H-[1,2,4]triazin-5-one

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ammonia / tetrahydrofuran / 20 °C
2.1: tertiary amine / dichloromethane / 0.08 h / Cooling
2.2: 1.17 h / 0 - 20 °C
3.1: trichlorophosphate / toluene / 2 h / Reflux
View Scheme
C13H16N4O2
1417529-56-6

C13H16N4O2

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tertiary amine / dichloromethane / 0.08 h / Cooling
1.2: 1.17 h / 0 - 20 °C
2.1: trichlorophosphate / toluene / 2 h / Reflux
View Scheme
2-Ethoxybenzamidine
53623-81-7

2-Ethoxybenzamidine

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrazine hydrate / ethanol / 20 °C
1.2: 3.25 h / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: hydrazine hydrate / ethanol / 20 °C
1.2: Reflux
2.1: ethanol / 3 h / Reflux
3.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
View Scheme
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenelsulfonic acid chloride
224789-26-8

4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenelsulfonic acid chloride

Conditions
ConditionsYield
With chlorosulfonic acid at 0 - 20℃;91%
With chlorosulfonic acid for 12h; Cooling with ice;76%
With chlorosulphuric acid for 12h; Cooling with ice;76%
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

2-(2-ethoxy-5-iodo-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4(3H)-one

2-(2-ethoxy-5-iodo-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4(3H)-one

Conditions
ConditionsYield
With N-iodo-succinimide; trifluoroacetic acid at 0 - 20℃;79%
With N-iodo-succinimide; trifluoroacetic acid at 0 - 20℃;79%
With N-iodo-succinimide In trifluoroacetic acid at 0 - 20℃;71%
With N-iodo-succinimide; trifluoroacetic acid at 0 - 20℃;
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

2-(2-ethoxy)-phenyl-5-methyl-7-n-propyl-3H-imidazolo[5,1-f][1,2,4]triazine-4-thione

2-(2-ethoxy)-phenyl-5-methyl-7-n-propyl-3H-imidazolo[5,1-f][1,2,4]triazine-4-thione

Conditions
ConditionsYield
Stage #1: 2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one With pyridine; diphosphorus pentasulfide In toluene for 6h; Reflux;
Stage #2: With ammonia; water In ethanol for 0.5h; Reflux;		72%
With pyridine; tetraphosphorus decasulfide for 6h; Reflux;72%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

vardenafil
224785-90-4

vardenafil

Conditions
ConditionsYield
Stage #1: 2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one With chlorosulfonic acid at 0 - 22℃; for 0.75h;
Stage #2: 4-ethylpiperazine In dichloromethane at -3 - 25℃; for 0.75h; Product distribution / selectivity;
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

citric acid
77-92-9

citric acid

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

vardenafil citrate
1193386-64-9

vardenafil citrate

Conditions
ConditionsYield
Stage #1: 2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one With chlorosulfonic acid at -5 - 20℃;
Stage #2: 4-ethylpiperazine With sodium hydroxide In tetrahydrofuran; water at 15℃; pH=9 - 9.5;
Stage #3: citric acid In tetrahydrofuran at 50 - 70℃;
...Expand
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

vardenafil
224785-90-4

vardenafil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: chlorosulfonic acid / -5 - 20 °C
1.2: 15 °C / pH 9 - 9.5
1.3: 50 - 70 °C
2.1: sodium hydroxide / water / pH 9 - 10
View Scheme
Multi-step reaction with 2 steps
1: chlorosulfonic acid / 0 - 5 °C
2: dichloromethane / 25 - 30 °C
View Scheme
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

2-[2-ethoxy-5-(4-ethyl-piperazine-1-sulphonyl)-phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one hydrochloride

2-[2-ethoxy-5-(4-ethyl-piperazine-1-sulphonyl)-phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: chlorosulfonic acid / -5 - 20 °C
1.2: 15 °C / pH 9 - 9.5
1.3: 50 - 70 °C
2.1: sodium hydroxide / water / pH 9 - 10
3.1: hydrogenchloride / water; acetone
View Scheme
Multi-step reaction with 3 steps
1: chlorosulfonic acid / 0 - 5 °C
2: dichloromethane / 25 - 30 °C
3: hydrogenchloride; water / acetone
View Scheme
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

2,2'-[(piperazine-1,4-disulfonyl)bis(2-ethoxy-5,1-phenylene)]-bis[5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one]
1255919-03-9

2,2'-[(piperazine-1,4-disulfonyl)bis(2-ethoxy-5,1-phenylene)]-bis[5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one]

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: chlorosulfonic acid / 0 - 5 °C
2: triethylamine / dichloromethane / 0.5 h / 25 - 30 °C
View Scheme
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

N-{[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f]-1,2,4-triazin-2-yl) phenyl]sulfonyl}glycene
448184-54-1

N-{[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f]-1,2,4-triazin-2-yl) phenyl]sulfonyl}glycene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: chlorosulfonic acid / 0 - 5 °C
2.1: sodium hydroxide / water / 0.5 h / 25 - 30 °C
2.2: 2.5 h / 2 - 20 °C
View Scheme
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

C19H26N6O4S
448184-52-9

C19H26N6O4S

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: chlorosulfonic acid / 0 - 5 °C
2: dichloromethane / 1.33 h / 2 °C
View Scheme
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

{[2-({[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f]-1,2,4-triazin-2-yl)phenyl]sulfonyl}amino)ethyl]amino}(oxo)acetic acid
448184-56-3

{[2-({[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f]-1,2,4-triazin-2-yl)phenyl]sulfonyl}amino)ethyl]amino}(oxo)acetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: chlorosulfonic acid / 0 - 5 °C
2: dichloromethane / 1.33 h / 2 °C
3: triethylamine / 0.25 h / 25 - 30 °C
4: water; sodium hydroxide / methanol / 0.25 h / 25 °C
View Scheme
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

C23H30N6O7S

C23H30N6O7S

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: chlorosulfonic acid / 0 - 5 °C
2: dichloromethane / 1.33 h / 2 °C
3: triethylamine / 0.25 h / 25 - 30 °C
View Scheme
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

2-{2-ethoxy-5-[(4-ethyl-4-hydroxy-4λ5-piperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propyl imidazo-[5,1-f]-1,2,4-triazin-4(3H)-one N-oxide
448184-48-3

2-{2-ethoxy-5-[(4-ethyl-4-hydroxy-4λ5-piperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propyl imidazo-[5,1-f]-1,2,4-triazin-4(3H)-one N-oxide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: chlorosulfonic acid / 0 - 5 °C
2: dichloromethane / 25 - 30 °C
3: peracetic acid / dichloromethane / 2 h / 0 - 5 °C
View Scheme
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

2-{2-ethoxy-5-[(3-oxo-1-piperazinyl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f]-1,2,4-triazin-4(3H)-one
448184-58-5

2-{2-ethoxy-5-[(3-oxo-1-piperazinyl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f]-1,2,4-triazin-4(3H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: chlorosulfonic acid / 0 - 5 °C
2: dichloromethane / 0.5 h / 25 - 30 °C
View Scheme
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
224789-21-3

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

vardenafil hydrochloride

vardenafil hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: chlorosulfonic acid / dichloromethane / 24 h / 23 - 90 °C
2: dichloromethane
3: hydrogenchloride / water; acetone / 50 °C
View Scheme

2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one Chemical Properties


Systematic Name: 2-(2-Ethoxyphenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one
SMILES: O=C2/N=C(\Nn1c(nc(c12)C)CCC)c3ccccc3OCC
InChI: InChI=1/C17H20N4O2/c1-4-8-14-18-11(3)15-17(22)19-16(20-21(14)15)12-9-6-7-10-13(12)23-5-2/h6-7,9-10H,4-5,8H2,1-3H3,(H,19,20,22)
InChIKey: YRRWQMBIMZMVDB-UHFFFAOYAC 
Empirical Formula: C17H20N4O2
Molecular Weight: 312.3663
Nominal Mass: 312
Average Mass: 312.3663
Monoisotopic Mass: 312.158626
H bond acceptors: 6
H bond donors: 1
Freely Rotating Bonds: 5
Index of Refraction: 1.632
Molar Refractivity: 88.049 cm3
Molar Volume: 246.814 cm3
Surface Tension: 45.786 dyne/cm
Density: 1.266 g/cm3
Flash Point: 268.105 °C
Enthalpy of Vaporization: 79.252 kJ/mol
Boiling Point: 519.699 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25 °C 
Appearance: Pale Yellow Solid
Melting Point: 198-200 °C
Product Categories of 2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one (CAS NO.224789-21-3): Heterocyclic Compounds; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals

2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one Uses

  2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one (CAS NO.224789-21-3) is used as vardenafil intermediate.

2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one Specification

 2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one (CAS NO.224789-21-3), its Synonyms are 2-(2-Ethoxyphenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4-ol ; Imidazo[5,1-f][1,2,4]triazin-4(1H)-one, 2-(2-ethoxyphenyl)-5-methyl-7-propyl- ; 2-(2-Ethoxyphenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one .

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