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Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE

Cas:101987-86-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

3-Chloro-2,4,5-trifluoro-b-oxo-benzenepropanoic acid, ethyl ester

Cas:101987-86-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Intermediate Of Sitafloxacin supplier in China

Cas:101987-86-4

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Intermediate Of Sitafloxacin

Cas:101987-86-4

Min.Order:1

Negotiable

Type:Other

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE

Cas:101987-86-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Ethyl 3-chloro-2,4,5-trifluorobenzoylacetate

Cas:101987-86-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE101987-86-4

Cas:101987-86-4

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Density: 1.413 Melting point: 80-83 ℃ Boiling point: 325 ℃ Flash point: 130 ℃ Steam pressure: 0mmHg at 25 ° C Refractive index: 1.484 Acidity coefficient: 10.32 ± 0.50 (Predicted) Appearance:White powder Storage:Sealed in dry,Room Tempera

ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE 101987-86-4

Cas:101987-86-4

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 101987-86-4 with competitive price

Cas:101987-86-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzenepropanoic acid,3-chloro-2,4,5-trifluoro-b-oxo-, ethyl ester 101987-86-4

Cas:101987-86-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE CAS:8101987-86-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, spe

ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE CAS:8101987-86-4

Cas:101987-86-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzenepropanoic acid,3-chloro-2,4,5-trifluoro-b-oxo-, ethyl ester

Cas:101987-86-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzenepropanoic acid,3-chloro-2,4,5-trifluoro-b-oxo-, ethyl ester

Cas:101987-86-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

ethyl 3-(3-chloro-2,4,5-trifluorophenyl)-3-oxopropanoate

Cas:101987-86-4

Min.Order:1 Kilogram

FOB Price: $10.0 / 20.0

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:Off-white to white solid powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:By Sea/Air/Courier Port:

DFSX-2 intermediates|Ethyl 3-chloro-2,4,5-trifluorobenzoylacetate

Cas:101987-86-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE

Cas:101987-86-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE

Cas:101987-86-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

3-(3-Chloro-2,4,5-trifluoro-phenyl)-3-oxo-propionic acid ethyl ester

Cas:101987-86-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzenepropanoic acid,3-chloro-2,4,5-trifluoro-b-oxo-, ethyl ester

Cas:101987-86-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Send Pharmaceutical Technology Co., Ltd.

low price high quality high purity good sevice stock Appearance:white Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:Pharmaceutical interme

ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE

Cas:101987-86-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Intermediate Of Sitafloxacin

Cas:101987-86-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE

Cas:101987-86-4

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE

Cas:101987-86-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Ethyl 3-Chloro-2,4,5-Trifluorobenzoylacetate CAS No.:101987-86-4 Molecule Formula:C11H8ClF3O3 Molecule Weight:280.62 Purity: 99% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard

High Quality Ethyl 3-Chloro-2,4,5-Trifluorobenzoylacetate in stock

Cas:101987-86-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE

Cas:101987-86-4

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

Compound C

Cas:101987-86-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE

Cas:101987-86-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE

Cas:101987-86-4

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Benzenepropanoic acid,3-chloro-2,4,5-trifluoro-b-oxo-, ethyl ester

Cas:101987-86-4

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

ethyl potassium malonate
6148-64-7

ethyl potassium malonate

3-Chloro-2,4,5-trifluorobenzoyl chloride
101513-78-4

3-Chloro-2,4,5-trifluorobenzoyl chloride

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

Conditions
ConditionsYield
With triethylamine; magnesium chloride 1.) MeCN, 20 to 25 deg C, 2.5 h, 2.) 20 to 25 deg C, 12 h; Yield given. Multistep reaction;
dipyridyl

dipyridyl

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

3-Chloro-2,4,5-trifluorobenzoyl chloride
101513-78-4

3-Chloro-2,4,5-trifluorobenzoyl chloride

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

Conditions
ConditionsYield
With hydrogenchloride; n-butyllithium In tetrahydrofuran
With hydrogenchloride; n-butyllithium In tetrahydrofuran
3-Chloro-2,4,5-trifluorobenzoic acid
101513-77-3

3-Chloro-2,4,5-trifluorobenzoic acid

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 4 h / Reflux
2.1: magnesium / tetrachloromethane; ethanol / 3.25 h / Reflux
2.2: 2.33 h / -10 °C
3.1: toluene-4-sulfonic acid / water / 5 h / Reflux
View Scheme
3-Chloro-2,4,5-trifluorobenzoyl chloride
101513-78-4

3-Chloro-2,4,5-trifluorobenzoyl chloride

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: magnesium / tetrachloromethane; ethanol / 3.25 h / Reflux
1.2: 2.33 h / -10 °C
2.1: toluene-4-sulfonic acid / water / 5 h / Reflux
View Scheme
C14H12ClF3O5

C14H12ClF3O5

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In water for 5h; Reflux;
(1R,2S)-2-fluorocyclopropylamine p-toluenesulfonic acid salt
143062-84-4

(1R,2S)-2-fluorocyclopropylamine p-toluenesulfonic acid salt

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

(Z)-ethyl 2-(3-chloro-2,4,5-trifluorobenzoyl)-3-[{(1R,2S)-2-fluorocyclopropyl}amino]acrylate

(Z)-ethyl 2-(3-chloro-2,4,5-trifluorobenzoyl)-3-[{(1R,2S)-2-fluorocyclopropyl}amino]acrylate

Conditions
ConditionsYield
Stage #1: ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate; orthoformic acid triethyl ester With acetic anhydride at 110 - 120℃; for 1.5h;
Stage #2: (1R,2S)-2-fluorocyclopropylamine p-toluenesulfonic acid salt With triethylamine; trifluoroacetic acid In dichloromethane at 20℃; for 1h;
78%
ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

tert-butyl (5-amino-2,4-difluorophenyl)carbamate
179741-60-7

tert-butyl (5-amino-2,4-difluorophenyl)carbamate

methyl iodide
74-88-4

methyl iodide

Ethyl 3-ethoxy-2-(3'-chloro-2',4',5'-trifluorobenzoyl)acrylate

Ethyl 3-ethoxy-2-(3'-chloro-2',4',5'-trifluorobenzoyl)acrylate

Conditions
ConditionsYield
With potassium carbonate In ethanol; chloroform; water; N,N-dimethyl-formamide
3,5-diamino-2-chloropyridine
5632-81-5

3,5-diamino-2-chloropyridine

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

ethyl 3-[(5-amino-6-chloropyridin-3-yl)amino]-2-(3-chloro-2,4,5-trifluorobenzoyl)acrylate

ethyl 3-[(5-amino-6-chloropyridin-3-yl)amino]-2-(3-chloro-2,4,5-trifluorobenzoyl)acrylate

Conditions
ConditionsYield
With acetic anhydride In ethanol; chloroform; toluene
N-tert-butoxycarbonyl-2,4-difluoro-m-phenylenediamine
208166-48-7

N-tert-butoxycarbonyl-2,4-difluoro-m-phenylenediamine

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

formic acid ethyl ester
109-94-4

formic acid ethyl ester

ethyl 1-(5-tert-butoxycarbonylamino-2,4-difluorophenyl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
197520-73-3

ethyl 1-(5-tert-butoxycarbonylamino-2,4-difluorophenyl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Conditions
ConditionsYield
With acetic anhydride; potassium carbonate In chloroform methanol; hexane; chloroform; N,N-dimethyl-formamide
Ethyl 3-ethoxy-2-(3'-chloro-2',4',5'-trifluorobenzoyl)acrylate

Ethyl 3-ethoxy-2-(3'-chloro-2',4',5'-trifluorobenzoyl)acrylate

2-Amino-3,5,6-trifluoropyridine
3534-50-7

2-Amino-3,5,6-trifluoropyridine

ethanolamine
141-43-5

ethanolamine

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

ethyl 8-Chloro-6,7-difluoro-1-[3,5-difluoro-6-(2-hydroxyethylamino)pyridin-2-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylate

ethyl 8-Chloro-6,7-difluoro-1-[3,5-difluoro-6-(2-hydroxyethylamino)pyridin-2-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylate

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one; potassium carbonate In ethanol; chloroform; water; N,N-dimethyl-formamide
4-fluoro-3-methoxyaniline
64465-53-8

4-fluoro-3-methoxyaniline

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

ethyl 8-chloro-6,7-difluoro-1-(4-fluoro-3-methoxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate
208166-16-9

ethyl 8-chloro-6,7-difluoro-1-(4-fluoro-3-methoxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

Conditions
ConditionsYield
With potassium carbonate In ethanol; chloroform; water; N,N-dimethyl-formamide
ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

ethyl 2-(3-chloro-2,4,5-trifluorobenzoyl)-3-ethoxyacrylate

ethyl 2-(3-chloro-2,4,5-trifluorobenzoyl)-3-ethoxyacrylate

Conditions
ConditionsYield
With acetic anhydride
With acetic anhydride
3-aminoisoxazole
1750-42-1

3-aminoisoxazole

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

citric acid
77-92-9

citric acid

ethyl 8-chloro-6,7-difluoro-1-(isoxazol-3-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylate

ethyl 8-chloro-6,7-difluoro-1-(isoxazol-3-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylate

Conditions
ConditionsYield
With acetic anhydride; potassium carbonate In N-methyl-acetamide; hexane; chloroform
3-acetylaminopyrrolidine
79286-74-1

3-acetylaminopyrrolidine

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

ethyl 2-[4-(3-acetamido-1-pyrrolidinyl)-3-chloro-2,5-difluorobenzoyl]acetate

ethyl 2-[4-(3-acetamido-1-pyrrolidinyl)-3-chloro-2,5-difluorobenzoyl]acetate

Conditions
ConditionsYield
With sodium hydrogencarbonate In acetonitrile
ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

2-(3-chloro-2,4,5-trifluorobenzoyl)-3-{[(1R,2S)-2-fluorocyclopropyl]amino}acrylate ethyl ester

2-(3-chloro-2,4,5-trifluorobenzoyl)-3-{[(1R,2S)-2-fluorocyclopropyl]amino}acrylate ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic anhydride / 8 h / Reflux
2: triethylamine / dichloromethane / 2 h / 20 °C
View Scheme
ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

8-chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester
127199-25-1

8-chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic anhydride / 8 h / Reflux
2: triethylamine / dichloromethane / 2 h / 20 °C
3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C
View Scheme
Multi-step reaction with 2 steps
1.1: acetic anhydride / 1.5 h / 110 - 120 °C
1.2: 1 h / 20 °C
2.1: sodium hydride / 1,4-dioxane / 1 h
View Scheme
ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

C17H12BClF3NO7

C17H12BClF3NO7

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: acetic anhydride / 8 h / Reflux
2.1: triethylamine / dichloromethane / 2 h / 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C
4.1: 1.5 h / 110 °C
4.2: 95 - 110 °C
View Scheme
ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

7-[3-amino-4-(methoxyimino)piperidin-1-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

7-[3-amino-4-(methoxyimino)piperidin-1-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: acetic anhydride / 8 h / Reflux
2.1: triethylamine / dichloromethane / 2 h / 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C
4.1: 1.5 h / 110 °C
4.2: 95 - 110 °C
5.1: acetonitrile / 20 °C / Inert atmosphere
6.1: sodium hydroxide / 1 h / 20 °C
6.2: pH 6.5 - 7
View Scheme
ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

7-[3-(aminomethyl)-4-(methoxyimino)pyrrolidin-1-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

7-[3-(aminomethyl)-4-(methoxyimino)pyrrolidin-1-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: acetic anhydride / 8 h / Reflux
2.1: triethylamine / dichloromethane / 2 h / 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C
4.1: 1.5 h / 110 °C
4.2: 95 - 110 °C
5.1: acetonitrile / 20 °C / Inert atmosphere
6.1: sodium hydroxide / 1 h / 20 °C
6.2: pH 6.5 - 7
View Scheme
ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

7-[3-(aminomethyl)-4-(ethoxyimino)pyrrolidin-1-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

7-[3-(aminomethyl)-4-(ethoxyimino)pyrrolidin-1-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: acetic anhydride / 8 h / Reflux
2.1: triethylamine / dichloromethane / 2 h / 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C
4.1: 1.5 h / 110 °C
4.2: 95 - 110 °C
5.1: acetonitrile / 20 °C / Inert atmosphere
6.1: sodium hydroxide / 1 h / 20 °C
6.2: pH 6.5 - 7
View Scheme
ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

7-[3-(aminomethyl)-4-(benzyloxyimino)pyrrolidin-1-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

7-[3-(aminomethyl)-4-(benzyloxyimino)pyrrolidin-1-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: acetic anhydride / 8 h / Reflux
2.1: triethylamine / dichloromethane / 2 h / 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C
4.1: 1.5 h / 110 °C
4.2: 95 - 110 °C
5.1: acetonitrile / 20 °C / Inert atmosphere
6.1: sodium hydroxide / 1 h / 20 °C
6.2: pH 6.5 - 7
View Scheme
ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

C23H24BClF2N4O8

C23H24BClF2N4O8

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: acetic anhydride / 8 h / Reflux
2.1: triethylamine / dichloromethane / 2 h / 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C
4.1: 1.5 h / 110 °C
4.2: 95 - 110 °C
5.1: acetonitrile / 20 °C / Inert atmosphere
View Scheme
ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

C23H24BClF2N4O8

C23H24BClF2N4O8

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: acetic anhydride / 8 h / Reflux
2.1: triethylamine / dichloromethane / 2 h / 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C
4.1: 1.5 h / 110 °C
4.2: 95 - 110 °C
5.1: acetonitrile / 20 °C / Inert atmosphere
View Scheme
ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

C24H26BClF2N4O8

C24H26BClF2N4O8

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: acetic anhydride / 8 h / Reflux
2.1: triethylamine / dichloromethane / 2 h / 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C
4.1: 1.5 h / 110 °C
4.2: 95 - 110 °C
5.1: acetonitrile / 20 °C / Inert atmosphere
View Scheme
ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

C29H28BClF2N4O8

C29H28BClF2N4O8

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: acetic anhydride / 8 h / Reflux
2.1: triethylamine / dichloromethane / 2 h / 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C
4.1: 1.5 h / 110 °C
4.2: 95 - 110 °C
5.1: acetonitrile / 20 °C / Inert atmosphere
View Scheme
ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

ethyl 3-ethoxy-2-(3-chloro-2,4,5-trifluorobenzoyl)acrylate

ethyl 3-ethoxy-2-(3-chloro-2,4,5-trifluorobenzoyl)acrylate

Conditions
ConditionsYield
With acetic anhydride for 8h; Reflux;
With acetic anhydride for 8h; Reflux;
With acetic anhydride at 139℃; for 3h;
at 120 - 130℃; for 4h;
ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

ethyl 3-[(6-amino-3,5-difluoropyridin-2-yl)amino]-2-(3-chloro-2,4,5-trifluorobenzoyl)acrylate

ethyl 3-[(6-amino-3,5-difluoropyridin-2-yl)amino]-2-(3-chloro-2,4,5-trifluorobenzoyl)acrylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic anhydride / 8 h / Reflux
2: 1-methyl-pyrrolidin-2-one; acetonitrile / 6 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: acetic anhydride / 3 h / 139 °C
2: 1-methyl-pyrrolidin-2-one; acetonitrile / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 4 h / 120 - 130 °C
2: acetonitrile / 10 - 30 °C
View Scheme
ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

1-(6-amino-3,5-difluoro-2-pyridyl)-8-chloro-6-fluoro-1,4-dihydro-7-fluoro-4-oxo-3-quinolinecarboxylic acid ethyl ester
189279-51-4

1-(6-amino-3,5-difluoro-2-pyridyl)-8-chloro-6-fluoro-1,4-dihydro-7-fluoro-4-oxo-3-quinolinecarboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic anhydride / 8 h / Reflux
2: 1-methyl-pyrrolidin-2-one; acetonitrile / 6 h / 20 °C
3: potassium carbonate / butanone / 5 h / 60 °C
View Scheme
Multi-step reaction with 3 steps
1: acetic anhydride / 3 h / 139 °C
2: 1-methyl-pyrrolidin-2-one; acetonitrile / 1 h / 20 °C
3: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / N,N-dimethyl-formamide / 2 h / 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 3 steps
1: 4 h / 120 - 130 °C
2: acetonitrile / 10 - 30 °C
3: potassium carbonate / N,N-dimethyl-formamide
View Scheme
ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

1-(6-amino-3,5-difluoro-2-pyridinyl)-8-chloro-6,7-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid
189279-53-6

1-(6-amino-3,5-difluoro-2-pyridinyl)-8-chloro-6,7-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetic anhydride / 8 h / Reflux
2: 1-methyl-pyrrolidin-2-one; acetonitrile / 6 h / 20 °C
3: potassium carbonate / butanone / 5 h / 60 °C
4: acetic acid; hydrogenchloride / water / 1.5 h / 95 °C
View Scheme
Multi-step reaction with 4 steps
1: 4 h / 120 - 130 °C
2: acetonitrile / 10 - 30 °C
3: potassium carbonate / N,N-dimethyl-formamide
4: hydrogenchloride; formic acid
View Scheme
ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate
101987-86-4

ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate

C23H22ClF3N6O4

C23H22ClF3N6O4

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetic anhydride / 8 h / Reflux
2: 1-methyl-pyrrolidin-2-one; acetonitrile / 6 h / 20 °C
3: potassium carbonate / butanone / 5 h / 60 °C
4: lithium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 100 °C / Inert atmosphere
View Scheme
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