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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Licofelone Manufacturer/High quality/Best price/In stock

Cas:156897-06-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Licofelone 156897-06-2 GMP Manufacturer

Cas:156897-06-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Licofelone

Cas:156897-06-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - Licofelone

Cas:156897-06-2

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Licofelone CAS 156897-06-2

Cas:156897-06-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFU-CHEM - Licofelone

Cas:156897-06-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-

Cas:156897-06-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Licofelone CAS:156897-06-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Licofelone CAS:156897-06-2

Cas:156897-06-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-

Cas:156897-06-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Superiority We can customize and synthesize products that other suppliers may not be able to provide. Advantage cof, mof ligand manufacturer best service, company and transport

Riboflavin sodium phosphate; Licofelone 99% ;CAS:156897-06-2

Cas:156897-06-2

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-

Cas:156897-06-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Licofelone

Cas:156897-06-2

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Licofelone 156897-06-2

Cas:156897-06-2

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Licofelone

Cas:156897-06-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

LICOFELONE

Cas:156897-06-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl- 1H-pyrrolizine-5-acetic Acid

Cas:156897-06-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

TIANFU-CHEM - LicofeloneAppearance:Solid Storage:In Room Temperature Package:according to customers' requirements Application:Organic synthesis Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or according t

Licofelone

Cas:156897-06-2

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

moderate price & quick delivery. Appearance:Yellowish Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum;200kg/drum as per your request Application: Dual inhibitor of cyclooxygenase and 5-lipo

Licofelone

Cas:156897-06-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Licofelone Manufacturer/High quality/Best price/In stock

Cas:156897-06-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Buy Top Purity Licofelone

Cas:156897-06-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Licofelone

Cas:156897-06-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFU-CHEM - Licofelone

Cas:156897-06-2

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

Licofelone

Cas:156897-06-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Licofelone

Cas:156897-06-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TIANFU-CHEM - Licofelone

Cas:156897-06-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Riboflavin sodium phosphate; Licofelone 99% ;CAS:156897-06-2 CAS NO.156897-06-2

Cas:156897-06-2

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service an

Licofelone

Cas:156897-06-2

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Licofelone

Cas:156897-06-2

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

TIANFU-CHEM - Licofelone

Cas:156897-06-2

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-

Cas:156897-06-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

ethyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate
156897-35-7

ethyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 80℃;77%
With sodium hydroxide In ethanol at 80℃; for 0.25h;77%
With sodium hydroxide In ethanol for 0.166667h; Heating;75.5%
Stage #1: ethyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate With sodium hydroxide; water In ethanol for 0.5h; Heating / reflux;
Stage #2: With hydrogenchloride In ethanol; water Product distribution / selectivity;
64%
With aq. alkaline hydroxide at 60 - 70℃; for 1h;
methyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetate
1061179-20-1

methyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetate

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Stage #1: methyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetate With sodium hydroxide; water In ethanol for 0.5h; Heating / reflux;
Stage #2: With hydrogenchloride In ethanol; water Product distribution / selectivity;
71%
With aq. alkaline hydroxide at 60 - 70℃; for 1h;
[6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizin-5-yl]acetic acid tert-butyl ester
262426-70-0

[6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizin-5-yl]acetic acid tert-butyl ester

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Stage #1: [6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizin-5-yl]acetic acid tert-butyl ester With sodium hydroxide; water In ethanol for 8h; Heating / reflux;
Stage #2: With hydrogenchloride In ethanol; water Product distribution / selectivity;
60%
With aq. alkaline hydroxide at 60 - 70℃; for 10h;
C23H20ClNO3

C23H20ClNO3

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
With hydrazine hydrate; potassium hydroxide In ethylene diglycol at 85 - 145℃; for 7h; Wolff-Kishner reduction;55%
With hydrazine hydrate; potassium hydroxide In diethylene glycol at 85 - 145℃; for 7h; Wolff-Kishner reduction;55%
With hydrazine hydrate; potassium hydroxide In diethylene glycol at 50 - 145℃; Wolff-Kishner reduction;55.6%
2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetamide
1061179-22-3

2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetamide

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Stage #1: 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetamide With sulfuric acid; water In methanol for 4h; Heating / reflux;
Stage #2: With sodium hydroxide; water In methanol for 4h; Heating / reflux;
Stage #3: With hydrogenchloride In methanol; water Product distribution / selectivity;
50%
1-chloro-3-phenyl-2-propyne
3355-31-5

1-chloro-3-phenyl-2-propyne

(1,2-dimethyl-3-zirconacyclopent-1-ene)(C5H5)2

(1,2-dimethyl-3-zirconacyclopent-1-ene)(C5H5)2

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 90 percent / aq. NaOH, NaI, n-Bu4NI / toluene / 24 h / 50 °C
2: 1.) Et3N, 2.) NaBH(OAc)3 / 1) CH2Cl2, rt, 15 min; 2) CH2Cl2, rt, 12 h
3: 68 percent / pivalic acid / 5 h / 150 °C
4: 77 percent / EtONa / ethanol / 15 h / Ambient temperature
5: 1.) NaH / 1) THF, rt, 1 h; 2) THF, rt, 12 h
6: 92 percent / Pd(PPh3)4, Na2CO3 / tetrahydrofuran; H2O / 1) rt, 1 h; 2) reflux, 1 h
7: 1.) p-toluenesulfonhydrazide, p-TsOH*H2O, 2.) NaBH3CN / 1) EtOH, reflux, 7 h; 2) EtOH, reflux, 4 h
8: 77 percent / aq. NaOH / ethanol / 0.25 h / 80 °C
View Scheme
2,2-dimethyl-5-phenylpent-4-ynal
197963-29-4

2,2-dimethyl-5-phenylpent-4-ynal

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 1.) Et3N, 2.) NaBH(OAc)3 / 1) CH2Cl2, rt, 15 min; 2) CH2Cl2, rt, 12 h
2: 68 percent / pivalic acid / 5 h / 150 °C
3: 77 percent / EtONa / ethanol / 15 h / Ambient temperature
4: 1.) NaH / 1) THF, rt, 1 h; 2) THF, rt, 12 h
5: 92 percent / Pd(PPh3)4, Na2CO3 / tetrahydrofuran; H2O / 1) rt, 1 h; 2) reflux, 1 h
6: 1.) p-toluenesulfonhydrazide, p-TsOH*H2O, 2.) NaBH3CN / 1) EtOH, reflux, 7 h; 2) EtOH, reflux, 4 h
7: 77 percent / aq. NaOH / ethanol / 0.25 h / 80 °C
View Scheme
Multi-step reaction with 7 steps
1: 80 percent / NaBH(OAc)3, Et3N / CH2Cl2 / Ambient temperature
2: 68 percent / t-BuCO2H / 150 °C
3: 77 percent / EtONa / ethanol / Ambient temperature
4: 80 percent / NaH / tetrahydrofuran / Ambient temperature
5: 92 percent / Pd(PPh3)4, Na2CO3 / H2O; tetrahydrofuran / Heating
6: 1.) p-toluenesulfonyl hydrazide, p-TsOH, 2.) NaBH3CN / 1.) EtOH, reflux, 2.) EtOH, reflux
7: 77 percent / NaOH / ethanol; H2O / 80 °C
View Scheme
2,2-dimethyl-7-phenyl-2,3,5,6-tetrahydro-1H-pyrrolizin-6-one
197963-31-8

2,2-dimethyl-7-phenyl-2,3,5,6-tetrahydro-1H-pyrrolizin-6-one

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 77 percent / EtONa / ethanol / 15 h / Ambient temperature
2: 1.) NaH / 1) THF, rt, 1 h; 2) THF, rt, 12 h
3: 92 percent / Pd(PPh3)4, Na2CO3 / tetrahydrofuran; H2O / 1) rt, 1 h; 2) reflux, 1 h
4: 1.) p-toluenesulfonhydrazide, p-TsOH*H2O, 2.) NaBH3CN / 1) EtOH, reflux, 7 h; 2) EtOH, reflux, 4 h
5: 77 percent / aq. NaOH / ethanol / 0.25 h / 80 °C
View Scheme
Multi-step reaction with 5 steps
1: 77 percent / EtONa / ethanol / Ambient temperature
2: 80 percent / NaH / tetrahydrofuran / Ambient temperature
3: 92 percent / Pd(PPh3)4, Na2CO3 / H2O; tetrahydrofuran / Heating
4: 1.) p-toluenesulfonyl hydrazide, p-TsOH, 2.) NaBH3CN / 1.) EtOH, reflux, 2.) EtOH, reflux
5: 77 percent / NaOH / ethanol; H2O / 80 °C
View Scheme
methyl N-(2,2-dimethyl-5-phenylpent-4-ynyl)glycinate
197963-30-7

methyl N-(2,2-dimethyl-5-phenylpent-4-ynyl)glycinate

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 68 percent / pivalic acid / 5 h / 150 °C
2: 77 percent / EtONa / ethanol / 15 h / Ambient temperature
3: 1.) NaH / 1) THF, rt, 1 h; 2) THF, rt, 12 h
4: 92 percent / Pd(PPh3)4, Na2CO3 / tetrahydrofuran; H2O / 1) rt, 1 h; 2) reflux, 1 h
5: 1.) p-toluenesulfonhydrazide, p-TsOH*H2O, 2.) NaBH3CN / 1) EtOH, reflux, 7 h; 2) EtOH, reflux, 4 h
6: 77 percent / aq. NaOH / ethanol / 0.25 h / 80 °C
View Scheme
Multi-step reaction with 6 steps
1: 68 percent / t-BuCO2H / 150 °C
2: 77 percent / EtONa / ethanol / Ambient temperature
3: 80 percent / NaH / tetrahydrofuran / Ambient temperature
4: 92 percent / Pd(PPh3)4, Na2CO3 / H2O; tetrahydrofuran / Heating
5: 1.) p-toluenesulfonyl hydrazide, p-TsOH, 2.) NaBH3CN / 1.) EtOH, reflux, 2.) EtOH, reflux
6: 77 percent / NaOH / ethanol; H2O / 80 °C
View Scheme
ethyl 2-(2,2-dimethyl-6-hydroxy-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-2-oxoacetate
197963-32-9

ethyl 2-(2,2-dimethyl-6-hydroxy-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-2-oxoacetate

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) NaH / 1) THF, rt, 1 h; 2) THF, rt, 12 h
2: 92 percent / Pd(PPh3)4, Na2CO3 / tetrahydrofuran; H2O / 1) rt, 1 h; 2) reflux, 1 h
3: 1.) p-toluenesulfonhydrazide, p-TsOH*H2O, 2.) NaBH3CN / 1) EtOH, reflux, 7 h; 2) EtOH, reflux, 4 h
4: 77 percent / aq. NaOH / ethanol / 0.25 h / 80 °C
View Scheme
Multi-step reaction with 4 steps
1: 80 percent / NaH / tetrahydrofuran / Ambient temperature
2: 92 percent / Pd(PPh3)4, Na2CO3 / H2O; tetrahydrofuran / Heating
3: 1.) p-toluenesulfonyl hydrazide, p-TsOH, 2.) NaBH3CN / 1.) EtOH, reflux, 2.) EtOH, reflux
4: 77 percent / NaOH / ethanol; H2O / 80 °C
View Scheme
ethyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-2-oxoacetate
197963-34-1

ethyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-2-oxoacetate

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) p-toluenesulfonhydrazide, p-TsOH*H2O, 2.) NaBH3CN / 1) EtOH, reflux, 7 h; 2) EtOH, reflux, 4 h
2: 77 percent / aq. NaOH / ethanol / 0.25 h / 80 °C
View Scheme
Multi-step reaction with 2 steps
1: 1.) p-toluenesulfonyl hydrazide, p-TsOH, 2.) NaBH3CN / 1.) EtOH, reflux, 2.) EtOH, reflux
2: 77 percent / NaOH / ethanol; H2O / 80 °C
View Scheme
ethyl 2-(2,2-dimethyl-7-phenyl-6-trifluoromethanesulfonyloxy-2,3-dihydro-1H-pyrrolizin-5-yl)-2-oxoacetate
197963-33-0

ethyl 2-(2,2-dimethyl-7-phenyl-6-trifluoromethanesulfonyloxy-2,3-dihydro-1H-pyrrolizin-5-yl)-2-oxoacetate

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / Pd(PPh3)4, Na2CO3 / tetrahydrofuran; H2O / 1) rt, 1 h; 2) reflux, 1 h
2: 1.) p-toluenesulfonhydrazide, p-TsOH*H2O, 2.) NaBH3CN / 1) EtOH, reflux, 7 h; 2) EtOH, reflux, 4 h
3: 77 percent / aq. NaOH / ethanol / 0.25 h / 80 °C
View Scheme
Multi-step reaction with 3 steps
1: 92 percent / Pd(PPh3)4, Na2CO3 / H2O; tetrahydrofuran / Heating
2: 1.) p-toluenesulfonyl hydrazide, p-TsOH, 2.) NaBH3CN / 1.) EtOH, reflux, 2.) EtOH, reflux
3: 77 percent / NaOH / ethanol; H2O / 80 °C
View Scheme
1-chloro-3-phenyl-2-propyne
3355-31-5

1-chloro-3-phenyl-2-propyne

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 90 percent / n-Bu4NI, NaI, NaOH / H2O; toluene / 50 °C
2: 80 percent / NaBH(OAc)3, Et3N / CH2Cl2 / Ambient temperature
3: 68 percent / t-BuCO2H / 150 °C
4: 77 percent / EtONa / ethanol / Ambient temperature
5: 80 percent / NaH / tetrahydrofuran / Ambient temperature
6: 92 percent / Pd(PPh3)4, Na2CO3 / H2O; tetrahydrofuran / Heating
7: 1.) p-toluenesulfonyl hydrazide, p-TsOH, 2.) NaBH3CN / 1.) EtOH, reflux, 2.) EtOH, reflux
8: 77 percent / NaOH / ethanol; H2O / 80 °C
View Scheme
4-chlorobenzoylmethyl bromide
536-38-9

4-chlorobenzoylmethyl bromide

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaHCO3 / diethyl ether; ethanol; H2O / 36 h / Ambient temperature
2: Cu / toluene / 0.25 h / Heating
3: 75.5 percent / 10percent aq. NaOH / ethanol / 0.17 h / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: ethanol / 0.5 h
2.1: tetrahydrofuran / 18 - 25 °C / Inert atmosphere
2.2: 0.33 h / 25 - 30 °C
3.1: hydrazine hydrate; potassium hydroxide / diethylene glycol / 50 - 145 °C
View Scheme
5-benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole
116673-95-1

5-benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaHCO3 / diethyl ether; ethanol; H2O / 36 h / Ambient temperature
2: Cu / toluene / 0.25 h / Heating
3: 75.5 percent / 10percent aq. NaOH / ethanol / 0.17 h / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / ethanol / 36 h / 20 °C
2.1: tetrahydrofuran / 10 - 15 °C
2.2: 0.33 h / 25 - 30 °C
3.1: hydrazine hydrate; potassium hydroxide / ethylene diglycol / 7 h / 85 - 145 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium hydrogencarbonate / ethanol; water / 36 h / 20 °C
2: tetrahydrofuran / 10 - 15 °C
3: water / tetrahydrofuran / 0.33 h / 25 - 30 °C
4: hydrazine hydrate; potassium hydroxide / diethylene glycol / 7 h / 85 - 145 °C
View Scheme
Multi-step reaction with 3 steps
1.1: ethanol / 0.5 h
2.1: tetrahydrofuran / 18 - 25 °C / Inert atmosphere
2.2: 0.33 h / 25 - 30 °C
3.1: hydrazine hydrate; potassium hydroxide / diethylene glycol / 50 - 145 °C
View Scheme
2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Cu / toluene / 0.25 h / Heating
2: 75.5 percent / 10percent aq. NaOH / ethanol / 0.17 h / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: tetrahydrofuran / 10 - 15 °C
1.2: 0.33 h / 25 - 30 °C
2.1: hydrazine hydrate; potassium hydroxide / ethylene diglycol / 7 h / 85 - 145 °C
View Scheme
Multi-step reaction with 3 steps
1: tetrahydrofuran / 10 - 15 °C
2: water / tetrahydrofuran / 0.33 h / 25 - 30 °C
3: hydrazine hydrate; potassium hydroxide / diethylene glycol / 7 h / 85 - 145 °C
View Scheme
Multi-step reaction with 2 steps
1.1: tetrahydrofuran / 18 - 25 °C / Inert atmosphere
1.2: 0.33 h / 25 - 30 °C
2.1: hydrazine hydrate; potassium hydroxide / diethylene glycol / 50 - 145 °C
View Scheme
6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-ylacetic acid toluene solvate

6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-ylacetic acid toluene solvate

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
In methanol; ethyl acetate at 0 - 5℃; for 5h;
oxalyl dichloride
79-37-8

oxalyl dichloride

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Stage #1: oxalyl dichloride; 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine In tetrahydrofuran at 10 - 25℃; for 0.5 - 0.75h;
Stage #2: With water In tetrahydrofuran at 0 - 30℃; for 0.0833333 - 0.166667h;
Stage #3: With hydrogenchloride; potassium hydroxide; hydrazine more than 3 stages;
5.5-dimethyl-1,3,2-dioxathiane-2-oxide
1003-85-6

5.5-dimethyl-1,3,2-dioxathiane-2-oxide

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: dimethyl sulfoxide / 36 h / 100 °C
2.1: pyridine; thionyl chloride / 0 °C
3.1: diethyl ether / 2 h / Reflux
3.2: 3 h / Reflux
4.1: sodium hydrogencarbonate / ethanol / 36 h / 20 °C
5.1: tetrahydrofuran / 10 - 15 °C
5.2: 0.33 h / 25 - 30 °C
6.1: hydrazine hydrate; potassium hydroxide / ethylene diglycol / 7 h / 85 - 145 °C
View Scheme
3,3-dimethyl-4-hydroxy butyronitrile
103804-80-4

3,3-dimethyl-4-hydroxy butyronitrile

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: pyridine; thionyl chloride / 0 °C
2.1: diethyl ether / 2 h / Reflux
2.2: 3 h / Reflux
3.1: sodium hydrogencarbonate / ethanol / 36 h / 20 °C
4.1: tetrahydrofuran / 10 - 15 °C
4.2: 0.33 h / 25 - 30 °C
5.1: hydrazine hydrate; potassium hydroxide / ethylene diglycol / 7 h / 85 - 145 °C
View Scheme
2,2-Dimethyl-1,3-propanediol
126-30-7

2,2-Dimethyl-1,3-propanediol

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: thionyl chloride / dichloromethane / 5 - 10 °C
2.1: dimethyl sulfoxide / 36 h / 100 °C
3.1: pyridine; thionyl chloride / 0 °C
4.1: diethyl ether / 2 h / Reflux
4.2: 3 h / Reflux
5.1: sodium hydrogencarbonate / ethanol / 36 h / 20 °C
6.1: tetrahydrofuran / 10 - 15 °C
6.2: 0.33 h / 25 - 30 °C
7.1: hydrazine hydrate; potassium hydroxide / ethylene diglycol / 7 h / 85 - 145 °C
View Scheme
4-chloro-3,3-dimethylbutyronitrile
116673-94-0

4-chloro-3,3-dimethylbutyronitrile

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: diethyl ether / 2 h / Reflux
1.2: 3 h / Reflux
2.1: sodium hydrogencarbonate / ethanol / 36 h / 20 °C
3.1: tetrahydrofuran / 10 - 15 °C
3.2: 0.33 h / 25 - 30 °C
4.1: hydrazine hydrate; potassium hydroxide / ethylene diglycol / 7 h / 85 - 145 °C
View Scheme
Multi-step reaction with 5 steps
1.1: magnesium
1.2: 5 h / Reflux
2.1: sodium hydrogencarbonate / ethanol; water / 36 h / 20 °C
3.1: tetrahydrofuran / 10 - 15 °C
4.1: water / tetrahydrofuran / 0.33 h / 25 - 30 °C
5.1: hydrazine hydrate; potassium hydroxide / diethylene glycol / 7 h / 85 - 145 °C
View Scheme
C23H19Cl2NO2
1310936-45-8

C23H19Cl2NO2

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: water / tetrahydrofuran / 0.33 h / 25 - 30 °C
2: hydrazine hydrate; potassium hydroxide / diethylene glycol / 7 h / 85 - 145 °C
View Scheme
benzyl chloride
100-44-7

benzyl chloride

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: magnesium
1.2: 5 h / Reflux
2.1: sodium hydrogencarbonate / ethanol; water / 36 h / 20 °C
3.1: tetrahydrofuran / 10 - 15 °C
4.1: water / tetrahydrofuran / 0.33 h / 25 - 30 °C
5.1: hydrazine hydrate; potassium hydroxide / diethylene glycol / 7 h / 85 - 145 °C
View Scheme
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

licofelone
156897-06-2

licofelone

licofelone-NHS

licofelone-NHS

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 20℃;100%
With dicyclohexyl-carbodiimide In dichloromethane at 20℃;
licofelone
156897-06-2

licofelone

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-1-(1H-imidazol-1-yl)ethanone
1175530-60-5

2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-1-(1H-imidazol-1-yl)ethanone

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 24h;97%
In tetrahydrofuran at 20℃; for 0.5h;
licofelone
156897-06-2

licofelone

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-ylacetic acid tromethamine salt

6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-ylacetic acid tromethamine salt

Conditions
ConditionsYield
In ethanol at 47℃; Industry scale;92%
cholin hydroxide
123-41-1

cholin hydroxide

licofelone
156897-06-2

licofelone

6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-ylacetic acid choline salt
1224948-00-8

6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-ylacetic acid choline salt

Conditions
ConditionsYield
In ethanol; water at 75 - 77℃; Product distribution / selectivity; Industry scale;87%
2,2,2-trichloroethyl 2,3,4-tri-O-tert-butyldimethylsilyl-D-glucopyranuronate

2,2,2-trichloroethyl 2,3,4-tri-O-tert-butyldimethylsilyl-D-glucopyranuronate

licofelone
156897-06-2

licofelone

(2S,3R,4S,5R)-3,4,5-Tris-(tert-butyl-dimethyl-silanyloxy)-6-{2-[2-(4-chloro-phenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl]-acetoxy}-tetrahydro-pyran-2-carboxylic acid 2,2,2-trichloro-ethyl ester

(2S,3R,4S,5R)-3,4,5-Tris-(tert-butyl-dimethyl-silanyloxy)-6-{2-[2-(4-chloro-phenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl]-acetoxy}-tetrahydro-pyran-2-carboxylic acid 2,2,2-trichloro-ethyl ester

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at -50 - 20℃; for 2h;72%
1,8-diiodooctane
24772-63-2

1,8-diiodooctane

licofelone
156897-06-2

licofelone

8-iodooctyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate
1332505-35-7

8-iodooctyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate

Conditions
ConditionsYield
With potassium carbonate In acetone at 56℃;70.1%
toluene
108-88-3

toluene

licofelone
156897-06-2

licofelone

6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-ylacetic acid toluene hemisolvate

6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-ylacetic acid toluene hemisolvate

Conditions
ConditionsYield
In diethyl ether at 60℃;70%
1,3-dibromo-propane
109-64-8

1,3-dibromo-propane

licofelone
156897-06-2

licofelone

3-bromopropyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate
1332505-34-6

3-bromopropyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate

Conditions
ConditionsYield
With potassium carbonate In acetone at 56℃;68.7%
ethylene dibromide
106-93-4

ethylene dibromide

licofelone
156897-06-2

licofelone

2-bromoethyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate
1025054-99-2

2-bromoethyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate

Conditions
ConditionsYield
With potassium carbonate In acetone at 56℃;60.3%
1,4-dibromo-butane
110-52-1

1,4-dibromo-butane

licofelone
156897-06-2

licofelone

4-bromobutyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate
912341-47-0

4-bromobutyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate

Conditions
ConditionsYield
With potassium carbonate In acetone at 56℃;56.9%
1,12-dibromododecane
3344-70-5

1,12-dibromododecane

licofelone
156897-06-2

licofelone

12-bromododecyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate
1332505-36-8

12-bromododecyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate

Conditions
ConditionsYield
With potassium carbonate In acetone at 56℃;43.1%
licofelone
156897-06-2

licofelone

[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl]acetic acid 2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl ester

[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl]acetic acid 2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl ester

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In diethyl ether at 20℃; for 0.5h;1.3%
toluene
108-88-3

toluene

licofelone
156897-06-2

licofelone

6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-ylacetic acid toluene solvate

6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-ylacetic acid toluene solvate

Conditions
ConditionsYield
In ethyl acetate at 40 - 50℃;
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