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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZINE

Cas:133111-56-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZINE CAS 133111-56-5

Cas:133111-56-5

Min.Order:1 Kilogram

FOB Price: $60.0 / 100.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

1H-Pyrrolizine,6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-

Cas:133111-56-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-DiMethyl-7-Phenyl-1H-Pyrrolizine CAS:133111-56-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermed

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-DiMethyl-7-Phenyl-1H-Pyrrolizine CAS:133111-56-5

Cas:133111-56-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1H-Pyrrolizine,6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-

Cas:133111-56-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Pyrrolizine,6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-

Cas:133111-56-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-Dimethyl-7-phenyl-1H-Pyrrolizine

Cas:133111-56-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1H-Pyrrolizine,6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-

Cas:133111-56-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-1,3-dihydropyrrolizine

Cas:133111-56-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-Dimethyl-7-phenyl-1H-Pyrrolizine

Cas:133111-56-5

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZINE

Cas:133111-56-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Buy Top Purity 6-(4-Chlorophenyl)-2,3-Dihydro-2,2-DiMethyl-7-Phenyl-1H-Pyrrolizine

Cas:133111-56-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-Dimethyl-7-phenyl-1H-Pyrrolizine

Cas:133111-56-5

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-DiMethyl-7-Phenyl-1H-Pyrrolizine

Cas:133111-56-5

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-Dimethyl-7-phenyl-1H-Pyrrolizine

Cas:133111-56-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-Dimethyl-7-phenyl-1H-Pyrrolizine

Cas:133111-56-5

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-DiMethyl-7-Phenyl-1H-Pyrrolizine

Cas:133111-56-5

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-Dimethyl-7-phenyl-1H-Pyrrolizine

Cas:133111-56-5

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-Dimethyl-7-phenyl-1H-Pyrrolizine

Cas:133111-56-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-DiMethyl-7-Phenyl-1H-Pyrrolizine

Cas:133111-56-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

1H-Pyrrolizine,6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-

Cas:133111-56-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-DiMethyl-7-Phenyl-1H-Pyrrolizine

Cas:133111-56-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

1,we produce and sell good chemicals around the world.2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.3,our staff consists of highly qualified in

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-DiMethyl-7-Phenyl-1H-Pyrrolizine

Cas:133111-56-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

1H-Pyrrolizine,6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-

Cas:133111-56-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-Dimethyl-7-phenyl-1H-Pyrrolizine Application:6-(4-Chlorophenyl)-2,3-Dihydro-2,2-Dimethyl-7-phenyl-1H-Pyrrolizine

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-Dimethyl-7-phenyl-1H-Pyrrolizine

Cas:133111-56-5

Min.Order:0

Negotiable

Type:Other

inquiry

DB BIOTECH CO., LTD

best seller Application:API

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-DiMethyl-7-Phenyl-1H-Pyrrolizine

Cas:133111-56-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-DiMethyl-7-Phenyl-1H-Pyrrolizine

Cas:133111-56-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. is focused on customization, research and development and production of APIs and advanced intermediates, which can effectively compensate for the deficiencies of traditional CRO and CMO. Priority of high-tech barri

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-Dimethyl-7-phenyl-1H-Pyrrolizine

Cas:133111-56-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Newgreat Chemical Co., Ltd

Wuhan Xinweiye Chemical Co., Ltd. is mainly engaged in the process development and production of customized synthesis and pharmaceutical intermediates. We have professional researchers in organic synthesis, analytical chemistry and production process

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-Dimethyl-7-phenyl-1H-Pyrrolizine

Cas:133111-56-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changzhou Helios Biomedical Science and Technology Co.,LTD.

Changzhou Helios Biochemical Co., Ltd is a leading manufacturer and supplier for medical intermediates and pesticide intermediates . We specialize in custom synthesis of benzene ring, pyridine and pyrimidine derivatives to help customers to accelerat

6-(4-Chlorophenyl)-2,3-Dihydro-2,2-DiMethyl-7-Phenyl-1H-Pyrrolizine

Cas:133111-56-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

4-chlorobenzoylmethyl bromide
536-38-9

4-chlorobenzoylmethyl bromide

5-benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole
116673-95-1

5-benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

Conditions
ConditionsYield
Stage #1: 5-benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole With sodium hydrogencarbonate In methanol
Stage #2: 4-chlorobenzoylmethyl bromide In methanol for 20h;
Stage #3: With water at 40℃; for 1h;
84%
With sodium hydrogencarbonate In ethanol at 20℃; for 36h;25%
With sodium hydrogencarbonate In ethanol; water at 20℃; for 36h;25%
4-Chlorophenylboronic acid
1679-18-1

4-Chlorophenylboronic acid

2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-6-yl trifluoromethanesulfonate
226900-28-3

2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-6-yl trifluoromethanesulfonate

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

Conditions
ConditionsYield
With potassium hydroxide; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran 1) rt, overnight; 2) reflux, 24 h;15%
(4-chlorphenyl)magnesium bromide
873-77-8

(4-chlorphenyl)magnesium bromide

N,N-diethyl 2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-6-yl carbamate
226900-31-8

N,N-diethyl 2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-6-yl carbamate

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

Conditions
ConditionsYield
With Ni(aca)2 In tetrahydrofuran Heating; Yield given;
(4-chlorphenyl)magnesium bromide
873-77-8

(4-chlorphenyl)magnesium bromide

diethyl 2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-6-yl phosphate
226900-35-2

diethyl 2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-6-yl phosphate

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

Conditions
ConditionsYield
With Ni(aca)2 In tetrahydrofuran Heating; Yield given;
1-chloro-3-phenyl-2-propyne
3355-31-5

1-chloro-3-phenyl-2-propyne

(1,2-dimethyl-3-zirconacyclopent-1-ene)(C5H5)2

(1,2-dimethyl-3-zirconacyclopent-1-ene)(C5H5)2

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 90 percent / aq. NaOH, NaI, n-Bu4NI / toluene / 24 h / 50 °C
2: 1.) Et3N, 2.) NaBH(OAc)3 / 1) CH2Cl2, rt, 15 min; 2) CH2Cl2, rt, 12 h
3: 68 percent / pivalic acid / 5 h / 150 °C
4: 1.) NaH / 1) THF, rt, 1 h; 2) THF, 0 deg C, 5 min, rt, 20 h
5: 15 percent / Pd(PPh3)4, aq. KOH / tetrahydrofuran / 1) rt, overnight; 2) reflux, 24 h
View Scheme
Multi-step reaction with 5 steps
1: 90 percent / aq. NaOH, NaI, n-Bu4NI / toluene / 24 h / 50 °C
2: 1.) Et3N, 2.) NaBH(OAc)3 / 1) CH2Cl2, rt, 15 min; 2) CH2Cl2, rt, 12 h
3: 68 percent / pivalic acid / 5 h / 150 °C
4: 1.) NaH / 1) THF, rt, 1 h; 2) THF, 0 deg C, 5 min, rt, 20 h
5: Ni(aca)2 / tetrahydrofuran / Heating
View Scheme
Multi-step reaction with 5 steps
1: 90 percent / aq. NaOH, NaI, n-Bu4NI / toluene / 24 h / 50 °C
2: 1.) Et3N, 2.) NaBH(OAc)3 / 1) CH2Cl2, rt, 15 min; 2) CH2Cl2, rt, 12 h
3: 68 percent / pivalic acid / 5 h / 150 °C
4: 1.) NaH / 1) THF, rt, 1 h; 2) THF, 0 deg C, 5 min, rt, 20 h
5: Ni(aca)2 / tetrahydrofuran / Heating
View Scheme
2,2-dimethyl-5-phenylpent-4-ynal
197963-29-4

2,2-dimethyl-5-phenylpent-4-ynal

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) Et3N, 2.) NaBH(OAc)3 / 1) CH2Cl2, rt, 15 min; 2) CH2Cl2, rt, 12 h
2: 68 percent / pivalic acid / 5 h / 150 °C
3: 1.) NaH / 1) THF, rt, 1 h; 2) THF, 0 deg C, 5 min, rt, 20 h
4: 15 percent / Pd(PPh3)4, aq. KOH / tetrahydrofuran / 1) rt, overnight; 2) reflux, 24 h
View Scheme
Multi-step reaction with 4 steps
1: 1.) Et3N, 2.) NaBH(OAc)3 / 1) CH2Cl2, rt, 15 min; 2) CH2Cl2, rt, 12 h
2: 68 percent / pivalic acid / 5 h / 150 °C
3: 1.) NaH / 1) THF, rt, 1 h; 2) THF, 0 deg C, 5 min, rt, 20 h
4: Ni(aca)2 / tetrahydrofuran / Heating
View Scheme
Multi-step reaction with 4 steps
1: 1.) Et3N, 2.) NaBH(OAc)3 / 1) CH2Cl2, rt, 15 min; 2) CH2Cl2, rt, 12 h
2: 68 percent / pivalic acid / 5 h / 150 °C
3: 1.) NaH / 1) THF, rt, 1 h; 2) THF, 0 deg C, 5 min, rt, 20 h
4: Ni(aca)2 / tetrahydrofuran / Heating
View Scheme
2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,6-dihydro-pyrrolizin-3-one

2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,6-dihydro-pyrrolizin-3-one

Conditions
ConditionsYield
Stage #1: 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine With dipotassium peroxodisulfate; acetic acid; [2,2]bipyridinyl; palladium diacetate at 20 - 100℃; for 8h;
Stage #2: With sodium carbonate In water pH=7;
88%
methanol
67-56-1

methanol

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-carboxylic acid methyl ester
262426-69-7

6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-carboxylic acid methyl ester

Conditions
ConditionsYield
Stage #1: 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine; trichloromethyl chloroformate With triethylamine In tetrahydrofuran at 20℃; for 7h;
Stage #2: methanol In tetrahydrofuran at 20℃; for 12h;
84%
methyl 2-iodoacetate
5199-50-8

methyl 2-iodoacetate

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

methyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetate
1061179-20-1

methyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetate

Conditions
ConditionsYield
With dihydrogen peroxide; iron(II) sulfate; dimethyl sulfoxide In water at 10 - 20℃; for 0.25h; Product distribution / selectivity; Cooling with cold water bath;78%
With dihydrogen peroxide; iron(II) sulfate; dimethyl sulfoxide; sodium iodide at 10 - 20℃; for 0.333333h; Product distribution / selectivity; Cooling with cold water bath;45%
With dihydrogen peroxide; iron(II) sulfate In dimethyl sulfoxide for 1h;
2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

ethyl iodoacetae
623-48-3

ethyl iodoacetae

ethyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate
156897-35-7

ethyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate

Conditions
ConditionsYield
With dihydrogen peroxide; iron(II) sulfate In dimethyl sulfoxide for 1h;78%
With dihydrogen peroxide; iron(II) sulfate; dimethyl sulfoxide In water; acetonitrile at 5 - 18℃; for 0.25h; Product distribution / selectivity; Cooling with cold water bath;59%
With dihydrogen peroxide; iron(II) sulfate; dimethyl sulfoxide In water at 10 - 20℃; for 0.25 - 2h; Product distribution / selectivity; Cooling with cold water bath;51%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

ethyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate
156897-35-7

ethyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate

Conditions
ConditionsYield
With dihydrogen peroxide; iron(II) sulfate; sodium iodide In dimethyl sulfoxide for 1h;75%
propionic acid anhydride
123-62-6

propionic acid anhydride

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)propan-1-one
1281816-31-6

1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)propan-1-one

Conditions
ConditionsYield
With aluminum (III) chloride In diethyl ether at 20℃; Inert atmosphere;73.2%
hexyl iodoacetate
5436-99-7

hexyl iodoacetate

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

hexyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetate

hexyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetate

Conditions
ConditionsYield
With dihydrogen peroxide; iron(II) sulfate; dimethyl sulfoxide In water at 10 - 20℃; for 0.25h; Product distribution / selectivity; Cooling with cold water bath;73%
iodoacetonitrile
624-75-9

iodoacetonitrile

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]acetonitrile
1061179-18-7

2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]acetonitrile

Conditions
ConditionsYield
With dihydrogen peroxide; iron(II) sulfate In dimethyl sulfoxide for 4.5h;65%
With dihydrogen peroxide; iron(II) sulfate; dimethyl sulfoxide In water at 10 - 20℃; for 0.25h; Product distribution / selectivity; Cooling with cold water bath;65%
bromoacetic acid tert-butyl ester
5292-43-3

bromoacetic acid tert-butyl ester

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

[6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizin-5-yl]acetic acid tert-butyl ester
262426-70-0

[6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizin-5-yl]acetic acid tert-butyl ester

Conditions
ConditionsYield
With dihydrogen peroxide; iron(II) sulfate; sodium iodide In dimethyl sulfoxide; acetonitrile for 10h;62%
t-butyl iodoacetate
49827-15-8

t-butyl iodoacetate

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

[6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizin-5-yl]acetic acid tert-butyl ester
262426-70-0

[6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizin-5-yl]acetic acid tert-butyl ester

Conditions
ConditionsYield
With dihydrogen peroxide; iron(II) sulfate; dimethyl sulfoxide In water at 10 - 20℃; for 0.25 - 1.83333h; Product distribution / selectivity; Cooling with cold water bath;60%
With dihydrogen peroxide; iron(II) sulfate In dimethyl sulfoxide for 10h;
chloroacetyl chloride
79-04-9

chloroacetyl chloride

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

2-chloro-1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)ethanone
1281816-34-9

2-chloro-1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)ethanone

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In diethyl ether at 20℃; Inert atmosphere;59.3%
With boron trifluoride diethyl etherate at 20℃; for 3h; Inert atmosphere;59%
bromoacetic acid methyl ester
96-32-2

bromoacetic acid methyl ester

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

methyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetate
1061179-20-1

methyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetate

Conditions
ConditionsYield
With dihydrogen peroxide; iron(II) sulfate; sodium iodide In dimethyl sulfoxide for 1h;57%
n-hexanoic anhydride
2051-49-2

n-hexanoic anhydride

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)hexan-1-one
1281816-32-7

1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)hexan-1-one

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In diethyl ether at 20℃; Inert atmosphere;56.3%
2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

dibenzoyl peroxide
94-36-0

dibenzoyl peroxide

benzoic acid [2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl] ester

benzoic acid [2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl] ester

Conditions
ConditionsYield
Stage #1: 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine With tert.-butyl lithium In diethyl ether; pentane at -70 - 20℃; for 3h;
Stage #2: dibenzoyl peroxide In diethyl ether; pentane at -70 - 20℃; for 16 - 29h;
53%
acetic anhydride
108-24-7

acetic anhydride

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)ethanone
1281816-29-2

1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)ethanone

Conditions
ConditionsYield
With aluminum (III) chloride In diethyl ether at 20℃; Inert atmosphere;43.2%
2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

diazo-<2-(14)C>-acetic acid ethylester

diazo-<2-(14)C>-acetic acid ethylester

C24(14)CH26ClNO2

C24(14)CH26ClNO2

Conditions
ConditionsYield
With copper In tetrahydrofuran for 1h; Heating;26.5%
diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

ethyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate
156897-35-7

ethyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate

Conditions
ConditionsYield
With copper In toluene for 0.25h; Heating;
2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Cu / toluene / 0.25 h / Heating
2: 75.5 percent / 10percent aq. NaOH / ethanol / 0.17 h / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: tetrahydrofuran / 10 - 15 °C
1.2: 0.33 h / 25 - 30 °C
2.1: hydrazine hydrate; potassium hydroxide / ethylene diglycol / 7 h / 85 - 145 °C
View Scheme
Multi-step reaction with 3 steps
1: tetrahydrofuran / 10 - 15 °C
2: water / tetrahydrofuran / 0.33 h / 25 - 30 °C
3: hydrazine hydrate; potassium hydroxide / diethylene glycol / 7 h / 85 - 145 °C
View Scheme
Multi-step reaction with 2 steps
1.1: tetrahydrofuran / 18 - 25 °C / Inert atmosphere
1.2: 0.33 h / 25 - 30 °C
2.1: hydrazine hydrate; potassium hydroxide / diethylene glycol / 50 - 145 °C
View Scheme
oxalyl dichloride
79-37-8

oxalyl dichloride

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

licofelone
156897-06-2

licofelone

Conditions
ConditionsYield
Stage #1: oxalyl dichloride; 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine In tetrahydrofuran at 10 - 25℃; for 0.5 - 0.75h;
Stage #2: With water In tetrahydrofuran at 0 - 30℃; for 0.0833333 - 0.166667h;
Stage #3: With hydrogenchloride; potassium hydroxide; hydrazine more than 3 stages;
Reaxys ID: 19180192

Reaxys ID: 19180192

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine
133111-56-5

2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine

Reaxys ID: 19180191

Reaxys ID: 19180191

Conditions
ConditionsYield
With dihydrogen peroxide; iron(II); dimethyl sulfoxide

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