2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine supplier

Name
2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine
EINECS 1806241-263-5
CAS No. 122368-54-1
Article Data7
CAS DataBase
Density 1.217 g/cm³
Solubility
Melting Point
Formula C₁₇H₁₉ClN₂O
Boiling Point 421.68 °C at 760 mmHg
Molecular Weight 302.804
Flash Point 208.825 °C
Transport Information
Appearance Brown Viscous liquid
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms (RS)-4-[(4-Chlorophenyl)(2-pyridyl)methoxy]piperidine;
PSA 34.15000
LogP 3.92180

Synthetic route

: 4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidine fumaric acid salt

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane at 20℃; for 0.166667h;	99%
With sodium hydroxide In dichloromethane	86.6%

: 2-((1-benzylpiperidin-4-yloxy)(4-chlorophenyl)methyl)pyridine

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions

Conditions	Yield
With 5%-palladium/activated carbon In methanol at 30℃; under 2068.65 Torr; for 4h; Inert atmosphere; Autoclave;	94%

: 78539-93-2
3-(4-chlorophenyl)-[1,2,3]triazolo[1,5-a]pyridine

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions

Conditions	Yield
Stage #1: 3-(4-chlorophenyl)-[1,2,3]triazolo[1,5-a]pyridine; t-butyl 4-hydroxy piperidine-1-carboxylate With potassium carbonate In benzene at 20℃; for 10h; UV-irradiation; Stage #2: With trifluoroacetic acid at 20℃; for 1h;	71%

: 27652-89-7
(4-chlorophenyl)-2-pyridylmethanol

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: triethylamine / toluene / 1 h / 0 - 20 °C 2: N-ethyl-N,N-diisopropylamine / 3 h / 80 °C 3: sodium hydroxide / isopropyl alcohol / 12 h / Reflux 4: 5 h / 20 °C 5: sodium hydroxide / dichloromethane / 0.17 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 20 h / Reflux 2: 5%-palladium/activated carbon / methanol / 4 h / 30 °C / 2068.65 Torr / Inert atmosphere; Autoclave View Scheme

: C13H12ClNO3S

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: N-ethyl-N,N-diisopropylamine / 3 h / 80 °C 2: sodium hydroxide / isopropyl alcohol / 12 h / Reflux 3: 5 h / 20 °C 4: sodium hydroxide / dichloromethane / 0.17 h / 20 °C View Scheme

: 207726-35-0
4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidine-1-carboxylic acid ethyl ester

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium hydroxide / isopropyl alcohol / 12 h / Reflux 2: 5 h / 20 °C 3: sodium hydroxide / dichloromethane / 0.17 h / 20 °C View Scheme
With isopropyl alcohol; sodium hydroxide at 88℃; for 6h;

: C18H19ClN2O3

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 5 h / 20 °C 2: sodium hydroxide / dichloromethane / 0.17 h / 20 °C View Scheme

: 4045-22-1
N-acetyl-4-hydroxypiperidine

: 142404-69-1
2-(chloro(4-chlorophenyl)methyl)pyridine

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions

Conditions	Yield
Stage #1: N-acetyl-4-hydroxypiperidine; 2-[chloro(4-chlorophenyl)methyl]pyridine at 130℃; for 5h; Large scale; Stage #2: With hydrogenchloride In water at 80℃; for 15h; Large scale;

: 5382-16-1
4-HYDROXYPIPERIDINE

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: triethylamine / dichloromethane / 1 h / -70 °C / Large scale 1.2: 20 °C / Large scale 2.1: 5 h / 130 °C / Large scale 2.2: 15 h / 80 °C / Large scale View Scheme

: 109-04-6
2-bromo-pyridine

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: isopropylmagnesium bromide / tetrahydrofuran / 1 h / 10 - 20 °C / Inert atmosphere 1.2: 4 h / Inert atmosphere 2.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / Reflux 3.1: 5%-palladium/activated carbon / methanol / 4 h / 30 °C / 2068.65 Torr / Inert atmosphere; Autoclave View Scheme

: 104-88-1
4-chlorobenzaldehyde

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: isopropylmagnesium bromide / tetrahydrofuran / 1 h / 10 - 20 °C / Inert atmosphere 1.2: 4 h / Inert atmosphere 2.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / Reflux 3.1: 5%-palladium/activated carbon / methanol / 4 h / 30 °C / 2068.65 Torr / Inert atmosphere; Autoclave View Scheme

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

: (R)-(+)-2-((4-chlorophenyl)(piperidin-4-yloxy)methyl)pyridine

Conditions

Conditions	Yield
Stage #1: 4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine With (+)-dibenzoyl-D-tartaric acid monohydrate In acetic acid methyl ester Stage #2: With D-tartaric acid In ethanol at 20℃; Stage #3: With sodium hydroxide In water	99.6%
With (R)-Mandelic Acid In methanol at 60℃; for 2h; Reflux;	40%
Stage #1: 4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine With (S)-2-acetylamino-3-phenylpropanoic acid In ethyl acetate Heating; Stage #2: With Cbz-Met-OH In acetonitrile Heating;	38.2%

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

: 668486-64-4
menthyl 4-chlorobutyrate

: 1092777-15-5
(R/S)-bepotastine L-menthyl ester

Conditions

Conditions	Yield
Stage #1: menthyl 4-chlorobutyrate With sodium iodide for 5h; Heating / reflux; Stage #2: 4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine With potassium carbonate for 1h; Product distribution / selectivity; Heating / reflux;	99%
Stage #1: menthyl 4-chlorobutyrate With sodium iodide In 4-methyl-2-pentanone for 5h; Reflux; Stage #2: 4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine With potassium carbonate In 4-methyl-2-pentanone for 1h; Reflux;	99%

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

: 1092777-14-4
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-bromobutanoate

: 1092777-15-5
(R/S)-bepotastine L-menthyl ester

Conditions

Conditions	Yield
With potassium carbonate In acetone for 7h; Product distribution / selectivity; Heating / reflux;	99%
With potassium carbonate In acetone for 7h; Reflux;	99%
With potassium carbonate In acetone for 7h; Reflux;	99%

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

: (S)-(-)-2-((4-chlorophenyl)(piperidin-4-yloxy)methyl)pyridine

Conditions

Conditions	Yield
Stage #1: 4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine With (-)-O,O′-dibenzoyl-L-tartaric acid monohydrate In acetic acid methyl ester Stage #2: With L-Tartaric acid In ethanol Stage #3: With sodium hydroxide In water	98.6%
With (S)-2-acetylamino-3-phenylpropanoic acid In ethyl acetate at 50 - 60℃;	45.4%
With (S)-Mandelic acid In methanol at 60℃; for 2h; Reflux;	42%
Multi-step reaction with 2 steps 1: ethyl acetate / 1 h / 65 °C / Large scale 2: hydrogenchloride / water / Large scale View Scheme

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

: 2018-61-3
(S)-2-acetylamino-3-phenylpropanoic acid

: (S)-2-[(4-chlorophenyl)(4-piperidinyloxy)methyl]pyridine N-acetyl-L-phenylalanine

Conditions

Conditions	Yield
In ethyl acetate at 65℃; for 1h; Solvent; Temperature; Large scale;	80%

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

: 58534-64-8
3,4-Diacetoxy-benzoesaeure

: (4-((4-chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-yl)(3,4-dihydroxyphenyl)methanone

Conditions

Conditions	Yield
Stage #1: 3,4-Diacetoxy-benzoesaeure With phosphorus pentachloride In dichloromethane at 0 - 10℃; for 2h; Stage #2: 4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine With triethylamine In dichloromethane at 0 - 20℃; for 2h;	78.1%

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

: 490-79-9
2,5-dihydroxybenzoic acid.

: (4-((4-chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-yl)(2,5-dihydroxyphenyl)methanone

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1,2-dichloro-ethane; triethylamine In N,N-dimethyl-formamide at 60 - 80℃; for 4h;	54.9%

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

: 35193-63-6, 35193-64-7, 39648-67-4, 50574-52-2
(S)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate

: C17H19ClN2O*C20H13O4P

Conditions

Conditions	Yield
In N,N-dimethyl-formamide; acetone at 45℃; for 0.166667h; Solvent; Temperature;	40%

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

: 121-34-6
3-methoxy-4-hydroxybenzoic acid

: 4-((4-chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-yl(4-hydroxy-3-methoxyphenyl)methanone

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1,2-dichloro-ethane; triethylamine In N,N-dimethyl-formamide at 60 - 80℃; for 4h;	31.6%

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

: 540-51-2
2-bromoethanol

: 125602-93-9
2-[4-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-1-piperidyl]ethanol

Conditions

Conditions	Yield
With potassium carbonate In acetone	0.64 g (56%)

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

: 574-98-1
2-(2-bromoethyl)isoindoline-1,3-dione

: 7803-57-8
hydrazine hydrate

: 125602-94-0
2-[4-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-1-piperidyl]ethylamine

Conditions

Conditions	Yield
With sodium hydroxide; potassium carbonate In 1,4-dioxane; ethanol	3.50 g (41%)

...Expand

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

: 539-74-2
Ethyl 3-bromopropionate

: 125602-67-7
ethyl 3-[4-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-1-piperidyl]propionate

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane; methanol; chloroform	1.78 g (67%)

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

: 2969-81-5
4-bromoethylbutanoate

: 4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidine-1-yl]butyric acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In methanol; chloroform; acetone	6.26 g (91%)

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

A: 5891-21-4
5-chloro-2-pentanone

B: 5-[4-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-1-piperidyl]-2-pentanone

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

A: propyl 4-[4-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-1-piperidyl]butanoate

B: 3153-35-3
4-chloro-butyric acid propyl ester

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

A: ethyl 4-[4-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-1-piperidyl]-2-butenoate

B: 37746-78-4
4-bromo-trans-crotonic acid ethyl ester

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

A: 4-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-1-(3-benzoylpropyl)piperidine

B: 939-52-6
4-chloro-1-phenylbutan-1-one

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

A: 4-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-1-[3-(4-tert-butylbenzoyl)propyl]piperidine

B: 43076-61-5
4'-tert-butyl-4-chlorobutyrophenone

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

A: N,N-dimethyl-4-[4-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-1-piperidyl]butanamide

B: 22813-58-7
N,N-dimethyl-4-chlorobutyramide

: 2-((2-bromoethyl)thio)benzo[d]oxazole

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

: 2-[2-[4-[(4-Chlorophenyl)-pyridin-2-ylmethoxy]-1-piperidyl]-ethylthio]benzoxazole

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane	1.51 g (84%)

: 2-(2-bromoethylthio)-5-chlorobenzoxazole

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

: 5-chloro-2-[2-[4-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-1-piperidyl]ethylthio]benzoxazole

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane; methanol; chloroform	1.83 g (54%)

: 2-(2-bromoethylthio)-6-methylbenzoxazole

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

: 2-[2-[4-[(4-Chlorophenyl)-pyridin-2-ylmethoxy]-1-piperidyl]-ethylthio]-6-methylbenzoxazole

Conditions

Conditions	Yield
With potassium carbonate In methanol; chloroform; acetone	1.55 g (91%)

: 2-(2-chloroethylthio)benzoxazole

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

: 2-[2-[4-[(4-Chlorophenyl)-pyridin-2-ylmethoxy]-1-piperidyl]-ethylthio]benzothiazole

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane	0.52 g (20%)

: 122368-54-1
4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

: 125603-00-1
2-((3-bromopropyl)thio)benzo[d]thiazole

: 2-[3-[4-[(4-Chlorophenyl)-pyridin-2-ylmethoxy]-1-piperidyl]-propylthio]benzothiazole

Conditions

Conditions	Yield
With potassium carbonate In methanol; chloroform; acetone	0.52 g (41%)

2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine Chemical Properties

Molecular Structure of 2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine (CAS NO.122368-54-1):

Systematic Name: 2-[(4-Chlorophenyl)(piperidin-4-yloxy)methyl]pyridine
Molecular Formula: C₁₇H₁₉ClN₂O
Molecular Weight: 302.80
H bond acceptors: 3
H bond donors: 1
Freely Rotating Bonds: 4
Nominal Mass: 302
Average Mass: 302.7986
Monoisotopic Mass: 302.118591
Index of Refraction: 1.601
Molar Refractivity: 85.178 cm³
Molar Volume: 248.708 cm³
Surface Tension: 51.295 dyne/cm
Density: 1.217 g/cm³
Flash Point: 208.825 °C
Enthalpy of Vaporization: 67.573 kJ/mol
Boiling Point: 421.68 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25 °C
SMILES: Clc1ccc(cc1)C(OC2CCNCC2)c3ncccc3
InChI: InChI=1/C17H19ClN2O/c18-14-6-4-13(5-7-14)17(16-3-1-2-10-20-16)21-15-8-11-19-12-9-15/h1-7,10,15,17,19H,8-9,11-12H2
InChIKey: OTZYADIPHOGUDN-UHFFFAOYAW

2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine Specification

2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine (CAS NO.122368-54-1), its Synonyms are Pyridine,2-[(4-chlorophenyl)(4-piperidinyloxy)methyl]- ; (RS)-4-[(4-Chlorophenyl)(2-pyridyl)methoxy]piperidine .

Product Name

2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine

Synthetic route

2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine Chemical Properties

2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine Specification

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