• Name

  2,2'-Methylenebis(4-ethyl-6-tert-butylphenol)

• EINECS 201-814-0
• CAS No. 88-24-4
• Article Data43
• CAS DataBase
• Density 1.01 g/cm³
• Solubility
• Melting Point 123 ºC
• Formula C₂₅H₃₆O₂
• Boiling Point 452.1 ºC at 760 mmHg
• Molecular Weight 368.56
• Flash Point 187.5 ºC
• Transport Information
• Appearance white to pale creamy crystalline powder
• Safety 26-36
• Risk Codes 36/37/38
• Molecular Structure
• Hazard Symbols Xi
• Synonyms Phenol,2,2'-methylenebis[6-tert-butyl-4-ethyl- (6CI,7CI,8CI);2,2-Methylenebis(4-ethyl-6-t-butylphenol);2,2-Methylenebis(4-ethyl-6-tert-butylphenol);2,2'-Methylenebis(6-tert-butyl-4-ethylphenol);2,2'-Methylenebis[4-ethyl-6-tert-butylphenol];2,2'-Methylenebis[6-(1,1-dimethylethyl)-4-ethylphenol];AO 425;Agidol 7;Antage W 500;Antioxidant 425;Bis(2-hydroxy-3-tert-butyl-5-ethylphenyl)methane;Bis(3-tert-butyl-5-ethyl-2-hydroxyphenyl)methane;Chemanox 22;Cyanox 425;NS5;NSC 7782;Nocrac NS 5;Nonflex EBP;Plastanox 425;Swanox 425;
• PSA 40.46000
• LogP 6.40840

Synthetic route

50-00-0

formaldehyd

96-70-8

6-di-t-butyl-4-ethylphenol

88-24-4

2,2'-methylenebis-(4-ethyl-6-tert-butylphenol)

Conditions

Conditions	Yield
With hydrogenchloride
With potassium hydroxide
With sulfuric acid

88-24-4

2,2'-methylenebis-(4-ethyl-6-tert-butylphenol)

C14H21IrO4*H2O

C45H62Ir2O2

Conditions

Conditions	Yield
In toluene at 100℃; for 3h; Inert atmosphere; Schlenk technique;	86%

88-24-4

2,2'-methylenebis-(4-ethyl-6-tert-butylphenol)

7550-45-0

titanium tetrachloride

162583-17-7

CH2(CH3CH2C(CH3)3C6H2O)2TiCl2

Conditions

Conditions	Yield
In diethyl ether (N2 or Ar); -30°C, stirring (2 h, 25°C); removing of the solvent, recrystn. (ether); elem. anal.;	68%

88-24-4

2,2'-methylenebis-(4-ethyl-6-tert-butylphenol)

17520-19-3

tetrabenzyl titanium

CH2(CH3CH2C(CH3)3C6H2O)2Ti(CH2C6H5)2

Conditions

Conditions	Yield
In hexane (N2 or Ar); -40°C, stirring (2 h, 20°C); evapn. of the solvent, recrystn. (hexane, -40°C); elem. anal.;	58%

88-24-4

2,2'-methylenebis-(4-ethyl-6-tert-butylphenol)

7550-45-0

titanium tetrachloride

162583-18-8

(CH2(CH3CH2C(CH3)3C6H2O)2)2Ti

Conditions

Conditions	Yield
With NEt3 In diethyl ether (N2 or Ar); -40°C, stirring (20°C, 3 h), centrifugation; extn. (ether), removal of the solvent, recrystn. (hexane, -40°C);elem. anal.;	50%

88-24-4

2,2'-methylenebis-(4-ethyl-6-tert-butylphenol)

1638-75-1

dimethylchloromethylphosphine oxide

139605-08-6

2,2'-methylene-bis(6-tert-butyl-4-ethyl-1-dimethylphosphinylmethylenoxybenzene)

Conditions

Conditions	Yield
With sodium hydroxide
With sodium 1) xylene, MeOH, 2) xylene, reflux, 8 h; Yield given. Multistep reaction;

546-68-9

titanium(IV) isopropylate

88-24-4

2,2'-methylenebis-(4-ethyl-6-tert-butylphenol)

936366-05-1

[Ti(OCH(CH3)2)2(CH2(C6H2(O)(C(CH3)3)(CH2CH3))2)]

Conditions

Conditions	Yield
In toluene byproducts: isopropanol; complex obtained by react. of CH2(C6H2(OH)(t-Bu)Et)2 and Ti(OPri)4 in toluene at 60°C for 3 h; elem. anal.; complex washed with toluene and azeotropic distilated;

2,2'-Methylenebis(4-ethyl-6-tert-butylphenol) Consensus Reports

2,2'-Methylenebis(4-ethyl-6-tert-butylphenol) Specification