Product Name

  • Name

    METHAPYRILENE HYDROCHLORIDE

  • EINECS
  • CAS No. 135-23-9
  • Density 1.148g/cm3
  • Solubility
  • Melting Point 162°
  • Formula C14H19N3S•ClH
  • Boiling Point 389.6°Cat760mmHg
  • Molecular Weight 297.852
  • Flash Point 189.4°C
  • Transport Information
  • Appearance
  • Safety Poison by ingestion, intravenous, and subcutaneous routes. Human systemic effects by ingestion: gastritis. Questionable carcinogen with experimental carcinogenic and tumorigenic data. Mutation data reported. An antihistamine. When heated to decomposition it emits very toxic fumes of Cl−, SOx, and NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 135-23-9 (METHAPYRILENE HYDROCHLORIDE)
  • Hazard Symbols
  • Synonyms N,N-dimethyl-N'-pyridin-2-yl-N'-(thiophen-2-ylmethyl)ethane-1,2-diamine,hydrochloride;Methoxylene;METHAPYRILENE HYDROCHLORIDE;Methacon;Lullamin;Histadyl;Methapyrilene HCl;Somnicaps;Barhist;Coryzol;Capathyn;
  • PSA 47.61000
  • LogP 3.51330

2-((2-(DIMETHYLAMINO)ETHYL)-2-THENYL-AMINO)PYRIDINE HYDROCHLORIDE Toxicity Data With Reference

1.   

mmo-smc 500 mg/L

    IAPUDO    IARC Publications. 57 (1984),721.
2.   

mrc-smc 1250 mg/L

    IAPUDO    IARC Publications. 57 (1984),721.
3.   

dns-rat :lvr 1 µmol/L

    CNREA8    Cancer Research. 42 (1982),3010.
4.   

oms-rat:lvr 100 µmol/L

    MUREAV    Mutation Research. 135 (1984),131.
5.   

orl-man TDLo:429 µg/kg:GIT

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 90 (1947),83.
6.   

orl-rat LD50:521 mg/kg

    29ZVAB    Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,73.
7.   

scu-rat LD50:150 mg/kg

    29ZVAB    Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,73.
8.   

orl-mus LD50:182 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 90 (1947),83.
9.   

scu-mus LD50:75 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 93 (1948),210.
10.   

ivn-mus LD50:17,500 µg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 93 (19

2-((2-(DIMETHYLAMINO)ETHYL)-2-THENYL-AMINO)PYRIDINE HYDROCHLORIDE Consensus Reports

NCI Carcinogenesis Studies (feed): Clear Evidence: rat FCTOD7    Food and Chemical Toxicology. 22 (1984),27. ; Clear Evidence: rat SCIEAS    Science. 209 (1980),817. ; (gavage); No Evidence: guinea pig, ham JTEHD6    Journal of Toxicology and Environmental Health. 12 (1983),653. . Reported in EPA TSCA Inventory.

2-((2-(DIMETHYLAMINO)ETHYL)-2-THENYL-AMINO)PYRIDINE HYDROCHLORIDE Safety Profile

Poison by ingestion, intravenous, and subcutaneous routes. Human systemic effects by ingestion: gastritis. Questionable carcinogen with experimental carcinogenic and tumorigenic data. Mutation data reported. An antihistamine. When heated to decomposition it emits very toxic fumes of Cl−, SOx, and NOx.

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