2,2-Diethoxyethylamine supplier

Name
2,2-Diethoxyethylamine
EINECS 211-439-4
CAS No. 645-36-3
Article Data29
CAS DataBase
Density 0.922 g/cm³
Solubility Soluble in water
Melting Point -78 °C
Formula C₆H₁₅NO₂
Boiling Point 163 °C at 760 mmHg
Molecular Weight 133.191
Flash Point 45.6 °C
Transport Information UN 1989 3/PG 3
Appearance clear colourless to light yellow liquid
Safety 23-24/25-26-45-36/37/39-16-36
Risk Codes 10-36/37/38-34
Molecular Structure
Hazard Symbols Xi, C, F
Synonyms Acetaldehyde,amino-, diethyl acetal (6CI,7CI,8CI);1,1-Diethoxy-2-aminoethane;1-Amino-2,2-diethoxyethane;2,2-Bis(ethyloxy)ethanamine;2-Aminoacetaldehyde diethylacetal;Aminoacetaldehyde diethyl acetal;Glycinaldehyde diethyl acetal;NSC19501;a-Aminoacetaldehyde diethylacetal;b,b-Diethoxyethylamine;
PSA 44.48000
LogP 1.04450

Synthetic route

: 6136-93-2
2,2-diethoxyacetonitrile

: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
With hydrazine hydrate; nickel In ethanol at 55℃;	97%
With cyclohexane; ammonia; nickel at 75 - 90℃; under 73550.8 Torr; Hydrogenation;

: 108230-73-5
3-N-(2',2'-diethoxyethyl)quinazolin-4-one

A: 118-92-3
anthranilic acid

B: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
With sodium hydroxide Heating;	A n/a B 83%

: 5344-23-0
diethoxyacetaldehyde

: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
With ammonia; hydrogen; nickel In ethanol at 70℃; under 67505.4 Torr; for 0.5h;	80%
Multi-step reaction with 2 steps 1: 1.) hydroxylamine chlorhydrate, triethylamine; 2.) mesyl chloride / 1.) dichloromethane, r.t.; 2.) 0 deg C, 3 h 2: 97 percent / hydrazin hydrate / Raney nickel / ethanol / 55 °C View Scheme

: nitroso-acetaldehyde diethylacetal

: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
With ethanol; acetic acid; zinc
With nickel; benzene under 36775.4 - 51485.6 Torr; Hydrogenation;

: 34560-16-2
1,1-diethoxy-2-nitroethane

: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
With ethanol; sodium at 110 - 120℃; under 13239.1 Torr;

: 102913-44-0
(3,4,3',4'-tetramethoxy-bibenzyl-α-ylidenamino)-acetaldehyde diethylacetal

A: 4927-55-3
1,2-bis(3,4-dimethoxyphenyl)ethanone

B: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
an feuchter Luft;

: 2032-35-1
Bromoacetaldehyde diethyl acetal

: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
With ammonia at 105℃;
With ethanol; ammonia

: 2032-35-1
Bromoacetaldehyde diethyl acetal

A: 625-77-4
N-acetylacetamide

B: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
With ethanol; ammonia at 110 - 115℃;

: 2032-35-1
Bromoacetaldehyde diethyl acetal

A: 67856-69-3
iminodiacetaldehyde bis(diethyl acetal)

B: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
With ethanol; ammonia at 110 - 115℃;
With ammonia at 105℃;

: 621-62-5
chloroacetaldehyde diethyl acetal

: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
With ethanol; ammonia at 130℃; durch Zusatz von Natriumjodid wird die Reaktion beschleunigt;
With ethanol; ammonia
With ethanol; ammonia

: 621-62-5
chloroacetaldehyde diethyl acetal

A: 67856-69-3
iminodiacetaldehyde bis(diethyl acetal)

B: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
With ammonia; benzene at 128℃; under 55163.1 Torr;
With methanol; ammonia at 140℃; unter Druck;

: 51806-20-3
1,1-diethoxy-2-iodoethane

: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
With ethanol; ammonia at 110 - 125℃; im Autoklaven;

: 61189-99-9
diethoxyacetamide

: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran Heating;

hydrochloride of glycocoll ester: hydrochloride of glycocoll ester

: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
With hydrogenchloride; sodium amalgam unter Kuehlung und behandelt das Reduktionsprodukt mit alkoh.Salzsaeure;

: 621-62-5
chloroacetaldehyde diethyl acetal

(NH4)2CO3: (NH4)2CO3

: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
With ethanol; ammonia; water; potassium iodide at 110 - 114℃;

nitroacetal: nitroacetal

: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
With ethanol; sodium

: 7664-41-7
ammonia

: 2032-35-1
Bromoacetaldehyde diethyl acetal

A: 67856-69-3
iminodiacetaldehyde bis(diethyl acetal)

B: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
at 110 - 125℃;
at 105℃;

...Expand

: 621-62-5
chloroacetaldehyde diethyl acetal

A: 645-36-3
2,2-diethoxy-ethanamine

B diacetalylamine; triacetalylamine: diacetalylamine; triacetalylamine

Conditions

Conditions	Yield
With ammonia

: ammonium hydroxide

: 621-62-5
chloroacetaldehyde diethyl acetal

A: 625-77-4
N-acetylacetamide

B: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
at 130℃;

...Expand

: 7664-41-7
ammonia

: 51806-20-3
1,1-diethoxy-2-iodoethane

A: 67856-69-3
iminodiacetaldehyde bis(diethyl acetal)

B: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
at 110 - 125℃;

...Expand

: 64-17-5
ethanol

: 34560-16-2
1,1-diethoxy-2-nitroethane

sodium: sodium

: 645-36-3
2,2-diethoxy-ethanamine

...Expand

: 105-57-7
diethyl acetal

: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: durch Bromierung 2: alcohol; ammonia / 110 - 115 °C View Scheme
Multi-step reaction with 2 steps 1: durch Bromierung 2: alcohol; ammonia / 110 - 115 °C View Scheme

: 6065-82-3
Ethyl diethoxyacetate

: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NH3 / H2O 2: LiAlH4 / tetrahydrofuran / Heating View Scheme

: 113738-28-6
2-azidoethanal diethyl acetal

: 645-36-3
2,2-diethoxy-ethanamine

Conditions

Conditions	Yield
Stage #1: 2-azidoethanal diethyl acetal With triphenylphosphine In tetrahydrofuran at 0℃; for 1h; Stage #2: With water In tetrahydrofuran at 20℃;

: 872-85-5
pyridine-4-carbaldehyde

: 645-36-3
2,2-diethoxy-ethanamine

: 93138-82-0
(2,2-diethoxyethyl)pyridin-4-ylmethyleneamine

Conditions

Conditions	Yield
With magnesium sulfate	100%

: 645-36-3
2,2-diethoxy-ethanamine

: 624-83-9
methyl isocyanate

: 61224-27-9
N-(2,2-diethoxyethyl)-N-methylurea

Conditions

Conditions	Yield
In benzene	100%
In benzene

: 5779-99-7
4-methoxybenzo[d][1,3]dioxole-5-carbaldehyde

: 645-36-3
2,2-diethoxy-ethanamine

: 108261-00-3
amino>acetaldehyde diethyl acetal

Conditions

Conditions	Yield
In ethanol	100%
With hydrogen; palladium on activated charcoal In ethanol	98%

: 645-36-3
2,2-diethoxy-ethanamine

: 79235-49-7
3-formyl-5,6,7-trimethoxy-1,4-dimethylcarbazole

: 79228-25-4
3-(2,2-diethoxyethyliminomethyl)-5,6,7-trimethoxy-1,4-dimethylcarbazole

Conditions

Conditions	Yield
for 2h; Heating;	100%

: 645-36-3
2,2-diethoxy-ethanamine

: 139617-25-7
6,8-dimethoxy-1,4-dimethylcarbazole-3-carbaldehyde

: 139617-26-8
3-(2,2-diethoxyethyliminomethyl)-6,8-dimethoxy-1,4-dimethylcarbazole

Conditions

Conditions	Yield
In benzene for 3.5h; Heating;	100%

: 645-36-3
2,2-diethoxy-ethanamine

: 159116-81-1
3-formyl-8-methoxy-7-pivaloyloxy-1,4-dimethylcarbazole

: 159116-68-4
3--8-methoxy-7-pivaloyloxy-1,4-dimethylcarbazole

Conditions

Conditions	Yield
	100%
In benzene for 5.5h; Heating;	99%

: 645-36-3
2,2-diethoxy-ethanamine

: 160757-62-0
3-formyl-5,7-dimethoxy-1,4-dimethylcarbazole

: 176385-65-2
3-(2,2-diethoxyethyliminomethyl)-5,7-dimethoxy-1,4-dimethylcarbazole

Conditions

Conditions	Yield
In toluene for 2.5h; Heating;	100%

: 88111-74-4
bromo-4 dimethyl-2,5 benzaldehyde

: 645-36-3
2,2-diethoxy-ethanamine

: 4-(2,2-diethoxyethyliminomethyl)-1-bromo-2,5-dimethylbenzene

Conditions

Conditions	Yield
In benzene for 3.75h; Addition;	100%

: 95-72-7
2-chloro-1,4-dimethyl-benzene

: 645-36-3
2,2-diethoxy-ethanamine

: 75934-30-4
N-(2,5-dimethylphenyl)aminoacetoaldehyde diethyl acetal

Conditions

Conditions	Yield
With palladium diacetate; johnphos; sodium t-butanolate In toluene at 100℃; for 15h; Arylation;	100%

: 59748-90-2
4-Bromo-2-chloro-benzoic Acid

: 645-36-3
2,2-diethoxy-ethanamine

: 343564-03-4
4-bromo-2-chloro-N-(2,2-diethoxyethyl)benzamide

Conditions

Conditions	Yield
In dichloromethane	100%

: 10203-08-4
3,5-dichlorobenzaldehyde

: 645-36-3
2,2-diethoxy-ethanamine

: 1000210-73-0
(3,5-dichloro-benzylidene)-(2,2-diethoxy-ethyl)-amine

Conditions

Conditions	Yield
In toluene for 2.5h; Reflux;	100%
In ethanol at 20 - 78℃; for 2h;	94%
In ethanol at 20℃; for 8h;	70.68%
In ethanol at 75℃; for 3h; Temperature;	125 g

: 1227409-75-7
5-(5-fluoro-1H-indol-2-yl)-1-methyl-1H-pyrazol-3-carboxylic acid

: 645-36-3
2,2-diethoxy-ethanamine

: 1227410-02-7
N-(2,2-dimethoxyethyl)-5-(5-fluoro-1H-indol-2-yl)-1-methyl-1H-pyrazole-3-carboxamide

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate In acetonitrile at 18 - 25℃; for 16h;	100%

: trans-4-chlorocarbonyl-cyclohexanecarboxylic acid methyl ester

: 645-36-3
2,2-diethoxy-ethanamine

: trans-4-(2,2-diethoxy-ethylcarbamoyl)-cyclohexanecarboxylic acid methyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 2h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 2h;	100%

: 1351594-25-6
2-methoxymethoxy-3-(2,2,2-trifluoro-ethoxy)-benzaldehyde

: 645-36-3
2,2-diethoxy-ethanamine

: 1351594-26-7
(E)-2,2-diethoxy-N-(2-(methoxymethoxy)-3-(2,2,2-trifluoroethoxy)benzylidene) ethanamine

Conditions

Conditions	Yield
In toluene for 4h; Reflux;	100%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 645-36-3
2,2-diethoxy-ethanamine

: 1604832-23-6
(E)-N-(3,4-dimethoxybenzylidene)-2,2-diethoxyethanamine

Conditions

Conditions	Yield
In toluene at 150℃; for 4h; Dean-Stark;	100%
In toluene at 150℃; for 4h; Dean-Stark;	100%

: 1835-04-7
ethyl 3,4-dimethoxyphenyl ketone

: 645-36-3
2,2-diethoxy-ethanamine

: 1604832-26-9
(E)-N-(1-(3,4-dimethoxyphenyl)propylidene)-2,2-diethoxyethanamine

Conditions

Conditions	Yield
In toluene at 170℃; for 2h; Dean-Stark;	100%

: 54419-21-5
1-(3,4-dimethoxyphenyl)butan-1-one

: 645-36-3
2,2-diethoxy-ethanamine

: 1604832-27-0
(E)-N-(1-(3,4-dimethoxyphenyl)butylidene)-2,2-diethoxyethanamine

Conditions

Conditions	Yield
In toluene at 180℃; for 2h; Dean-Stark;	100%

: 645-36-3
2,2-diethoxy-ethanamine

: 1131-62-0
1-(3,4-dimethoxyphenyl)ethanone

: 1604832-25-8
(E)-N-(1-(3,4-dimethoxyphenyl)ethylidene)-2,2-diethoxyethanamine

Conditions

Conditions	Yield
In toluene at 170℃; for 6h; Dean-Stark;	100%

: 136650-08-3
4,9-dimethyl-9H-carbazole-3-carbaldehyde

: 645-36-3
2,2-diethoxy-ethanamine

: N-((4,9-dimethyl-9H-carbazol-3-yl)methylene)-2,2-diethoxyethanamine

Conditions

Conditions	Yield
In neat (no solvent) at 100℃; for 4h; Inert atmosphere;	100%

: 845267-78-9
tert-butyl 2,4-dioxopiperidine-1-carboxylate

: 645-36-3
2,2-diethoxy-ethanamine

: 1609679-00-6
4-(2,2-diethoxy-ethylamino)-6-oxo-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
In toluene at 20 - 70℃; for 1.25h;	100%

2,2-Diethoxyethylamine Chemical Properties

IUPAC Name: 2,2-Diethoxyethanamine
Following is the structure of Ethanamine,2,2-diethoxy- (CAS NO.645-36-3):

Empirical Formula: C₆H₁₅NO₂
Molecular Weight: 133.1888
EINECS: 211-439-4
Index of Refraction: 1.423
Molar Refractivity: 36.83 cm³
Molar Volume: 144.3 cm³
Density: 0.922 g/cm³
Flash Point: 45.6 °C
Melting point: -78 °C
Water Solubility: soluble
Storage temp.: Flammables area
Surface Tension: 29.5 dyne/cm
Enthalpy of Vaporization: 39.95 kJ/mol
Boiling Point: 163 °C at 760 mmHg
Vapour Pressure: 2.11 mmHg at 25 °C
Appearance of Ethanamine,2,2-diethoxy- (CAS NO.645-36-3): Clear colorless to light yellow liquid
Product Categories of Ethanamine,2,2-diethoxy- (CAS NO.645-36-3): Pharmaceutical Intermediates; Small molecule
Canonical SMILES: CCOC(CN)OCC
InChI: InChI=1S/C6H15NO2/c1-3-8-6(5-7)9-4-2/h6H,3-5,7H2,1-2H3
InChIKey: HJKLEAOXCZIMPI-UHFFFAOYSA-N

2,2-Diethoxyethylamine Toxicity Data With Reference

Ethanamine,2,2-diethoxy- (CAS NO.645-36-3) hasn't been listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. And the toxicological properties have not been fully investigated.

2,2-Diethoxyethylamine Safety Profile

Hazard Codes: Irritant Xi, Corrosive CF
Risk Statements: 10-36/37/38-34
R10:Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin.
R34:Causes burns.
Safety Statements: 23-24/25-26-45-36/37/39-16-36
S23:Do not breathe vapour.
S24/25:Avoid contact with skin and eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S16:Keep away from sources of ignition.
S36:Wear suitable protective clothing.
RIDADR: UN 1989 3/PG 3
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 3
PackingGroup: III

2,2-Diethoxyethylamine Specification

Ethanamine,2,2-diethoxy- , its cas register number is 645-36-3. It also can be called Aminoacetaldehyde diethyl acetal ; and 2,2-Diethoxyethylamine .
Ethanamine,2,2-diethoxy- (CAS NO.645-36-3) could be stable under normal temperatures and pressures. It should avoid the condition like incompatible materials, ignition sources. It is not compatible with strong oxidizing agents, acids, acid chlorides, carbon dioxide, acid anhydrides. And also prevent it to broken down into hazardous decomposition products: nitrogen oxides, carbon monoxide, carbon dioxide. However, its hazardous polymerization has not been reported.

Product Name

2,2-Diethoxyethylamine

Synthetic route

2,2-Diethoxyethylamine Chemical Properties

2,2-Diethoxyethylamine Toxicity Data With Reference

2,2-Diethoxyethylamine Safety Profile

2,2-Diethoxyethylamine Specification

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