2,2-Dimethoxypropane supplier

Name
2,2-Dimethoxypropane
EINECS 201-056-0
CAS No. 77-76-9
Article Data66
CAS DataBase
Density 0.84 g/cm³
Solubility 18 g/100 mL (25 °C)
Melting Point -47 °C
Formula C₅H₁₂O₂
Boiling Point 83 °C at 760 mmHg
Molecular Weight 104.149
Flash Point -5oC
Transport Information UN 1993 3/PG 2
Appearance clear liquid
Safety 26-9-37/39-33-16-33,37/39
Risk Codes 11-36-36/37/38
Molecular Structure
Hazard Symbols F,Xi
Synonyms Acetone,dimethyl acetal (6CI,8CI);2,2-Bis(methyloxy)propane;Acetone dimethyl ketal;NSC 62085;
PSA 18.46000
LogP 1.01530

Synthetic route

: 67-56-1
methanol

: 5447-97-2
2-bromo-2-nitropropane

: 124-41-4
sodium methylate

: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
at 40℃; for 5h; Irradiation;	96%
at 40℃; for 5h; Product distribution; Irradiation; further primary alcohols;	96%

...Expand

: 67-64-1
acetone

: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
With dihydrogen peroxide In water; acetonitrile at 20℃; for 0.25h; Green chemistry;	95%

: 58-56-0
pyridoxal hydrochloride

A: 948-00-5
1,5-dihydro-3,3,8-trimethyl<1,3>dioxepino<5,6-y>pyridin-9-ol

B: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
With sulfuric acid In dichloromethane for 6h; Heating; Title compound not separated from byproducts;	A n/a B 92%

: 1193-11-9, 116944-25-3
2,2,4-trimethyl-1,3-dioxolane

: 67-56-1
methanol

: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
With aluminum (III) chloride at 70℃; for 5.6h; Temperature;	91%

: 542-92-7
cyclopenta-1,3-diene

: 123-73-9
crotonaldehyde

A: 153380-53-1
(1R,2R,3S,4S)-3-methylbicyclo[2.2.1]hept-5-en-2-carboxaldehyde

B: C9H12O

C: 249730-06-1
(1S,2S,3R,4R)-3-methylbicyclo[2.2.1]hept-5-ene-2-carboxaldehyde

D: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
With 3-(5-(2-(4-benzyl-2,2-dimethyl-5-oxoimidazolidin-1-yl)ethoxy)-5-oxopentyl)-1-methyl-1H-imidazol-3-ium bromide; trifluoroacetic acid In methanol at 20℃; Catalytic behavior; Solvent; Reagent/catalyst; Diels-Alder Cycloaddition;	A n/a B n/a C n/a D 88%

...Expand

: 67-56-1
methanol

: 595-49-3
2,2-dinitropropane

: 124-41-4
sodium methylate

: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
at 40℃; for 12h; Irradiation;	84%
at 40℃; for 12h; Product distribution; Irradiation; further primary alcohols;	84%

...Expand

: 67-56-1
methanol

: 41774-06-5
α-nitroisopropyl phenyl sulfone

: 124-41-4
sodium methylate

: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
at 40℃; for 5h; Irradiation;	82%
at 40℃; for 5h; Product distribution; Irradiation; further primary alcohols;	82%

...Expand

: 67-56-1
methanol

: 5-t-Butylperoxycyclo-octene

A: 507-19-7
t-butyl bromide

: 32654-19-6, 89071-84-1, 92617-21-5
trans-2-bromo-9-oxabicyclo<4.2.1>nonane

: 32654-27-6, 89071-85-2, 92617-22-6
trans-2-bromo-9-oxabicyclo<3.3.1>nonane

D: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
With N-Bromosuccinimide for 0.75h; Product distribution; Mechanism; further in CD3OD;	A 1.5% B n/a C n/a D 74%

...Expand

: 67-56-1
methanol

: 85620-94-6, 107494-71-3
2-azido-2-nitropropane

: 124-41-4
sodium methylate

: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
at 40℃; for 24h; Irradiation;	74%
at 40℃; for 24h; Product distribution; Irradiation; further primary alcohols;	74%

...Expand

: 90593-00-3
methyl 5-deoxy-5-C-(diethoxyphosphinyl)-2,3-O-isopropylidene-β-D-ribofuranoside

A: 77-76-9
2,2-dimethoxy-propane

B: 194412-32-3
methyl 5-deoxy-5-C-diethoxyphosphinyl-β-D-ribofuranoside

Conditions

Conditions	Yield
With methanol; iodine for 4.5h;	A n/a B 73%

: 97581-38-9
12,12-dimethoxy-5,5-dimethyl-4,6-dioxatricyclo<7.2.1.02,8>dodec-10-ene

A: 122601-54-1
endo-7,7-dimethoxy-2,3-bis-hydroxymethylbicyclo[2.2.1]hept-5-ene

B: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In methanol Heating;	A 68% B n/a

: 67-56-1
methanol

: 67-64-1
acetone

: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
With formylmorpholine-dimethylsulfate-adduct for 24h; Ambient temperature;	52.9%
With formylmorpholine-dimethylsulfate-adduct for 24h; Product distribution; Ambient temperature; var. other 1-dialkylamino-1-methoxycarbenium methyl sulfates; var. carbonyl compounds; rate of dimethyl ketal formation;	52.9%
AMBERLYST A 15; AMBERLITE IRA 96 at -36 - -34℃; Neat liquid(s);	44.9%

: 2916-31-6
2,2-dimethyl-1,3-dioxolane

Cu(CF3SO3)2: Cu(CF3SO3)2

: 121-43-7
Trimethyl borate

: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
	50.31%

...Expand

: 2916-31-6
2,2-dimethyl-1,3-dioxolane

Cu(CF3 SO3)2: Cu(CF3 SO3)2

: 121-43-7
Trimethyl borate

: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
	50.31%

...Expand

: 67-56-1
methanol

: 52755-34-7
1-methyl-1-nitroethyl p-chlorophenyl sulphide

: 124-41-4
sodium methylate

: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
at 40℃; for 2h; Irradiation;	11%
at 40℃; for 2h; Product distribution; Irradiation; further primary alcohols;	11%

...Expand

: 67-56-1
methanol

: 108-20-3
di-isopropyl ether

A: 87025-34-1
2-methoxy-2-i-propyloxypropane

B: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
With potassium hydroxide; tris (2,4-dibromophenyl)amine; lithium perchlorate at 40℃; electrochem. oxidation;	A 0.03% B 3.6%
With tris (2,4-dibromophenyl)amine; sodium methylate; lithium perchlorate at 40℃; electrochem. oxidation;	A 3% B 0.5%

...Expand

: 67-56-1
methanol

: 108-22-5
Isopropenyl acetate

: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
With boron fluoride ether; mercury(II) oxide
With boron fluoride ether; mercury(II) diacetate

: 67-56-1
methanol

: 463-49-0
1,2-propanediene

: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
With boron fluoride ether; mercury(II) oxide at 40℃;

: 67-56-1
methanol

: 681-84-5
tetramethylorthosilicate

: 67-64-1
acetone

: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
With phosphoric acid

...Expand

: 681-84-5
tetramethylorthosilicate

: 67-64-1
acetone

: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
With hydrogenchloride; methanol
With sulfuric acid

: 15755-09-6
formimidomethylester hydrochloride

: 67-64-1
acetone

: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
With methanol

: 67-56-1
methanol

: 74-99-7
prop-1-yne

: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate; mercury(II) oxide
With methyl(triphenylphosphine)gold(I); methanesulfonic acid at 40℃;

: 67-56-1
methanol

: 463-49-0
1,2-propanediene

A: 116-11-0
2-Methoxypropene

B: 77-76-9
2,2-dimethoxy-propane

C: 67-64-1
acetone

Conditions

Conditions	Yield
sodium hydroxide at 190℃; Rate constant; other temperatures;

...Expand

: 67-56-1
methanol

: 91481-65-1
t-butyl heptafluoroperoxybutyrate

A: 75-91-2
tert.-butylhydroperoxide

B: 356-24-1
methyl heptafluorobutyrate

C: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
at 40℃; for 3h; Yield given. Yields of byproduct given;
In methanol at 10 - 40℃; for 3h; Rate constant; Kinetics; Thermodynamic data; ΔH(act.), ΔS(act.), various temperature;

...Expand

: 29328-23-2
1,1-dimethoxycyclopropane

: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol Product distribution;

: 91481-65-1
t-butyl heptafluoroperoxybutyrate

A: 375-22-4
heptafluorobutyric Acid

B: 116-11-0
2-Methoxypropene

C: 425-24-1
tert-butyl heptafluorobutyrate

D: 77-76-9
2,2-dimethoxy-propane

E: 1-methoxy-1-methylethyl heptafluorobutyrate

Conditions

Conditions	Yield
In nitrobenzene at 70℃; for 7h; Product distribution;	A 0.90 % Turnov. B 0.19 % Turnov. C 0.02 % Turnov. D 0.06 % Turnov. E 0.05 % Turnov.

...Expand

: 67-64-1
acetone

: 149-73-5
trimethyl orthoformate

: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
With ammonium nitrite In methanol for 8h; Heating;
With sulfuric acid In methanol at 20℃;
With sodium montmorillonite In neat (no solvent) at 60℃; for 0.25h; Microwave irradiation; Green chemistry;
With toluene-4-sulfonic acid In methanol Reflux; Molecular sieve;

: 67-56-1
methanol

: 74-99-7
prop-1-yne

A: 116-11-0
2-Methoxypropene

B: 77-76-9
2,2-dimethoxy-propane

C: 67-64-1
acetone

Conditions

Conditions	Yield
sodium hydroxide at 190℃; Rate constant; other temperatures;

...Expand

: 67-56-1
methanol

: 5447-97-2
2-bromo-2-nitropropane

: 865-33-8
potassium methanolate

: 77-76-9
2,2-dimethoxy-propane

Conditions

Conditions	Yield
at 35℃; Product distribution; Mechanism; Irradiation; initial kinetic chain lengths; further alkoxides; with or without (t-Bu)2NO. or oxygen;

...Expand

: 50603-71-9
3-methoxycarbonyl-2H-cyclohepta[b]furan-2-one

: 77-76-9
2,2-dimethoxy-propane

: 54654-48-7
methyl 2-methylazulene-1-carboxylate

Conditions

Conditions	Yield
In toluene at 200℃; for 24h;	100%
In toluene at 200℃;	100%
at 160 - 190℃;	92%

: 146-77-0
2-Chloroadenosine

: 77-76-9
2,2-dimethoxy-propane

: 24639-06-3
((3aR,4R,6R,6aR)-6-(6-amino-2-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 20℃; Cycloaddition;	100%
With perchloric acid In water at 20℃; for 8h; Reagent/catalyst; Inert atmosphere;	88%
With toluene-4-sulfonic acid In acetone at 45℃;	85%

: 16758-34-2
1-thiophenyl-β-D-galactopyranoside

: 77-76-9
2,2-dimethoxy-propane

: 270075-72-4
phenyl 1-thio-3,4-O-isopropylidene-6-O-(1-methoxyl-1-methylethyl)-β-D-galactopyranoside

Conditions

Conditions	Yield
With camphor-10-sulfonic acid at 20℃; for 24h;	100%
With scandium tris(trifluoromethanesulfonate) In acetone at 23℃; for 0.5h; Addition;	86%
With toluene-4-sulfonic acid In water at 20℃; for 4h;	76%

: 66224-56-4
methyl 6-azido-6-deoxy-α-D-mannopyranoside

: 77-76-9
2,2-dimethoxy-propane

: 120138-99-0
methyl 6-azido-6-deoxy-2,3-O-isopropylidene-α-D-mannopyranoside

Conditions

Conditions	Yield
With CSA at 20℃; for 3h;	100%
With toluene-4-sulfonic acid for 1.5h; Ambient temperature;	97%
With toluene-4-sulfonic acid In acetone at 20℃; for 18h; Inert atmosphere;	78%
camphor-10-sulfonic acid at 20℃; for 1h;

: 43179-48-2
L-arabinose di(ethylthio)acetal

: 77-76-9
2,2-dimethoxy-propane

: 92936-93-1
(4R,5S)-4-(bis(ethylthio)methyl)-5-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyl-1,3-dioxolane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In acetone at 20℃; for 5h;	100%
With phosphorus pentoxide In acetone	92%
With phosphorus pentoxide In acetone at 40℃; for 0.25h;	85%
With toluene-4-sulfonic acid In acetone 1.) RT, 30 min, 2.) 40 deg C, 2 h;

: 87-91-2
diethyl (2R,3R)-tartrate

: 77-76-9
2,2-dimethoxy-propane

A: 59779-75-8
diethyl (4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate

B: (4R,5R)-2,2-Dimethyl-[1,3]dioxolane-4,5-dicarboxylic acid 4-ethyl ester 5-methyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 8h; Heating; Title compound not separated from byproducts.;	A 100% B n/a
for 2.5h; Heating;

...Expand

: 116-11-0
2-Methoxypropene

: 77-76-9
2,2-dimethoxy-propane

: 4-Hydroxy-2-((Z)-8-hydroxy-7-oxo-oct-2-enyl)-cyclopent-2-enone

: 2-[(Z)-6-(4-Methoxy-2,2-dimethyl-[1,3]dioxolan-4-yl)-hex-2-enyl]-4-(1-methoxy-1-methyl-ethoxy)-cyclopent-2-enone

Conditions

Conditions	Yield
With toluene-4-sulfonic acid	100%

...Expand

: 20605-01-0
diethyl bis(hydroxymethyl)malonate

: 77-76-9
2,2-dimethoxy-propane

: 51335-75-2
2,2-Dimethyl-1,3-dioxacyclohexane-5,5-dicarboxylic acid,diethyl ester

Conditions

Conditions	Yield
With APTS*H2O at 20℃; for 17h;	100%
With sulfuric acid In acetone at 20℃; for 19h;	94%
With toluene-4-sulfonic acid In acetone for 6h; Heating;	90%

: 1676-81-9
N-benzyloxycarbonyl-L-serine methyl ester

: 77-76-9
2,2-dimethoxy-propane

: 117833-99-5
N-benzyloxycarbonyl 4(S)-(1'-methoxycarbonyl)-2,2-dimethyl-1,3-oxazolidine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 1h; Heating;	100%
With toluene-4-sulfonic acid	99%
With toluene-4-sulfonic acid In benzene for 1h; Heating;	97%

: 108393-28-8
(2S,3R,4S)-5-benzyloxy-2,3-dimethylpentane-1,4-diol

: 77-76-9
2,2-dimethoxy-propane

: 81470-77-1, 98102-72-8, 100760-30-3, 115181-74-3, 133006-91-4, 135211-99-3, 138124-14-8, 145514-09-6
(2S,3S,4S)-5-Benzyloxy-1,3-isopropylidenedioxy-2,4-dimethylpentane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid for 5.5h;	100%

: 129056-37-7
(7S,13E,16S,17R,18R)-2-Benzoyl-7-tert-butyldimethylsilyloxy-17,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13-diene-1,21-dione

: 77-76-9
2,2-dimethoxy-propane

: 129056-38-8
(7S,13E,16S,17R,18R)-2-Benzoyl-7-tert-butyldimethylsilyloxy-17,18-isopropylidenedioxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13-diene-1,21-dione

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In chloroform	100%
With toluene-4-sulfonic acid In chloroform at 20℃; for 5h; Cyclization; Etherification;	99%

: 85148-25-0
(S)-4-(2',5'-dimethoxy-3',4',6'-trimethylphenyl)-2-methyl-1,2-butanediol

: 77-76-9
2,2-dimethoxy-propane

: 69821-03-0
(S)-4-<2-(2,5-dimethoxy-3,4,6-trimethylphenyl)ethyl>-2,2,4-trimethyl-1,3-dioxorane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid for 0.25h; Ambient temperature;	100%
toluene-4-sulfonic acid optical purity more than 95percent;

: 95715-85-8
2-(tert-butoxycarbonylamino)-3-hydroxypropionic acid methyl ester

: 77-76-9
2,2-dimethoxy-propane

: 108149-60-6, 95715-86-9
methyl [(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]carboxylate

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In acetone	100%
With boron trifluoride diethyl etherate In acetone at 20℃; for 3.5h;	92%
With boron trifluoride diethyl etherate In acetone at 20℃; for 2h;	91%

: 130718-72-8
threo (2S,3R)-3-(4-methoxyphenyl)-1,1-bis(p-tolylthio)propane-2,3-diol

: 77-76-9
2,2-dimethoxy-propane

: 130796-28-0
(4S,5R)-trans-4--5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan

Conditions

Conditions	Yield
With toluene-4-sulfonic acid Ambient temperature;	100%

: 180628-57-3
(2S,3S,4R)-1-(tert-Butyl-diphenyl-silanyloxy)-3-methyl-hex-5-ene-2,4-diol

: 77-76-9
2,2-dimethoxy-propane

: 180628-58-4
tert-Butyl-diphenyl-((4S,5S,6R)-2,2,5-trimethyl-6-vinyl-[1,3]dioxan-4-ylmethoxy)-silane

Conditions

Conditions	Yield
	100%

: 67451-62-1, 82683-92-9, 132958-32-8, 130792-45-9
cis-(1S,2S)-1,2-dihydroxy-3-bromocyclohexa-3,5-diene

: 77-76-9
2,2-dimethoxy-propane

: 130669-75-9
(3aS,7aS)-4-bromo-2,2-dimethyl-3a,7a-dihydro-1,3-benzodioxole

Conditions

Conditions	Yield
With toluene-4-sulfonic acid	100%
toluene-4-sulfonic acid at 18℃; for 1h;	99%
With toluene-4-sulfonic acid In acetone at 20℃; for 0.5h;	98%

: 131164-81-3
(S)-3-Benzylsulfanyl-propane-1,2-diol

: 77-76-9
2,2-dimethoxy-propane

: 192999-30-7
(-)-(S)-(2,3-isopropylidenedioxy)propyl benzyl sulfide

Conditions

Conditions	Yield
With toluene-4-sulfonic acid Ambient temperature;	100%

: 77-76-9
2,2-dimethoxy-propane

: 5336-08-3
D-Ribono-1,4-lactone

: 30725-00-9
2,3-O-isopropylidene-D-ribonic-γ-lactone

Conditions

Conditions	Yield
With hydrogen cation In acetone	100%
With boron trifluoride diethyl etherate In acetone at 20℃; for 1.5h; Condensation;	90%
With boron trifluoride diethyl etherate In acetone at 20℃; Inert atmosphere;	86%

: 124575-00-4
5,6-exo-dihydroxy-2-(N-methylcarbamoyl)-2-azabicyclo<2.2.1>heptan-3-one

: 77-76-9
2,2-dimethoxy-propane

: 124575-01-5
5,6-exo-dimethylmethylenedioxy-2-(N-methylcarbamoyl)-2-azabicyclo<2.2.1>heptan-3-one

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In acetone for 0.666667h; Ambient temperature;	100%
With toluene-4-sulfonic acid In acetone

: 114826-03-8
Methanesulfonic acid (2S,3R,4S,5R)-2-benzyloxymethyl-5-((4S,5R)-5-ethyl-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-3,5-dihydroxy-4-methyl-pentyl ester

: 77-76-9
2,2-dimethoxy-propane

: Methanesulfonic acid (S)-3-benzyloxy-2-[(4R,5S,6R)-6-((4R,5R)-5-ethyl-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-propyl ester

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate In dichloromethane at 25℃; for 16h;	100%

: 67470-70-6
(2S,3R)-2,3-Dihydroxy-4-methyl-5-phenylpent-4-ene

: 77-76-9
2,2-dimethoxy-propane

: 81653-01-2
(4R,5R)-2,2,4-Trimethyl-5-((E)-1-methyl-2-phenyl-vinyl)-[1,3]dioxolane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene	100%

: 106693-44-1
4-(R,S)-(t-butoxycarbonylamino)-3-oxo-1,2-diazolidine

: 77-76-9
2,2-dimethoxy-propane

: 106893-80-5
C11H19N3O3

Conditions

Conditions	Yield
camphor-10-sulfonic acid In methanol for 1h; Heating;	100%

: 153025-58-2
(3S,5S)-6-(benzyloxy)-1-(tert-butyldiphenylsilyloxy)-3,5-dihydroxyhexane

: 77-76-9
2,2-dimethoxy-propane

: 112497-22-0
(3S,5S)-6-<(benzyloxy)methyl>-4-<1-(tert-butyldiphenylsilyloxy)ethyl>-2,2-dimethyl-1,3-dioxacyclohexane

Conditions

Conditions	Yield
With camphor-10-sulfonic acid for 1h;	100%
With camphor-10-sulfonic acid	99%

: 138383-64-9
(4S,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-((1S,2S)-1,2-dihydroxy-2-thiazol-2-yl-ethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 77-76-9
2,2-dimethoxy-propane

: 138319-94-5
(4S,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-((4R,5S)-2,2-dimethyl-5-thiazol-2-yl-[1,3]dioxolan-4-yl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With o-toluenesulfonic acid; magnesium sulfate; acetone for 4h; Ambient temperature;	100%

: (1aR,8R,9aR)-7-Benzyloxy-3-hydroxy-8-hydroxymethyl-5-(4-methoxy-phenoxymethyl)-1a,3,8,9a-tetrahydro-2H-1-oxa-3-aza-benzo[a]cyclopropa[e]cycloocten-9-one

: 77-76-9
2,2-dimethoxy-propane

: 138008-38-5
C30H31NO7

Conditions

Conditions	Yield
With camphor-10-sulfonic acid In dichloromethane at 23℃;	100%

: 59992-02-8, 82570-09-0
DL-(1α,2α,3β,4β,5α,7α)-2,5-Dibrom-8-oxabicyclo<5.1.0>octan-3,4-diol

: 77-76-9
2,2-dimethoxy-propane

: 91303-56-9
DL-(1α,2α,3β,4β,5α,7α)-2,5-Dibrom-3,4-O-isopropyliden-8-oxabicyclo<5.1.0>octan-3,4-diol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid Heating;	100%

: 108714-02-9
(2R,3R)-4-(tert-butyl-diphenyl-silanyloxy)-1,1-bisethylsulfanyl-butane-2,3-diol

: 77-76-9
2,2-dimethoxy-propane

: 105265-86-9
4-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-erythrose diethyl dithioacetal

Conditions

Conditions	Yield
With (1S)-10-camphorsulfonic acid In acetone for 4h; Ambient temperature;	100%
With toluene-4-sulfonic acid In acetone Yield given;

: 81481-12-1
(22E,24S)-2α,3α-dihydroxy-5α-stigmast-22-en-6-one

: 77-76-9
2,2-dimethoxy-propane

: 81481-13-2
(22E,24S)-2α,3α-Dihydroxy-5α-stigmast-22-en-6-one 2,3-acetonide

Conditions

Conditions	Yield
With toluene-4-sulfonic acid	100%
With camphor-10-sulfonic acid In dichloromethane; acetonitrile for 1h; Ambient temperature;	98%
With toluene-4-sulfonic acid In dichloromethane for 1h; Ambient temperature; Yield given;

: 109240-70-2
(R)-3-(tert-butyldimethylsilyloxy)-2-methylpropane-1,2-diol

: 77-76-9
2,2-dimethoxy-propane

: 109240-71-3
tert-Butyl-dimethyl-((R)-2,2,4-trimethyl-[1,3]dioxolan-4-ylmethoxy)-silane

Conditions

Conditions	Yield
camphor-10-sulfonic acid for 3h; Ambient temperature;	100%

: 109240-67-7
(S)-1-benzyloxy-2-methylpropane-2,3-diol

: 77-76-9
2,2-dimethoxy-propane

: 109240-68-8
4-benzyloxymethyl-2,2,4-trimethyl-1,3-dioxolane

Conditions

Conditions	Yield
camphor-10-sulfonic acid for 3h; Ambient temperature;	100%

2,2-Dimethoxypropane Specification

1. Introduction of 2,2-Dimethoxypropane
2,2-Dimethoxypropane, is an organic compound and an alkylating reagent. Dimethoxypropane is an intermediate for the synthesis of 2-methoxypropene.

2. Properties of 2,2-Dimethoxypropane
Melting Point: -47 °C
Boiling point: 83 °C at 760 mmHg
Storage Temperature: Flammables area
Density: 0.84 g/cm³
Refractive index: n20/D 1.378(lit.)
Water Solubility: 18 g/100 mL (25 °C)
Stability: Stable. Highly flammable - note low flash point. Vapour may form an explosive mixture with air. May form explosive peroxides when exposed to air. Incompatible with strong oxidizing agents.
Index of Refraction: 1.379
Molar Refractivity: 28.66 cm³
Molar Volume: 123.8 cm³
Surface Tension: 21.1 dyne/cm
Enthalpy of Vaporization: 31.01 kJ/mol
Vapour Pressure: 85.6 mmHg at 25°C
XLogP3-AA: 0.6
H-Bond Donor: 0
H-Bond Acceptor: 2

3. Structure Descriptors of 2,2-Dimethoxypropane
Canonical SMILES: CC(C)(OC)OC
InChI: InChI=1S/C5H12O2/c1-5(2,6-3)7-4/h1-4H3
InChIKey: HEWZVZIVELJPQZ-UHFFFAOYSA-N

4. Safety Information of 2,2-Dimethoxypropane
A very dangerous fire hazard when exposed to heat, flame or oxidizers. When heated to 210°C it burns with a cool flame and then explodes. Explosive reaction with metal perchlorates (e.g., manganese(II) perchlorate; nickel(II) perchlorate) above 65°C. When heated to decomposition it emits acrid smoke and fumes.
Hazard Codes F,Xi Irritant
Risk Statements 11-36-36/37/38
R11:Highly flammable.
R36:Irritating to eyes.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 26-9-37/39-33-16-33,37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S9:Keep container in a well-ventilated place.
S37/39:Wear suitable gloves and eye/face protection.
S33:Take precautionary measures against static discharges.
S16:Keep away from sources of ignition.
S37/39:Wear suitable gloves and eye/face protection.
RIDADR UN 1993 3/PG 2
WGK Germany 2
F 10-21
HazardClass 3
PackingGroup II
HS Code 29110000

5. Use of 2,2-Dimethoxypropane
2,2-Dimethoxypropane is used as a pharmaceutical intermediate, mainly used for hydroxyl protection and dehydration.

6. Preparation of 2,2-Dimethoxypropane
The reaction mechanism for this reaction is sketched below. It is an acid catalysed process. Acids like camphorsulfonic acid or tosic acid can be used.

Product Name

2,2-Dimethoxypropane

Synthetic route

2,2-Dimethoxypropane Specification

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