• Name

  2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE

• EINECS
• CAS No. 230615-52-8
• Article Data3
• CAS DataBase
• Density
• Solubility
• Melting Point
• Formula C₁₁H₁₃N^.HCl
• Boiling Point 277.9 °C at 760 mmHg
• Molecular Weight 195.692
• Flash Point 128.9 °C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms 1,5-Methano-1H-3-benzazepine,2,3,4,5-tetrahydro-, hydrochloride (9CI);
• PSA 12.03000
• LogP 2.99150

Synthetic route

69718-72-5

10-Aza-tricyclo[6.3.1.02.7]dodeca-2(7),3,5-triene

230615-52-8

2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In methanol at 0 - 5℃; Solvent;	96%

230615-48-2

3-benzyl-2,3,4,5-tetrahydro-1,5-methano-1H-3-benzazepine

230615-52-8

2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; palladium(II) hydroxide In methanol at 20 - 40℃; under 3677.86 - 4413.43 Torr;	89.24%
Stage #1: 3-benzyl-2,3,4,5-tetrahydro-1,5-methano-1H-3-benzazepine With ammonium formate; palladium(II) hydroxide In methanol for 0.5h; Inert atmosphere of nitrogen; Reflux; Stage #2: With hydrogenchloride In ethyl acetate at 0 - 5℃; for 1h; pH=1 - 2;

615-13-4

2-indanone

230615-52-8

2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: acetic acid; bromine / 2 h / 25 °C / Cooling with ice 2.1: ethanol; water / 5 h / 20 °C 3.1: potassium hydroxide; water / ethanol / 4 h / 75 °C 4.1: acetic anhydride / 5 h / 100 °C 4.2: 3 h / 75 °C 5.1: sodium tetrahydroborate / tetrahydrofuran / 6 h / 20 °C / Cooling with ice 6.1: hydrogenchloride / methanol / 0 - 5 °C View Scheme

39094-23-0

1,3-dibromo-indan-2-one

230615-52-8

2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: ethanol; water / 5 h / 20 °C 2.1: potassium hydroxide; water / ethanol / 4 h / 75 °C 3.1: acetic anhydride / 5 h / 100 °C 3.2: 3 h / 75 °C 4.1: sodium tetrahydroborate / tetrahydrofuran / 6 h / 20 °C / Cooling with ice 5.1: hydrogenchloride / methanol / 0 - 5 °C View Scheme

C11H6N2O

230615-52-8

2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: potassium hydroxide; water / ethanol / 4 h / 75 °C 2.1: acetic anhydride / 5 h / 100 °C 2.2: 3 h / 75 °C 3.1: sodium tetrahydroborate / tetrahydrofuran / 6 h / 20 °C / Cooling with ice 4.1: hydrogenchloride / methanol / 0 - 5 °C View Scheme

C11H8O5

230615-52-8

2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: acetic anhydride / 5 h / 100 °C 1.2: 3 h / 75 °C 2.1: sodium tetrahydroborate / tetrahydrofuran / 6 h / 20 °C / Cooling with ice 3.1: hydrogenchloride / methanol / 0 - 5 °C View Scheme

230615-52-8

2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride

70258-18-3

2-chloro-5-(chloromethyl)pyridine

C17H17ClN2

Conditions

Conditions	Yield
With tetrabutylammomium bromide; potassium carbonate In acetone for 6h; pH=10; Reflux;	78.2%

230615-52-8

2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride

C11H7BrF7NO

C22H19F7N2O

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide In acetonitrile at 60℃; for 18h;	70%

230615-52-8

2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride

1184086-20-1

4-methoxy-3-(2,2,2-trifluoroacetamido)benzenesulfonyl chloride

2-methoxy-5-((1,2,4,5-tetrahydro-3H-1,5-methanobenzo[d]azepin-3-yl)sulfonyl)aniline

Conditions

Conditions	Yield
Stage #1: 2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride; 4-methoxy-3-(2,2,2-trifluoroacetamido)benzenesulfonyl chloride With dmap; triethylamine In dichloromethane for 1h; Inert atmosphere; Stage #2: With hydrogenchloride In ethanol; water for 16h; Inert atmosphere; Reflux;	65%

230615-52-8

2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride

407-25-0

trifluoroacetic anhydride

230615-51-7

1-(10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; Product distribution / selectivity;
With pyridine In dichloromethane at 0℃; for 0.166667h;
With pyridine In dichloromethane

230615-52-8

2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride

230615-53-9

(+/-)-2,2,2-trifluoro-1-(4-nitro-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-ethanone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: pyridine / dichloromethane 2: trifluorormethanesulfonic acid; nitric acid / dichloromethane View Scheme

230615-52-8

2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride

230615-77-7

1-(4-Iodo-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: pyridine / dichloromethane 2: trifluorormethanesulfonic acid; nitric acid / dichloromethane 3: palladium-carbon / methanol 4: potassium iodide / sulfuric acid; water View Scheme

230615-52-8

2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride

230615-56-2

1-(4-amino-10-aza-tricyclo[6.3.1.02,7]dodeca-2,4,6-trien-10-yl)-2,2,2-trifluoro-ethanone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: pyridine / dichloromethane 2: trifluorormethanesulfonic acid; nitric acid / dichloromethane 3: palladium-carbon / methanol View Scheme

230615-52-8

2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride

230615-81-3

4-Acetyl-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-10-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: pyridine / dichloromethane 2: acetyl chloride 3: 1,4-dioxane; methanol; water View Scheme

230615-52-8

2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride

230615-80-2

1-(4-Acetyl-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: pyridine / dichloromethane 2: acetyl chloride View Scheme

230615-52-8

2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride

357425-94-6

N-(10-Trifluorothioacetyl-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-4-yl)-thioacetamide

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: pyridine / dichloromethane 2: trifluorormethanesulfonic acid; nitric acid / dichloromethane 3: palladium-carbon / methanol 4: triethylamine / dichloromethane 5: toluene View Scheme

230615-52-8

2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride

230615-57-3

N-(10-Trifluoroacetyl-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-4-yl)-acetamide

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: pyridine / dichloromethane 2: trifluorormethanesulfonic acid; nitric acid / dichloromethane 3: palladium-carbon / methanol 4: triethylamine / dichloromethane View Scheme

230615-52-8

2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride

230615-31-3

1-(10-AZATRICYCLO[6.3.1.02,7]DODECA-2(7),3,5-TRIEN-4-YL)-1-ETHANONE HYDROCHLORIDE

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: pyridine / dichloromethane 2: acetyl chloride 3: 1,4-dioxane; methanol; water 4: methanol View Scheme

230615-52-8

2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride

230615-06-2

N1-[10-AZATRICYCLO[6.3.1.02,7]DODECA-2(7),3,5-TRIEN-4-YL]-ACETAMIDE HYDROCHLORIDE

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: pyridine / dichloromethane 2: trifluorormethanesulfonic acid; nitric acid / dichloromethane 3: palladium-carbon / methanol 4: triethylamine / dichloromethane 5: sodium carbonate / methanol; water View Scheme

2,3,4,5-Tetrahydro-1,5-methano-1H-3-benzazepine hydrochloride Chemical Properties

2,3,4,5-Tetrahydro-1,5-methano-1H-3-benzazepine hydrochloride Specification