1-(naphthalen-1-yl)-2,3-dihydroquinazolin-4(1H)-one

IUPAC Name: 1-Naphthalen-1-yl-2,3-dihydroquinazolin-4-one 
Molecular Formula: C₁₈H₁₄N₂O
Molecular Weight: 274.34g/mol
Density: 1.257g/cm³
Boiling Point: 563.6°C at 760mmHg
Flash Point: 294.6°C
Freely Rotating Bonds: 1
Polar Surface Area: 23.55 Å²
Index of Refraction: 1.687
Molar Refractivity: 83.14 cm³
Molar Volume: 218.1 cm³
Polarizability: 32.96 ×10^-24 cm³
Surface Tension: 53.8 dyne/cm
Enthalpy of Vaporization: 84.69 kJ/mol
Vapour Pressure: 1E-12 mmHg at 25°C
The Cas Register Number  of 2,3-Dihydro-2-(1-naphthyl)-4(1h)-quinazolinone is 31785-60-1.The chemical synonyms of 2,3-Dihydro-2-(1-naphthyl)-4(1h)-quinazolinone (CAS NO.31785-60-1) are 2,3-Dihydro-(1-naphthyl)-4-(1H)-quinazolinone ; 2,3-Dihydro-2-(1-naphthyl)-4(1H)-quinazolinone ;  2,3-Dihydro-2-(1-naphthalenyl)-4(1H)-quinazolinone ;  4(1H)-Quinazolinone, 2,3-dihydro-2-(1-naphthyl)- .The molecular structure of 2,3-Dihydro-2-(1-naphthyl)-4(1h)-quinazolinone (CAS NO.31785-60-1) is .

 2,3-Dihydro-2-(1-naphthyl)-4(1h)-quinazolinone (CAS NO.31785-60-1) can be used as pharmaceutical intermediate.

Moderately toxic by intraperitoneal route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.

A series of derivatives of 2,3-Dihydro-2-(1-naphthyl)-4(1h)-quinazolinone (CAS NO.31785-60-1)  (DHQZ) with known antitumor activity was re-evaluated in the National Cancer Institute cancer cell line screen. Analysis by the COMPARE algorithm suggested that their cytotoxicity derived from interactions with tubulin. Significant inhibition of tubulin assembly and of the binding of radiolabeled colchicine to tubulin was demonstrated with several of the compounds, particularly NSC 145669, 175635, and 175636. The DHQZ derivatives are structurally analogous to a number of antimitotic agents, flavonols and derivatives of 2-styrylquinazolin-4(3H)-one and of 2-phenyl-4-quinolone. Structure-activity analogies between these agents, the combretastatins, and the colchicinoids were analyzed and summarized.