2',4'-Dichloro-5'-fluoroacetophenone supplier

Name
2,4-Dichloro-5-fluoroacetophenone
EINECS -0
CAS No. 704-10-9
Article Data10
CAS DataBase
Density 1.388 g/cm³
Solubility
Melting Point 33-36 °C
Formula C₈H₅Cl₂FO
Boiling Point 254.9 °C at 760 mmHg
Molecular Weight 207.032
Flash Point 107.9 °C
Transport Information
Appearance white to light yellow cryst. low melting solid
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi,F
Synonyms Acetophenone,2',4'-dichloro-5'-fluoro- (7CI,8CI);
PSA 17.07000
LogP 3.33510

Synthetic route

: 1435-48-9
1,3-dichloro-4-fluorobenzene

: 75-36-5
acetyl chloride

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

Conditions

Conditions	Yield
With aluminum (III) chloride at 110℃; Reagent/catalyst; Temperature;	89.3%
With aluminum (III) chloride Friedel Crafts acylation;	52%
With aluminum (III) chloride at 30 - 120℃; Product distribution / selectivity;
aluminum (III) chloride

: 1435-48-9
1,3-dichloro-4-fluorobenzene

: 108-24-7
acetic anhydride

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

Conditions

Conditions	Yield
With aluminium trichloride
With aluminum (III) chloride at 70 - 120℃; for 25h;	165 g

: 1-(1-butoxy-vinyl)-2,4-dichloro-5-fluoro-benzene

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

Conditions

Conditions	Yield
With hydrogenchloride for 0.5h;

: 1481-63-6
1-bromo-2,4-dichloro-5-fluorobenzene

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1-butyl-3-methylimidazolium*BF4; 1,3-bis(diphenylphosphino)propane; Et3N / Ni(OAc)2 / 30 h / 130 °C 2: aq. HCl / 0.5 h View Scheme

: 1435-48-9
1,3-dichloro-4-fluorobenzene

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

Conditions

Conditions	Yield
With hydrogenchloride; acetic anhydride; aluminium trichloride

: 95-50-1
1,2-dichloro-benzene

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: nitric acid; sulfuric acid / 2 h / 95 - 100 °C 2.1: potassium fluoride / 3 h / 140 - 150 °C 2.2: 7 h / 165 - 170 °C 3.1: chlorine / 8 h / 170 - 180 °C 4.1: aluminum (III) chloride / 110 °C View Scheme

: 99-54-7
3,4-dichloronitrobenzene

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: potassium fluoride / 3 h / 140 - 150 °C 1.2: 7 h / 165 - 170 °C 2.1: chlorine / 8 h / 170 - 180 °C 3.1: aluminum (III) chloride / 110 °C View Scheme

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 86522-89-6
2,4-dichloro-5-fluoro-benzoic acid

Conditions

Conditions	Yield
With oxygen; nitric acid In water; acetic acid at 70℃; under 1500.15 Torr; for 0.15h; Catalytic behavior; Temperature; Time; Pressure; Flow reactor; Industrial scale; Green chemistry;	99.9%
With sodium hypochlorite In 1,4-dioxane	98%
With sodium hydroxide; chlorine In ethanol pH=10;	90%
With sodium percarbonate; potassium tert-butylate; sphingosylphosphorylcholine; meta-dinitrobenzene In tert-butyl alcohol at 80℃; for 5h;	35%
With sodium hydroxide; chlorine In ethanol for 6h; pH=8 - 10;

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: α,α,α,2,4-pentachloro-5-fluoroacetophenone

Conditions

Conditions	Yield
With chlorine In water	96%

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 106809-14-7
2,4-dichloro-5-fluoro-3-nitro-benzoic acid

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 103 - 110℃; for 3h; Temperature;	91%
With sulfuric acid; nitric acid 1.) 55 deg C; 2.) 75 deg C, 3 h;	82%

: 34035-03-5
5-(4-chlorophenyl)-2-furaldehyde

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: (E)-3-[5-(4-Chloro-phenyl)-furan-2-yl]-1-(2,4-dichloro-5-fluoro-phenyl)-propenone

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 20℃; for 4h; Claisen-Schmidt condensation;	90%

: 34035-04-6
5-(2-chlorophenyl)furan-2-carbaldehyde

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: (E)-3-[5-(2-Chloro-phenyl)-furan-2-yl]-1-(2,4-dichloro-5-fluoro-phenyl)-propenone

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 20℃; for 4h; Claisen-Schmidt condensation;	89%

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 855715-32-1
C8H8Cl2FN

Conditions

Conditions	Yield
With N,N'-bis(salicylidene)-1,2-phenylene-diaminocobalt(II); ammonia; hydrogen In water at 130℃; for 24h; Autoclave;	89%

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 95-92-1
oxalic acid diethyl ester

: ethyl (Z)-4-(2,4-dichloro-5-fluorophenyl)-2-hydroxy-4-oxobut-2-enoate

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at 20℃; Claisen Condensation;	88%

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 357915-19-6
α-bromo-(2,4-dichloro-5-fluoro)acetophenone

Conditions

Conditions	Yield
With 1-butyl-3-methylimidazolium tribromide In neat (no solvent) for 0.266667h;	83.2%
With bromine In chloroform Photolysis;
With bromine In tetrachloromethane at 0 - 20℃;

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 105-58-8
Diethyl carbonate

: 86483-51-4
ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate

Conditions

Conditions	Yield
With sodium hydride at 80℃; for 1.5h;	80%
	47%
With sodium hydride In tetrahydrofuran at 45 - 55℃; for 5h; Inert atmosphere;	215 g
With sodium hydride

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 100-47-0
benzonitrile

: 3-(2,4-dichloro-5-fluorobenzoyl)-5-phenyl-1,2,4-oxadiazole

Conditions

Conditions	Yield
With nitric acid at 80℃; for 4h;	80%

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 616-38-6
carbonic acid dimethyl ester

: 103319-17-1
methyl 2,4-dichloro-5-fluoro-benzoylacetate

Conditions

Conditions	Yield
Stage #1: carbonic acid dimethyl ester With sodium methylate at 75℃; for 0.25h; Stage #2: 2,4-dichloro-5-fluoroacetophenone at 85℃; for 3h;	80%

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 1-(2,4-dichloro-5-fluorophenyl)-6,7-dimethoxy-1-methylisochroman-3-one

Conditions

Conditions	Yield
Stage #1: (3,4-Dimethoxyphenyl)acetic acid With trifluoroacetic anhydride In acetonitrile at 25℃; for 0.166667h; Green chemistry; Stage #2: 2,4-dichloro-5-fluoroacetophenone In acetonitrile at 25℃; for 10h; Green chemistry;	80%

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 103-72-0
phenyl isothiocyanate

: 1181767-93-0
(2,4-dichloro-5-fluorophenyl)((3Z)-5-(phenylamino)-3-(phenylimino)-3H-1,2-dithiol-4-yl)methanone

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane at 20℃; for 9h;	78.5%

: 7147-77-5
5-(4-nitrophenyl)-2-furaldehyde

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 395060-33-0
(E)-1-(2,4-Dichloro-5-fluoro-phenyl)-3-[5-(4-nitro-phenyl)-furan-2-yl]-propenone

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 20℃; for 4h; Claisen-Schmidt condensation;	78%

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 91-56-5
indole-2,3-dione

: 903596-57-6
2-(2,4-dichloro-5-fluorophenyl)quinoline-4-carboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide In water for 2h; Heating;	78%
With sodium hydroxide Pfitzinger reaction; Heating;

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 87-48-9
5-Bromo-1H-indole-2,3-dione

: 903596-58-7
6-bromo-2-(2,4-dichloro-5-fluorophenyl)quinoline-4-carboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide In water for 2h; Heating;	76%

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 875119-43-0
2,4-dihloro-5-fluorophenylglyoxal

Conditions

Conditions	Yield
With selenium(IV) oxide; silica gel for 0.133333h; microwave irradiation;	75%
With selenium(IV) oxide In 1,4-dioxane; water for 4h; Reflux;

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 20005-42-9
5-(4-bromophenyl)-2-furancarboxyaldehyde

: (E)-3-[5-(4-Bromo-phenyl)-furan-2-yl]-1-(2,4-dichloro-5-fluoro-phenyl)-propenone

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 20℃; for 4h; Claisen-Schmidt condensation;	73%

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 103-72-0
phenyl isothiocyanate

: 1181768-07-9
(3Z)-7-chloro-6-fluoro-9-phenyl-3-(phenylimino)-3H-[1,2]dithiolo[3,4-b]quinolin-4(9H)-one

Conditions

Conditions	Yield
Stage #1: 2,4-dichloro-5-fluoroacetophenone With potassium; potassium hydroxide In 1,4-dioxane for 0.166667h; Reflux; Stage #2: phenyl isothiocyanate In 1,4-dioxane for 9h; Reflux; Stage #3: With cerous nitrate In water	70.5%

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 75-05-8
acetonitrile

: 3-(2,4-dichloro-5-fluorobenzoyl)-5-methyl-1,2,4-oxadiazole

Conditions

Conditions	Yield
With nitric acid at 80℃; for 30h;	68%

: 13148-43-1
5-(3-nitrophenyl)furfural

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: (E)-1-(2,4-Dichloro-5-fluoro-phenyl)-3-[5-(3-nitro-phenyl)-furan-2-yl]-propenone

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 20℃; for 4h; Claisen-Schmidt condensation;	61%

: 20000-96-8
5-(2-nitrophenyl)-2-furaldehyde

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: (E)-1-(2,4-Dichloro-5-fluoro-phenyl)-3-[5-(2-nitro-phenyl)-furan-2-yl]-propenone

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 20℃; for 4h; Claisen-Schmidt condensation;	60%

: 504-29-0
2-aminopyridine

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 2,4-dichloro-5-fluoro-N-(pyridin-2-yl)benzamide

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; trifluorormethanesulfonic acid; tetra-(n-butyl)ammonium iodide In water at 80℃; Sealed tube;	59%

: 90-14-2
1-Iodonaphthalene

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 1149756-67-1
9-chloro-8-fluorochrysen-6-ol

Conditions

Conditions	Yield
With norborn-2-ene; palladium diacetate; caesium carbonate; triphenylphosphine In acetonitrile at 90℃; for 24h; Inert atmosphere; regioselective reaction;	52%

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 19335-11-6
1H-indazol-5-ylamine

: 1-[5-(5-amino-1H-indazol-1-yl)-2,4-dichlorophenyl]ethan-1-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 20h;	6%
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 20h;	6%

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: methyl magnesium carbonate

: 111760-50-0
2,4-dichloro-5-fluorobenzoylacetic acid

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 110℃; for 1h; Yield given;

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 704-09-6
Methyl-<2,4-dichlor-5-fluor-phenyl>-carbinol

Conditions

Conditions	Yield
With sodium hydroxide; sodium tetrahydroborate

: 17823-58-4
ethyl 2-cyano-3,3-di(methylsulfanyl)acrylate

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 6-(2,4-Dichloro-5-fluoro-phenyl)-4-methylsulfanyl-2-oxo-2H-pyran-3-carbonitrile

Conditions

Conditions	Yield
With potassium hydroxide In N,N-dimethyl-formamide

2',4'-Dichloro-5'-fluoroacetophenone Chemical Properties

Synonyms:2',4'-Dichloro-5'-Fluoroacetophenone 2,4-Dichloro-5-Fluoroacetophenone;2',4'-Dichloro-5'-fluoroacetophenone 98%;2',4'-Dichloro-5'-fluoroacetophenone98% ; 2',4'-DICHLORO-5'-FLUOROACETOPHENONE;1-(2,4-DICHLORO-5-FLUORO-PHENYL)-ETHANONE;2',4'-DICHLORO-5'-FLUOROACETOPHENONE, 90;2,4-DICHLORO-5-FLUOROACETOPHENONE;1-(2,4-DICHLORO-5-FLUOROPHENYL)ETHAN-1-ONE;
The Molecular formula of 2,4-DICHLORO-5-FLUOROACETOPHENONE(704-10-9) : C₈H₅Cl₂FO
The Molecular Weight of 2,4-DICHLORO-5-FLUOROACETOPHENONE(704-10-9) : 207.03
Molecular Structure :

Melting point: 33-36 °C
Boiling point:167 °C(lit.)
Flash point: >230 °F
density: 1.425 g/mL at 25 °C(lit.)
refractive index: n20/D 1.546(lit.)

2',4'-Dichloro-5'-fluoroacetophenone Uses

2,4-DICHLORO-5-FLUOROACETOPHENONE(704-10-9) is used as pharmaceutical intermediates.

2',4'-Dichloro-5'-fluoroacetophenone Safety Profile

The Hazard Codes of 2,4-DICHLORO-5-FLUOROACETOPHENONE(704-10-9):

Xi,

F
Hazard Note: Flammable
The Risk Statements information of 2,4-DICHLORO-5-FLUOROACETOPHENONE(704-10-9):
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of 2,4-DICHLORO-5-FLUOROACETOPHENONE(704-10-9):
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
37/39: Wear suitable gloves and eye/face protection
WGK Germany: 3

Product Name

2,4-Dichloro-5-fluoroacetophenone

Synthetic route

2',4'-Dichloro-5'-fluoroacetophenone Chemical Properties

2',4'-Dichloro-5'-fluoroacetophenone Uses

2',4'-Dichloro-5'-fluoroacetophenone Safety Profile

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