Product Name

  • Name

    2,4-Dichloroquinazoline

  • EINECS 612-020-2
  • CAS No. 607-68-1
  • Article Data134
  • CAS DataBase
  • Density 1.486 g/cm3
  • Solubility
  • Melting Point 117-121oC
  • Formula C8H4Cl2N2
  • Boiling Point 273.3 °C at 760 mmHg
  • Molecular Weight 199.039
  • Flash Point 145.4 °C
  • Transport Information
  • Appearance white crystalline powder
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 607-68-1 (2,4-Dichloroquinazoline)
  • Hazard Symbols
  • Synonyms NSC 75192;
  • PSA 25.78000
  • LogP 2.93660

Synthetic route

1,2,3,4-tetrahydro-quinazoline-2,4-dione
86-96-4

1,2,3,4-tetrahydro-quinazoline-2,4-dione

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

Conditions
ConditionsYield
With trichlorophosphate at 115℃; for 16h;100%
With trichlorophosphate at 115℃; for 16h;100%
With trichlorophosphate for 18h; Heating / reflux;96%
methyl carbamate
598-55-0

methyl carbamate

2-aminobenzoyl chloride
21563-73-5

2-aminobenzoyl chloride

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

Conditions
ConditionsYield
With pyridine; tetrachloromethane; titanium(IV) oxide; vanadia; tungsten(VI) oxide; tin(IV) oxide In N,N-dimethyl-formamide at 120 - 230℃; under 2250.23 - 6000.6 Torr; for 32h; Solvent; Temperature; Pressure; Reagent/catalyst;99.1%
quinazoline-2,4-diol
86-96-4

quinazoline-2,4-diol

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

Conditions
ConditionsYield
With trichlorophosphate for 2.5h; Heating / reflux;99%
With N-ethyl-N,N-diisopropylamine; trichlorophosphate at 110℃; for 3h;98.4%
With N-ethyl-N,N-diisopropylamine; trichlorophosphate at 90℃; for 6h;95%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

anthranilic acid nitrile
1885-29-6

anthranilic acid nitrile

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate With triethylamine; Triphenylphosphine oxide In chlorobenzene at 20℃; for 0.5h; Cooling with ice;
Stage #2: anthranilic acid nitrile In chlorobenzene at 120℃; for 6h;
95%
Stage #1: bis(trichloromethyl) carbonate With triethylamine; Triphenylphosphine oxide In chlorobenzene at 0℃; for 0.5h;
Stage #2: anthranilic acid nitrile In chlorobenzene at 120℃; for 5h;
45%
3-tert-butyl-1,2,3,4-tetrahydroquinazoline-2,4-dione
1209-77-4

3-tert-butyl-1,2,3,4-tetrahydroquinazoline-2,4-dione

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; trichlorophosphate at 100℃; for 4h; Sealed tube;93%
3-(hydroxyimino)indolin-2-one
607-28-3, 73859-64-0, 73859-66-2

3-(hydroxyimino)indolin-2-one

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

Conditions
ConditionsYield
With bis(trichloromethyl) carbonate; Tris(4-methoxyphenyl)phosphine oxide In chlorobenzene at 120℃; for 3h; Mechanism; Reagent/catalyst;93%
1-Methylpyrrolidine
120-94-5

1-Methylpyrrolidine

2-chloro-4(3H)-quinazolinone
607-69-2

2-chloro-4(3H)-quinazolinone

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

Conditions
ConditionsYield
With trichlorophosphate at 80 - 85℃; for 0.5h;90%
2-chloro-4(3H)-quinazolinone
607-69-2

2-chloro-4(3H)-quinazolinone

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

Conditions
ConditionsYield
With 1-Methylpyrrolidine; trichlorophosphate at 20 - 25℃; for 0.5h;90%
N-tert-butyl-pyrrolidine
15185-01-0

N-tert-butyl-pyrrolidine

1,2,3,4-tetrahydro-quinazoline-2,4-dione
86-96-4

1,2,3,4-tetrahydro-quinazoline-2,4-dione

A

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

B

tert-Butyl-(4-chloro-butyl)-(4-chloro-quinazolin-2-yl)-amine

tert-Butyl-(4-chloro-butyl)-(4-chloro-quinazolin-2-yl)-amine

Conditions
ConditionsYield
With trichlorophosphate at 80 - 85℃; for 0.333333h;A 88.5%
B n/a
anthranilic acid nitrile
1885-29-6

anthranilic acid nitrile

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

Conditions
ConditionsYield
In acetonitrile at 130℃; for 12h;86%
1,2,3,4-tetrahydro-quinazoline-2,4-dione
86-96-4

1,2,3,4-tetrahydro-quinazoline-2,4-dione

(pyrrolidine-1)-2 butane

(pyrrolidine-1)-2 butane

A

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

B

sec-Butyl-(4-chloro-butyl)-(4-chloro-quinazolin-2-yl)-amine

sec-Butyl-(4-chloro-butyl)-(4-chloro-quinazolin-2-yl)-amine

Conditions
ConditionsYield
With trichlorophosphate at 80 - 85℃; for 0.333333h;A 84.6%
B n/a
2-Hydroxy-3H-quinazolin-4-one

2-Hydroxy-3H-quinazolin-4-one

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

Conditions
ConditionsYield
With N,N-dimethyl-formamide; trichlorophosphate80%
1-Methylpyrrolidine
120-94-5

1-Methylpyrrolidine

1,2,3,4-tetrahydro-quinazoline-2,4-dione
86-96-4

1,2,3,4-tetrahydro-quinazoline-2,4-dione

A

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

B

4-chloro-2-quinazoline
81093-71-2

4-chloro-2-quinazoline

Conditions
ConditionsYield
With trichlorophosphate at 80 - 85℃; for 0.333333h;A 3.3%
B 77.3%
With trichlorophosphate at 80 - 85℃; for 0.333333h;A 3.3%
B 77.3%
With trichlorophosphate at 20 - 25℃; for 0.166667h;A 12.7%
B 70.5%
2,4-dioxo-1,2,3,4-tetrahydroquinoline
52851-41-9

2,4-dioxo-1,2,3,4-tetrahydroquinoline

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

Conditions
ConditionsYield
Stage #1: 2,4-dioxo-1,2,3,4-tetrahydroquinoline With trichlorophosphate for 48h; Reflux;
Stage #2: With water at 30℃;
71%
1,2,3,4-tetrahydro-quinazoline-2,4-dione
86-96-4

1,2,3,4-tetrahydro-quinazoline-2,4-dione

A

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

B

4-chloro-2-quinazoline
81093-71-2

4-chloro-2-quinazoline

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one; trichlorophosphate at 20 - 25℃; for 0.166667h;A 12.7%
B 70.5%
N-propylpyrrolidine
7335-07-1

N-propylpyrrolidine

1,2,3,4-tetrahydro-quinazoline-2,4-dione
86-96-4

1,2,3,4-tetrahydro-quinazoline-2,4-dione

A

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

B

4-chloro-2-(N-propyl-4-chlorobutylamino)quinazoline
81683-45-6

4-chloro-2-(N-propyl-4-chlorobutylamino)quinazoline

Conditions
ConditionsYield
With trichlorophosphate at 80 - 85℃; for 0.333333h;A 19.5%
B 59.4%
With trichlorophosphate at 80 - 85℃; for 0.333333h;A 19.5%
B 59.4%
1-ethylpyrrolidine
7335-06-0

1-ethylpyrrolidine

1,2,3,4-tetrahydro-quinazoline-2,4-dione
86-96-4

1,2,3,4-tetrahydro-quinazoline-2,4-dione

A

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

B

4-chloro-2-(N-ethyl-4-chlorobutylamino)quinazoline
81683-44-5

4-chloro-2-(N-ethyl-4-chlorobutylamino)quinazoline

Conditions
ConditionsYield
With trichlorophosphate at 80 - 85℃; for 0.333333h;A 17.9%
B 58.7%
With trichlorophosphate at 80 - 85℃; for 0.333333h;A 17.9%
B 58.7%
1-butylpyrrolidine
767-10-2

1-butylpyrrolidine

1,2,3,4-tetrahydro-quinazoline-2,4-dione
86-96-4

1,2,3,4-tetrahydro-quinazoline-2,4-dione

A

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

B

4-chloro-2-(N-butyl-4-chlorobutylamino)quinazoline
81683-46-7

4-chloro-2-(N-butyl-4-chlorobutylamino)quinazoline

Conditions
ConditionsYield
With trichlorophosphate at 80 - 85℃; for 0.333333h;A 48.5%
B 34.7%
With trichlorophosphate at 80 - 85℃; for 0.333333h;A 48.5%
B 34.7%
N-methylcyclohexylamine
626-67-5

N-methylcyclohexylamine

1,2,3,4-tetrahydro-quinazoline-2,4-dione
86-96-4

1,2,3,4-tetrahydro-quinazoline-2,4-dione

A

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

B

(5-Chloro-pentyl)-(4-chloro-quinazolin-2-yl)-methyl-amine
83369-15-7

(5-Chloro-pentyl)-(4-chloro-quinazolin-2-yl)-methyl-amine

Conditions
ConditionsYield
With trichlorophosphate at 80 - 85℃; for 0.333333h;A 41.9%
B 28.2%
3-methyl-2,4(1H,3H)-quinazolinedione
607-19-2

3-methyl-2,4(1H,3H)-quinazolinedione

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

Conditions
ConditionsYield
With phosphorus pentachloride at 160 - 170℃; im Rohr;
1-Methylpyrrolidine
120-94-5

1-Methylpyrrolidine

1,2,3,4-tetrahydro-quinazoline-2,4-dione
86-96-4

1,2,3,4-tetrahydro-quinazoline-2,4-dione

A

2-chloro-4(3H)-quinazolinone
607-69-2

2-chloro-4(3H)-quinazolinone

B

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

C

4-chloro-2-quinazoline
81093-71-2

4-chloro-2-quinazoline

D

2--4(3H)-quinazoline
84148-67-4

2--4(3H)-quinazoline

Conditions
ConditionsYield
With trichlorophosphate Product distribution; Mechanism; ratio of products vs. conditions;
2.4-dioxy-quinazoline

2.4-dioxy-quinazoline

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

Conditions
ConditionsYield
With phosphorus pentachloride; phosphorus trichloride at 150 - 160℃; im Rohr;
With phosphorus pentachloride; trichlorophosphate
3-methyl-2,4(1H,3H)-quinazolinedione
607-19-2

3-methyl-2,4(1H,3H)-quinazolinedione

phosphorus pentachloride
10026-13-8, 874483-75-7

phosphorus pentachloride

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

Conditions
ConditionsYield
at 160 - 170℃; im Rohr;
phosphorus pentachloride
10026-13-8, 874483-75-7

phosphorus pentachloride

1,2,3,4-tetrahydro-quinazoline-2,4-dione
86-96-4

1,2,3,4-tetrahydro-quinazoline-2,4-dione

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

phosphorus pentachloride
10026-13-8, 874483-75-7

phosphorus pentachloride

1,2,3,4-tetrahydro-quinazoline-2,4-dione
86-96-4

1,2,3,4-tetrahydro-quinazoline-2,4-dione

phosphorus trichloride
7719-12-2, 52843-90-0

phosphorus trichloride

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

Conditions
ConditionsYield
at 150 - 160℃; im Rohr;
N-(2-Cyanophenyl)-2,2,2-trifluoroacetamide
64718-13-4

N-(2-Cyanophenyl)-2,2,2-trifluoroacetamide

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. K2CO3 / methanol / 12 h / 20 °C
2: 86 percent / acetonitrile / 12 h / 130 °C
View Scheme
2-iodophenylamine
615-43-0

2-iodophenylamine

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: dimethylformamide / 0.5 h / 20 °C
2: dimethylformamide / 0.5 h / 100 °C
3: aq. K2CO3 / methanol / 12 h / 20 °C
4: 86 percent / acetonitrile / 12 h / 130 °C
View Scheme
2,2,2-trifluoro-N-(2-iodophenyl)acetamide
143321-89-5

2,2,2-trifluoro-N-(2-iodophenyl)acetamide

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dimethylformamide / 0.5 h / 100 °C
2: aq. K2CO3 / methanol / 12 h / 20 °C
3: 86 percent / acetonitrile / 12 h / 130 °C
View Scheme
aniline
62-53-3

aniline

α-chloro-propionic acid amide

α-chloro-propionic acid amide

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: ICl / dimethylformamide / 0.5 h / 20 °C
2: dimethylformamide / 0.5 h / 20 °C
3: dimethylformamide / 0.5 h / 100 °C
4: aq. K2CO3 / methanol / 12 h / 20 °C
5: 86 percent / acetonitrile / 12 h / 130 °C
View Scheme
2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

2-chloro-quinazolin-4-ylamine
59870-43-8

2-chloro-quinazolin-4-ylamine

Conditions
ConditionsYield
With ammonia In methanol at 20℃; Substitution;100%
With ammonium hydroxide at 20℃; for 28.5h;96%
With ammonia In tetrahydrofuran; water at 20℃;72%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

2-chloro-4-(4-methylpiperazin-1-yl)quinazoline
39216-68-7

2-chloro-4-(4-methylpiperazin-1-yl)quinazoline

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In ethyl acetate at 0 - 20℃; for 1.5h;100%
Stage #1: 1-methyl-piperazine; 2,4-dichloroquinazoline In tetrahydrofuran for 3.5h;
Stage #2: With sodium hydroxide In tetrahydrofuran; dichloromethane; water
96%
With sodium carbonate In ethanol Heating;87%
In tetrahydrofuran at 20℃; Condensation;
2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

3-methyl-5-aminopyrazole
31230-17-8

3-methyl-5-aminopyrazole

2-chloro-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine
404828-30-4

2-chloro-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine

Conditions
ConditionsYield
With triethylamine In ethanol at 20℃;100%
With triethylamine In ethanol at 20℃; for 3h;
In ethanol
2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

N-(3-aminophenyl)cyclopropanesulfonamide
1203416-45-8

N-(3-aminophenyl)cyclopropanesulfonamide

2-chloro-N4-[3-(cyclopropanesulfonamido)phenyl]quinazoline-4-amine

2-chloro-N4-[3-(cyclopropanesulfonamido)phenyl]quinazoline-4-amine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol for 16h; Reflux;100%
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol for 16h; Reflux;100%
2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

(S)-Alaninol
2749-11-3

(S)-Alaninol

C11H12ClN3O

C11H12ClN3O

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran100%
2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

(2R)-hydroxypropylamine
2799-16-8

(2R)-hydroxypropylamine

C11H12ClN3O

C11H12ClN3O

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran100%
2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

4-(naphthalene-2-yl)phenylboronic acid pinacol ester
918655-03-5

4-(naphthalene-2-yl)phenylboronic acid pinacol ester

C24H15ClN2
1373265-69-0

C24H15ClN2

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; water; toluene at 100℃; for 5h;99.9%
TETRAHYDROFURFURYLAMINE
4795-29-3

TETRAHYDROFURFURYLAMINE

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

2-chloro-N-((tetrahydrofuran-2-yl)methyl)quinazolin-4-amine

2-chloro-N-((tetrahydrofuran-2-yl)methyl)quinazolin-4-amine

Conditions
ConditionsYield
Stage #1: TETRAHYDROFURFURYLAMINE With triethylamine In methanol at 0℃; for 0.166667h; Inert atmosphere;
Stage #2: 2,4-dichloroquinazoline In methanol; dichloromethane at 0 - 20℃; for 0.5h; Inert atmosphere;
99%
Stage #1: TETRAHYDROFURFURYLAMINE With triethylamine In methanol at 0℃; for 0.166667h; Inert atmosphere;
Stage #2: 2,4-dichloroquinazoline In methanol; dichloromethane at 0 - 20℃; for 0.5h; Inert atmosphere;
99%
With sodium acetate In tetrahydrofuran; water at 65℃;82%
With sodium hydroxide 1.) THF, 30 min, 2.) THF, 30 min; Multistep reaction;
With sodium acetate In tetrahydrofuran; water at 60℃;
2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

4-chloro-3-ethoxyphenylamine
852854-42-3

4-chloro-3-ethoxyphenylamine

2-chloro-N4-(4-chloro-3-ethoxyphenyl)quinazoline-4-amine

2-chloro-N4-(4-chloro-3-ethoxyphenyl)quinazoline-4-amine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol for 18h; Reflux;99%
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol for 18h; Reflux;99%
2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

2-chloro-4(3H)-quinazolinone
607-69-2

2-chloro-4(3H)-quinazolinone

Conditions
ConditionsYield
Stage #1: 2,4-dichloroquinazoline With sodium hydride at 17 - 24℃; for 4h; Inert atmosphere;
Stage #2: With acetic acid In water at 21 - 24℃; Inert atmosphere;
98.4%
With sodium hydroxide In tetrahydrofuran; water96%
With sodium hydroxide In tetrahydrofuran at 20℃; Inert atmosphere;91%
1-(2-aminoethyl)pyrrolidine
7154-73-6

1-(2-aminoethyl)pyrrolidine

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

2-chloro-N-<2-(1-pyrrolidinyl)ethyl>-4-quinazolinamine
76004-35-8

2-chloro-N-<2-(1-pyrrolidinyl)ethyl>-4-quinazolinamine

Conditions
ConditionsYield
In diethyl ether at 20℃; for 12h;98%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 18h;65%
In diethyl ether for 1.5h;56%
6-methoxy-pyridin-3-ylamine
6628-77-9

6-methoxy-pyridin-3-ylamine

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

2-chloro-N-(6-methoxypyridin-3-yl)quinazolin-4-amine

2-chloro-N-(6-methoxypyridin-3-yl)quinazolin-4-amine

Conditions
ConditionsYield
With sodium acetate In tetrahydrofuran; water at 60℃; for 0.75h;98%
With sodium acetate In tetrahydrofuran; water at 60℃; for 0.75h;98%
2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

glycine ethyl ester hydrochloride
623-33-6

glycine ethyl ester hydrochloride

methyl-2-(2-chloroquinazolin-4-ylamino)acetate
881310-74-3

methyl-2-(2-chloroquinazolin-4-ylamino)acetate

Conditions
ConditionsYield
With triethylamine In ethanol at 70℃; for 16h;98%
2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

furan-2-ylmethanamine
617-89-0

furan-2-ylmethanamine

2-chloro-N-(furan-2-ylmethyl)quinazoline-4-amine

2-chloro-N-(furan-2-ylmethyl)quinazoline-4-amine

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃;97%
With triethylamine In tetrahydrofuran for 0.5h; Reflux;92%
With triethylamine In tetrahydrofuran at 60℃; for 1h;88%
2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

aniline
62-53-3

aniline

2-chloro-N-phenylquinazolin-4-amine
144511-93-3

2-chloro-N-phenylquinazolin-4-amine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol Substitution; Heating;97%
With sodium acetate In tetrahydrofuran; water at 65℃;94%
With triethylamine In tetrahydrofuran at 60℃;89%
orcinol
504-15-4

orcinol

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

3,5-bis(2-chloroquinazolin-4-yloxy)toluene
1242243-70-4

3,5-bis(2-chloroquinazolin-4-yloxy)toluene

Conditions
ConditionsYield
With 18-crown-6 ether; potassium carbonate In acetone at 20℃; for 48h; Inert atmosphere; regioselective reaction;97%
3-Aminomethylpyridine
3731-52-0

3-Aminomethylpyridine

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

2-chloro-N-(pyridin-3-yl-methyl)quinazolin-4-amine

2-chloro-N-(pyridin-3-yl-methyl)quinazolin-4-amine

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; Inert atmosphere;97%
Stage #1: 3-Aminomethylpyridine With triethylamine In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: 2,4-dichloroquinazoline In tetrahydrofuran at 20℃;
92.3%
With triethylamine In tetrahydrofuran at 20℃;
2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

sodium methylate
124-41-4

sodium methylate

2-chloro-4-methoxyquinazoline
77767-98-7

2-chloro-4-methoxyquinazoline

Conditions
ConditionsYield
With methanol at 20℃; for 48h;96%
In methanol at 20℃; for 48h;96%
With methanol; phenol
2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

4-(diphenylamino)phenyl boronic acid
201802-67-7

4-(diphenylamino)phenyl boronic acid

C26H18ClN3

C26H18ClN3

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 75℃;95.5%
2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

4-methoxy-aniline
104-94-9

4-methoxy-aniline

2-chloro-N-(4-methoxyphenyl)quinazolin-4-amine
192217-99-5

2-chloro-N-(4-methoxyphenyl)quinazolin-4-amine

Conditions
ConditionsYield
With sodium acetate In tetrahydrofuran; water at 65℃; for 1h;95%
With hydrogenchloride In water; isopropyl alcohol at 20℃;77%
With triethylamine In tetrahydrofuran at 30℃;69.2%
With sodium acetate In tetrahydrofuran; water43%
2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

4-phenoxyanilin
139-59-3

4-phenoxyanilin

(2-chloro-quinazolin-4-yl)-(4-phenoxy-phenyl)-amine
827031-01-6

(2-chloro-quinazolin-4-yl)-(4-phenoxy-phenyl)-amine

Conditions
ConditionsYield
With sodium acetate In tetrahydrofuran; water at 60℃;95%
2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

(±)-trans-methyl 3-aminobicyclo[2.2.2]octane-2-carboxylate

(±)-trans-methyl 3-aminobicyclo[2.2.2]octane-2-carboxylate

(+/-)-trans-methyl 3-((2-chloroquinazolin-4-yl)amino)bicyclo[2.2.2]octane-2-carboxylate

(+/-)-trans-methyl 3-((2-chloroquinazolin-4-yl)amino)bicyclo[2.2.2]octane-2-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;95%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;67%
2-pyridin-3-ylethylamine
20173-24-4

2-pyridin-3-ylethylamine

2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

2-chloro-N-(2-(pyridin-3-yl)ethyl)quinazolin-4-amine

2-chloro-N-(2-(pyridin-3-yl)ethyl)quinazolin-4-amine

Conditions
ConditionsYield
Stage #1: 2-pyridin-3-ylethylamine With triethylamine In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: 2,4-dichloroquinazoline In tetrahydrofuran at 20℃;
94.3%
2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

2-aminomethylpyrazine
20010-99-5

2-aminomethylpyrazine

2-chloro-N-(pyrazin-2-ylmethyl)quinazolin-4-amine

2-chloro-N-(pyrazin-2-ylmethyl)quinazolin-4-amine

Conditions
ConditionsYield
Stage #1: 2-aminomethylpyrazine With triethylamine In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: 2,4-dichloroquinazoline In tetrahydrofuran at 20℃;
94.2%
With triethylamine In tetrahydrofuran at 20℃;
2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

dimethyl amine
124-40-3

dimethyl amine

2-chloro-N,N-dimethylquinazolin-4-amine
35691-16-8

2-chloro-N,N-dimethylquinazolin-4-amine

Conditions
ConditionsYield
In tetrahydrofuran; water at 20℃; for 1.33333h;94%
In tetrahydrofuran; water at 20℃; for 1.33333h;94%
In tetrahydrofuran; water at 4 - 20℃; for 1.33333h;94%
With triethylamine In water; N,N-dimethyl-formamide at 20℃; Ice cooling;
With sodium acetate In tetrahydrofuran; water0.037 g
2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

methylamine
74-89-5

methylamine

2-chloro-4-(N-methylamino)quinazoline
83260-68-8

2-chloro-4-(N-methylamino)quinazoline

Conditions
ConditionsYield
In tetrahydrofuran; water at 20℃; for 0.666667h;94%
With sodium acetate In tetrahydrofuran; water at 65℃;92%
With N-ethyl-N,N-diisopropylamine In ethanol at 20℃; for 4.5h; Inert atmosphere;91%

2,4-Dichloroquinazoline Chemical Properties

IUPAC Name: 2,4-Dichloroquinazoline 
Following is the structure of Quinazoline,2,4-dichloro- (CAS NO.607-68-1):
                                   
Empirical Formula: C8H4Cl2N2
Molecular Weight: 199.0368 
Index of Refraction: 1.67
Molar Refractivity: 50.06 cm3
Molar Volume: 133.8 cm3 
Density: 1.486 g/cm3
Flash Point: 145.4 °C
Surface Tension: 59 dyne/cm
Enthalpy of Vaporization: 49.1 kJ/mol
Boiling Point of Quinazoline,2,4-dichloro- (CAS NO.607-68-1): 273.3 °C at 760 mmHg
Vapour Pressure of Quinazoline,2,4-dichloro- (CAS NO.607-68-1): 0.00968 mmHg at 25 °C
Canonical SMILES: C1=CC=C2C(=C1)C(=NC(=N2)Cl)Cl
InChI: InChI=1S/C8H4Cl2N2/c9-7-5-3-1-2-4-6(5)11-8(10)12-7/h1-4H
InChIKey: TUQSVSYUEBNNKQ-UHFFFAOYSA-N

2,4-Dichloroquinazoline Specification

 Quinazoline,2,4-dichloro- , its cas register number is 607-68-1. It also can be called 2,4-Dichloroquinazoline .

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