• Name

  2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

• EINECS 433-170-3
• CAS No. 56830-58-1
• Article Data2
• CAS DataBase
• Density
• Solubility
• Melting Point >300 °C
• Formula C₄H₆N₄O₂^.HCl
• Boiling Point 490 °C at 760 mmHg
• Molecular Weight 178.578
• Flash Point 250.1 °C
• Transport Information
• Appearance orange-pink powder
• Safety 37/39-26
• Risk Codes 36/37/38
• Molecular Structure
• Hazard Symbols Xi
• Synonyms 2,5-Diamino-2,6-dihydroxypyridine hydrochloride;2,5-Diamino-4,6-dihydroxy pyrimidine HCl. (DADHP HCl );2,5-Diamino-4,6-Dihydroxypyrimidine HCl;
• PSA 118.02000
• LogP 0.60430

Synthetic route

5-acetylamino-2-aminopyrimidine-4,6-diol

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water at 270℃; for 2h; Inert atmosphere;	49%

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

56893-25-5

methyl 4-(2-bromoacetyl)benzoate

85828-45-1

4-(2-Amino-4-oxo-3,7-dihydro-4H-pyrimido[4,5-b][1,4]oxazin-6-yl)-benzoic acid methyl ester

Conditions

Conditions	Yield
With sodium hydrogencarbonate In methanol for 2h; Heating;	94%

10516-71-9

3-(3-Methoxy-phenyl)-propionic acid

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

1245319-69-0

N-(2-amino-4,6-dihydroxypyrimidin-5-yl)-3-(3-methoxyphenyl)propanamide

Conditions

Conditions	Yield
Stage #1: 3-(3-Methoxy-phenyl)-propionic acid With thionyl chloride for 1h; Reflux; Stage #2: 2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride With sodium hydroxide In 1,4-dioxane; water at 0 - 20℃; for 1h;	87%
Stage #1: 3-(3-Methoxy-phenyl)-propionic acid With thionyl chloride for 1h; Reflux; Stage #2: 2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride With sodium hydroxide In 1,4-dioxane at 0 - 20℃; for 1h;	87%

40478-49-7

3-(3-methoxyphenyl)propanoyl chloride

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

1245319-69-0

N-(2-amino-4,6-dihydroxypyrimidin-5-yl)-3-(3-methoxyphenyl)propanamide

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane; water at 0 - 20℃; for 1h;	87%

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

55583-59-0

2,5-diamino-4,6-dichloropyrimidine

Conditions

Conditions	Yield
Stage #1: 2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride With tetramethlyammonium chloride; trichlorophosphate In 1,2,3-trichloropropane at 115℃; for 24h; Stage #2: With sodium hydroxide In 1,2,3-trichloropropane; water at 50 - 60℃; for 0.5h; pH=6.5 - 7.0;	65%
With tetraethylammonium chloride; trichlorophosphate at 105℃; for 20h;	64%
With tetraethylammonium chloride; trichlorophosphate at 105℃; for 20h;	64%

40215-83-6

N-ethyl-N-methyl piperidinium chloride

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

55583-59-0

2,5-diamino-4,6-dichloropyrimidine

Conditions

Conditions	Yield
With trichlorophosphate	65%

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

85828-56-4

4-(3-Bromo-2-oxo-propyl)-benzoic acid methyl ester

85828-57-5

2-amino-4-hydroxy-6-(p-carbomethoxybenzyl)-7,8-dihydro-8-oxapteridine

Conditions

Conditions	Yield
With magnesium oxide In methanol for 4h; Heating;	50%

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

68-12-2, 33513-42-7

N,N-dimethyl-formamide

171887-03-9

N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl-formamide With trichlorophosphate at 50℃; for 0.75h; Stage #2: 2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride at 70 - 90℃; for 17.45 - 20.45h; Stage #3: With sodium hydroxide; water at 20 - 97℃; for 4 - 8h; pH=0.5 - 4.0; Product distribution / selectivity;	37.4%

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

85828-53-1

diethyl N--L-glutamate

85828-54-2

diethyl N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-pteridinyl)methyl>benzoyl>-L-glutamate

Conditions

Conditions	Yield
With magnesium oxide In methanol for 3h; Heating;	30%

937-38-2

1-chloro-3-phenylpropan-2-one

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

70080-71-6

2-amino-6-benzyl-3,7-dihydro-pyrimido[4,5-b][1,4]oxazin-4-one

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethanol Heating;

41055-92-9

1-chloro-2-heptanone

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

70080-74-9

2-amino-6-pentyl-3,7-dihydro-pyrimido[4,5-b][1,4]oxazin-4-one

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethanol Heating;

70-23-5

ethyl Bromopyruvate

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

73217-09-1

2-amino-4-oxo-3,7-dihydro-4H-pyrimido[4,5-b][1,4]oxazine-6-carboxylic acid ethyl ester

Conditions

Conditions	Yield
In ethanol Heating;

638-07-3

ethyl (2-chloroaceto)acetate

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

73217-06-8

(2-amino-4-oxo-3,5-dihydro-4H-pyrimido[4,5-b][1,4]oxazin-6-ylidene)-acetic acid ethyl ester

Conditions

Conditions	Yield
In ethanol Heating;

58009-85-1

1-chloro-5-phenyl-pentan-2-one

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

70080-72-7

2-amino-6-(3-phenyl-propyl)-3,7-dihydro-pyrimido[4,5-b][1,4]oxazin-4-one

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethanol Heating;

20845-80-1

1-chloro-4-phenylbutan-2-one

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

70080-77-2

2-amino-6-phenethyl-3,7-dihydro-pyrimido[4,5-b][1,4]oxazin-4-one

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethanol Heating;

70080-70-5

1-chloro-6-phenyl-hexan-2-one

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

70080-73-8

2-amino-6-(4-phenyl-butyl)-3,7-dihydro-pyrimido[4,5-b][1,4]oxazin-4-one

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethanol Heating;

4,6-Dichloro-2,5-bis-[(dimethylamino)methyleneamino]pyrimidine

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

171887-03-9

N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide

Conditions

Conditions	Yield
With sodium hydroxide; phosphoric acid; trichlorophosphate In N-methyl-acetamide; water; toluene

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

171887-03-9

N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide

Conditions

Conditions	Yield
With sodium hydroxide; trichlorophosphate In N-methyl-acetamide; water
With sodium hydroxide; trichlorophosphate In N-methyl-acetamide; water

10052-47-8

triethylmethylammonium chloride

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

55583-59-0

2,5-diamino-4,6-dichloropyrimidine

Conditions

Conditions	Yield
With sodium hydroxide; trichlorophosphate In ethyl acetate; acetonitrile

96-18-4

1,2,3-trichloropropane

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

55583-59-0

2,5-diamino-4,6-dichloropyrimidine

Conditions

Conditions	Yield
With sodium hydroxide; tetramethlyammonium chloride; trichlorophosphate In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; hexane

5834-04-8

3-(2-thienyl)-propanoic acid chloride

56830-58-1

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

1245318-71-1

N-(2-amino-4,6-dihydroxypyrimidin-5-yl)-3-thiophen-2-yl-propionamide

Conditions

Conditions	Yield
With sodium hydroxide In water at 20℃; for 18h;
With sodium hydroxide In water
With sodium hydroxide In water at 20℃; for 18h;	1.25 g

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride Chemical Properties

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride Safety Profile

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride Specification