2,5-Dihydro-2,5-dimethoxyfuran supplier

Name
2,5-Dihydro-2,5-dimethoxyfuran
EINECS 206-367-5
CAS No. 332-77-4
Article Data26
CAS DataBase
Density 1.06 g/cm³
Solubility
Melting Point < -40°C
Formula C₆H₁₀O₃
Boiling Point 161 °C at 760 mmHg
Molecular Weight 130.144
Flash Point 47.2 °C
Transport Information UN 1993
Appearance Colorless to light yellow liquid
Safety 16-29-33
Risk Codes 10
Molecular Structure
Hazard Symbols R10:;
Synonyms 2,5-Dihydro-2,5-dimethoxyfuran;2,5-Dimethoxy-2,5-dihydrofuran;NSC 43243;
PSA 27.69000
LogP 0.51780

Synthetic route

: 110-00-9
furan

: 67-56-1
methanol

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

Conditions

Conditions	Yield
With ammonium bromide at -22℃; for 7.5h; Electrochemical reaction;	85%
With triethylmethylammonium chloride; sodium carbonate at -5 - 5℃; for 10h;	85.3%
With tris(2,2'-bipyridyl)ruthenium dichloride at 20℃; under 760.051 Torr; Reagent/catalyst; Irradiation;	82%

: 67-56-1
methanol

: 821-11-4, 6117-80-2, 110-64-5
1,4-butenediol

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

Conditions

Conditions	Yield
Stage #1: methanol; 1,4-butenediol With tributylmethylammonium methanesulfonate; phosphoric acid at 22℃; for 19h; Electrolysis; Stage #2: With sodium methylate In methanol pH=8 - 9;	46%

: 110-00-9
furan

: 67-56-1
methanol

: 127-08-2
potassium acetate

A: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

B: 859303-52-9
2-Acetoxy-5-methoxy-2,5-dihydro-furan

Conditions

Conditions	Yield
With bromine

...Expand

: 110-00-9
furan

: 67-56-1
methanol

: 7726-95-6
bromine

: 127-08-2
potassium acetate

A: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

B: 859303-52-9
2-Acetoxy-5-methoxy-2,5-dihydro-furan

...Expand

: 110-00-9
furan

: 67-56-1
methanol

: ammonium bromide

A: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

B: 5370-08-1
1,1,4,4-tetramethoxy-2-butene

Conditions

Conditions	Yield
Electrolysis;

...Expand

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: 23008-77-7
3-(2-hydroxyphenyl)-3-oxopropanoate ethyl ester

: ethyl 2-(furan-2-yl)-3-(2-hydroxyphenyl)-3-oxopropanoate

Conditions

Conditions	Yield
With K10 Montmorillonite Clay In neat (no solvent) at 80℃; for 2h; Catalytic behavior; Solvent; Temperature; Green chemistry;	96%

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: (Carboxy-methoxy-methoxy)-methoxy-acetic acid

Conditions

Conditions	Yield
With potassium permanganate In potassium hydroxide for 2h;	95%

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: 107-02-8
acrolein

Conditions

Conditions	Yield
With potassium permanganate In potassium hydroxide for 2.5h;	95%

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: 2881-83-6
ethyl 4-methoxybenzoylacetate

: 719311-02-1
2-furan-2-yl-3-(4-methoxy-phenyl)-3-oxo-propionic acid ethyl ester

Conditions

Conditions	Yield
With zinc(II) chloride at 80℃;	95%

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: 57595-95-6
methyl 6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

: 116672-79-8
carbomethoxy-2 (furyl-2)-2 dimethoxy-6,7 dihydro-3,4 naphtalenone-1

Conditions

Conditions	Yield
With zinc(II) chloride In tetrahydrofuran; acetic acid for 1h; Heating;	94%
With acetic acid; zinc(II) chloride In tetrahydrofuran Heating;	90%

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: 105-53-3
diethyl malonate

: 40572-09-6
α-(furan-2-yl) diethyl malonate

Conditions

Conditions	Yield
Zinc chloride In water; acetic acid	94%

: 67-56-1
methanol

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: 50299-15-5, 70837-19-3, 81136-73-4, 105929-46-2
methyl (S)-allylglycinate

: C11H17NO4

Conditions

Conditions	Yield
Stage #1: 2,5-dihydro-2,5-dimethoxyfuran; methyl (S)-allylglycinate With hydrogenchloride Stage #2: methanol With sulfuric acid for 3h; Heating; Further stages.;	93%

...Expand

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: ethyl 3-(2-hydroxy-4,5-dimethoxyphenyl)-3-oxopropanoate

: 3-(furan-2-yl)-4-hydroxy-6,7-dimethoxy-2H-chromen-2-one

Conditions

Conditions	Yield
Stage #1: 2,5-dihydro-2,5-dimethoxyfuran; ethyl 3-(2-hydroxy-4,5-dimethoxyphenyl)-3-oxopropanoate at 80℃; for 1h; Stage #2: With sodium hydroxide In ethanol Temperature; Reflux;	93%

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 33545-52-7
(+/-)-8,9-dimethoxy-1,5,6,10b-tetrahydro-2H-pyrrolo[2,1-a]isoquinolin-3-one

Conditions

Conditions	Yield
With 1,2,3-Benzotriazole In acetic acid for 24h; Heating;	92%
With acetic acid Heating;	53%

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: 17422-32-1
5-chloro-1H-indole

: C20H12Cl2N2

Conditions

Conditions	Yield
With 3-(1,1-dioxido-4-(3-(3-(3-sulfopropyl)-1H-imidazol-3-ium-1-yl)propyl)thiomorpholino-4-ium)propane-1-sulfonate trifluoromethanesulfonate In acetic acid butyl ester at 80℃; for 2h;	92%

: 67-56-1
methanol

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: 865-33-8
potassium methanolate

: 149-73-5
trimethyl orthoformate

A: 107-31-3
Methyl formate

B: 5370-08-1
1,1,4,4-tetramethoxy-2-butene

Conditions

Conditions	Yield
Stage #1: methanol; 2,5-dihydro-2,5-dimethoxyfuran; trimethyl orthoformate; toluene-4-sulfonic acid under 760.051 Torr; Stage #2: potassium methanolate With Pluriol E400 at 100 - 130℃; Product distribution / selectivity;	A n/a B 91.3%

...Expand

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: ethyl 3-(2-hydroxy-4,6-dimethoxyphenyl)-3-oxopropanoate

: 3-(furan-2-yl)-4-hydroxy-5,7-dimethoxy-2H-chromen-2-one

Conditions

Conditions	Yield
Stage #1: 2,5-dihydro-2,5-dimethoxyfuran; ethyl 3-(2-hydroxy-4,6-dimethoxyphenyl)-3-oxopropanoate at 80℃; for 1h; Stage #2: With sodium hydroxide In ethanol Temperature; Reflux;	91%

: 603-76-9
1-methylindole

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: C22H18N2

Conditions

Conditions	Yield
With 3-(1,1-dioxido-4-(3-(3-(3-sulfopropyl)-1H-imidazol-3-ium-1-yl)propyl)thiomorpholino-4-ium)propane-1-sulfonate trifluoromethanesulfonate In acetic acid butyl ester at 80℃; for 2h; Catalytic behavior; Reagent/catalyst; Solvent;	91%

: 67-56-1
methanol

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: 4220-66-0
methyl 4,4-dimethoxybutanoate

Conditions

Conditions	Yield
(carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II) at 150℃; for 12h;	90%

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: 40153-87-5
methyl 6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

: 116672-78-7
carbomethoxy-2 (furyl-2)-2 methoxy-6 dihydro-3,4 naphtalenone-1

Conditions

Conditions	Yield
With acetic acid; zinc(II) chloride In tetrahydrofuran Heating;	90%
With zinc(II) chloride In tetrahydrofuran; acetic acid for 1h; Heating;	84%

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: 7442-52-6, 125117-36-4
methyl 1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

: 116672-77-6
carbomethoxy-2 (furyl-2)-2 dihydro-3,4 naphtalenone-1

Conditions

Conditions	Yield
With acetic acid; zinc(II) chloride In tetrahydrofuran Heating;	90%
With zinc(II) chloride In tetrahydrofuran; acetic acid for 1h; Heating;	88%

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: 109-92-2
ethyl vinyl ether

: 2-furylacetaldehyde diethyl acetal

Conditions

Conditions	Yield
With magnesium bromide In diethyl ether at 20℃; for 0.25h; Product distribution; Further Variations:; Reaction partners; reaction times;	90%

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: 78917-44-9
2-Benzofuranpropionic acid-β-oxo-ethylester

: ethyl 3-(benzofuran-2-yl)-2-(furan-2-yl)-3-oxopropanoate

Conditions

Conditions	Yield
With K10 montmorillonite clay In hexane at 80℃; for 3h;	90%

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: ethyl 3-(2-hydroxy-6-methoxyphenyl)-3-oxopropanoate

: 3-(furan-2-yl)-4-hydroxy-5-methoxy-2H-chromen-2-one

Conditions

Conditions	Yield
Stage #1: 2,5-dihydro-2,5-dimethoxyfuran; ethyl 3-(2-hydroxy-6-methoxyphenyl)-3-oxopropanoate at 80℃; for 1h; Stage #2: With sodium hydroxide In ethanol Temperature; Reflux;	90%

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: 10604-59-8
N-Ethylindole

: C24H22N2

Conditions

Conditions	Yield
With 3-(1,1-dioxido-4-(3-(3-(3-sulfopropyl)-1H-imidazol-3-ium-1-yl)propyl)thiomorpholino-4-ium)propane-1-sulfonate trifluoromethanesulfonate In acetic acid butyl ester at 80℃; for 2h;	90%

: 332-77-4
2,5-dihydro-2,5-dimethoxyfuran

: 22014-99-9
N-butylindole

: C28H30N2

Conditions

Conditions	Yield
With 3-(1,1-dioxido-4-(3-(3-(3-sulfopropyl)-1H-imidazol-3-ium-1-yl)propyl)thiomorpholino-4-ium)propane-1-sulfonate trifluoromethanesulfonate In acetic acid butyl ester at 80℃; for 2h;	90%

2,5-Dihydro-2,5-dimethoxyfuran Specification

The Furan,2,5-dihydro-2,5-dimethoxy-, with CAS registry number 332-77-4, belongs to the following product categories: (1)Aromatic Hydrocarbons (substituted) & Derivatives; (2)Furan&Benzofuran; (3)Furans; (4)Pharmaceutical. It has the systematic name of 2,5-dimethoxy-2,5-dihydrofuran. This chemical is a kind of colorless to light yellow liquid. This chemical is used as the intermediate of Atropine Sulfate. What's more, its EINECS is 206-367-5.

Physical properties of Furan,2,5-dihydro-2,5-dimethoxy-: (1)ACD/LogP: -1.00; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1; (4)ACD/LogD (pH 7.4): -1; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 6.78; (8)ACD/KOC (pH 7.4): 6.78; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 27.69 Å²; (13)Index of Refraction: 1.448; (14)Molar Refractivity: 32.86 cm³; (15)Molar Volume: 122.7 cm³; (16)Polarizability: 13.02×10^-24cm³; (17)Surface Tension: 29.1 dyne/cm; (18)Density: 1.06 g/cm³; (19)Flash Point: 47.2 °C; (20)Enthalpy of Vaporization: 38.12 kJ/mol; (21)Boiling Point: 161 °C at 760 mmHg; (22)Vapour Pressure: 3.02 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
The Furan,2,5-dihydro-2,5-dimethoxy- is flammable, so keep it away from sources of ignition. You should not empty it into drains. And you should take precautionary measures against static discharges.

You can still convert the following datas into molecular structure:
(1)SMILES: O(C)C/1OC(OC)\C=C\1
(2)InChI: InChI=1/C6H10O3/c1-7-5-3-4-6(8-2)9-5/h3-6H,1-2H3
(3)InChIKey: WXFWXFIWDGJRSC-UHFFFAOYAI
(4)Std. InChI: InChI=1S/C6H10O3/c1-7-5-3-4-6(8-2)9-5/h3-6H,1-2H3
(5)Std. InChIKey: WXFWXFIWDGJRSC-UHFFFAOYSA-N

Product Name

2,5-Dihydro-2,5-dimethoxyfuran

Synthetic route

2,5-Dihydro-2,5-dimethoxyfuran Specification

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