Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen In methanol at 75℃; under 22502.3 Torr; for 5h; Pressure; Temperature; Solvent; | 97.2% |
With hydrogen at 15 - 30℃; Autoclave; | 70% |
With diethyl ether; aluminium amalgam; water | |
With hydrogen; oxalic acid; palladium | |
With hydrogen; platinum(IV) oxide; Co(dmgH)2 In ethanol at 25℃; increase in hydrogenation rate in presence of Co catalyst, another catalyst: H-Co(DG)2Py; |
Conditions | Yield |
---|---|
With ammonium hydroxide; hydrogen In methanol; water at 65℃; under 12929 Torr; for 6h; Reagent/catalyst; Autoclave; | A 71% B n/a |
With ammonia; hydrogen In methanol; water at 65℃; under 12929 Torr; for 5h; | A n/a B 61% |
dimethyl 2-aminomalonate
serinol
Conditions | Yield |
---|---|
With hydrogen at 180℃; under 71257.1 Torr; Reagent/catalyst; Pressure; Temperature; Flow reactor; Green chemistry; | 96% |
Conditions | Yield |
---|---|
With (S)-1-phenyl-ethylamine; Halomonas elongata ω-transaminase In aq. phosphate buffer at 37℃; pH=8; Enzymatic reaction; | |
With L-alanin; pyridoxal 5'-phosphate In aq. buffer at 30℃; for 24h; pH=8; Enzymatic reaction; |
1,3-benzylideneglycerol-2-amine
serinol
Conditions | Yield |
---|---|
With methanol at 20℃; for 12h; | 53% |
Conditions | Yield |
---|---|
With hydrogen; Nishimura catalyst <(45.9% Rh/19.9% Pt) oxide> In methanol at 25℃; under 75007.5 Torr; | A 10 mg B 90 % Spectr. |
Conditions | Yield |
---|---|
With ethanol; nickel at 100℃; under 250073 Torr; Hydrogenation; |
Conditions | Yield |
---|---|
With sodium cyanoborohydride; ammonium chloride; acetic acid In methanol at 20℃; | A n/a B 87% |
Conditions | Yield |
---|---|
With sulfuric acid; hydrogen In water at 79.84℃; under 60006 Torr; | 92.8% |
With sulfuric acid; hydrogen In water at 79.84℃; under 60006 Torr; for 4h; Catalytic behavior; Autoclave; |
Conditions | Yield |
---|---|
With potassium borohydride In methanol; water at 20℃; for 12h; | 11.3% |
4-Hydroxymethyl-2-trichlormethyl-4,5-dihydrooxazol
serinol
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane at 50℃; for 1.5h; |
2-amino-1,3-propanediol oxalate
serinol
Conditions | Yield |
---|---|
With ammonia In water Conversion of starting material; |
Conditions | Yield |
---|---|
With L-alanin; pyridoxal 5'-phosphate In aq. buffer at 30℃; for 23h; pH=8; Time; Microbiological reaction; Enzymatic reaction; |
serinol
Conditions | Yield |
---|---|
With sodium hydroxide In water |
Conditions | Yield |
---|---|
at 100℃; under 250073 Torr; Hydrogenation; |
Ser-OMe
serinol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride; diethyl ether |
1,3-dihydroxyacetone oxime
A
serinol
Conditions | Yield |
---|---|
With aluminum(III) sulfate; sodium amalgam |
A
serinol
Conditions | Yield |
---|---|
With water at 95℃; Rate constant; var. pH; |
Conditions | Yield |
---|---|
aminosulfonic acid at 25 - 28℃; for 0.0833333h; | 100% |
In ethanol at 20℃; for 16h; Solvent; | 100% |
In dichloromethane at 22 - 25℃; for 4h; | 97% |
8-Cyclohexyl-4-(4-fluoro-2-methylphenyl)-2-methanesulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one
serinol
8-cyclohexyl-4-(4-fluoro-2-methylphenyl)-2-[N-dihydroxymethylmethylamino]-8H-pyrido[2,3-d]pyrimidin-7-one
Conditions | Yield |
---|---|
In tetrahydrofuran at 90℃; for 16h; | 100% |
serinol
N,N'-bis(benzyloxycarbonyl)-N''-(2-hydroxy-1-hydroxymethyl-ethyl)-guanidine
Conditions | Yield |
---|---|
In tetrahydrofuran for 1h; | 100% |
N,N-bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine
serinol
N,N'-bis(benzyloxycarbonyl)-N"-(2-hydroxy-1-hydroxymethyl-ethyl)-guanidine
Conditions | Yield |
---|---|
In tetrahydrofuran for 1h; | 100% |
In tetrahydrofuran at 25℃; for 7h; | 95% |
In tetrahydrofuran at 25℃; for 16h; | 58% |
Conditions | Yield |
---|---|
Stage #1: C13H15NO5 With 2,3,4,5,6-pentafluorophenol; diisopropyl-carbodiimide In N,N-dimethyl-formamide for 0.5h; Stage #2: serinol In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere; | 100% |
Conditions | Yield |
---|---|
In methanol at 20℃; | 100% |
dimethyl 5-nitroisophthalate
serinol
N,N'-bis-(2-hydroxy-1-hydroxymethylethyl)-5-nitroisophthalamide
Conditions | Yield |
---|---|
In methanol at 20℃; for 48h; Reflux; | 99% |
Conditions | Yield |
---|---|
In ethanol for 16h; Reflux; | 99% |
Conditions | Yield |
---|---|
In butan-1-ol for 0.166667h; Zincke's reaction; microwave irradiation; | 98% |
Conditions | Yield |
---|---|
With triethylamine In methanol at 0 - 20℃; | 98% |
bis(trichloromethyl) carbonate
serinol
4-Hydroxymethyl oxazolidin-2-one
Conditions | Yield |
---|---|
With sodium carbonate In water at 20℃; for 4h; | 98% |
With sodium carbonate In water at 20℃; for 16h; | 58% |
With sodium carbonate In water at 20℃; for 12h; | 39% |
Conditions | Yield |
---|---|
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h; | 98% |
Conditions | Yield |
---|---|
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h; | 98% |
4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoro-methyl)-pyridin-4-yl)-1,3,5-triazin-2-amine
serinol
Conditions | Yield |
---|---|
In tetrahydrofuran at 70℃; for 12h; | 97.4% |
tert-butyldimethylsilyl chloride
serinol
1,3-di-tert-butyldimethylsilyloxy-2-propylamine
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 20℃; Inert atmosphere; | 96% |
With triethylamine; dmap In dichloromethane for 12h; | 82% |
With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 0.5h; | 17% |
With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane | 17% |
Conditions | Yield |
---|---|
Stage #1: piperonal; serinol In methanol at 20℃; for 3h; Autoclave; Stage #2: With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 3750.38 Torr; Autoclave; | 96% |
serinol
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 20℃; for 72h; | 96% |
Conditions | Yield |
---|---|
With potassium carbonate In ethanol for 3h; Reflux; | 95% |
With potassium carbonate In ethanol for 3h; Heating; | 94% |
With potassium carbonate In ethanol at 20℃; for 96h; | 88% |
5-Amino-3-acetoxymethyl-2,4,6-triiodobenzoyl chloride
serinol
Conditions | Yield |
---|---|
95% | |
95% | |
95% |
1. Introduction of 2-Amino-1,3-propanediol
2-Amino-1,3-propanediol can be called 1,3-Propanediol, 2-amino- ; 2-Aminopropane-1,3-diol .It is a white to off-white adhering crystalline powder.
2. Properties of 2-Amino-1,3-propanediol
XLogP3-AA: -2
H-Bond Donor: 3
H-Bond Acceptor: 3
EINECS: 208-584-0
Surface Tension: 56.4 dyne/cm
Density: 1.181 g/cm3
Flash Point: 115.1 °C
Enthalpy of Vaporization: 58.61 kJ/mol
Boiling Point: 266.7 °C at 760 mmHg
Vapour Pressure: 0.00116 mmHg at 25°C
Melting Point: 52-55 °C(lit.)
Product Categories: Pharmaceutical Intermediates;Alcohols and Derivatives;API intermediates
3. Safety Information of 2-Amino-1,3-propanediol
Hazard Codes: CC,Xi
Risk Statements: 34
R34:Causes burns.
Safety Statements: 26-27-28-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27:Take off immediately all contaminated clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3263 8/PG 2
WGK Germany: 1
F: 3-10-34
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: III
4. Preparation of 2-Amino-1,3-propanediol
1,3-Dihydroxyacetone oxime (5 g; 47.6 mmoles), methanol (30 ml) and rhodium on alumina at 5% (0.1 g; 0.048 mmoles) were loaded into an autoclave-provided with mechanical stirring. After removing the surrounding air, hydrogen at a pressure of 70 bars (7×106 Pa) was loaded.The resultant system was then kept under stirring at 70° C. for 16 hours. At the end of the reaction, after emptying the reactor, the catalyst was filtered off on a celite bed and the solvent was evaporated at reduced pressure.A crude product (4.5 g) was thus obtained.From the crude, pure serinol was obtained by conversion into the corresponding hydrochloride according to the following method.The reaction crude was treated with HCl 1 N up to nearly pH 1 and heated at 40° C. for 2 hours.At the end, water was evaporated at reduced pressure and the resultant residue was collected with acetone (20 ml).The mixture was kept under vigorous stirring for 3 hours.Then, the precipitate was separated by filtration and dried at 50° C. and 25 mm/Hg.Serinol hydrochloride (2.1 g) was thus isolated.Alternatively, serinol can be purified by converting it into the corresponding oxalate, for instance, as described in the aforementioned patent application EP 0238961.
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