2-Aminophenol-4-sulfonic acid supplier

Name
Benzenesulfonic acid,3-amino-4-hydroxy-
EINECS 202-662-8
CAS No. 98-37-3
Article Data15
CAS DataBase
Density 1.675 g/cm³
Solubility <0.1 g/100 mL at 21.5℃
Melting Point ≥300°C(lit.)
Formula C₆H₇NO₄S
Boiling Point 398.09℃[at 101 325 Pa]
Molecular Weight 189.192
Flash Point
Transport Information UN 2585 8/PG 3
Appearance brown crystals
Safety 26-36/37/39-45
Risk Codes 34
Molecular Structure
Hazard Symbols C
Synonyms 1-Phenol-4-sulfonicacid, 2-amino- (4CI);Metanilic acid, 4-hydroxy- (7CI,8CI);1-Amino-2-hydroxy-5-benzenesulfonic acid;1-Hydroxy-2-aminobenzene-4-sulfonicacid;2-Amino-1-phenol-4-sulfonic acid;2-Amino-4-sulfophenol;2-Aminophenol-4-sulfonic acid;2-Hydroxy-5-sulfoaniline;3-Amino-4-hydroxybenzenesulfonic acid;4-Hydroxy-3-aminobenzenesulfonic acid;NSC 1491;o-Aminophenol-p-sulfonic acid;
PSA 109.00000
LogP 1.88310

Synthetic route

: 121-18-6
3-nitro-4-chlorobenzenesulfonic acid

: 98-37-3
2-aminophenol-4-sulfonic acid

Conditions

Conditions	Yield
With sodium hydrogensulfite

: 616-85-3
4-hydroxy-3-nitrobenzene sulfonic acid

: 98-37-3
2-aminophenol-4-sulfonic acid

Conditions

Conditions	Yield
With hydrogenchloride; tin
With sodium sulfide

: 95-55-6
2-amino-phenol

: 98-37-3
2-aminophenol-4-sulfonic acid

Conditions

Conditions	Yield
With sulfuric acid

3-nitro-4-hydroxy-benzene-sulfonic acid-(1): 3-nitro-4-hydroxy-benzene-sulfonic acid-(1)

: 98-37-3
2-aminophenol-4-sulfonic acid

Conditions

Conditions	Yield
With sodium sulfide; sodium hydroxide

: 7664-93-9
sulfuric acid

: 95-55-6
2-amino-phenol

: 98-37-3
2-aminophenol-4-sulfonic acid

disodium-salt of/the/ 3-nitro-4-hydroxy-benzene-sulfonic acid-(1): disodium-salt of/the/ 3-nitro-4-hydroxy-benzene-sulfonic acid-(1)

: 98-37-3
2-aminophenol-4-sulfonic acid

Conditions

Conditions	Yield
With water; nickel at 70 - 100℃; Hydrogenation;

: 121-18-6
3-nitro-4-chlorobenzenesulfonic acid

: sodium hydrogensulfite

: 98-37-3
2-aminophenol-4-sulfonic acid

: 108-24-7
acetic anhydride

: 98-37-3
2-aminophenol-4-sulfonic acid

: 123687-02-5
3-acetamido-4-acetoxybenzenesulfonic acid

Conditions

Conditions	Yield
With sulfuric acid In methanol for 4h; Reflux;	97%
With sulfuric acid In methanol for 4h; Reflux;	97%
With pyridine

: 98-88-4
benzoyl chloride

: 98-37-3
2-aminophenol-4-sulfonic acid

: 23117-22-8
3-benzoylamino-4-hydroxy-benzenesulfonic acid

Conditions

Conditions	Yield
In water	96.3%

: 444-30-4
2-(trifluoromethyl)phenol

: 98-37-3
2-aminophenol-4-sulfonic acid

: 1276122-50-9
2-(2-hydroxyphenyl)benzo[d]oxazole-5-sulfonic acid

Conditions

Conditions	Yield
With sodium hydroxide In water at 80℃; for 2h;	92%

: 5977-14-0
acetoacetamido

: 98-37-3
2-aminophenol-4-sulfonic acid

: [Na(μ-1κO1,2κO2-((Z)-3-(2-(1-amino-1,3-dioxobutan-2-ylidene)hydrazineyl)-4-hydroxybenzenesulfonate))(H2O)3]2

Conditions

Conditions	Yield
Stage #1: 2-aminophenol-4-sulfonic acid With water; sodium hydroxide; sodium nitrite at 0 - 5℃; for 0.0833333h; Stage #2: With hydrogenchloride; water at 0 - 5℃; for 0.5h; Stage #3: acetoacetamido With water; sodium acetate; sodium hydroxide In ethanol for 1h;	86%

: 2835-97-4
2-amino-3-methylphenol

: 98-37-3
2-aminophenol-4-sulfonic acid

: C13H10N2O5S

Conditions

Conditions	Yield
With 3,4,5-trihydroxybenzoic acid; cobalt(II) acetate; sodium hydroxide In water at 25℃; under 3000.3 Torr; for 36h;	84%

: 98-37-3
2-aminophenol-4-sulfonic acid

: 488-17-5
3-methylbenzene-1,2-diol

: 2-hydroxy-4-methyl-3-oxo-3H-phenoxazine-8-sulfonic acid

Conditions

Conditions	Yield
With 3,4,5-trihydroxybenzoic acid; oxygen; manganese(II) acetate; sodium hydroxide In water at 25℃; under 2250.23 Torr; for 0.416667h; pH=10; Sonication; Autoclave; Green chemistry; regioselective reaction;	72%

: 98-37-3
2-aminophenol-4-sulfonic acid

: 188724-74-5
4-benzoyl-1,5-diphenyl-1H-3-pyrazole carboxylic acid chloride

: 2-{[(4-benzoyl-1,5-diphenyl-1H-pyrazol-3-yl)carbonyl]amino}phenyl-4-benzoyl-1,5-diphenyl-1H-pyrazole-3-carboxylate

Conditions

Conditions	Yield
With triethylamine In benzene for 10h; Heating;	65%

: 122-01-0
4-chloro-benzoyl chloride

: 98-37-3
2-aminophenol-4-sulfonic acid

: 2-(4-chlorophenyl)benzo[d]oxazole-5-sulfonic acid

Conditions

Conditions	Yield
Stage #1: 4-chloro-benzoyl chloride; 2-aminophenol-4-sulfonic acid at 180℃; for 14h; Stage #2: With thionyl chloride In chloroform Reflux;	55%

: 89-57-6
5-Aminosalicylic Acid

: 98-37-3
2-aminophenol-4-sulfonic acid

: 2-(5-amino-2-hydroxyphenyl)benzo[d]oxazole-5-sulfonic acid

Conditions

Conditions	Yield
With polyphosphoric acid at 140 - 180℃;	54%

: 67984-81-0
2,3-dihydroxybenzonitrile

: 98-37-3
2-aminophenol-4-sulfonic acid

: 2-hydroxy-3-oxo-8-sulfo-3H-phenoxazine-4-carboxylic acid

Conditions

Conditions	Yield
With 3,4,5-trihydroxybenzoic acid; water; oxygen; manganese(II) acetate; sodium hydroxide at 25℃; under 2250.23 Torr; for 0.916667h; pH=10; Sonication; Autoclave; Green chemistry; regioselective reaction;	52%

: 98-37-3
2-aminophenol-4-sulfonic acid

: 87-66-1
2-hydroxyresorcinol

: 1367626-03-6
2,3,4,6'-tetrahydroxy-3'-sulfoazobenzene

Conditions

Conditions	Yield
Stage #1: 2-aminophenol-4-sulfonic acid With hydrogenchloride In water at 0℃; Stage #2: With sodium nitrite In water at 0℃; for 2.5h; Stage #3: 2-hydroxyresorcinol With hydrogenchloride In water at 0℃; for 2.5h; pH=3;	47.8%

: 98-37-3
2-aminophenol-4-sulfonic acid

: 107-02-8
acrolein

: 84-88-8
8-quinolinol-5-sulfonic acid

Conditions

Conditions	Yield
With hydrogenchloride In water at 100℃; for 1h; Skraup Quinoline Synthesis; Inert atmosphere;	39%

: 16670-63-6
2-hydroxy-N-phenylnaphthalene-1-carboxamide

: 98-37-3
2-aminophenol-4-sulfonic acid

: 1314111-39-1
C23H16N3O6S(1-)*Na(1+)

Conditions

Conditions	Yield
Stage #1: 2-aminophenol-4-sulfonic acid With hydrogenchloride; sodium nitrite In water at -2 - 2℃; Stage #2: 2-hydroxy-N-phenylnaphthalene-1-carboxamide With sodium carbonate In water at 5 - 10℃; for 2h;	35.4%
Stage #1: 2-aminophenol-4-sulfonic acid With hydrogenchloride; sodium nitrite In water at -2 - 2℃; for 0.166667h; Stage #2: 2-hydroxy-N-phenylnaphthalene-1-carboxamide With sodium carbonate In water at 5 - 10℃; for 2h;	35%

: 92-77-3
2,3-oxynaphthoic acid phenylamide

: 98-37-3
2-aminophenol-4-sulfonic acid

: C26H20N3O7S(1-)

Conditions

Conditions	Yield
Stage #1: 2-aminophenol-4-sulfonic acid With hydrogenchloride; sodium nitrite In water at -2 - 2℃; for 0.166667h; Stage #2: 2,3-oxynaphthoic acid phenylamide With sodium carbonate In water at 5 - 10℃; for 2h;	35.4%

: 556-52-5
oxiranyl-methanol

: 98-37-3
2-aminophenol-4-sulfonic acid

: 3-(2,3-dihydroxy-propylamino)-4-hydroxy-benzenesulfonic acid

Conditions

Conditions	Yield
With sodium hydroxide

: 4515-26-8
2-chloro-3,5-dinitro-benzenesulfonic acid

: 98-37-3
2-aminophenol-4-sulfonic acid

: 4'-hydroxy-3,5-dinitro-2,3'-imino-bis-benzenesulfonic acid

: 333-20-0
potassium thioacyanate

: 98-37-3
2-aminophenol-4-sulfonic acid

: 58089-26-2
2-thioxo-2,3-dihydro-benzoxazole-5-sulfonic acid

Conditions

Conditions	Yield
With water anschliessend Erhitzen auf 150grad;

: 98-37-3
2-aminophenol-4-sulfonic acid

: 97-00-7
1-chloro-2,4-dinitro-benzene

: 3-(2,4-dinitro-anilino)-4-hydroxy-benzenesulfonic acid

Conditions

Conditions	Yield
With sodium carbonate

: 98-37-3
2-aminophenol-4-sulfonic acid

: 121-90-4
m-nitrobenzoic acid chloride

: 3-(3-amino-benzoylamino)-4-hydroxy-benzenesulfonic acid

Conditions

Conditions	Yield
nachfolgend Reduktion;

: 98-37-3
2-aminophenol-4-sulfonic acid

: 391859-81-7
2-hydroxy-5-sulfo-benzenediazonium-betaine

Conditions

Conditions	Yield
Diazotization;
With water; cis-nitrous acid
With nitrous anhydride
With water; nitrous anhydride

: 98-37-3
2-aminophenol-4-sulfonic acid

: 33943-12-3
2-oxo-2,3-dihydro-benzoxazole-5-sulfonic acid

Conditions

Conditions	Yield
With sodium hydroxide

: 98-37-3
2-aminophenol-4-sulfonic acid

: 96-93-5
2-hydroxy-3-nitroaniline-5-sulfonic acid

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 0 - 3℃;

: 98-37-3
2-aminophenol-4-sulfonic acid

: 80-20-6
2-amino-1-hydroxybenzene-4-sulphonic acid-N-phenylamide

Conditions

Conditions	Yield
With phosphorus pentachloride Hinzufuegen von Anilin zu dem Reaktionsprodukt;

: 1603-79-8
phenylglyoxylic acid ethyl ester

: 98-37-3
2-aminophenol-4-sulfonic acid

: 10502-39-3
2-oxo-3-phenyl-2H-benzo[1,4]oxazine-6-sulfonic acid

Conditions

Conditions	Yield
With ammonium hydroxide In ethanol

: 84-87-7
1-hydroxy-4-naphthalenesulfonate

: 98-37-3
2-aminophenol-4-sulfonic acid

: 132281-56-2
C16H10N2O8S2(2-)*2Na(1+)

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide; sodium carbonate; sodium chloride; sodium nitrite Multistep reaction;

: 53819-36-6
sodium resorcinol-4-sulphonate

: 98-37-3
2-aminophenol-4-sulfonic acid

: 132281-49-3
C12H8N2O9S2(2-)*2Na(1+)

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide; sodium carbonate; sodium chloride; sodium nitrite Multistep reaction;

: 132281-58-4
sodium 2-methylresorcinol-4-sulphonate

: 98-37-3
2-aminophenol-4-sulfonic acid

: 132281-51-7
C13H10N2O9S2(2-)*2Na(1+)

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide; sodium carbonate; sodium chloride; sodium nitrite 1b) 0 to 5 deg C, 2) 6 to 8 deg C, 1 d; Multistep reaction;

2-Aminophenol-4-sulfonic acid Specification

The Benzenesulfonic acid,3-amino-4-hydroxy-, with the CAS registry number 98-37-3 and EINECS registry number 202-662-8, has the systematic name of 3-amino-4-hydroxybenzenesulfonic acid. It is a kind of brown crystals, and belongs to the proudct category of Intermediates of Dyes and Pigments. And the molecular formula of this chemical is C₆H₇NO₄S.

The physical properties of Benzenesulfonic acid,3-amino-4-hydroxy- are as following: (1)ACD/LogP: -2.96; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -6.35; (4)ACD/LogD (pH 7.4): -6.5; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 5; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 64.22 Å²; (13)Index of Refraction: 1.671; (14)Molar Refractivity: 42.24 cm³; (15)Molar Volume: 112.9 cm³; (16)Polarizability: 16.74×10^-24cm³; (17)Surface Tension: 85.5 dyne/cm; (18)Density: 1.675 g/cm³.

You should be cautious while dealing with this chemical. It may cause burns. Therefore, you had better take the following instructions: Wear suitable protective clothing, gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice; In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: O=S(=O)(O)c1ccc(O)c(N)c1
(2)InChI: InChI=1/C6H7NO4S/c7-5-3-4(12(9,10)11)1-2-6(5)8/h1-3,8H,7H2,(H,9,10,11)
(3)InChIKey: ULUIMLJNTCECJU-UHFFFAOYAT

Product Name

Benzenesulfonic acid,3-amino-4-hydroxy-

Synthetic route

2-Aminophenol-4-sulfonic acid Specification

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