2-Bromo-3'-methoxyacetophenone supplier

Name
3'-METHOXYPHENACYL BROMIDE
EINECS 225-666-1
CAS No. 5000-65-7
Article Data92
CAS DataBase
Density 1.448 g/cm³
Solubility
Melting Point 60-62 °C(lit.)
Formula C₉H₉BrO₂
Boiling Point 278.1 °C at 760 mmHg
Molecular Weight 229.073
Flash Point 122 °C
Transport Information UN 3261 8/PG 2
Appearance WHITE TO SLIGHTLY YELLOW-GREEN CRYST. POWDER
Safety 26-27-28-36/37/39-45
Risk Codes 34-36/37-22
Molecular Structure
Hazard Symbols C
Synonyms Acetophenone,2-bromo-3'-methoxy- (6CI,7CI,8CI);3-Methoxyphenacyl bromide;NSC 405833;m-(Bromoacetyl)anisole;m-Methoxyphenacyl bromide;a-Bromo-m-methoxyacetophenone;
PSA 26.30000
LogP 2.27280

Synthetic route

: 586-37-8
1-(3-Methoxyphenyl)ethanone

: 5000-65-7
2-bromo-3'-methoxyacetophenone

Conditions

Conditions	Yield
With phenyltrimethylammonium tribromide In tetrahydrofuran at 20℃; for 1h;	100%
With bromine In chloroform at 20℃; for 24h;	100%
With bromine In chloroform at 20℃; for 4h;	97%

: 98-86-2
acetophenone

: 5000-65-7
2-bromo-3'-methoxyacetophenone

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: sulfuric acid; nitric acid / 0.33 h / -10 - -5 °C 2.1: hydrogenchloride; iron / water / Reflux 3.1: sulfuric acid / water / 0.5 h / 45 - 50 °C 3.2: 0.5 h / 0 - 5 °C 3.3: 2 h / 90 °C 4.1: 50 - 60 °C 5.1: N-Bromosuccinimide / ethyl acetate / 3 h / 20 °C View Scheme

: 121-89-1
3-Nitroacetophenone

: 5000-65-7
2-bromo-3'-methoxyacetophenone

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: hydrogenchloride; iron / water / Reflux 2.1: sulfuric acid / water / 0.5 h / 45 - 50 °C 2.2: 0.5 h / 0 - 5 °C 2.3: 2 h / 90 °C 3.1: 50 - 60 °C 4.1: N-Bromosuccinimide / ethyl acetate / 3 h / 20 °C View Scheme

: 99-03-6
1-(3-aminophenyl)ethanone

: 5000-65-7
2-bromo-3'-methoxyacetophenone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sulfuric acid / water / 0.5 h / 45 - 50 °C 1.2: 0.5 h / 0 - 5 °C 1.3: 2 h / 90 °C 2.1: 50 - 60 °C 3.1: N-Bromosuccinimide / ethyl acetate / 3 h / 20 °C View Scheme

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 2227-79-4
benzenecarbothioamide

: 1013593-35-5
C16H13NOS

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 100℃; for 8h; Reflux;	100%

: 1414942-27-0
1-[3-(2-pyridyl)-2-pyridyl]piperazine

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 1414942-20-3
1-(3-methoxyphenyl)-2-[4-[3-(2-pyridyl)-2-pyridyl]piperazin-1-yl]ethanone

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile Reflux;	100%
With potassium carbonate In acetonitrile Reflux;	100%

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 10387-40-3
potassium thioacetate

: 175657-38-2
2-(acetylsulfanyl)-1-(3-methoxyphenyl)ethan-1-one

Conditions

Conditions	Yield
In ethanol; acetone at 20℃; for 2h;	100%

: 63468-90-6
phenylglyoxylic acid potassium salt

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 2-(3-methoxyphenyl)-2-oxoethyl 2-oxo-2-phenylacetate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 0.5h; Inert atmosphere; Schlenk technique;	100%

: 620-08-6
4-methoxypyridine

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 4-methoxy-1-(2-(3-methoxyphenyl)-2-oxoethyl)pyridin-1-ium bromide

Conditions

Conditions	Yield
In tetrahydrofuran for 0.5h; Reflux;	99%
In acetonitrile at 45℃; Kinetics; pyridinolysis;
In acetone at 20℃; for 5h; Inert atmosphere;

: 1447204-38-7
[(2,2'-bipyridine)Cu(SeCF3)]2

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: C10H9F3O2Se

Conditions

Conditions	Yield
With potassium phosphate In dichloromethane at 45℃; for 16h; Inert atmosphere;	98%

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 1663-45-2
1,2-bis-(diphenylphosphino)ethane

: (3-methoxybenzoylmethyldiphenyl-2-diphenylphosphinoethylphosphonium)-bromide

Conditions

Conditions	Yield
In chloroform	98%
In chloroform at 20℃; for 15h; Inert atmosphere; Schlenk technique;	98%

: 106-49-0
p-toluidine

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 1-(3-methoxyphenyl)-2-(4-methylphenylamino)ethanone

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethanol; water at 20℃; for 24h;	98%

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 2-bromo-1-(3-methoxyphenyl)ethan-1-one oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride In methanol; water at 0 - 20℃;	98%

: 695-34-1
2-Amino-4-methylpyridine

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 2-(3-Methoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
In neat (no solvent) at 25 - 30℃; Milling; Green chemistry;	98%

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 693-02-7
hex-1-yne

: 1536405-99-8
2-(4-butyl-1H-1,2,3-triazol-1-yl)-1-(3-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With sodium azide; sodium ascorbate In ethanol; water at 20℃; for 0.333333h; regioselective reaction;	97%
With sodium azide; sodium L-ascorbate In ethanol; water at 85℃; for 0.416667h;	96%

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 370583-62-3
7-hydroxy-4-(4-methoxyphenyl)-8-methyl-2H-2-chromenone

: 500203-99-6
4-(4-methoxyphenyl)-7-[2-(3-methoxyphenyl)-2-oxoethoxy]-8-methyl-2-chromenone

Conditions

Conditions	Yield
With potassium carbonate In acetone at 50 - 56℃; Williamson reaction;	96%

: 1161-13-3
N-Cbz-L-Phe

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 2-(1-(S)-((Phenylmethoxy)carbonyl)-amino-2-phenylethyl)-4-(4-methoxyphenyl)-imidazole

Conditions

Conditions	Yield
With ammonium acetate; caesium carbonate In water; N,N-dimethyl-formamide	96%

: 123-11-5
4-methoxy-benzaldehyde

: 79-19-6
thiosemicarbazide

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: (E)-2-(2-(4-methoxybenzylidene)hydrazinyl)-4-(3-methoxyphenyl)thiazole

Conditions

Conditions	Yield
In water at 25 - 30℃;	96%

...Expand

: 55047-37-5
3-Hydroxy-4-methyl-7,8,9,10-tetrahydro-6H-dibenzopyran-6-one

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 3-[2-(3-methoxyphenyl)-2-oxoethoxy]-4-methyl-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one

Conditions

Conditions	Yield
Stage #1: 3-Hydroxy-4-methyl-7,8,9,10-tetrahydro-6H-dibenzopyran-6-one With potassium carbonate In acetone at 50 - 56℃; Williamson reaction; Stage #2: 2-bromo-3'-methoxyacetophenone In acetone for 1h; Williamson reaction; Heating;	95%

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 37687-24-4
diethyl 1H-pyrazole-3,5-dicarboxylate

: 1316761-36-0
C18H20N2O6

Conditions

Conditions	Yield
With potassium carbonate In acetone at 20℃; for 12h;	95%

: 5350-57-2
benzophenone hydrazone

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 2131-61-5
p-nitrophenyl isothiocyanate

: N-(diphenylmethylene)-4-(3-methoxyphenyl)-2-(4-nitrophenylimino)thiazol-3(2H)-amine

Conditions

Conditions	Yield
With triethylamine In ethanol for 3h; Reflux;	95%

...Expand

: 79-19-6
thiosemicarbazide

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 613-45-6
2,4-Dimethoxybenzaldehyde

: (E)-2-(2-(2,4-dimethoxybenzylidene)hydrazinyl)-4-(3-methoxyphenyl)thiazole

Conditions

Conditions	Yield
In water at 25 - 30℃;	95%

...Expand

: 1570-45-2
isonicotinic acid ethylester

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 4-(ethoxycarbonyl)-1-[2-(3-methoxyphenyl)-2-oxoethyl]pyridinium bromide

Conditions

Conditions	Yield
In acetone at 20℃; for 24h;	95%

: 54287-99-9
5-hydroxy-2,2-dimethyl-2H-chromene-6-carbaldehyde

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: (7,7-dimethyl-7H-furo[2,3-f]chromen-2-yl)(3-methoxyphenyl)methanone

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20 - 120℃; for 4h;	95%

2-Bromo-3'-methoxyacetophenone Specification

The 2-Bromo-3'-methoxyacetophenone is an organic compound with the formula C₉H₉BrO₂. The IUPAC name of this chemical is 2-bromo-1-(3-methoxyphenyl)ethanone. With the CAS registry number 5000-65-7, it is also named as Ethanone, 2-bromo-1-(3-methoxyphenyl)-. The product's categories are Aromatic Halides (substituted); Analytical Chemistry; Carboxyl Group Labeling Reagents for HPLC; HPLC Labeling Reagents; UV Detection (HPLC Labeling Reagents). Besides, it is a white to slightly yellow-green cryst, which should be stored in a cool,dry place at temperature of 0 - 6 °C.

Physical properties about 2-Bromo-3'-methoxyacetophenone are: (1)ACD/LogP: 2.37; (2)ACD/LogD (pH 5.5): 2.37; (3)ACD/LogD (pH 7.4): 2.37; (4)ACD/BCF (pH 5.5): 36.97; (5)ACD/BCF (pH 7.4): 36.97; (6)ACD/KOC (pH 5.5): 461.17; (7)ACD/KOC (pH 7.4): 461.17; (8)#H bond acceptors: 2; (9)#Freely Rotating Bonds: 3; (10)Polar Surface Area: 26.3 Å²; (11)Index of Refraction: 1.554; (12)Molar Refractivity: 50.69 cm³; (13)Molar Volume: 158.1 cm³; (14)Polarizability: 20.09×10^-24cm³; (15)Surface Tension: 41.4 dyne/cm; (16)Density: 1.448 g/cm³; (17)Flash Point: 122 °C; (18)Enthalpy of Vaporization: 51.67 kJ/mol; (19)Boiling Point: 278.1 °C at 760 mmHg; (20)Vapour Pressure: 0.00434 mmHg at 25°C.

Preparation: this chemical can be prepared by 1-(3-methoxy-phenyl)-ethanone. This reaction will need reagentBr₂, HCl and solvent acetic acid. The reaction temperature is 20 °C.

Uses of 2-Bromo-3'-methoxyacetophenone: it can be used to produce 2-(3-methoxy-phenyl)-imidazo[1,2-a]pyrimidine by heating. It will need solvent 1,2-dimethoxy-ethane with reaction time of 48 hours. The yield is about 75%.

When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed and can cause burns. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to eyes and respiratory system. After contact with skin, take off immediately all contaminated clothing, and wash immediately with plenty of ... (to be specified by the manufacturer). When you are using it, wear suitable gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: BrCC(=O)c1cc(OC)ccc1
(2)InChI: InChI=1/C9H9BrO2/c1-12-8-4-2-3-7(5-8)9(11)6-10/h2-5H,6H2,1H3
(3)InChIKey: IOOHBIFQNQQUFI-UHFFFAOYAC
(4)Std. InChI: InChI=1S/C9H9BrO2/c1-12-8-4-2-3-7(5-8)9(11)6-10/h2-5H,6H2,1H3
(5)Std. InChIKey: IOOHBIFQNQQUFI-UHFFFAOYSA-N

Product Name

3'-METHOXYPHENACYL BROMIDE

Synthetic route

2-Bromo-3'-methoxyacetophenone Specification

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