2-CHLORO-4-METHYL-3-NITROPYRIDINE supplier

Name
2-Chloro-4-methyl-3-nitropyridine
EINECS
CAS No. 23056-39-5
Article Data15
CAS DataBase
Density 1.406 g/cm³
Solubility
Melting Point 51-53 °C(lit.)
Formula C₆H₅ClN₂O₂
Boiling Point 279.6 °C at 760 mmHg
Molecular Weight 172.571
Flash Point 122.9 °C
Transport Information UN 2811
Appearance Off-white to light yellow crystal
Safety 26-37/39-36/37/39-36
Risk Codes 36/37/38-21/22
Molecular Structure
Hazard Symbols Xi,Xn
Synonyms 4-Picoline,2-chloro-3-nitro- (6CI,8CI);2-Chloro-3-nitro-4-methylpyridine;NSC 402977;
PSA 58.71000
LogP 2.47480

2-CHLORO-4-METHYL-3-NITROPYRIDINE Chemical Properties

2-Chloro-4-methyl-3-nitropyridine(23056-39-5) exists as off-white to light yellow crystal.
Molecular Structure:

Molecular Formula:C₆H₅ClN₂O₂
Molecular Weight:172.57
Density:1.406 g/cm³
Melting Point:51-53 ℃
Boiling Point:279.6 ℃ at 760 mmHg
Flash Point:113 ℃

2-CHLORO-4-METHYL-3-NITROPYRIDINE Uses

2-Chloro-4-methyl-3-nitropyridine(23056-39-5) is used as intermediates in organic synthesis. 2-Chloro-4-methyl-3-nitropyridine(23056-39-5) is an important raw material for fine chemistry industry.

2-CHLORO-4-METHYL-3-NITROPYRIDINE Production

The diazonium salt from 2-AMINO-4-METHYLPYRIDINE is converted to 2-hydroxy-4-methylpyridine, which is nitrated to give 2-hydroxy-4-methyl-3-nitropyridine. Conversion to 2-chloro-4-methyl-3-nitropyridine is effected with phosphorous oxychloride and phosphorous pentachloride. Reduction of 2-chloro-4-methyl-3-nitropyridine with HYDROGEN/Raney NICKEL provides 3-amino-2-chloro-4-methylpyridine, which is condensed with 2-chloronicotinoyl chloride to give 2-chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide . Treatment with cyclopropylamine affords N-(2-chloro-4-methyl-3-pyridinyl)-2-(cyclopropylamino)-3-pyridinecarboxamide, which is cyclized in the presence of Sodium hydride to yield Nevirapine.

2-CHLORO-4-METHYL-3-NITROPYRIDINE Safety Profile

Hazard Codes:

Xi,Xn
Risk Statements: 36/37/38-21/22
36/37/38: Irritating to eyes, respiratory system and skin
21/22: Harmful in contact with skin and if swallowed
Safety Statements: 26-37/39-36/37/39-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
36: Wear suitable protective clothing
RIDADR: UN2811
WGK Germany: 3
HazardClass: 6.1
PackingGroup: III

Product Name

2-Chloro-4-methyl-3-nitropyridine

2-CHLORO-4-METHYL-3-NITROPYRIDINE Chemical Properties

2-CHLORO-4-METHYL-3-NITROPYRIDINE Uses

2-CHLORO-4-METHYL-3-NITROPYRIDINE Production

2-CHLORO-4-METHYL-3-NITROPYRIDINE Safety Profile

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