2-Chloro-3-picoline

The 2-Chloro-3-methylpyridine is an organic compound with the formula C₆H₆ClN. The IUPAC name of this chemical is 2-chloro-3-methylpyridine. With the CAS registry number 18368-76-8, it is also named as pyridine, 2-chloro-3-methyl-. The product's categories are Pyridine; Pyridines; Chloropyridines; Halopyridines; Boronic Acid; C6 Heterocyclic Building Blocks; Halogenated Heterocycles; Heterocyclic Building Blocks; Chlorinated Heterocyclic Series. Besides, it is colorless to light yellow liquid, which should be stored in a closed dark and well-ventilated place.

Physical properties about 2-Chloro-3-methylpyridine are: (1)ACD/LogP: 1.86; (2)ACD/LogD (pH 5.5): 1.86; (3)ACD/LogD (pH 7.4): 1.86; (4)ACD/BCF (pH 5.5): 15.19; (5)ACD/BCF (pH 7.4): 15.19; (6)ACD/KOC (pH 5.5): 244; (7)ACD/KOC (pH 7.4): 244.01; (8)#H bond acceptors: 1 ; (9)Polar Surface Area: 12.89 Å²; (10)Index of Refraction: 1.526; (11)Molar Refractivity: 34.06 cm³; (12)Molar Volume: 110.8 cm³; (13)Polarizability: 13.5×10^-24cm³; (14)Surface Tension: 37.7 dyne/cm; (15)Density: 1.15 g/cm³; (16)Flash Point: 84.3 °C; (17)Enthalpy of Vaporization: 41.12 kJ/mol; (18)Boiling Point: 192.5 °C at 760 mmHg; (19)Vapour Pressure: 0.679 mmHg at 25°C.

Preparation: this chemical can be prepared by 3-methyl-1H-pyridin-2-one. This reaction will need reagent phosphorus oxychloride. The reaction time is 6 hours by heating. The yield is about 65%.

Uses of 2-Chloro-3-methylpyridine: it can be used to produce 3-methyl-2-phenoxy-pyridine at temperature of 160 °C. It will need reagent dibenzo-18-crown-6 with reaction time of 7 hours. The yield is about 68%.

When you are using this chemical, please be cautious about it as the following:
It is harmful by inhalation, in contact with skin and if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)SMILES: Clc1ncccc1C
(2)InChI: InChI=1/C6H6ClN/c1-5-3-2-4-8-6(5)7/h2-4H,1H3
(3)InChIKey: RKVUCIFREKHYTL-UHFFFAOYAE
(4)Std. InChI: InChI=1S/C6H6ClN/c1-5-3-2-4-8-6(5)7/h2-4H,1H3
(5)Std. InChIKey: RKVUCIFREKHYTL-UHFFFAOYSA-N