2-Chloroquinoline

IUPAC Name: 2-chloroquinoline 
Synonyms of of 2-Chloroquinoline (CAS NO.612-62-4): 5-20-07-00312 (Beilstein Handbook Reference) ; AI3-08909 ; BRN 0112561 ; CCRIS 3977 ; EINECS 210-317-8 ; NSC 6163 ; Quinoline, 2-chloro-
CAS NO: 612-62-4
Molecular Formula of 2-Chloroquinoline (CAS NO.612-62-4): C₉H₆ClN
Molecular Weight: 163.6036 
H bond acceptors: 1
H bond donors: 0
Freely Rotating Bonds: 0
Polar Surface Area: 12.89 Å²
Index of Refraction: 1.652
Molar Refractivity: 47.08 cm³
Molar Volume: 128.7 cm³ 
Surface Tension: 49.3 dyne/cm
Density: 1.27 g/cm³
Flash Point: 141.2 °C
Enthalpy of Vaporization: 48.49 kJ/mol
Boiling Point: 267.3 °C at 760 mmHg
Vapour Pressure: 0.0136 mmHg at 25°C
Molecular Structure:

Hazard Codes of 2-Chloroquinoline (CAS NO.612-62-4): Xi
Risk Statements: 36/37/38 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-37/39 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36: Wear suitable protective clothing. S37/39: Wear suitable gloves and eye/face protection.
WGK Germany :3
RTECS: VB2320000
F: 8 

The effects of prolonged p.o. administration of quinoline or 2-Chloroquinoline (CAS NO.612-62-4) on rat liver were examined histologically. Hepatocellular carcinomas and hemangioendotheliomas were observed in the livers of rats fed a basal diet containing 0.05, 0.10, or 0.25% quinoline for about 16 to 40 weeks. However, no neoplastic changes were seen in the livers of rats fed a basal diet containing 0.05, 0.10, or 0.25% 2-chloroquinoline for 40 weeks. In groups that received low concentrations of quinoline, the incidences of hepatocellular carcinomas were higher and the incidences of hemangioendotheliomas were lower than in the group that received a high concentration of quinoline.

The liver tumors induced by quinoline were classified histologically as hemangioendotheliomas or hemangiosarcomas and trabecular hepatocellular carcinomas. Typical nodular hyperplasias were occasionally seen in the livers of rats treated with quinoline. 2-Chloroquinoline (CAS NO.612-62-4) did not induce any nodular hyperplasia or other neoplastic changes, but it caused diffuse fatty changes of parenchymal cells. Oval cell infiltration and bile duct proliferation were slight or moderate. Cirrhotic changes were rare in the livers of rats treated with either quinoline or 2-chloroquinoline.