2-Hydroxyethylhydrazine

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

The 2-Hydrazinoethanol, with its CAS registry number 109-84-2, is a kind of clear colorless oily liquid. And as to its usage, it is usually applied as the inhibitor of phospholipid methylation in yeast.

The physical properties of this chemical are as below: (1)ACD/LogP: -1.68; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.56; (4)ACD/LogD (pH 7.4): -1.98; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1.45; (9)#H bond acceptors: 3; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 15.71; (13)Index of Refraction: 1.47; (14)Molar Refractivity: 19.97 cm³; (15)Molar Volume: 71.5 cm³; (16)Polarizability: 7.92×10^-24 cm³; (17)Surface Tension: 45.1 dyne/cm; (18)Density: 1.063 g/cm³; (19)Flash Point: 73.9 °C; (20)Enthalpy of Vaporization: 56.48 kJ/mol; (21)Boiling Point: 248.9 °C at 760 mmHg; (22)Vapour Pressure: 0.00381 mmHg at 25°C; (23)Exact Mass: 76.063663; (24)MonoIsotopic Mass: 76.063663; (25)Topological Polar Surface Area: 58.3; (26)Heavy Atom Count: 5; (27)Complexity: 17.1.

Use of this chemical: 2-Hydrazinoethanol could react with (E)-3-dimethylamino-2-formylpropenenitrile to produce 1-(2-hydroxy-ethyl)-1H-pyrazole-4-carbonitrile. This reaction happens in the presence of the reagent of conc. HCl and the solvent of ethanol. And it requires 30 min to react in the conditon of heating, with its yield of 64%.

When you are dealing with this chemical, you should be very careful. This is a kind of toxic chemical and may at low levels cause damage to health. This is irritating to eyes, respiratory system and skin and it will be very dangerous to our body if by inhalation, in contact with skin and if swallowed. Then it has limited evidence of a carcinogenic effect. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. And if in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Then do remember not to breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer).

In addition, you could convert the following datas into the molecular structure:
(1)Canonical SMILES: C(CO)NN
(2)InChI: InChI=1S/C2H8N2O/c3-4-1-2-5/h4-5H,1-3H2
(3)InChIKey: GBHCABUWWQUMAJ-UHFFFAOYSA-N 

Below are the toxicity information of this chemical:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LDLo	skin	5mL/kg (5mL/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION	National Technical Information Service. Vol. OTS0555935,
mouse	LD50	oral	139mg/kg (139mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 76, 1968.
rat	LD50	intraperitoneal	100mg/kg (100mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	National Technical Information Service. Vol. OTS0555935,