2-Mercaptoethanol

The 2-Mercaptoethanol with CAS registry number of 60-24-2 is also known as Ethanol, 2-mercapto-. The IUPAC name is 2-Sulfanylethanol. It belongs to product categories of Industrial/Fine Chemicals; Antioxidant; Biochemistry; Reagents for Electrophoresis. Its EINECS registry number is 200-464-6. In addition, the formula is C₂H₆OS and the molecular weight is 78.13. This chemical is a clear colorless liquid and should be sealed in cool ang dry place without light.

Physical properties about 2-Mercaptoethanol are: (1)ACD/BCF (pH 5.5): 1; (2)ACD/BCF (pH 7.4): 1; (3)ACD/KOC (pH 5.5): 17.859; (4)ACD/KOC (pH 7.4): 17.782; (5)#H bond acceptors: 1; (6)#H bond donors: 1; (7)#Freely Rotating Bonds: 3; (8)Index of Refraction: 1.479; (9)Molar Refractivity: 20.746 cm³; (10)Molar Volume: 73.103 cm³; (11)Surface Tension: 37.013 dyne/cm; (12)Density: 1.069 g/cm³; (13)Flash Point: 73.889 °C; (14)Enthalpy of Vaporization: 45.853 kJ/mol; (15)Boiling Point: 156.999 °C at 760 mmHg; (16)Vapour Pressure: 1.011 mmHg at 25 °C.

Preparation of 2-Mercaptoethanol: it is prepared by reaction of ethylene oxide and hydrogen sulfide with the molar ratio of 1:3.5. The reaction occurs with catalyst strong alkaline anionic exchange resin at the temperature of 40 °C.

Uses of 2-Mercaptoethanol: it is used to make some proteins be denatured via its ability to cleave disulfide bonds. Besides, it is used in some RNA isolation procedures to eliminate ribonuclease released during cell lysis.

When you are using this chemical, please be cautious about it. As a chemical, it is irritating to eyes, respiratory system and skin. What's more, it is toxic by inhalation, in contact with skin and if swallowed. It is toxic to aquatic organisms that may cause long-term adverse effects in the aquatic environment. It also may cause burns. During using it, wear suitable protective clothing, gloves and eye/face protection. Do not breathe gas/fumes/vapour/spray and do not empty into drains. It's necessary to avoid release to the environment. After using it, take off immediately all contaminated clothing. If contact with eyes accidently, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell seek medical advice immediately.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: C(CS)O
2. InChI: InChI=1S/C2H6OS/c3-1-2-4/h3-4H,1-2H2
3. InChIKey: DGVVWUTYPXICAM-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	skin	300uL/kg (0.3mL/kg)		Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 269, 1944.
mouse	LC50	inhalation	13200mg/m3 (13200mg/m3)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 15(2), Pg. 56, 1971.
mouse	LD50	intraperitoneal	200mg/kg (200mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	oral	190mg/kg (190mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 15(2), Pg. 56, 1971.
mouse	LD50	unreported	480mg/kg (480mg/kg)	BEHAVIORAL: TREMOR GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmaceutical Sciences. Vol. 62, Pg. 237, 1973.
rabbit	LD50	skin	150uL/kg (0.15mL/kg)		Union Carbide Data Sheet. Vol. 3/23/1973,
rat	LCLo	inhalation	250ppm/8H (250ppm)		Union Carbide Data Sheet. Vol. 3/23/1973,
rat	LD50	oral	244mg/kg (244mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 15(2), Pg. 56, 1971