Empirical Formula: C19H26O3
Molecular Weight: 302.4079 g/mol
Index of Refraction: 1.586
Density: 1.178 g/cm3
Flash Point: 234.7 °C
Enthalpy of Vaporization: 76.48 kJ/mol
Boiling Point: 464.4 °C at 760 mmHg
Vapour Pressure: 2E-09 mmHg at 25 °C
Melting point: 188-190 °C
Storage temp.: -20 4 °C
Appearance: Off-white solid
The structure of 2-Methoxyestradiol (CAS.362-07-2):
IUPAC Name: (8R,9S,13S,14S,17S)-2-Methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
Canonical SMILES: CC12CCC3C(C1CCC2O)CCC4=CC(=C(C=C34)OC)O
Isomeric SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=C(C=C34)OC)O
InChI: InChI=1S/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1
InChIKey: CQOQDQWUFQDJMK-SSTWWWIQSA-N
Product Categories of 2-Methoxyestradiol (CAS.362-07-2): Intermediates & Fine Chemicals;Steroids;Metabolites & Impurities;Pharmaceuticals
2-Methoxyestradiol (CAS.362-07-2) is a natural metabolite which is devoid of estrogenic activity. It is inhibits cell proliferation and angiogenesis.
1. | mnt-ham-emb 300 µg/ | CRNGDP Carcinogenesis. 21 (2000),735. | ||
2. | mor-ham-emb 100 µg/ | CRNGDP Carcinogenesis. 21 (2000),735. | ||
3. | cyt-ham-emb 300 µg/ | CRNGDP Carcinogenesis. 21 (2000),735. | ||
4. | sln-ham-emb 300 µg/ | CRNGDP Carcinogenesis. 21 (2000),735. | ||
5. | msc-ham-emb 100 µg/ | CRNGDP Carcinogenesis. 21 (2000),735. | ||
6. | mor-ham-emb 0.1 mg/L/48H | CRNGDP Carcinogenesis. 21 (2000),735. | ||
7. | cyt-ham-emb 0.3 mg/L/24H | CRNGDP Carcinogenesis. 21 (2000),735. |
Mutation data reported. When heated to decomposition 2-Methoxyestradiol (CAS.362-07-2) emits acrid smoke and irritating vapors.
Hazard Codes: T,Xi
Risk Statements: 23/24/25-36/37/38-48-61-60-46-45
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R45:May cause cancer.
R46:May cause heritable genetic damage.
R60:May impair fertility.
R61:May cause harm to the unborn child.
Safety Statements: 22-26-36/37/39-45-53-36
S22:Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S53:Avoid exposure - obtain special instructions before use.
2-Methoxyestradiol ,its cas register number is 362-07-2. It also can be called Panzem ; 2-Hydroxyestradol 2-methyl ether ; and 2-Methoxyestradiol-17beta .
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