Product Name

  • Name

    2-Methylquinoxaline

  • EINECS 230-664-9
  • CAS No. 7251-61-8
  • Article Data94
  • CAS DataBase
  • Density 1.141 g/cm3
  • Solubility miscible with water
  • Melting Point 180.5°C
  • Formula C9H8N2
  • Boiling Point 243.9 °C at 760 mmHg
  • Molecular Weight 144.176
  • Flash Point 107.2 °C
  • Transport Information
  • Appearance dark red to brown liquid.
  • Safety 26-36-24/25
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 7251-61-8 (2-Methylquinoxaline)
  • Hazard Symbols IrritantXi
  • Synonyms NSC 65587;
  • PSA 25.78000
  • LogP 1.93820

Synthetic route

hydroxy-2-propanone
116-09-6

hydroxy-2-propanone

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper(II) acetate monohydrate In N,N-dimethyl-formamide at 20℃; Temperature;88%
With triethylamine; palladium diacetate In tetrahydrofuran; toluene at 20℃; for 3h;87%
With zinc(II) iodide In ethanol; water at 80℃; for 0.5h;86%
1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2-oxopropanal
78-98-8

2-oxopropanal

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
In water for 0.0333333h; Isay condensation; microwave irradiation;95%
Stage #1: 2-oxopropanal With sodium disulfite In water for 0.166667h; Addition;
Stage #2: 1,2-diamino-benzene In water at 20℃; for 18h; Condensation; Cyclization;
91%
In water at 20℃; for 0.5h; Green chemistry;85%
propylene glycol
57-55-6

propylene glycol

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
With cesiumhydroxide monohydrate In toluene at 150℃; for 24h; Inert atmosphere; Sealed tube;96%
With cesiumhydroxide monohydrate; C17H14Br2CoN4 In toluene at 150℃; for 24h; Reagent/catalyst; Temperature; Sealed tube; Inert atmosphere;93%
With 1,10-Phenanthroline; cesiumhydroxide monohydrate; nickel dibromide In toluene at 150℃; for 24h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Sealed tube;93%
propylene glycol
57-55-6

propylene glycol

2-nitro-aniline
88-74-4

2-nitro-aniline

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
With cesiumhydroxide monohydrate In toluene at 150℃; for 24h; Inert atmosphere; Sealed tube;93%
With 1,10-Phenanthroline; cesiumhydroxide monohydrate; nickel dibromide In toluene at 150℃; for 24h; Inert atmosphere; Sealed tube;93%
With C18H24ClIrN3O(1+)*Cl(1-); potassium hydroxide In water for 24h; Mechanism; Schlenk technique; Reflux; Green chemistry;87%
3-amino-2-propanol
78-96-6, 1674-56-2

3-amino-2-propanol

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
With cesiumhydroxide monohydrate; [(η6-p-cymene)2Ru2(2,7-bis(di-2-pyridinyl)-1,8-naphthyridine)Cl2](PF6)2; oxygen at 120℃; for 23h; Inert atmosphere; Molecular sieve;43%
2-methyl-1,2,3,4-tetrahydroquinoxaline
6640-55-7, 24463-30-7, 24463-31-8, 49849-47-0

2-methyl-1,2,3,4-tetrahydroquinoxaline

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
With 1,10-Phenanthroline; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium tert-butylate; oxygen; nickel dibromide In tert-Amyl alcohol at 95℃; for 48h;99%
With C21H21ClIrNO2 In tetrahydrofuran; 2,2,2-trifluoroethanol for 20h; Inert atmosphere;92%
With potassium tert-butylate In o-xylene at 140℃; for 36h; Inert atmosphere;91%
2-chloroquinoxaline
1448-87-9

2-chloroquinoxaline

trimethylbismuthine
593-91-9

trimethylbismuthine

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In N,N-dimethyl-formamide at 130℃; for 18h; Inert atmosphere;38 mg
quinoxaline-N-oxide
6935-29-1

quinoxaline-N-oxide

methyl-triphenylphosphonium iodide
2065-66-9

methyl-triphenylphosphonium iodide

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 80℃; for 6h; Sealed tube; Inert atmosphere;78%
propylene glycol
57-55-6

propylene glycol

1,2-Dinitrobenzene
528-29-0

1,2-Dinitrobenzene

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
Stage #1: 1,2-Dinitrobenzene With hydrogen In diethylene glycol dimethyl ether at 80℃; under 7500.75 Torr; for 24h;
Stage #2: propylene glycol In diethylene glycol dimethyl ether at 140℃; for 30h;
83%
N1-(prop-2-yn-1-yl)benzene-1,2-diamine
291536-12-4

N1-(prop-2-yn-1-yl)benzene-1,2-diamine

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
With tin(II) chloride hydrate In water; isopropyl alcohol at 82℃; for 12h;85%
1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

1-bromoacetone
598-31-2

1-bromoacetone

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
With perchloric acid In acetonitrile at 20℃; for 0.25h;95%
2-nitro-N-(prop-2-yn-1-yl)aniline

2-nitro-N-(prop-2-yn-1-yl)aniline

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
With hydrogenchloride; tin(II) chloride hydrate In water; isopropyl alcohol Reflux;82%
Multi-step reaction with 2 steps
1: sodium dithionite; water / ethanol / 1 h / 0 - 20 °C
2: tin(II) chloride hydrate / isopropyl alcohol; water / 12 h / 82 °C
View Scheme
propylene glycol
57-55-6

propylene glycol

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

A

2,3-diethynylquinoxaline
91-19-0

2,3-diethynylquinoxaline

B

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
With oxygen; zeolite; titanium(IV) oxide In acetonitrile at 20℃; for 10h; Irradiation;A 12.6%
B 22.5%
1,1-dihydroxyacetone
1186-47-6

1,1-dihydroxyacetone

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
With (R)-3,3'-bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diylhydrogenphosphate In chloroform; water at 35℃; for 8h; Inert atmosphere; Molecular sieve; enantioselective reaction;63%
2-nitro-aniline
88-74-4

2-nitro-aniline

glycerol
56-81-5

glycerol

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
With dodecacarbonyl-triangulo-triruthenium; cesiumhydroxide monohydrate; 1,3-bis-(diphenylphosphino)propane In tert-Amyl alcohol at 150℃; for 12h; Schlenk technique; Inert atmosphere;36%
2-nitro-aniline
88-74-4

2-nitro-aniline

hydroxy-2-propanone
116-09-6

hydroxy-2-propanone

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
With sodium hydroxide In toluene at 150℃; for 12h; Inert atmosphere; Sealed tube; Green chemistry;44%
1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

propanone 1-oxime
306-44-5

propanone 1-oxime

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
In ethanol for 1.25h;74%
With acetic acid
With hydrogenchloride; acetic acid
quinoxaline-N-oxide
6935-29-1

quinoxaline-N-oxide

4,4,5,5-tetramethyl-2-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-1,3,2-dioxaborolane
78782-17-9

4,4,5,5-tetramethyl-2-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-1,3,2-dioxaborolane

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
With sodium methylate In toluene at 80℃; for 3h; regioselective reaction;32%
2,3-diethynylquinoxaline
91-19-0

2,3-diethynylquinoxaline

dimethyl cobalt
108890-31-9

dimethyl cobalt

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
In diethyl ether at -70℃; for 120h;53%
propargyl alcohol
107-19-7

propargyl alcohol

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
With mercury(II) diacetate In tetrahydrofuran for 14h; Ambient temperature;51%
2,3-diethynylquinoxaline
91-19-0

2,3-diethynylquinoxaline

cyclohexane
110-82-7

cyclohexane

A

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

B

2-pyridylcyclohexane
15787-49-2

2-pyridylcyclohexane

C

4-cyclohexylpyridine
13669-35-7

4-cyclohexylpyridine

D

2-cyclohexyl-quinoxaline
40115-00-2

2-cyclohexyl-quinoxaline

Conditions
ConditionsYield
With tert.-butylhydroperoxide; iron(II) nitrate; acetic acid In pyridine at 60℃; for 18h; Further byproducts given;A n/a
B n/a
C n/a
D 15%
1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

1-bromo-1-acetamidoacetone
65765-30-2

1-bromo-1-acetamidoacetone

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
With sodium carbonate; sodium sulfite In water 1.) 20 deg C, 2 h, 2.) 100 deg C, 1 h;59%
4-[5-Methyl-3-(2-nitro-phenyl)-4,5-dihydro-3H-[1,2,3]triazol-4-yl]-morpholine

4-[5-Methyl-3-(2-nitro-phenyl)-4,5-dihydro-3H-[1,2,3]triazol-4-yl]-morpholine

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 70 percent / H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
2: 92 percent / 2) DDQ / multistep reaction thermal rearrangement of other 1,2,3-triazoles
View Scheme
Multi-step reaction with 2 steps
1: 70 percent / H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
2: 27 percent / 2) 10percent Pd/C / 1) toluene, reflux, 1h, 2) ethanol, reflux, 30 min
View Scheme
5-(diethoxymethyl)-3-methylisoxazole
87074-49-5

5-(diethoxymethyl)-3-methylisoxazole

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
With formic acid at 80℃; for 0.0833333h;21%
(Z)-hex-3-ene-2,5-dione
17559-81-8

(Z)-hex-3-ene-2,5-dione

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
In dichloromethane for 72h; Ambient temperature;80%
2-chloroquinoxaline
1448-87-9

2-chloroquinoxaline

methylmagnesium bromide
75-16-1

methylmagnesium bromide

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one; iron(II) acetylacetonate In tetrahydrofuran for 0.5h;
2,3-diethynylquinoxaline
91-19-0

2,3-diethynylquinoxaline

dimethyl sulfoxide
67-68-5

dimethyl sulfoxide

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
With 1-Phenylethanol; sodium t-butanolate at 100℃; for 8h; Schlenk technique; Irradiation; Green chemistry; chemoselective reaction;12%
dihydroxyacetone
96-26-4

dihydroxyacetone

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Conditions
ConditionsYield
In water for 0.0180556h; Isay condensation; microwave irradiation;48%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

(S)-1,2,3,4-tetrahydro-2-methylquinoxaline

(S)-1,2,3,4-tetrahydro-2-methylquinoxaline

Conditions
ConditionsYield
With {[IrH((S)-Difluorophos)]2(μ-Cl)3}+Cl-; hydrogen In toluene at 30℃; under 22502.3 Torr; for 20h; Inert atmosphere; Autoclave; optical yield given as %ee; enantioselective reaction;99%
With [(Ir(H){(S)-[(4,4-bi-2,2-difluoro-1,3-benzodioxole)-5,5-diyl]bis(diphenylphosphine)})2(μ-Cl)3]Cl; hydrogen In toluene at 30℃; under 22502.3 Torr; for 20h; Autoclave; optical yield given as %ee; enantioselective reaction;99%
With RuCl[(R)-1-isopropyl-2,2-bis(4-methoxyphenyl)ethylenediamine][(R)-((4,4'-bi-1,3-benzodioxole)-5,5’-diyl)bis(di(3,5-xylyl)phosphine)]; potassium tert-butylate; hydrogen In toluene at 40℃; under 15001.5 Torr; for 13h; Reagent/catalyst; Solvent; Temperature; Autoclave; enantioselective reaction;99.9%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

benzaldehyde
100-52-7

benzaldehyde

2-<(E)-2-Phenylethenyl>chinoxalin
112193-05-2

2-<(E)-2-Phenylethenyl>chinoxalin

Conditions
ConditionsYield
With malononitrile In diethylene glycol dimethyl ether at 120℃; under 2585.81 Torr; for 0.416667h; Microwave irradiation;84%
In water at 120℃; for 36h; Sealed tube;80%
With Fe3O(biphenyl-4,4'-dicarboxylate)3; acetic acid In toluene at 120℃; for 24h; Inert atmosphere;66%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

2-(bromomethyl)quinoxaline
54804-43-2

2-(bromomethyl)quinoxaline

Conditions
ConditionsYield
With N-Bromosuccinimide; trityl tetrafluoroborate In dichloromethane at 20℃; Irradiation; Inert atmosphere; chemoselective reaction;82%
With tetra-(n-butyl)ammonium iodide; ethylene dibromide; urea In acetonitrile at 95℃; for 0.5h; Microwave irradiation;70%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In tetrachloromethane at 60℃; for 1h; Irradiation;57%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

benzyl alcohol
100-51-6

benzyl alcohol

2-phenethylquinoxaline
1210881-27-8

2-phenethylquinoxaline

Conditions
ConditionsYield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; 18-crown-6 ether; potassium tert-butylate In tetrahydrofuran at 120℃; for 20h; Inert atmosphere; Schlenk technique; Sealed tube;93%
With [(1,5-cyclooctadiene)(OH)iridium(I)]2; potassium tert-butylate; triphenylphosphine In 1,4-dioxane at 130℃; for 24h; Inert atmosphere;90%
With C17H14Br2CoN4; potassium tert-butylate In toluene at 150℃; for 24h; Inert atmosphere; Sealed tube; Green chemistry;89%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

1-(4-nitrophenyl)-2-(quinoxalin-2-yl)ethanol
1450605-01-2

1-(4-nitrophenyl)-2-(quinoxalin-2-yl)ethanol

Conditions
ConditionsYield
With H2O4P(1-)*C4H7N2(1+) In 1,4-dioxane; water at 100℃; for 24h; Schlenk technique; Sealed tube;87%
With morpholin-4-ium hydrogen sulphate; 1-butyl-3-methylimidazolium Tetrafluoroborate at 110℃; for 24h; Sealed tube;87%
With copper(II) ferrite; tetrabutyl-ammonium chloride In ethylene glycol at 100℃; for 24h; Green chemistry;73%
In water at 102℃; for 0.416667h; Sealed tube; Microwave irradiation;60%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

2-methyl-1,2,3,4-tetrahydroquinoxaline
6640-55-7, 24463-30-7, 24463-31-8, 49849-47-0

2-methyl-1,2,3,4-tetrahydroquinoxaline

Conditions
ConditionsYield
With lithium borohydride; methyl iodide In tetrahydrofuran at 20℃; for 0.25h;99%
With ammonium borohydride In methanol at 60℃; for 21h; Schlenk technique;99%
Stage #1: 2-methylquinoxaline With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; N-(2-aminoethyl)-4-(trifluoromethyl)benzenesulfonamide; sodium formate; sodium acetate; acetic acid In water at 80℃; for 0.25h; pH=5.5;
Stage #2: With potassium hydroxide In water regioselective reaction;
96%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

2-(methyl-d3)quinoxaline
41035-18-1

2-(methyl-d3)quinoxaline

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile); [bis(acetoxy)iodo]benzene; water-d2 In N,N-dimethyl-formamide at 80℃; for 12h; Schlenk technique; Inert atmosphere;97%
With water-d2; benzoic acid at 90℃; for 8h; Inert atmosphere; Schlenk technique;
With potassium tert-butylate; water-d2 In dimethyl sulfoxide at 20℃; for 0.166667h; Sealed tube;
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

2-chloromethyl-quinoxaline
106435-53-4

2-chloromethyl-quinoxaline

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide; 1,2-dichloro-ethane; urea at 110℃; for 0.5h; Microwave irradiation;87%
With trichloroisocyanuric acid In chloroform at 60℃; for 1h;76.2%
With trichloroisocyanuric acid In chloroform for 0.5h; Chlorination; Heating;
Multi-step reaction with 3 steps
1: 60 percent / KOH, Ac2O
2: 1.) O3, 2.) NaBH4 / 1.) MeOH, CH2Cl2, -78 deg C, 2.) MeOH, CH2Cl2, from 0 deg C to RT, 2 h
3: 67 percent / SOCl2 / benzene / 2 h / Ambient temperature
View Scheme
With trichloroisocyanuric acid In chloroform for 1.5h; Inert atmosphere; Reflux;
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

Diphenylphosphine oxide
4559-70-0

Diphenylphosphine oxide

(3-methylquinoxalin-2-yl)diphenylphosphine oxide

(3-methylquinoxalin-2-yl)diphenylphosphine oxide

Conditions
ConditionsYield
With dipotassium peroxodisulfate In acetonitrile at 20℃; for 2h; Inert atmosphere; Sealed tube;94%
With oxygen In acetonitrile at 20℃; for 12h; Irradiation; Green chemistry;69%
With oxygen In neat (no solvent) at 65℃; for 1h; Green chemistry;57%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

benzyl alcohol
100-51-6

benzyl alcohol

2-<(E)-2-Phenylethenyl>chinoxalin
112193-05-2

2-<(E)-2-Phenylethenyl>chinoxalin

Conditions
ConditionsYield
With bromopentacarbonylmanganese(I); potassium tert-butylate; 1-(pyridin-2-yl)-2-(1-(pyridin-2-yl)ethylidene)hydrazine In tert-butyl alcohol at 140℃; for 14h; Inert atmosphere; Schlenk technique;91%
With potassium hydroxide In toluene at 120℃; for 18h; Sealed tube;87%
With potassium tert-butylate; nickel dibromide; N-(8-quinolyl)pyridine-2-carboxamide In tert-butyl alcohol at 140℃; for 48h; Schlenk technique; Inert atmosphere; Sealed tube;84%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

pentan-1-ol
71-41-0

pentan-1-ol

4-[2-(3-methylquinoxalin)yl]-1-pentanol

4-[2-(3-methylquinoxalin)yl]-1-pentanol

Conditions
ConditionsYield
With dipotassium peroxodisulfate; trifluorormethanesulfonic acid; silver trifluoroacetate In dichloromethane; water at 45℃; for 20h; Inert atmosphere;76.8%
With 4,5,6,7-tetrafluoro-1-hydroxybenzo[d][1,2]iodaoxol-3(1H)-one; Ru(bpy)3Cl2 at 30℃; for 24h; Minisci Aromatic Substitution; Inert atmosphere; Irradiation; regioselective reaction;63%
With dipotassium peroxodisulfate; sulfuric acid; silver nitrate In water at 50℃; for 24h; Inert atmosphere; Sealed tube; regioselective reaction;59%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

glyoxylic acid ethyl ester
924-44-7

glyoxylic acid ethyl ester

NSC 48961

NSC 48961

Conditions
ConditionsYield
With iron(II) acetate In 1,4-dioxane at 120℃; for 24h; Schlenk technique; Inert atmosphere;88%
With iron(II) acetate In 1,4-dioxane at 120℃; for 24h; Inert atmosphere; Schlenk technique; Green chemistry;88%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

LEUCINE
328-39-2

LEUCINE

1-isobutylimidazo[1,5-a]quinoxaline

1-isobutylimidazo[1,5-a]quinoxaline

Conditions
ConditionsYield
With tert.-butylhydroperoxide; diphenyl-phosphinic acid; tetra-(n-butyl)ammonium iodide In dimethyl sulfoxide at 90℃; for 8h; Sealed tube;85%
2-methylquinoxaline

2-methylquinoxaline

4-Methoxybenzyl alcohol
105-13-5

4-Methoxybenzyl alcohol

2-(4-methoxyphenethyl)quinoxaline

2-(4-methoxyphenethyl)quinoxaline

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

4-Methylbenzyl alcohol
589-18-4

4-Methylbenzyl alcohol

2-(4-methylphenethyl)quinoxaline

2-(4-methylphenethyl)quinoxaline

Conditions
ConditionsYield
With C17H14Br2CoN4; potassium tert-butylate In toluene at 150℃; for 24h; Inert atmosphere; Sealed tube; Green chemistry;88%
With potassium hydroxide In toluene at 140℃; for 12h;86%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

4-cyclohexyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
1539-59-9

4-cyclohexyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

2‐cyclohexyl‐3‐methylquinoxaline

2‐cyclohexyl‐3‐methylquinoxaline

Conditions
ConditionsYield
Stage #1: 2-methylquinoxaline; 4-cyclohexyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester With trifluoroacetic acid In 2,2,2-trifluoroethanol at 20℃; for 4h; Sealed tube; Irradiation; Inert atmosphere;
Stage #2: In 2,2,2-trifluoroethanol at 20℃; for 4h;
66%
Stage #1: 2-methylquinoxaline; 4-cyclohexyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester With trifluoroacetic acid In 2,2,2-trifluoroethanol at 35℃; for 4h; Irradiation; Inert atmosphere; Sealed tube;
Stage #2: In 2,2,2-trifluoroethanol for 4h; Irradiation; Inert atmosphere;
66%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2-(1H-benzo[d]imidazol-2-yl)quinoxaline
2215-43-2

2-(1H-benzo[d]imidazol-2-yl)quinoxaline

Conditions
ConditionsYield
With iodine; oxygen In dimethyl sulfoxide at 110℃;98%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

2-(iodomethyl)quinoxaline

2-(iodomethyl)quinoxaline

Conditions
ConditionsYield
With copper(ll) sulfate pentahydrate; iodine In acetonitrile at 70℃; for 3h; regioselective reaction;81%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

D,L-valine
516-06-3

D,L-valine

1-isopropylimidazo[1,5-a]quinoxaline

1-isopropylimidazo[1,5-a]quinoxaline

Conditions
ConditionsYield
With tert.-butylhydroperoxide; diphenyl-phosphinic acid; tetra-(n-butyl)ammonium iodide In dimethyl sulfoxide at 90℃; for 8h; Sealed tube;69%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

2-amino-3,3-dimethylbutanoic acid
33105-81-6

2-amino-3,3-dimethylbutanoic acid

Conditions
ConditionsYield
With tert.-butylhydroperoxide; diphenyl-phosphinic acid; tetra-(n-butyl)ammonium iodide In dimethyl sulfoxide at 90℃; for 8h; Sealed tube;74%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

1-naphthalene methanol
4780-79-4

1-naphthalene methanol

2-(2-(naphthalen-1-yl)ethyl)quinoxaline

2-(2-(naphthalen-1-yl)ethyl)quinoxaline

Conditions
ConditionsYield
With C17H14Br2CoN4; potassium tert-butylate In toluene at 150℃; for 24h; Inert atmosphere; Sealed tube; Green chemistry;86%
With potassium hydroxide In toluene at 140℃; for 12h;67%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

sodium benzenesulfonate
873-55-2

sodium benzenesulfonate

2-((phenylsulfonyl)methyl)quinoxaline

2-((phenylsulfonyl)methyl)quinoxaline

Conditions
ConditionsYield
With tert-Butyl peroxybenzoate; tetra-(n-butyl)ammonium iodide In water at 100℃; for 10h; Sealed tube; Green chemistry;83%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

9-anthracene aldehyde
642-31-9

9-anthracene aldehyde

(E)-2-(2-(anthracen-9-yl)vinyl)quinoxaline

(E)-2-(2-(anthracen-9-yl)vinyl)quinoxaline

Conditions
ConditionsYield
Stage #1: 2-methylquinoxaline With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Knoevenagel Condensation; Inert atmosphere;
Stage #2: 9-anthracene aldehyde In tetrahydrofuran at 20℃; for 4h; Knoevenagel Condensation; Inert atmosphere;
88%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

(R)-2-methyl-1,2,3,4-tetrahydroquinoxaline

(R)-2-methyl-1,2,3,4-tetrahydroquinoxaline

Conditions
ConditionsYield
With C25H30N2O2RuS(1+)*C32H12BF24(1-); hydrogen In 1,1-dichloroethane at 40℃; under 38002.6 Torr; for 8h; Autoclave; optical yield given as %ee; enantioselective reaction;95%
With C71H73ClN2O2P2Ru; potassium tert-butylate; hydrogen In isopropyl alcohol at 25℃; under 15201 Torr; for 22h; Autoclave; enantioselective reaction;89 %Spectr.
4-(N,N-di-(pyridine-2-ylmethyl)amino)benzaldehyde
946005-73-8

4-(N,N-di-(pyridine-2-ylmethyl)amino)benzaldehyde

2-methylquinoxaline
7251-61-8

2-methylquinoxaline

2-[2-(4-di-2-picolylaminophenyl)vinyl]quinoxaline

2-[2-(4-di-2-picolylaminophenyl)vinyl]quinoxaline

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 20℃; for 15h; Aldol Condensation; Reflux;84%
2-methylquinoxaline
7251-61-8

2-methylquinoxaline

2,3-diphenyl-3,4-dihydroquinazolin-4-ol
1440513-46-1

2,3-diphenyl-3,4-dihydroquinazolin-4-ol

2,3-diphenyl-4-(quinoxalin-2-ylmethyl)-3,4-dihydroquinazoline

2,3-diphenyl-4-(quinoxalin-2-ylmethyl)-3,4-dihydroquinazoline

Conditions
ConditionsYield
With iron(III) chloride In 1,2-dichloro-ethane at 80℃; for 6h;84%

2-Methylquinoxaline Chemical Properties

IUPAC Name: 2-Methylquinoxaline
CAS: 7251-61-8
EINECS: 230-664-9
Product Categories: Quinolines, Quinazolines and Derivatives ; Building Blocks ; Heterocyclic Building Blocks ; Quinoxalines ; Alphabetical Listings ; Flavors and Fragrances ; M-N.
Following is the Molecular Structure of 2-Methylquinoxaline (7251-61-8):


SMILES: n1c2ccccc2nc(c1)C
InChI: InChI=1/C9H8N2/c1-7-6-10-8-4-2-3-5-9(8)11-7/h2-6H,1H3
InChIKey: ALHUXMDEZNLFTA-UHFFFAOYAA
Std. InChI: InChI=1S/C9H8N2/c1-7-6-10-8-4-2-3-5-9(8)11-7/h2-6H,1H3
Std. InChIKey: ALHUXMDEZNLFTA-UHFFFAOYSA-N
Molecular Formula: C9H8N2
Molecular Weight: 144.17
Boiling Point: 243.9℃ at 760mmHg
Flash Point: 107.2℃
Molar Volume: 126.2cm3
Density: 1.141g/cm3
Molar Refractivity: 45.1cm3
Surface Tension: 50.7dyne/cm
Polarizability: 17.88 10-24cm3
Enthalpy of Vaporization: 46.15 kJ/mol
Vapour Pressure: 0.0488mmHg at 25℃
Refractive Index: n20/D 1.613(lit.)
Water Solubility: Miscible
BRN: 113307

2-Methylquinoxaline Safety Profile

Hazard Codes: Xi Irritant.
Risk Statements: 36/37/38
R36 Irritating to eyes.
R37 Irritating to respiratory system.
R38 Irritating to skin
Safety Statements: 26-36-24/25
S24 Avoid contact with skin.
S25 Avoid contact with eyes.
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27 Take off immediately all contaminated clothing.
S28 After contact with skin, wash immediately with plenty of soap-suds.
S29 Do not empty into drains.
S30 Never add water to this product.
S33 Take precautionary measures against static discharges.
S35 This material and its container must be disposed of in a safe way.
S36 Wear suitable protective clothing.
WGK Germany:3
RTECS:VD3450000
F:10

2-Methylquinoxaline Specification

 2-Methylquinoxaline (7251-61-8),which also can be called for 2-Methyl-Quinoxalin ; Quinoxaline,2-Methyl- ; 2-Methylquinoxaline ; 2-Methylquinoxaline 97+% ; 2-Methylquinoxaline,96% ; Methylquinoxaline,2-Methylchinoxaline ; 2-Methylbenzopyrazine ; 3-Methylquinoxaline . 2-Methylquinoxaline (7251-61-8) is liquid,its colour is dark red to brown.It's slightly soluble in water.The followings are the first aid measures about this chemical:Ingestion:If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.Inhalation:Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.Skin:Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Remove contaminated clothing and shoes.Eyes:Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. 2-Methylquinoxaline(7251-61-8) should be stored in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. It is stable under normal temperatures and pressures.After decomposition,it turned into nitrogen oxides, carbon monoxide, carbon dioxide and nitrogen.

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