3-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one supplier

Name
3-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one
EINECS
CAS No. 79098-75-2
Article Data7
CAS DataBase
Density 1.18 g/cm³
Solubility
Melting Point
Formula C₁₃H₁₇N₃O
Boiling Point 459.008 °C at 760 mmHg
Molecular Weight 231.297
Flash Point 231.4 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 3-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one;3-Piperidin-4-yl-3,4-dihydro-1H-quinazolin-2-one;
PSA 44.37000
LogP 2.19080

Synthetic route

: 79098-88-7
1-benzyl-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol for 48h;	100%
With hydrogen; Pd/C In ethanol at 60℃; under 1500.15 Torr;	85%
With hydrogen; palladium on activated charcoal In ethanol at 60℃; under 1500.15 Torr;	85%

: 960221-97-0
tert-butyl 4-(2-oxo-1,2,3,4-tetrahydroquinazolin-3-yl)piperidine-1-carboxylate

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 20℃;	92%

: 552-89-6
2-nitro-benzaldehyde

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium tetrahydroborate; methanol 2: hydrogen / palladium on activated charcoal / ethanol 3: acetonitrile / Reflux View Scheme

: 50541-93-0
4-amino-1-benzylpiperidine

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

Conditions

Yield

Multi-step reaction with 3 steps
1: sodium tetrahydroborate; methanol
2: hydrogen / palladium on activated charcoal / ethanol
3: acetonitrile / Reflux
View Scheme

Multi-step reaction with 5 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 5 h / 70 °C
2: trifluoroacetic acid / dichloromethane / 20 h / 0 - 20 °C
3: lithium aluminium tetrahydride / 1,4-dioxane / 3 h / Reflux
4: tetrahydrofuran / 5 h / 20 °C
5: hydrogen; palladium 10% on activated carbon / methanol / 48 h
View Scheme

: 79099-03-9
2-amino-N-[1-(phenylmethyl)-4-piperidinyl]-benzenemethanamine

: 530-62-1
1,1'-carbonyldiimidazole

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

Conditions

Conditions	Yield
Stage #1: 2-amino-N-[1-(phenylmethyl)-4-piperidinyl]-benzenemethanamine; 1,1'-carbonyldiimidazole In acetonitrile Reflux; Stage #2: With hydrogen; palladium(II) hydroxide In methanol

: 98754-28-0
(1-benzyl-piperidin-4-yl)-(2-nitro-benzyl)-amine

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen / palladium on activated charcoal / ethanol 2: acetonitrile / Reflux View Scheme

: [2-(1-benzyl-piperidin-4-ylcarbamoyl)phenyl] tert-butyl carbamate

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: trifluoroacetic acid / dichloromethane / 20 h / 0 - 20 °C 2: lithium aluminium tetrahydride / 1,4-dioxane / 3 h / Reflux 3: tetrahydrofuran / 5 h / 20 °C 4: hydrogen; palladium 10% on activated carbon / methanol / 48 h View Scheme

: 83425-16-5
2-amino-N-(1-benzyl-piperidin-4-yl)-benzamide

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: lithium aluminium tetrahydride / 1,4-dioxane / 3 h / Reflux 2: tetrahydrofuran / 5 h / 20 °C 3: hydrogen; palladium 10% on activated carbon / methanol / 48 h View Scheme

: 79099-03-9
2-amino-N-[1-(phenylmethyl)-4-piperidinyl]-benzenemethanamine

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: tetrahydrofuran / 5 h / 20 °C 2: hydrogen; palladium 10% on activated carbon / methanol / 48 h View Scheme

: 68790-38-5
2-(tert-butyloxycarbonylamino)benzoic acid

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 5 h / 70 °C 2: trifluoroacetic acid / dichloromethane / 20 h / 0 - 20 °C 3: lithium aluminium tetrahydride / 1,4-dioxane / 3 h / Reflux 4: tetrahydrofuran / 5 h / 20 °C 5: hydrogen; palladium 10% on activated carbon / methanol / 48 h View Scheme

Yield

: 79098-98-9
tert-butyl 4-((2-aminobenzyl)amino)piperidine-1-carboxylate

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / acetonitrile / 18 h / 20 °C / Reflux 2: trifluoroacetic acid / dichloromethane / 20 °C View Scheme

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium tris(acetoxy)borohydride / dichloromethane / 48 h / 20 °C 2: triethylamine / acetonitrile / 18 h / 20 °C / Reflux 3: trifluoroacetic acid / dichloromethane / 20 °C View Scheme

: 4403-69-4
2-amino-1-benzylamine

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium tris(acetoxy)borohydride / dichloromethane / 48 h / 20 °C 2: triethylamine / acetonitrile / 18 h / 20 °C / Reflux 3: trifluoroacetic acid / dichloromethane / 20 °C View Scheme

: 41864-22-6
1,1'-Carbonyl-di-(1,2,4-triazole)

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: 61039-29-0
2-Amino-3-(3,5-dibromo-4-hydroxy-phenyl)-propionic acid methyl ester; hydrochloride

: C24H26Br2N4O5

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran	100%

...Expand

: 41864-22-6
1,1'-Carbonyl-di-(1,2,4-triazole)

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: methyl 2-amino-3-(3-methoxyphenyl)propanoate hydrochloride

: C25H30N4O5

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran	100%

...Expand

: 41864-22-6
1,1'-Carbonyl-di-(1,2,4-triazole)

: C8H12N2O2S*ClH

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: C22H27N5O4S

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran	100%

...Expand

: 41864-22-6
1,1'-Carbonyl-di-(1,2,4-triazole)

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: 3-Nitro-phenylalanin-methylester-hydrochlorid

: C24H27N5O6

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran	100%

...Expand

: C13H13F3O4

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: C26H28F3N3O4

Conditions

Conditions	Yield
With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran	100%

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: 78647-52-6
(+/-)-4-(3,4-dimethoxyphenyl)-3-methoxycarbonylbutanoic acid

: C27H33N3O6

Conditions

Conditions	Yield
With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran	100%

: 122872-06-4
β-(methoxycarbonyl)-1-naphthalenebutanoic acid

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: C29H31N3O4

Conditions

Conditions	Yield
With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran	100%

: 3,5-dimethyl-4-hydroxy-β-(methoxycarbonyl)-benzenebutanoic acid

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: C27H33N3O5

Conditions

Conditions	Yield
With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran	100%

: 855778-81-3
1-(methoxycarbonyl)-2-(2-((2-(trimethylsilyl)ethoxy)methyl)-7-methyl-2H-indazol-5-yl)ethyl 4-nitrophenyl carbonate

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: 865626-65-9
1-(Methoxycarbonyl)-2-(2-((2-(trimethylsilyl)ethoxy)methyl)-7-methyl-2H-indazol-5-yl)ethyl 4-(1,2-dihydro-2-oxoquinazolin-3(4H)-yl)piperidine-1-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 48h;	100%
With N-ethyl-N,N-diisopropylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 48h;	100%

: 890044-58-3
(R)-methyl 2-amino-3-(7-methyl-1H-indazol-5-yl)propanoate

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: 890044-59-4
(R)-methyl-2-(4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)piperidine-1-carboxamido)-3-(7-methyl-1H-indazol-5-yl)propanoate

Conditions

Conditions	Yield
Stage #1: methyl (R)-2-amino-3-(7-methyl-1H-indazol-5-yl)propanoate With di(succinimido) carbonate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: 3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one In N,N-dimethyl-formamide for 24h;	100%

: 204695-24-9
3,5-dibromo-4-hydroxy-β-(methoxycarbonyl)-benzenebutanoic acid

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: C25H27Br2N3O5

Conditions

Conditions	Yield
With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In tetrahydrofuran; N,N-dimethyl-formamide	98%

: 204695-24-9
3,5-dibromo-4-hydroxy-β-(methoxycarbonyl)-benzenebutanoic acid

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: C25H27Br2N3O5

Conditions

Conditions	Yield
With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran	98%

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: 688020-82-8
(S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butyric acid methyl ester

Conditions

Conditions	Yield
Stage #1: (S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-succinic acid 1-methyl ester With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In DMF (N,N-dimethylformamide) at 20℃; for 1h; Stage #2: 3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one In DMF (N,N-dimethylformamide) at 20℃; Stage #3: With potassium carbonate; citric acid more than 3 stages;	98%

Yield

Stage #1: (S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-succinic acid 1-methyl ester With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In DMF (N,N-dimethylformamide) at 20℃; for 1h;
Stage #2: 3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one In DMF (N,N-dimethylformamide) at 20℃;
Stage #3: With potassium carbonate; citric acid more than 3 stages;

98%

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: 688021-09-2
3-(4-bromo-3-methyl-phenyl)-2-{[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-carbonyl]-amino}-propionic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: 2-amino-3-(4-bromo-3-methyl-phenyl)-propionic acid ethyl ester hydrochloride With 1,1'-Carbonyl-di-(1,2,4-triazole); triethylamine In DMF (N,N-dimethylformamide) at 0 - 20℃; for 2h; Stage #2: 3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one In DMF (N,N-dimethylformamide) at 80℃; for 1.5h;	97%

: 41864-22-6
1,1'-Carbonyl-di-(1,2,4-triazole)

: 600725-39-1
2-amino-3-(3,4-diethyl-phenyl)-propionic acid methylester

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: 686297-92-7
3-(3,4-diethyl-phenyl)-2-{[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-carbonyl]-amino}-propionic acid methylester

Conditions

Conditions	Yield
Stage #1: 1,1'-Carbonyl-di-(1,2,4-triazole); 2-amino-3-(3,4-diethyl-phenyl)-propionic acid methylester With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 10℃; for 1.5h; Stage #2: In DMF (N,N-dimethyl-formamide) for 0.5h; Stage #3: 3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one for 10h; Heating / reflux;	97%

...Expand

: 31385-63-4
(5-bromouracil)acetic acid

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: 5-bromo-1-{2-oxo-2-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-ethyl}-1H-pyrimidine-2,4-dione

Conditions

Conditions	Yield
Stage #1: (5-bromouracil)acetic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: 3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one In N,N-dimethyl-formamide at 20℃; for 18h;	97%

: 635712-47-9
(+/-)-2-Amino-3-(7-chloro-1H-indazol-5-yl)-propionic acid methyl ester

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: 530-62-1
1,1'-carbonyldiimidazole

: 635710-82-6
(+/-)-3-(7-chloro-1H-indazol-5-yl)-2-{[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidine-1-carbonyl]-amino}-propionic acid methyl ester

Conditions

Conditions	Yield
Stage #1: (+/-)-2-Amino-3-(7-chloro-1H-indazol-5-yl)-propionic acid methyl ester; 1,1'-carbonyldiimidazole In tetrahydrofuran at 0 - 20℃; for 0.25h; Stage #2: 3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one In tetrahydrofuran at 20℃;	94%
In tetrahydrofuran

...Expand

: C17H20Br2O7

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: C30H35Br2N3O7

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In tetrahydrofuran; N,N-dimethyl-formamide	93%

: C16H16O4

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: C29H31N3O4

Conditions

Conditions	Yield
With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran	92%

: 635712-52-6
(+/-)-2-Amino-3-(7-ethyl-1H-indazol-5-yl)-propionic acid methyl ester

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: 530-62-1
1,1'-carbonyldiimidazole

: 635710-84-8
(+/-)-3-(7-ethyl-1H-indazol-5-yl)-2-{[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidine-1-carbonyl]-amino}-propionic acid methyl ester

Conditions

Conditions	Yield
Stage #1: (+/-)-2-Amino-3-(7-ethyl-1H-indazol-5-yl)-propionic acid methyl ester; 1,1'-carbonyldiimidazole In tetrahydrofuran at 0 - 20℃; for 0.333333h; Stage #2: 3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one In tetrahydrofuran at 20℃;	92%
In tetrahydrofuran

...Expand

: 41864-22-6
1,1'-Carbonyl-di-(1,2,4-triazole)

: C10H11Br2NO2*ClH

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: C24H26Br2N4O4

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran	90%

...Expand

: 635713-85-8
(R)-2-amino-3-[1-(2-trimethylsilanyl-ethanesulfonyl)-1H-indazol-5-yl]-propionic acid methyl ester

: 74124-79-1
di(succinimido) carbonate

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: 635713-93-8
(R)-2-{[4-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidine-1-carbonyl]-amino}-3-[1-(2-trimethylsilanyl-ethanesulfonyl)-1H-indazol-5-yl]-propionic acid methyl ester

Conditions

Conditions	Yield
Stage #1: (R)-2-amino-3-[1-(2-trimethylsilanyl-ethanesulfonyl)-1H-indazol-5-yl]-propionic acid methyl ester; di(succinimido) carbonate With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.666667h; Stage #2: 3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one In dichloromethane at 20℃;	90%
With N-ethyl-N,N-diisopropylamine In dichloromethane	1.15 g (90%)

...Expand

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: 688021-42-3
2-(4-chloro-3-trifluoromethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butanoic acid methyl ester

Conditions

Conditions	Yield
Stage #1: 2-(4-chloro-3-trifluoromethyl-benzyl)-succinic acid 1-methyl ester With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; water at 20℃; for 0.166667h; Stage #2: 3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one In tetrahydrofuran; water at 20℃; for 2h; Stage #3: With sodium hydrogencarbonate In water	89%

Yield

Stage #1: 2-(4-chloro-3-trifluoromethyl-benzyl)-succinic acid 1-methyl ester With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; water at 20℃; for 0.166667h;
Stage #2: 3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one In tetrahydrofuran; water at 20℃; for 2h;
Stage #3: With sodium hydrogencarbonate In water

89%

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: 530-62-1
1,1'-carbonyldiimidazole

: 3,5-dibromo-D-tyrosine methyl ester

: (R)-N-(1-oxo-(3,4-dihydroquinazolin-2(1H)-yl)piperidinyl)-3,5-dibromotyrosine methylester

Conditions

Conditions	Yield
Stage #1: 1,1'-carbonyldiimidazole; 3,5-dibromo-D-tyrosine methyl ester With 1,2,4-Triazole In DMF (N,N-dimethyl-formamide) at 10 - 20℃; for 2h; Stage #2: 3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one In DMF (N,N-dimethyl-formamide) at 50 - 55℃; for 1.5h;	88%
Stage #1: 1,1'-carbonyldiimidazole; 3,5-dibromo-D-tyrosine methyl ester With 1,2,4-Triazole In DMF (N,N-dimethyl-formamide) at 10 - 20℃; for 2h; Stage #2: 3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one In DMF (N,N-dimethyl-formamide) at 20 - 55℃; for 1.5h; Product distribution / selectivity;	88%
With 1,2,4-Triazole In N,N-dimethyl-formamide	51%

...Expand

: 936572-64-4
C15H22N2O2

: 74124-79-1
di(succinimido) carbonate

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: C29H37N5O4

Conditions

Conditions	Yield
In dichloromethane	87%

...Expand

: 600725-56-2
4-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-3,3-bis-ethoxycarbonyl-butanoic acid

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: 688020-58-8
2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-2-{2-oxo-2-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-ethyl}-malonic acid diethyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In tetrahydrofuran at 20℃; for 16h;	87%

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: 13790-39-1
6,7-dimethoxy-4-chloroquinazoline

: 99161-60-1
3-[1-(6,7-Dimethoxy-quinazolin-4-yl)-piperidin-4-yl]-3,4-dihydro-1H-quinazolin-2-one; hydrochloride

Conditions

Conditions	Yield
In methanol Heating;	86%

: 773887-24-4
(+/-)-2-amino-3-(7-ethyl-3 methyl-1H-indazol-5-yl)-propionic acid methyl ester

: 79098-75-2
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one

: 855776-60-2
(+/-)-3-(7-ethyl-3-methyl-1H-indazol-5-yl)-2-{[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidine-1-carbonyl]-amino}-propionic acid methyl ester

Conditions

Conditions	Yield
Stage #1: (+/-)-2-amino-3-(7-ethyl-3 methyl-1H-indazol-5-yl)-propionic acid methyl ester; 1,1'-carbonyldiimidazole In tetrahydrofuran at 0 - 20℃; for 0.25h; Stage #2: 3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one In tetrahydrofuran at 20℃;	86%

3-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one Specification

The 3-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one, its cas register number is 79098-75-2. It also can be called as 2(1H)-Quinazolinone,3,4-dihydro-3-(4-piperidinyl)- and the Systematic name about this chemical is 3-piperidin-4-yl-3,4-dihydroquinazolin-2(1H)-one.

Following are the chemical properties about 3-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one: (1)#H bond acceptors: 4; (2)#H bond donors: 2; (3)#Freely Rotating Bonds: 1; (4)Polar Surface Area: 44.37Å²; (5)Index of Refraction: 1.581; (6)Molar Refractivity: 65.311 cm³; (7)Molar Volume: 195.993 cm³; (8)Polarizability: 25.891x10^-24cm³; (9)Surface Tension: 45.599 dyne/cm; (10) Enthalpy of Vaporization: 71.942 kJ/mol; (11)Boiling Point: 459.008 °C at 760 mmHg

This chemical can be described computed from structure:
(1)SMILES:O=C2N(Cc1ccccc1N2)C3CCNCC3
(2)InChI: InChI=1/C13H17N3O/c17-13-15-12-4-2-1-3-10(12)9-16(13)11-5-7-14-8-6-11/h1-4,11,14H,5-9H2,(H,15,17)
(3)InChIKey: KSTFHYBYFDYWSD-UHFFFAOYAK
(4)Std. InChI: InChI=1S/C13H17N3O/c17-13-15-12-4-2-1-3-10(12)9-16(13)11-5-7-14-8-6-11/h1-4,11,14H,5-9H2,(H,15,17)
(5)Std. InChIKey: KSTFHYBYFDYWSD-UHFFFAOYSA-N

Product Name

3-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one

Synthetic route

3-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one Specification

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