3-Chloropropyltrimethoxysilane supplier

Name
3-Chloropropyltrimethoxysilane
EINECS 219-787-9
CAS No. 2530-87-2
Article Data17
CAS DataBase
Density 1.025 g/cm³
Solubility Hydrolyzes in water.
Melting Point -50 °C
Formula C₆H₁₅ClO₃Si
Boiling Point 195.5 °C at 760 mmHg
Molecular Weight 198.722
Flash Point 47.5 °C
Transport Information UN 1993 3/PG 3
Appearance Colorless transparent liquid
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms (3-Chloropropyl)trimethoxysilane;(g-Chloropropyl)trimethoxysilane;3-(Trimethoxysilyl)propyl chloride;A 143;C 3300;CPS-M;KBM 703;LS 1260;NSC83878;SH 6076;Sila-Ace S 620;Silquest A 143;Silquest A 1430;TSL 8320;TSL8326;Trimethoxy(3-chloropropyl)silane;Unisilan 311;Z 6076;d-Chloropropyltrimethoxysilane;
PSA 27.69000
LogP 1.49340

Synthetic route

: 67-56-1
methanol

: 2550-06-3
3-chloropropyltrichlorosilane

: 2530-87-2
3-Chloropropyltrimethoxysilan

Conditions

Conditions	Yield
at 50 - 60℃; under 400 Torr; Large scale;	99%
With urea In hexane for 4h; Reflux;	76%

: 2550-06-3
3-chloropropyltrichlorosilane

: 149-73-5
trimethyl orthoformate

: 2530-87-2
3-Chloropropyltrimethoxysilan

Conditions

Conditions	Yield
at 95 - 100℃; for 7h; Industrial scale;	81%

: 67-56-1
methanol

: 2550-06-3
3-chloropropyltrichlorosilane

A: 18132-73-5
1,3-Bis-(3-chlorpropyl)-tetramethoxydisiloxan

B: 2530-87-2
3-Chloropropyltrimethoxysilan

...Expand

: 2487-90-3
trimethoxysilane

: 107-05-1
3-chloroprop-1-ene

A: bis(trimethoxysilyl)propane

B: 253586-30-0
3-chloropropyltrichlorosilane

C: 4668-00-2
chlorotrimethoxysilane

D: 681-84-5
tetramethylorthosilicate

E: 540-54-5
1-Chloropropane

F: 1067-25-0
n-propyltrimethoxysilane

G: 2530-87-2
3-Chloropropyltrimethoxysilan

Conditions

Conditions	Yield
With toluene; ruthenium trichloride In methanol at 20 - 83℃; for 2h; Product distribution / selectivity;
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 In dichloromethane at 20 - 83℃; for 2h; Product distribution / selectivity;
ruthenium trichloride In methanol at 75 - 169℃; for 18h; Product distribution / selectivity; Continuous operation;

...Expand

: 2487-90-3
trimethoxysilane

: 107-05-1
3-chloroprop-1-ene

A: 253586-30-0
3-chloropropyltrichlorosilane

B: 4668-00-2
chlorotrimethoxysilane

C: 681-84-5
tetramethylorthosilicate

D: 540-54-5
1-Chloropropane

E: 1067-25-0
n-propyltrimethoxysilane

F: 2530-87-2
3-Chloropropyltrimethoxysilan

Conditions

Conditions	Yield
With toluene; ruthenium trichloride In methanol at 20 - 83℃; for 2h; Product distribution / selectivity;
Stage #1: trimethoxysilane; ruthenium trichloride In methanol; toluene at 20 - 80℃; Heating / reflux; Stage #2: 3-chloroprop-1-ene at 78 - 83℃; for 2h;

...Expand

: 107-05-1
3-chloroprop-1-ene

: 2530-87-2
3-Chloropropyltrimethoxysilan

Conditions

Conditions	Yield
With trichlorosilane; platinum In methanol

: 2487-90-3
trimethoxysilane

: 107-05-1
3-chloroprop-1-ene

: 2530-87-2
3-Chloropropyltrimethoxysilan

Conditions

Conditions	Yield
In 5,5-dimethyl-1,3-cyclohexadiene
(1,5-cyclooctadiene)(methoxy)iridium(I) dimer at -78 - 80℃; pressure tight tube;	42.7 %Chromat.
With rhodium(III) chloride hydrate; Diphenylmethane; tert-butyl peroxy-3,5,5-trimethylhexanoate In methanol at 75℃; Concentration; Reagent/catalyst; Time; Wavelength; Temperature; Inert atmosphere;	94.66 %Chromat.

: 1634-04-4
tert-butyl methyl ether

: 2550-06-3
3-chloropropyltrichlorosilane

: 2530-87-2
3-Chloropropyltrimethoxysilan

Conditions

Conditions	Yield
With bismuth(III) chloride at 0 - 20℃; Neat (no solvent); Inert atmosphere;	92 %Spectr.

: 2487-90-3
trimethoxysilane

: 107-05-1
3-chloroprop-1-ene

A: 681-84-5
tetramethylorthosilicate

B: 2530-87-2
3-Chloropropyltrimethoxysilan

Conditions

Conditions	Yield
With di-tert-butyl peroxide In methanol Concentration; Reagent/catalyst; Temperature;	A 10.73 %Chromat. B 75.29 %Chromat.

...Expand

: 1634-04-4
tert-butyl methyl ether

: 2550-06-3
3-chloropropyltrichlorosilane

A: 253586-30-0
3-chloropropyltrichlorosilane

B: 2530-87-2
3-Chloropropyltrimethoxysilan

Conditions

Conditions	Yield
With bismuth(III) chloride In acetonitrile at 20℃; for 6h; Schlenk technique; Inert atmosphere;

...Expand

: 616-47-7
1-methyl-1H-imidazole

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 3-methyl-1-(trimethoxysilylpropyl)imidazolium chloride

Conditions

Conditions	Yield
at 70℃; for 72h; Inert atmosphere; Schlenk technique;	100%
at 150℃; for 2h; Microwave irradiation;	99%
at 80℃; for 72h; Neat (no solvent);	98%

: potassium 9-anthracene carboxylate

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 9-anthracenecarboxylic acid (trimethoxysilyl) propyl ester

Conditions

Conditions	Yield
In DMF (N,N-dimethyl-formamide) at 120℃; for 2h;	100%

: 108-89-4
picoline

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 1-(3-trimethoxysilylpropyl)-4-methylpyridinium chloride

Conditions

Conditions	Yield
at 95℃; for 24h;	99%

: 2-methyl-1-{4-[2-(2-(prop-1-enyl)phenoxy)propoxy]butyl}-1H-imidazole

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 2-methyl-1-{4-[2-(2-(prop-1-enyl)phenoxy)propoxy]butyl}-3-[3-(trimethoxysilyl)propyl]-1H-imidazolium chloride

Conditions

Conditions	Yield
In toluene at 95℃; for 72h; Inert atmosphere; Schlenk technique;	99%
In toluene at 95℃; for 72h;	99%

: 106-44-5
p-cresol

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 3-(2-hydroxy-5-methylphenyl)-propyltrimethoxysilane

Conditions

Conditions	Yield
for 24h; Friedel-Crafts Alkylation; Reflux;	99%

: 188290-36-0
thiophene

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 3-thienyl-propyltrimethoxysilane

Conditions

Conditions	Yield
With aluminum (III) chloride for 24h; Friedel-Crafts Alkylation; Reflux;	99%

: 870-24-6
2-chloroethanamine hydrochloride

: 2530-87-2
3-Chloropropyltrimethoxysilan

: C8H20ClNO3Si

Conditions

Conditions	Yield
Stage #1: 2-chloroethanamine hydrochloride With sodium hydroxide In water for 2h; Cooling with ice; Stage #2: 3-Chloropropyltrimethoxysilan In toluene at 100℃; for 24h; Inert atmosphere;	99%

: 6276-54-6
3-chloropropylamine hydrochloride

: 2530-87-2
3-Chloropropyltrimethoxysilan

: C9H22ClNO3Si

Conditions

Conditions	Yield
Stage #1: 3-chloropropylamine hydrochloride With sodium hydroxide In water for 2h; Cooling with ice; Stage #2: 3-Chloropropyltrimethoxysilan In toluene at 100℃; for 24h; Inert atmosphere;	99%

: 2867-47-2
2-(dimethylamino)ethyl methacrylate

: 2530-87-2
3-Chloropropyltrimethoxysilan

: C14H30NO5Si(1+)

Conditions

Conditions	Yield
at 80℃; for 72h; Inert atmosphere;	98%

: 110-86-1
pyridine

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 53662-10-5
3-pyridiniumpropyltrimethoxysilane chloride

Conditions

Conditions	Yield
at 95℃; for 24h; Inert atmosphere;	98%

: 2851-60-7
N,N'-bis(salicylidene)diethylenetriamine

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 1202398-95-5
C24H35N3O5Si

Conditions

Conditions	Yield
In toluene for 24h; Reflux; Inert atmosphere;	98%

: 6674-22-2
1,8-diazabicyclo[5.4.0]undec-7-ene

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 10-(3-(trimethoxysilyl)propyl)-2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine

Conditions

Conditions	Yield
Stage #1: 1,8-diazabicyclo[5.4.0]undec-7-ene With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 1h; Inert atmosphere; Stage #2: 3-Chloropropyltrimethoxysilan In tetrahydrofuran; hexane at 20℃; for 12h; Inert atmosphere;	98%
Stage #1: 1,8-diazabicyclo[5.4.0]undec-7-ene With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 1h; Inert atmosphere; Stage #2: 3-Chloropropyltrimethoxysilan In tetrahydrofuran; hexane at 20℃; for 12h; Inert atmosphere;	98%

: N-(3-(dimethylamino)propyl)benzenesulfonamide

: 2530-87-2
3-Chloropropyltrimethoxysilan

: N,N-dimethyl-3-(phenylsulfonamido)-N-(3-(trimethoxysilyl)propyl)propan-1-aminium chloride

Conditions

Conditions	Yield
In acetonitrile for 4h; Heating;	97.5%
In acetonitrile for 6h; Reflux;	82%

: 4316-42-1
1-Butylimidazole

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 1-butyl-3-[3-(trimethoxysilyl)propyl]-1H-imidazol-3-ium chloride

Conditions

Conditions	Yield
at 120℃; for 8h;	97%
at 120℃; for 24h; Inert atmosphere;	96%
In toluene at 110℃; for 12h;	70%

: 4238-71-5
1-benzylimidazole

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 1-benzyl-3-(trimethoxysilylpropyl)imidazol-3-ium chloride

Conditions

Conditions	Yield
at 80℃; for 48h; Inert atmosphere;	97%

: N-(3-(dimethylamino)propyl)-4-methylbenzenesulfonamide

: 2530-87-2
3-Chloropropyltrimethoxysilan

: N,N-dimethyl-3-(4-methylphenylsulfonamido)-N-(3-(trimethoxysilyl)propyl)propan-1-aminium chloride

Conditions

Conditions	Yield
In acetonitrile for 3.5h; Heating;	97%
In acetonitrile for 6h; Reflux;	97%

: 61-82-5
3(5)-amino-1,2,4-triazole

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 3-amino-1-(3-(trimethoxysilyl)propyl)-1,2,4-triazole

Conditions

Conditions	Yield
Stage #1: 3(5)-amino-1,2,4-triazole With sodium methylate In methanol; N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: 3-Chloropropyltrimethoxysilan In ethanol; N,N-dimethyl-formamide at 86 - 90℃; for 8h;	96.4%

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 14867-28-8
3-iodopropyltrimethoxysilane

Conditions

Conditions	Yield
With sodium iodide In acetone Inert atmosphere; Reflux;	96%
With sodium iodide In acetone for 24h; Inert atmosphere; Reflux;	90%
With sodium iodide In acetone Reflux; Inert atmosphere;	90%

: octa(isobutylsilsesquioxane)

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 307531-92-6
1,3,5,7,9,11,14-heptaisobutyltricyclo[7.3.3.15,11]heptasiloxane-endo-3,7,14-triol

Conditions

Conditions	Yield
lithium hydroxide In methanol; water; acetone at 55℃; for 18h;	96%

: 553-26-4
4,4'-bipyridine

: 2530-87-2
3-Chloropropyltrimethoxysilan

: C22H38N2O6Si2(2+)*2Cl(1-)

Conditions

Conditions	Yield
for 24h; Darkness; Reflux;	96%

: 45534-08-5
5-methylsulfanyl-2H-[1,2,4]triazol-3-ylamine

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 5-amino-3-methylthio-1-(3-(trimethoxysilyl)propyl)-1,2,4-triazole

Conditions

Conditions	Yield
Stage #1: 5-methylsulfanyl-2H-[1,2,4]triazol-3-ylamine With sodium methylate In methanol; N,N-dimethyl-formamide at 20℃; for 0.333333h; Stage #2: 3-Chloropropyltrimethoxysilan at 88 - 90℃; for 4h;	95.7%

: 75-16-1
methylmagnesium bromide

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 18171-14-7
γ-chloropropyldimethylmethoxysilane

Conditions

Conditions	Yield
In diethyl ether	95%

: 865-34-9
lithium methanolate

: 2530-87-2
3-Chloropropyltrimethoxysilan

: (3-methoxypropyl)trimethoxysilane

Conditions

Conditions	Yield
at 190℃; for 0.5h;	95%

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 76788-88-0
(3-azidopropyl)trimethoxysilane

Conditions

Conditions	Yield
With sodium azide In N,N-dimethyl-formamide at 100℃; Inert atmosphere;	95%
With sodium azide; tetrabutylammomium bromide In acetonitrile for 20h; Inert atmosphere; Reflux;	94%
With sodium azide; cetyltrimethylammonim bromide at 140℃; for 3h; Inert atmosphere;	90%

: 1072-63-5
1-vinylimidazole

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 1-vinyl-3-(3-trimethoxysilylpropyl)imidazolium chloride

Conditions

Conditions	Yield
In water at 80℃; for 72h;	95%
at 90℃; for 60h; Autoclave; Inert atmosphere;	90%

: 24634-61-5
potassium sorbate

: 2530-87-2
3-Chloropropyltrimethoxysilan

: C12H22O5Si

Conditions

Conditions	Yield
With 10H-phenothiazine; 2,6-di-tert-butyl-4-methyl-phenol; tetrabutylammomium bromide; ethylene diamine tetraacetic acid tetrasodium salt In methanol; water at 105℃; for 0.166667h; Concentration; Temperature; Large scale;	95%

: 25364-44-7
N-(2,4,6-trimethylphenyl)imidazole

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 1174062-52-2
1-(2,4,6-trimethylphenyl)-3-[3-(trimethoxysilyl)propyl]imidazolium iodide

Conditions

Conditions	Yield
With potassium iodide In 1,2-dimethoxyethane at 85℃; for 60h; Inert atmosphere;	94%

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

Conditions

Conditions	Yield
With sodium sulfide; tetrabutyl-ammonium chloride; water In toluene at 88 - 92℃; for 4h;	93.5%
With N-octylpyridinium tetrafluoroborate; sodium hydrogen sulfide; triphenylethylphosphonium bromide In water at 48 - 120℃; for 3.5h; Reagent/catalyst; Inert atmosphere;	93.32%
With hydrogen sulfide; sodium In methanol
With hydrogen sulfide; ammonia In methanol
Multi-step reaction with 2 steps 1: dodecyltrimethylphosphonium bromide / methanol / 130 - 140 °C 2: ethylenediamine; sodium methylate / 80 - 90 °C View Scheme

3-Chloropropyltrimethoxysilane Specification

The 3-(Trimethoxysilyl)propyl chloride is an organic compound with the formula C₆H₁₅ClO₃Si. The IUPAC name of this chemical is 3-chloropropyl(trimethoxy)silane. With the CAS registry number 2530-87-2, it is also named as Silane, (3-chloropropyl)trimethoxy-. The product's categories are Industrial/Fine Chemicals; Chloro; Organics; Chloroal kylsilanes, etc. (Silane Coupling Agents); Functional Materials; Si (Classes of Silicon Compounds); Silane Coupling Agents; Si-O Compounds; Trialkoxysilanes; Alkoxy Silanes; Alpha Silanes; Silane series; Organometallic Reagents; Organosilicon. Besides, it is colorless transparent liquid, which should be stored in a closed cool and dry place.

Physical properties about 3-(Trimethoxysilyl)propyl chloride are: (1)ACD/LogP: 1.12; (2)ACD/LogD (pH 5.5): 1.12; (3)ACD/LogD (pH 7.4): 1.12; (4)ACD/BCF (pH 5.5): 4.21; (5)ACD/BCF (pH 7.4): 4.21; (6)ACD/KOC (pH 5.5): 97.3; (7)ACD/KOC (pH 7.4): 97.3; (8)#H bond acceptors: 3; (9)#Freely Rotating Bonds: 6; (10)Polar Surface Area: 27.69 Å²; (11)Index of Refraction: 1.416; (12)Molar Refractivity: 48.64 cm³; (13)Molar Volume: 193.7 cm³; (14)Polarizability: 19.28×10^-24cm³; (15)Surface Tension: 23.6 dyne/cm; (16)Density: 1.025 g/cm³; (17)Flash Point: 47.5 °C; (18)Enthalpy of Vaporization: 41.41 kJ/mol; (19)Boiling Point: 195.5 °C at 760 mmHg; (20)Vapour Pressure: 0.585 mmHg at 25°C.

Uses of 3-(Trimethoxysilyl)propyl chloride: it can be used to produce 3-iodopropyltrimethoxysilane. It will need reagent NaI.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: ClCCC[Si](OC)(OC)OC
(2)InChI: InChI=1/C6H15ClO3Si/c1-8-11(9-2,10-3)6-4-5-7/h4-6H2,1-3H3
(3)InChIKey: OXYZDRAJMHGSMW-UHFFFAOYAH
(4)Std. InChI: InChI=1S/C6H15ClO3Si/c1-8-11(9-2,10-3)6-4-5-7/h4-6H2,1-3H3
(5)Std. InChIKey: OXYZDRAJMHGSMW-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rabbit	LD50	skin	2830uL/kg (2.83mL/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	National Technical Information Service. Vol. OTS0555731,
rat	LD50	oral	6170uL/kg (6.17mL/kg)		Journal of Toxicology, Cutaneous and Ocular Toxicology. Vol. 15, Pg. 261, 1996.

Product Name

3-Chloropropyltrimethoxysilane

Synthetic route

3-Chloropropyltrimethoxysilane Specification

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