Product Name

  • Name

    COLCHICOSIDE

  • EINECS
  • CAS No. 477-29-2
  • Article Data2
  • CAS DataBase
  • Density 1.44g/cm3
  • Solubility
  • Melting Point 194-197°C
  • Formula C27H33 N O11
  • Boiling Point 929°Cat760mmHg
  • Molecular Weight 547.559
  • Flash Point 515.6°C
  • Transport Information
  • Appearance
  • Safety Poison by ingestion, parenteral, intracerebral, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx. See also COLCHICINE.
  • Risk Codes
  • Molecular Structure Molecular Structure of 477-29-2 (COLCHICOSIDE)
  • Hazard Symbols
  • Synonyms Acetamide,N-[3-(b-D-glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-,(S)-; Colchicoside (6CI,7CI,8CI); Benzo[a]heptalene, acetamide deriv.;3-Demethylcolchicine glucoside
  • PSA 173.24000
  • LogP 0.43260

3-Demethylcolchicine glucoside Chemical Properties

Molecule structure of 3-Demethylcolchicine glucoside (CAS NO.477-29-2) :

IUPAC Name: N-[1,2,10-trimethoxy-9-oxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide 
Molecular Weight: 547.55102 g/mol
Molecular Formula: C27H33NO11 
Density: 1.44 g/cm3 
Boiling Point: 929 °C at 760 mmHg 
Flash Point: 515.6 °C
Index of Refraction: 1.636
Molar Refractivity: 135.48 cm3
Molar Volume: 377.8 cm3
Polarizability: 53.71*10-24 cm3
Surface Tension: 71.1 dyne/cm 
Enthalpy of Vaporization: 141.56 kJ/mol
XLogP3: -1.1
H-Bond Donor: 5
H-Bond Acceptor: 11
Rotatable Bond Count: 7
Tautomer Count: 2
Exact Mass: 547.205361
MonoIsotopic Mass: 547.205361
Topological Polar Surface Area: 173
Heavy Atom Count: 39
Complexity: 1010
InChI: InChI=1S/C27H33NO11/c1-12(30)28-16-7-5-13-9-19(38-27-24(34)23(33)22(32)20(11-29)39-27)25(36-3)26(37-4)21(13)14-6-8-18(35-2)17(31)10-15(14)16/h6,8-10,16,20,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)
InChIKey: UXAFRQPVHYZDED-UHFFFAOYSA-N
EINECS: 207-513-0
Product Categories: Miscellaneous Natural Products

3-Demethylcolchicine glucoside Toxicity Data With Reference

1.    

ice-rat LDLo:75 µg/kg

     AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 109 (1957),386.
2.    

par-rat LDLo:75 µg/kg

     FRPSAX    Farmaco, Edizione Scientifica. 15 (1960),533.
3.    

orl-mus LD50:84 mg/kg

     AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 94 (1957),386.
4.    

ipr-mus LD50:280 mg/kg

     AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 109 (1957),386.
5.    

ivn-mus LD50:320 mg/kg

     AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 94 (1953),453.

3-Demethylcolchicine glucoside Safety Profile

Poison by ingestion, parenteral, intracerebral, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx. See also COLCHICINE.

3-Demethylcolchicine glucoside Specification

 3-Demethylcolchicine glucoside (CAS NO.477-29-2) is also called Colchicoside ; 4-17-00-03428 (Beilstein Handbook Reference) ; BRN 0072204 ; NSC 32992 ; NSC 624672 . 3-Demethylcolchicine glucoside (CAS NO.477-29-2) is high toxic. It is flammable. It will produce toxic nitrogen oxide fumes when buring. So the storage environment should be ventilate, low-temperature and dry. Keep 3-Demethylcolchicine glucoside (CAS NO.477-29-2) separate from raw materials of food.

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