3-Diethylaminopropylamine supplier

Name
3-Diethylaminopropylamine
EINECS 203-236-4
CAS No. 104-78-9
Article Data49
CAS DataBase
Density 0.84 g/cm³
Solubility miscible with water
Melting Point -60 °C
Formula C₇H₁₈N₂
Boiling Point 170.7 °C at 760 mmHg
Molecular Weight 130.233
Flash Point 58.9 °C
Transport Information UN 2684 3/PG 3
Appearance clear colorless to slightly yellowish liquid
Safety 26-36/37/39-45
Risk Codes 10-21/22-34-43
Molecular Structure
Hazard Symbols Xi, C
Synonyms 1,3-Propanediamine,N,N-diethyl- (6CI,7CI,8CI,9CI);(3-Diethylaminopropan-1-yl)amine;1-Amino-3-(diethylamino)propane;3-(Diethylamino)-n-propylamine;3-(Diethylamino)propanamine;3-(Diethylamino)propylamine;3-(N,N-Diethylamino)-1-propylamine;3-(N,N-Diethylamino)propylamine;3-Diethylamino-1-propylamine;Diethylaminotrimethylenamine;N,N-Diethyl-1,3-diaminopropane;N,N-Diethyl-1,3-propanediamine;N,N-Diethyl-1,3-propylenediamine;N,N-Diethyltrimethylenediamine;N,N-Ethylpropane-1,3-diamine;N-(3-Aminopropyl)-N,N-diethylamine;N-(3-Aminopropyl)diethylamine;N-(3-Diethylaminopropyl)amine;N-(Diethylaminopropyl)amine;N-Aminopropyl-N,N-diethylamine;N1,N1-Diethylpropane-1,3-diamine;NSC 7776;g-(Diethylamino)propylamine;
PSA 29.26000
LogP 1.37730

Synthetic route

: 20824-58-2
2-(3-diethylaminopropyl)-1H-isoindole-1,3(2H)-dione

: 104-78-9
diethylaminopropylamine

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol for 24h; Reflux;	73%
With hydrazine hydrate In ethanol for 3h; Reflux;	14%
With hydrazine

: 5351-04-2
3-diethylaminopropionitrile

: 104-78-9
diethylaminopropylamine

Conditions

Conditions	Yield
With ethanol; sodium for 3h; Reflux;	56%
With sodium-potassium alloy; butan-1-ol
With ethanol; sodium

: 136918-14-4
phthalimide

: 104-77-8
3-diethylaminopropyl chloride

: 104-78-9
diethylaminopropylamine

Conditions

Conditions	Yield
With xylene Hydrolyse des entstandenen N-<3-Diaethylamino-propyl>-phthalimids mit konz.HCl bei Siedetemperatur.;
With xylene Hydrolyse des entstandenen N-<3-Diaethylamino-propyl>-phthalimids mit konz.HCl bei Siedetemperatur.;

: 5460-29-7
2-(3-bromopropyl)isoindole-1,3-dione

: 109-89-7
diethylamine

: 104-78-9
diethylaminopropylamine

Conditions

Conditions	Yield
Hydrolyse des entstandenen N-<3-Diaethylamino-propyl>-phthalimids mit konz.HCl bei Siedetemperatur.;
(i) KOH, MeOH, (ii) aq. KOH, (heating); Multistep reaction;
Hydrolyse des entstandenen N-<3-Diaethylamino-propyl>-phthalimids mit konz.HCl bei Siedetemperatur.;

: 5351-04-2
3-diethylaminopropionitrile

A: 6050-28-8
bis-(3-diethylamino-propyl)-amine

B: 104-78-9
diethylaminopropylamine

Conditions

Conditions	Yield
With sodium-potassium alloy; butan-1-ol
With nickel at 100℃; under 62518.2 Torr; Hydrogenation;

: 100536-45-6
tetra-N-ethyl-ξ-propenediyldiamine

: 104-78-9
diethylaminopropylamine

Conditions

Conditions	Yield
With ammonia; nickel at 100℃; under 91938.4 Torr; Hydrogenation;
With ammonia; nickel at 100℃; under 91938.4 Torr; Hydrogenation;

: 109-89-7
diethylamine

: 156-87-6
propan-1-ol-3-amine

A: 107-11-9
1-amino-2-propene

B: 104-78-9
diethylaminopropylamine

Conditions

Conditions	Yield
With thorium dioxide at 270 - 290℃;

...Expand

: 503-29-7
azetidine

: 109-89-7
diethylamine

A: 103502-67-6
1-<(3-aminopropyl)aminopropyl>diethylamine

B: 104-78-9
diethylaminopropylamine

Conditions

Conditions	Yield
With perchloric acid at 25℃; Rate constant; Thermodynamic data; E(a), ΔS(excit.);

...Expand

N,N-diethyl-β-alynyne-nitrile: N,N-diethyl-β-alynyne-nitrile

: 104-78-9
diethylaminopropylamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether

: 5351-04-2
3-diethylaminopropionitrile

Raney nickel: Raney nickel

A: 6050-28-8
bis-(3-diethylamino-propyl)-amine

B: 104-78-9
diethylaminopropylamine

Conditions

Conditions	Yield
Hydrogenation;

...Expand

: 5351-04-2
3-diethylaminopropionitrile

: 71-36-3
butan-1-ol

sodium-potassium-alloy: sodium-potassium-alloy

A: 6050-28-8
bis-(3-diethylamino-propyl)-amine

B: 104-78-9
diethylaminopropylamine

...Expand

: 5351-04-2
3-diethylaminopropionitrile

: 64-17-5
ethanol

sodium: sodium

A: 6050-28-8
bis-(3-diethylamino-propyl)-amine

B: 104-78-9
diethylaminopropylamine

...Expand

: 5351-04-2
3-diethylaminopropionitrile

: 71-36-3
butan-1-ol

sodium: sodium

A: 6050-28-8
bis-(3-diethylamino-propyl)-amine

B: 104-78-9
diethylaminopropylamine

...Expand

: 57796-55-1
6-chloro-5-ethylamino-3-methoxy-pyrazine-2-carboxylic acid 3-diethylamino-propylamide

A: 104-78-9
diethylaminopropylamine

B: 57796-33-5
6-chloro-5-ethylamino-3-methoxy-pyrazine-2-carboxylic acid

: 109-89-7
diethylamine

: 107-02-8
acrolein

A: 104-78-9
diethylaminopropylamine

B: 626-56-2, 53152-98-0
3-Methylpiperidine

Conditions

Conditions	Yield
Stage #1: diethylamine; acrolein In tetrahydrofuran at 4℃; Stage #2: With ammonia; hydrogen; Raney cobalt In tetrahydrofuran at 80℃; under 45004.5 Torr; for 6h; Product distribution / selectivity; autoclave;	A 52 %Chromat. B 8 %Chromat.

...Expand

: 109-89-7
diethylamine

: 107-02-8
acrolein

: 104-78-9
diethylaminopropylamine

Conditions

Conditions	Yield
Stage #1: diethylamine; acrolein In tetrahydrofuran at 4℃; Stage #2: With ammonia; hydrogen; Raney cobalt In tetrahydrofuran at 80℃; under 45004.5 Torr; for 6h; Product distribution / selectivity; autoclave;	87 %Chromat.

: 66999-80-2
N-(3-(diethylamino)-propyl)benzamide

A: 104-78-9
diethylaminopropylamine

B: 100-51-6
benzyl alcohol

Conditions

Conditions	Yield
With Ag/γ-Al2O3 (5 mol%); potassium tert-butylate; hydrogen In 1,4-dioxane at 170℃; under 45004.5 Torr; for 120h; Green chemistry; chemoselective reaction;	A 83 %Spectr. B 84 %Spectr.

: 812699-95-9
N-{3-[4-(6-chloropyridin-3-yl)-pyrimidin-2-ylamino]-4-methylphenyl}-3-trifluoromethylbenzamide

: 104-78-9
diethylaminopropylamine

: N-(3-{4-[6-(3-diethylaminopropylamino)-pyridin-3-yl]-pyrimidin-2-ylamino}-4-methylphenyl)-3-trifluoromethylbenzamide

Conditions

Conditions	Yield
at 110℃;	100%

: C36H28Cl2N12O8S2(2-)*2Na(1+)

: 104-78-9
diethylaminopropylamine

: C50H64N16O8S2

Conditions

Conditions	Yield
Stage #1: C36H28Cl2N12O8S2(2-)*2Na(1+); diethylaminopropylamine In water at 70 - 97℃; for 4h; Stage #2: With hydrogenchloride In water pH=4.5;	100%

: 104-78-9
diethylaminopropylamine

: 112-67-4
n-hexadecanoyl chloride

: N,N-diethyl-N'-hexadecanoyl-1,3-propanediamine

Conditions

Conditions	Yield
In methanol; sodium hydroxide; dichloromethane; chloroform	100%

: 1711-09-7
3-bromobenzoyl chloride

: 104-78-9
diethylaminopropylamine

: 349405-27-2
3-bromo-N-(3-diethylamino-propyl)benzamide

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane; water at 0 - 20℃; for 18h; Cooling with ice; Inert atmosphere;	100%
With sodium hydroxide In dichloromethane; water at 0 - 20℃; for 18h; Product distribution / selectivity; Inert atmosphere;	99%

: 53063-03-9
2-Chloro-3-diisopropylaminocarbonylpyridine

: 104-78-9
diethylaminopropylamine

: 2-(3-Diethylaminopropylamino)-3-diisopropylaminocarbonylpyridine

Conditions

Conditions	Yield
at 150℃; for 1h;	99%

: 104-78-9
diethylaminopropylamine

: 173961-02-9
4-(4-Methoxy-phenyl)-3-oxiranylmethoxymethyl-butan-1-ol

: 3-[3-(3-Diethylamino-propylamino)-2-hydroxy-propoxymethyl]-4-(4-methoxy-phenyl)-butan-1-ol

Conditions

Conditions	Yield
In ethanol for 2h; Heating;	99%

: 108-24-7
acetic anhydride

: 104-78-9
diethylaminopropylamine

: 32039-09-1
3-diethylaminopropyl-1-acetamide

Conditions

Conditions	Yield
With pyridine for 18h; Ambient temperature;	99%

: 104-78-9
diethylaminopropylamine

: 173961-03-0
4-Benzo[1,3]dioxol-5-yl-3-oxiranylmethoxymethyl-butan-1-ol

: 4-Benzo[1,3]dioxol-5-yl-3-[3-(3-diethylamino-propylamino)-2-hydroxy-propoxymethyl]-butan-1-ol

Conditions

Conditions	Yield
In ethanol for 2h; Heating;	98%

: C38H32Cl2N12O10S2(2-)*2Na(1+)

: 104-78-9
diethylaminopropylamine

: C52H68N16O10S2

Conditions

Conditions	Yield
Stage #1: C38H32Cl2N12O10S2(2-)*2Na(1+); diethylaminopropylamine In water at 70 - 98℃; for 4h; Stage #2: With hydrogenchloride In water pH=2.0;	98%

: 24424-99-5
di-tert-butyl dicarbonate

: 104-78-9
diethylaminopropylamine

: 1360158-43-5
tert-butyl 3-(diethylamino)propylcarbamate

Conditions

Conditions	Yield
at 20℃;	98%

: 17669-01-1, 56190-51-3, 15853-98-2
(+)-usnic acid

: 104-78-9
diethylaminopropylamine

: (2R,4E)-10-acetyl-4-(1-{[2-(diethylamino)propyl]amino}ethylidene)-11,13-dihydroxy-2,12-dimethyl-8-oxatricyclo[7.4.0.02,7]trideca-1(9),6,10,12-tetraene-3,5-dione

Conditions

Conditions	Yield
In ethanol for 3h; Reflux;	98%

: 49627-27-2
sulindac sulfide

: 104-78-9
diethylaminopropylamine

: (Z)-N-(3-(diethylamino)propyl)-2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetamide

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In acetonitrile at 20℃; Inert atmosphere;	98%

: 21814-48-2
1-chloro-7-methoxy-4-nitro-10H-acridin-9-one

: 104-78-9
diethylaminopropylamine

: 99140-35-9
1-(3-Diethylamino-propylamino)-7-methoxy-4-nitro-10H-acridin-9-one

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 60℃; for 0.5h;	97%

: 185408-97-3
2-chloro-N-phenyl-9H-purin-6-amine

: 104-78-9
diethylaminopropylamine

: 903583-21-1
2-(N,N-diethylamino-3-propylamino)-6-phenylamino-purine

Conditions

Conditions	Yield
at 110℃; for 17h;	97%

: 38194-50-2
Sulindac

: 104-78-9
diethylaminopropylamine

: (Z)-N-(3-(diethylamino)propyl)-2-(5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetamide

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In acetonitrile at 20℃; Inert atmosphere;	97%

: 864244-98-4
4-(2-methyl-4-nitrophenoxy)pyridin-2-amine

: 104-78-9
diethylaminopropylamine

: 864245-03-4
1-(3-diethylaminopropyl)-3-[4-(2-methyl-4-nitrophenoxy)pyridin-2-yl]urea

Conditions

Conditions	Yield
Stage #1: 4-(2-methyl-4-nitrophenoxy)pyridin-2-amine; phenyl chloroformate With triethylamine In tetrahydrofuran at 0℃; for 0.5h; Stage #2: diethylaminopropylamine In N,N-dimethyl-formamide at 20℃; for 2h;	96.9%

: 2150-37-0
methyl 3,5-dimethoxybenzoate

: 104-78-9
diethylaminopropylamine

: 59741-89-8
methyl 1-(2-bromoethyl)-3,5-dimethoxycyclohexa-2,5-diene-1-carboxylate

Conditions

Conditions	Yield
Stage #1: methyl 3,5-dimethoxybenzoate With ammonia; lithium; tert-butyl alcohol In tetrahydrofuran at -78℃; Birch reduction alkylation; Stage #2: diethylaminopropylamine In tetrahydrofuran	96%

: 635-93-8
5-chlorosalicyclaldehyde

: 104-78-9
diethylaminopropylamine

: C14H21ClN2O

Conditions

Conditions	Yield
In methanol at 20℃; for 0.5h;	96%
In methanol at 20℃; for 72h;	86%

: 1493-27-2
ortho-nitrofluorobenzene

: 104-78-9
diethylaminopropylamine

: N-(3-diethylaminopropyl)-phenyl-1,2-diamine trihydrochloride

Conditions

Conditions	Yield
Stage #1: ortho-nitrofluorobenzene; diethylaminopropylamine Stage #2: With hydrogenchloride In isopropyl alcohol	96%

: 78676-35-4
benzo[b]thiophene-3-carbonyl azide

: 104-78-9
diethylaminopropylamine

: 1-Benzo[b]thiophen-3-yl-3-(3-diethylamino-propyl)-urea; hydrochloride

Conditions

Conditions	Yield
In benzene Heating;	95%

: 95072-47-2
1-(chloro(piperidin-1-yl)methylene)piperidin-1-ium chloride

: 104-78-9
diethylaminopropylamine

: N1-(dipiperidin-1-ylmethylene)-N3,N3-diethylpropan-1,3-diamine

Conditions

Conditions	Yield
With triethylamine In acetonitrile Inert atmosphere; Reflux;	95%

: 56043-45-9, 13829-06-6
N,N,N',N'-tetramethylchlorformamidinium chloride

: 104-78-9
diethylaminopropylamine

: 2-[3-(diethylamino)propyl]-1,1,3,3-tetramethylguanidine

Conditions

Conditions	Yield
With triethylamine In acetonitrile Inert atmosphere; Reflux;	95%
With triethylamine In acetonitrile at 0 - 80℃; for 5h; Inert atmosphere; Schlenk technique;

: 104-78-9
diethylaminopropylamine

: 104554-43-0
4-(3,3,4,4,5,5,5-heptafluoro-2,2-bis(trifluoromethyl)pentyl)benzoic acid

: N-(3-(diethylamino)propyl)-4-(3,3,4,4,5,5,5-heptafluoro-2,2-bis(trifluoromethyl)pentyl)benzamide

Conditions

Conditions	Yield
Stage #1: 4-(3,3,4,4,5,5,5-heptafluoro-2,2-bis(trifluoromethyl)pentyl)benzoic acid With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 0.166667h; Cooling; Stage #2: diethylaminopropylamine In dichloromethane at 20℃; for 5h;	95%
Stage #1: 4-(3,3,4,4,5,5,5-heptafluoro-2,2-bis(trifluoromethyl)pentyl)benzoic acid With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.166667h; Stage #2: diethylaminopropylamine In dichloromethane at 20℃; for 5h;	91%

: 10328-92-4
N-Methylisatoic anhydride

: 104-78-9
diethylaminopropylamine

: 158091-48-6
N-Methyl-N'-(3-diethylaminopropyl)anthranilic amide

Conditions

Conditions	Yield
In 1,4-dioxane at 70℃; for 8h;	94%

: 104-78-9
diethylaminopropylamine

: 220822-21-9
3-(2,6-dichlorophenyl)-7-fluoro-1-methyl-1,6-naphthyridin-2(1H)-one

: 3-(2,6-dichlorophenyl)-7-[3-(diethylamino)propylamino]-1-methyl-1H-[1,6]naphthyridin-2-one

Conditions

Conditions	Yield
In various solvent(s) for 17h; Amination; Heating;	94%

: 24066-82-8
ethyl 2-isothiocyanatoacetate

: 104-78-9
diethylaminopropylamine

: 3-(3-Diethylamino-propyl)-2-thioxo-imidazolidin-4-one

Conditions

Conditions	Yield
In Petroleum ether for 4h;	94%

: C16H6BrClN2O3

: 104-78-9
diethylaminopropylamine

: 1335015-53-6
N-(3-(diethylamino)propyl)-9-bromo-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxamide

Conditions

Conditions	Yield
With dmap In chloroform for 5h; Reflux;	94%

: 70976-93-1
N,N,N′,N′-tetraethylchloroformamidinium chloride

: 104-78-9
diethylaminopropylamine

: 2-[3-(diethylamino)propyl]-1,1,3,3-tetraethylguanidine

Conditions

Conditions	Yield
With triethylamine In acetonitrile Inert atmosphere; Reflux;	94%
With triethylamine In acetonitrile at 0 - 80℃; for 5h; Inert atmosphere; Schlenk technique;

: 642491-85-8
6,7-difluoro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one

: 104-78-9
diethylaminopropylamine

: 6-((3-(diethylamino)propyl)amino)-7-fluoro-2,3-dihydropyrrolo-[2,1-b]quinazolin-9(1H)-one

Conditions

Conditions	Yield
at 100℃; for 12h; Sealed tube;	94%
at 100℃; for 12h; Sealed tube;	74%
With sodium carbonate In N,N-dimethyl-formamide at 140℃; for 2h; regioselective reaction;	71%

: 446-33-3
3-fluoro-6-nitrotoluene

: 104-78-9
diethylaminopropylamine

: 329943-33-1
N1,N1-diethyl-N3-(3-methyl-4-nitrophenyl)-1,3-propanediamine

Conditions

Conditions	Yield
With pyridine; sodium hydrogencarbonate for 3h; Heating;	93%

3-Diethylaminopropylamine Chemical Properties

Product Name:3-Diethylaminopropylamine
The MF of 3-Diethylaminopropylamine(104-78-9) is C₇H₁₈N₂.

The MW of 3-Diethylaminopropylamine(104-78-9) is 130.23.
Synonyms:1-(Diethylamino)propylamine-3;1,3-Propanediamine,N,N-diethyl-;3-(N,N-Diethylamino)-1-propylamine;N-(3-Diethylaminopropyl)amine;3-Propanediamine,N,N-diethyl-1;Diethylaminotrimethylenamine;N,N-(Diethylamino)propylamine
EINECS: 203-236-4
Mol File: 104-78-9.mol
Surface Tension: 30.8 dyne/cm
Density: 0.84 g/ml
Flash Point: 58.9 °C
Enthalpy of Vaporization: 40.71 kJ/mol
Boiling Point: 170.7 °C at 760 mmHg
Vapour Pressure: 1.45 mmHg at 25°C
Water Solubility: MISCIBLE
Sensitive: Air Sensitive
BRN: 741879
CAS DataBase Reference: 104-78-9(CAS DataBase Reference)
NIST Chemistry Reference: 104-78-9(NIST)
EPA Substance Registry System: 104-78-9(EPA Substance)

3-Diethylaminopropylamine Uses

The 3-Diethylaminopropylamine(104-78-9) is used as a solvent, extraction agents and organic synthesis intermediates, dyes, pigments, surface active agent.

3-Diethylaminopropylamine Toxicity Data With Reference

1.	skn-rbt 100 µg/24H open	AIHAAP American Industrial Hygiene Association Journal. 23 (1962),95.
2.	orl-rat LD50:1410 mg/kg	UCDS** Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 2/27 ,1967.
3.	skn-rbt LD50:750 mg/kg	AIHAAP American Industrial Hygiene Association Journal. 23 (1962),95.

3-Diethylaminopropylamine Consensus Reports

Reported in EPA TSCA Inventory.

3-Diethylaminopropylamine Safety Profile

Moderately toxic by ingestion and skin contact. Corrosive to the eyes, skin, and mucous membranes. A sensitizer. See also AMINES. Flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO₂, dry chemical. When heated to decomposition it emits toxic fumes of NO_x.
Safety information of 3-Diethylaminopropylamine(104-78-9):
Hazard Codes:

Xi
Risk Statements: 10-21/22-34-43
R10:Flammable ;
R21/22:Harmful in contact with skin and if swallowed ;
R34:Causes burns ;
R43:May cause sensitization by skin contact ;
Safety Statements: 26-36/37/39-45
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice ;
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection ;
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) ;
RIDADR: UN 2684 3/PG 3
WGK Germany: 1
RTECS: TX7350000
HazardClass: 3
PackingGroup: III
HS Code: 29212900

3-Diethylaminopropylamine Standards and Recommendations

DOT Classification: 8; Label: Corrosive, Flammable Liquid

3-Diethylaminopropylamine Specification

The 3-Diethylaminopropylamine(104-78-9) is stable but imcompatible with strong oxidizing agents, acids, acid chlorides, carbon dioxide, nitrites, acid anhydrides, nitric oxide.Hazardous decomposition products are nitrogen oxides, carbon monoxide, carbon dioxide, nitrosamines.

Product Name

3-Diethylaminopropylamine

Synthetic route

3-Diethylaminopropylamine Chemical Properties

3-Diethylaminopropylamine Uses

3-Diethylaminopropylamine Toxicity Data With Reference

3-Diethylaminopropylamine Consensus Reports

3-Diethylaminopropylamine Safety Profile

3-Diethylaminopropylamine Standards and Recommendations

3-Diethylaminopropylamine Specification

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