3-Fluoro-4-methoxyaniline

The 3-Fluoro-4-methoxyaniline, with the CAS registry number 366-99-4, is a kind of light beige to yellow-brown crystalline powder, and belongs to the following product categories: Other fluorin-contained compounds; Anilines, Aromatic Amines and Nitro Compounds; Aniline; Miscellaneous; Anilines, Amides & Amines; Anisoles, Alkyloxy Compounds & Phenylacetates; Fluorine Compounds. And the molecular formula of this chemical is C₇H₈FNO.

The physical properties of 3-Fluoro-4-methoxyaniline are as following: (1)ACD/LogP: 1.14; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.12; (4)ACD/LogD (pH 7.4): 1.14; (5)ACD/BCF (pH 5.5): 4.16; (6)ACD/BCF (pH 7.4): 4.36; (7)ACD/KOC (pH 5.5): 95.3; (8)ACD/KOC (pH 7.4): 99.82; (9)#H bond acceptors: 2; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 12.47 Å²; (13)Index of Refraction: 1.531; (14)Molar Refractivity: 37.16 cm³; (15)Molar Volume: 119.9 cm³; (16)Polarizability: 14.73 ×10^-24cm³; (17)Surface Tension: 37.5 dyne/cm; (18)Density: 1.176 g/cm³; (19)Flash Point: 101.2 °C; (20)Enthalpy of Vaporization: 49.07 kJ/mol; (21)Boiling Point: 253.4 °C at 760 mmHg; (22)Vapour Pressure: 0.0184 mmHg at 25°C.

Preparation of 3-Fluoro-4-methoxyaniline: This chemical can be prepared by 2-fluoro-4-nitro-anisole. The reaction will need reagent tin(II) chloride. 

Uses of 3-Fluoro-4-methoxyaniline: It can react with trifluoroacetic acid anhydride to produce N-trifluoroacetyl-3-fluoro-4-methoxyaniline. This reaction will need solvent CH₂Cl₂. The reaction time is 45 minutes with heating, and the yield is about 94%. 

You should be cautious while dealing with this chemical. It irritates eyes, respiratory system and skin, and it is also harmful by inhalation, in contact with skin and if swallowed. What's more, it is toxic by inhalation, in contact with skin and if swallowed. Therefore, you had better take the following instructions: Wear suitable protective clothing, gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice; In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible); After contact with skin, wash immediately with plenty of soap-suds. 

You can still convert the following datas into molecular structure:
(1)SMILES: Fc1cc(ccc1OC)N
(2)InChI: InChI=1/C7H8FNO/c1-10-7-3-2-5(9)4-6(7)8/h2-4H,9H2,1H3
(3)InChIKey: LJWAPDSCYTZUJU-UHFFFAOYAI