3-methylquinoline
8-(chlorosulphonyl)-3-methylquinoline
Conditions | Yield |
---|---|
With chlorosulfonic acid; thionyl chloride In water | 1.58 g (18%) |
3-methyl-8-quinolinesulfonic acid
8-(chlorosulphonyl)-3-methylquinoline
Conditions | Yield |
---|---|
With bis(trichloromethyl) carbonate; triethylamine In toluene at 25 - 40℃; for 3h; Reagent/catalyst; Temperature; | 178 g |
8-(chlorosulphonyl)-3-methylquinoline
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; water at 0 - 20℃; for 16h; | 98% |
Conditions | Yield |
---|---|
With sodium carbonate; potassium hydroxide In methanol; water at 0 - 20℃; Concentration; Reagent/catalyst; Solvent; | 96.12% |
8-(chlorosulphonyl)-3-methylquinoline
Conditions | Yield |
---|---|
With potassium carbonate; potassium hydroxide In ethanol; water at 0 - 20℃; Concentration; Reagent/catalyst; Solvent; | 96.09% |
8-(chlorosulphonyl)-3-methylquinoline
(3S,6S,9aS)-6-(3-Methyl-quinoline-8-sulfonylamino)-5-oxo-octahydro-pyrrolo[1,2-a]azepine-3-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With triethylamine In dichloromethane | 89% |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0℃; | 86% |
8-(chlorosulphonyl)-3-methylquinoline
(2R,4R)-1-((S)-2-Amino-5-benzyloxycarbonylamino-pentanoyl)-4-methyl-piperidine-2-carboxylic acid ethyl ester
(2R,4R)-1-[(S)-5-Benzyloxycarbonylamino-2-(3-methyl-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 2.75h; Acylation; | 75% |
L-arginine
8-(chlorosulphonyl)-3-methylquinoline
5-guanidino-2(S)-[1-(3-methylquinolyl)sulfonylamino]pentanoic acid
Conditions | Yield |
---|---|
With potassium carbonate In 1,4-dioxane; water at 20℃; for 2h; sulfonylation; | 60% |
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 20℃; | 10.21% |
4-methoxy-3-amino-1,2-benzisoxazole
8-(chlorosulphonyl)-3-methylquinoline
Conditions | Yield |
---|---|
Stage #1: 4-methoxy-3-amino-1,2-benzisoxazole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.166667h; Stage #2: 8-(chlorosulphonyl)-3-methylquinoline In N,N-dimethyl-formamide; mineral oil for 16h; | 8% |
8-(chlorosulphonyl)-3-methylquinoline
(2R,4R)-1-[(S)-5-Benzyloxycarbonylamino-4,4-difluoro-2-(3-methyl-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0℃; for 2h; Acylation; |
8-(chlorosulphonyl)-3-methylquinoline
(S)-4-Hydroxy-2-(3-methyl-quinoline-8-sulfonylamino)-butyric acid benzhydryl ester
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water; ethyl acetate at 20℃; Acylation; |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation; |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation; |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation; |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation; |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation; |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation; |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation; |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation; |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation; |
8-(chlorosulphonyl)-3-methylquinoline
3-methylquinoline-8-sulfonic acid {4-(3-nitroguanidino)-1(S)-[4-(2-acetoxyethyl)piperidin-1-ylcarbonyl]butyl}amide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation; |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation; |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation; |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation; |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation; |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation; |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation; |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation; |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation; |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation; |
Molecular structure of 3-Methyl-8-quinolinesulphonyl chloride (CAS NO.74863-82-4) is:
Product Name: 3-Methyl-8-quinolinesulphonyl chloride
CAS Registry Number: 74863-82-4
Systematic Name: 3-methylquinoline-8-sulfonyl chloride
Molecular Formula: C10H8ClNO2S
Molecular Weight: 241.69
Melting Point: 158-159°C
Surface Tension: 54.4 dyne/cm
Density: 1.424 g/cm3
Flash Point: 178.5 °C
Enthalpy of Vaporization: 59.42 kJ/mol
Boiling Point: 371.5 °C at 760 mmHg
Vapour Pressure: 2.19E-05 mmHg at 25°C
Product Categories: Sulfonylhalide;Aromatics Compounds;Aromatics;Sulfonyl Chlorides;Sulfur & Selenium Compounds
3-Methyl-8-quinolinesulphonyl chloride , its cas register number is 74863-82-4. It also can be called 8-Chlorosulfonyl-3-Methylquinoline ; 3-Methyl Quinoline-8-Sulphonyl Chloride ; 8-Quinolinesulfonylchloride,3-methyl-(9CI) .It is a off-white to pale brown solid.
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