Product Name

  • Name

    1-(P-HYDROXYPHENYL)ETHYLAMINE

  • EINECS
  • CAS No. 134855-87-1
  • Article Data8
  • CAS DataBase
  • Density 1.096
  • Solubility Slightly soluble in water.
  • Melting Point
  • Formula C8H11 N O
  • Boiling Point 252℃
  • Molecular Weight 137.181
  • Flash Point 106℃
  • Transport Information
  • Appearance
  • Safety A severe eye irritant. When heated to decomposition it emits toxic vapors of NOx.
  • Risk Codes 36
  • Molecular Structure Molecular Structure of 134855-87-1 (1-(P-HYDROXYPHENYL)ETHYLAMINE)
  • Hazard Symbols A severe eye irritant.
  • Synonyms 1-(4-Hydroxyphenyl)ethylamine;4-(1-Aminoethyl)phenol
  • PSA 46.25000
  • LogP 2.11220

4-(1-AMINOETHYL)PHENOL Chemical Properties

4-(1-AMINOETHYL)PHENOL(134855-87-1) has the Molecular Formula of C8H11NO , the Molecular Weight of 137.20 .The Hazard Symbol of 4-(1-AMINOETHYL)PHENOL(134855-87-1) is a severe eye irritant.
The structure:

4-(1-AMINOETHYL)PHENOL Production

There is synthetic route of 4-(1-AMINOETHYL)PHENOL(134855-87-1).
 In the presence of DCC and pyridine,the protected (R)-ornithine (I) was converted to the active ester (III) upon coupling with 2-nitrophenol (II). And then the subsequent reaction is that the nitrophenyl ester (III) with (R)-4-hydroxy-alpha-methylbenzylamine (IV) produced the corresponding amide (V).
The resulting amine (VI) was acylated with diphenylacetyl chloride (VII) to give (VIII),after acid cleavage of the Boc protecting group of (V). Removal of the N-benzyloxycarbonyl group of (VIII) was achieved by catalytic hydrogenation over Pd/C. 
With reaction of N,N'-bis(benzyloxycarbonyl)-S-methylisothiourea (X),the resultant amine (IX) was then converted to the protected guanidine (XI).
At last,the protecting groups of (X) were removed by hydrogenation over Pd/C.

4-(1-AMINOETHYL)PHENOL Toxicity Data With Reference

1.   

eye-rbt 100 mg SEV

   NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0539162 .

4-(1-AMINOETHYL)PHENOL Safety Profile

A severe eye irritant. When heated to decomposition 4-(1-AMINOETHYL)PHENOL(134855-87-1) emits toxic vapors of NOx.

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