4'-Methoxy-2'-nitroacetanilide supplier

Name
4-METHOXY-2-NITROACETANILIDE
EINECS 204-353-3
CAS No. 119-81-3
Article Data40
CAS DataBase
Density 1.327g/cm³
Solubility
Melting Point 117-118°C
Formula C9H10 N2 O4
Boiling Point 433.8°Cat760mmHg
Molecular Weight 210.189
Flash Point 216.1°C
Transport Information
Appearance
Safety Poison by intravenous route. When heated to decomposition it emits toxic vapors of NO_x.
Risk Codes 22
Molecular Structure
Hazard Symbols
Synonyms p-Acetanisidide,2'-nitro- (6CI,7CI,8CI); 2'-Nitro-4'-methoxyacetanilide;2'-Nitro-p-acetanisidide; 4-Acetamido-1-methoxy-3-nitrobenzene;4-Acetylamino-1-methoxy-3-nitrobenzene; 4-Methoxy-2-nitroacetanilide; NSC 5516
PSA 84.15000
LogP 2.15800

Synthetic route

: 51-66-1
4-methoxyacetanilide

A: 119-81-3
4-methoxy-2-nitroacetanilide

B: 106-51-4
p-benzoquinone

Conditions

Conditions	Yield
With nitric acid; silica gel In dichloromethane for 0.166667h; Product distribution; Ambient temperature;	A 97% B 2%

: 51-66-1
4-methoxyacetanilide

: 119-81-3
4-methoxy-2-nitroacetanilide

Conditions

Conditions	Yield
With 3-(ethoxycarbonyl)-1-(5-methyl-5-(nitrosooxy)hexyl)pyridin-1-ium bis(trifluoromethanesulfonyl)imide at 20℃; for 6h; Ionic liquid;	94%
With sulfuric acid; nitric acid at 0 - 5℃;	91%
With nitric acid In dichloromethane at 20℃; for 2h; Heating / reflux;	90%

: 108-24-7
acetic anhydride

: 104-94-9
4-methoxy-aniline

: 119-81-3
4-methoxy-2-nitroacetanilide

Conditions

Conditions	Yield
With bismuth (III) nitrate pentahydrate In dichloromethane at 23℃; regioselective reaction;	86%
Stage #1: acetic anhydride; 4-methoxy-aniline With acetic acid In water at 0 - 5℃; Stage #2: With sulfuric acid In water at 60 - 65℃; for 0.166667h; Cooling with ice;

: 108-24-7
acetic anhydride

: 96-96-8
4-methoxy-2-nitroaniline

: 119-81-3
4-methoxy-2-nitroacetanilide

Conditions

Conditions	Yield
for 0.00277778h; Green chemistry;	78%
With sulfuric acid Heating;

: 4-acetylaminomethoxybenzene

: 119-81-3
4-methoxy-2-nitroacetanilide

Conditions

Conditions	Yield
With nitric acid; acetic anhydride; acetic acid In water	75%

: 67-56-1
methanol

: 103-84-4
Acetanilid

: 119-81-3
4-methoxy-2-nitroacetanilide

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate; nitric acid; bis-[(trifluoroacetoxy)iodo]benzene In water at 40℃; for 0.5h;	53%

: 21260-49-1
N-(4-methoxyphenyl)-N'-methylurea

: 119-81-3
4-methoxy-2-nitroacetanilide

Conditions

Conditions	Yield
With nitric acid In acetic acid for 0.333333h; Ambient temperature;	30%

: 108-24-7
acetic anhydride

: 104-94-9
4-methoxy-aniline

: 64-19-7
acetic acid

: 119-81-3
4-methoxy-2-nitroacetanilide

Conditions

Conditions	Yield
at 20℃; anschliessendes Behandeln mit Salpetersaeure in Essigsaeure unterhalb 15grad;

...Expand

: 14839-81-7
4-methoxy-N-nitrosoacetanilide

: 119-81-3
4-methoxy-2-nitroacetanilide

Conditions

Conditions	Yield
In tetrachloromethane at 33℃; for 0.733333h;	0.8 % Chromat.

: 7697-37-2
nitric acid

: 51-66-1
4-methoxyacetanilide

: 119-81-3
4-methoxy-2-nitroacetanilide

: 7697-37-2
nitric acid

: 51-66-1
4-methoxyacetanilide

: 64-19-7
acetic acid

: 119-81-3
4-methoxy-2-nitroacetanilide

...Expand

: 104-94-9
4-methoxy-aniline

: 119-81-3
4-methoxy-2-nitroacetanilide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 85 percent / acetic acid / 2 h / 110 °C 2: 91 percent / nitric acid; sulfuric acid / 0 - 5 °C View Scheme
Multi-step reaction with 2 steps 1: acetic acid 2: nitric acid; acetic acid View Scheme
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane 2: nitric acid; acetic anhydride / dichloromethane View Scheme

: 104-94-9
4-methoxy-aniline

p-azoanisole: p-azoanisole

: 119-81-3
4-methoxy-2-nitroacetanilide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetic acid / 0.25 h / Heating 2: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min View Scheme

: 119-81-3
4-methoxy-2-nitroacetanilide

: 96-96-8
4-methoxy-2-nitroaniline

Conditions

Conditions	Yield
With potassium hydroxide; sodium hydroxide In water for 0.5h; Heating;	99%
With hydrogenchloride; water In ethanol for 6h; Reflux; Inert atmosphere;	98%
With hydrogenchloride In water for 18h; Reflux;	97.9%

: 119-81-3
4-methoxy-2-nitroacetanilide

: 2-nitro-4-methoxybenzene diazonium tetrafluoroborate

Conditions

Conditions	Yield
Stage #1: 4-methoxy-2-nitroacetanilide With boron trifluoride - methanol (1/1) In methanol at 60℃; Inert atmosphere; Reflux; Stage #2: With tert.-butylnitrite In methanol at -15℃; Inert atmosphere;	92%

: 119-81-3
4-methoxy-2-nitroacetanilide

: 5472-37-7
2'-amino-p-acetanisidide

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol	91%
With hydrogen; palladium on activated charcoal In ethanol under 2585.7 Torr; for 2.5h;	80%
With ethanol; platinum Hydrogenation;

: 119-81-3
4-methoxy-2-nitroacetanilide

: 4887-81-4
6-methoxy-2-methyl-1H-benzo[d]imidazole

Conditions

Conditions	Yield
With iron; acetic acid at 60℃; for 0.5h;	84%

: 67-56-1
methanol

: 119-81-3
4-methoxy-2-nitroacetanilide

: 96-96-8
4-methoxy-2-nitroaniline

Conditions

Conditions	Yield
With potassium hydroxide

: 119-81-3
4-methoxy-2-nitroacetanilide

: 1568-70-3
4-methoxy-2-nitrophenol

Conditions

Conditions	Yield
With sodium hydroxide

: 119-81-3
4-methoxy-2-nitroacetanilide

: 4280-28-8
3,4-dinitroanisole

Conditions

Conditions	Yield
With dihydrogen peroxide; acetic acid

: 119-81-3
4-methoxy-2-nitroacetanilide

: 65183-00-8
N-(4-methoxy-2-nitro-phenyl)-thioacetamide

Conditions

Conditions	Yield
With potassium sulphide; phosphorous (V) sulfide; benzene

: 119-81-3
4-methoxy-2-nitroacetanilide

: 85020-96-8
acetic acid-(4-methoxy-N-methyl-2-nitro-anilide)

Conditions

Conditions	Yield
With sodium; benzene anschliessendes Behandeln mit Dimethylsulfat;

: 119-81-3
4-methoxy-2-nitroacetanilide

: 62153-30-4
acetic acid-(4-methoxy-2,3-dinitro-anilide)

Conditions

Conditions	Yield
With nitric acid
With nitric acid; acetic acid

: 119-81-3
4-methoxy-2-nitroacetanilide

: 64-19-7
acetic acid

: 5472-37-7
2'-amino-p-acetanisidide

Conditions

Conditions	Yield
With iron

: 119-81-3
4-methoxy-2-nitroacetanilide

: 100-35-6
2-(diethylamino)ethyl chloride

: acetic acid-[N-(2-diethylamino-ethyl)-4-methoxy-2-nitro-anilide]

Conditions

Conditions	Yield
With sodium amide; toluene

: 119-81-3
4-methoxy-2-nitroacetanilide

: 56-81-5
glycerol

: 85-81-4
6-methoxy-8-nitroquinoline

Conditions

Conditions	Yield
With sulfuric acid; orthoarsenic acid at 140℃;

: 119-81-3
4-methoxy-2-nitroacetanilide

: 51-79-6
urethane

: 4413-48-3
5-methoxy-benzo[1,2,5]oxadiazole

Conditions

Conditions	Yield
With phosphorus pentoxide; xylene

: 119-81-3
4-methoxy-2-nitroacetanilide

: 71-43-2
benzene

: 16098-16-1
4-methoxy-2-nitro-1,1'-biphenyl

Conditions

Conditions	Yield
(i) NO, NaOAc, (ii) /BRN= 969212/; Multistep reaction;
(i) N2O4, NaOAc, AcOH, Ac2O, (ii) /BRN= 969212/; Multistep reaction;

: 119-81-3
4-methoxy-2-nitroacetanilide

: 79938-45-7
4-methoxy-N1-ethylbenzene-1,2-diamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran for 1h;	472 mg

: 119-81-3
4-methoxy-2-nitroacetanilide

: 74-88-4
methyl iodide

: 85020-96-8
acetic acid-(4-methoxy-N-methyl-2-nitro-anilide)

Conditions

Conditions	Yield
With potassium hydroxide In acetone for 0.5h; Heating; Yield given;
In N-methyl-acetamide; ethyl acetate

: 119-81-3
4-methoxy-2-nitroacetanilide

: 10172-35-7
2-bromo-4-methoxy-6-nitrobenzenamine

Conditions

Conditions	Yield
(i) aq. KOH, MeOH, (ii) Br2, AcOH; Multistep reaction;

: 119-81-3
4-methoxy-2-nitroacetanilide

: 6161-61-1
2,3,4,5-tetrabromoanisole

Conditions

Conditions	Yield
With pyridine; bromine; acetic acid

: 119-81-3
4-methoxy-2-nitroacetanilide

: acetic acid-(4-methoxy-2,6-dinitro-anilide)

Conditions

Conditions	Yield
With sulfuric acid; nitric acid 1.) 0 deg C, 10 min, 2.) RT, 30 min;

4'-Methoxy-2'-nitroacetanilide Chemical Properties

Chemistry informtion about 2-Nitro-P-Acetanisidide (CAS NO.119-81-3) is:
IUPAC Name: N-(4-Methoxy-2-Nitrophenyl)Acetamide
Synonyms: 2-Nitro-P-Acetanisidid ; N-(4-Methoxy-2-Nitrophenyl)-Acetamid ; P-Acetaniside, 2'-Nitro- ; P-Acetanisidide, 2'-Nitro- ; P-Acetanisidide, 2-Nitro- ; N-Acetyl-4-Methoxy-2-Nitroaniline ; N-Acetyl-2-Nitro-P-Anisidine ; N-(4-Methoxy-2-Nitrophenyl)Acetamide
Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
MF: C₉H₁₀N₂O₄
MW: 210.19
EINECS: 204-353-3
Density: 1.327 g/cm³
Melting Point: 117-118°C
Flash Point: 216.1 °C
Boiling Point: 433.8 °C at 760 mmHg
Vapour Pressure: 9.99E-08 mmHg at 25°C
Enthalpy of Vaporization: 68.98 kJ/mol
BRN: 2809678
Following is the molecular structure of 2-Nitro-P-Acetanisidide (CAS NO.119-81-3) is:

4'-Methoxy-2'-nitroacetanilide Production

Raw materials is Sodium bisulfite-->N-(4-Methoxyphenyl)acetamide

4'-Methoxy-2'-nitroacetanilide Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravenous	180mg/kg (180mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00426,

4'-Methoxy-2'-nitroacetanilide Consensus Reports

Reported in EPA TSCA Inventory.

4'-Methoxy-2'-nitroacetanilide Safety Profile

Poison by intravenous route. When heated to decomposition it emits toxic vapors of NO_x.
Risk Statements:
R22:Harmful if swallowed.
Safety Statements:
S22:Do not breathe dust.
S36/37:Wear suitable protective clothing and gloves.
RIDADR: 2811
RTECS: AE8310000
HazardClass: 6.1
PackingGroup: III

Product Name

4-METHOXY-2-NITROACETANILIDE

Synthetic route

4'-Methoxy-2'-nitroacetanilide Chemical Properties

4'-Methoxy-2'-nitroacetanilide Production

4'-Methoxy-2'-nitroacetanilide Toxicity Data With Reference

4'-Methoxy-2'-nitroacetanilide Consensus Reports

4'-Methoxy-2'-nitroacetanilide Safety Profile

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