• Name

  4-(trans-4-Propylcyclohexyl)benzoic acid

• EINECS
• CAS No. 65355-29-5
• Article Data5
• CAS DataBase
• Density 1.038 g/cm³
• Solubility
• Melting Point 206°C(lit.)
• Formula C₁₆H₂₂O₂
• Boiling Point 383.7 °C at 760 mmHg
• Molecular Weight 246.349
• Flash Point 181.9 °C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Benzoicacid, 4-(4-propylcyclohexyl)-, trans-;
• PSA 37.30000
• LogP 4.45870

Synthetic route

61203-99-4

trans-4-propyl-(4'-cyanophenyl)cyclohexane

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

Conditions

Conditions	Yield
With sulfuric acid; water for 5h; Heating;

78531-61-0

1-[4-(4-Propyl-cyclohexyl)-phenyl]-ethanone

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

Conditions

Conditions	Yield
With sodium hydroxide; bromine In 1,4-dioxane at 35 - 40℃; for 3h; Yield given;
With bromine In 1,4-dioxane for 5h;

1655-03-4

1-cyclohex-1-enyl-propan-1-one

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: AlCl3 / 45 °C 2: hydrazine hydrate / bis-(2-hydroxy-ethyl) ether / or in 1:1 mixture of triethanolamine and glycerol 3: AlCl3 / 1,2-dichloro-ethane / 0.5 h 4: aq. NaOH, Br2 / dioxane / 3 h / 35 - 40 °C View Scheme
Multi-step reaction with 6 steps 1: AlCl3 / 45 °C 2: NaBH4 / propan-1-ol / 4 h / 30 - 35 °C 3: p-toluenesulfonic acid / toluene / Heating 4: H2 / 10percent Pd/C / ethanol 5: AlCl3 / 1,2-dichloro-ethane / 0.5 h 6: aq. NaOH, Br2 / dioxane / 3 h / 35 - 40 °C View Scheme

40649-36-3

4-propyl-cyclohexanone

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 2.) 10percent aq. HCl / 1.) diethyl ether, 1 h, heating 2: p-toluenesulfonic acid / toluene / Heating 3: H2 / 10percent Pd/C / ethanol 4: AlCl3 / 1,2-dichloro-ethane / 0.5 h 5: aq. NaOH, Br2 / dioxane / 3 h / 35 - 40 °C View Scheme

phenylmagnesium bromide

monomethyl ether of phenyloxanthranol

monomethyl ether of phenyloxanthranol

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 2.) 10percent aq. HCl / 1.) diethyl ether, 1 h, heating 2: p-toluenesulfonic acid / toluene / Heating 3: H2 / 10percent Pd/C / ethanol 4: AlCl3 / 1,2-dichloro-ethane / 0.5 h 5: aq. NaOH, Br2 / dioxane / 3 h / 35 - 40 °C View Scheme

88069-91-4

1-propionyl-2-chlorocyclohexane

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: AlCl3 / 45 °C 2: hydrazine hydrate / bis-(2-hydroxy-ethyl) ether / or in 1:1 mixture of triethanolamine and glycerol 3: AlCl3 / 1,2-dichloro-ethane / 0.5 h 4: aq. NaOH, Br2 / dioxane / 3 h / 35 - 40 °C View Scheme
Multi-step reaction with 6 steps 1: AlCl3 / 45 °C 2: NaBH4 / propan-1-ol / 4 h / 30 - 35 °C 3: p-toluenesulfonic acid / toluene / Heating 4: H2 / 10percent Pd/C / ethanol 5: AlCl3 / 1,2-dichloro-ethane / 0.5 h 6: aq. NaOH, Br2 / dioxane / 3 h / 35 - 40 °C View Scheme

81936-33-6

trans-1-(4-hydroxyphenyl)-4-propyl-cyclohexane

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: triethylamine / toluene / 2 h / Reflux 1.2: 10 h / 80 °C 2.1: dichloro bis(acetonitrile) palladium(II); 1,2-bis-(diphenylphosphino)ethane; caesium carbonate / 20 h / 70 °C / 52505.3 Torr / Autoclave 3.1: sodium hydroxide / water / 2 h / 70 °C View Scheme

trans-4-propylcyclohexyl ethyl benzoate

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

Conditions

Conditions	Yield
With sodium hydroxide In water at 70℃; for 2h;	149.46 g

123-08-0

4-hydroxy-benzaldehyde

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

C23H26O3

Conditions

Conditions	Yield
Stage #1: 4-(trans-4'-propylcyclohexyl)-benzoic acid With thionyl chloride Stage #2: 4-hydroxy-benzaldehyde	87%

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

65355-32-0

trans-4-(trans-4'-n-propylcyclohexyl)cyclohexanecarboxylic acid

Conditions

Conditions	Yield
Stage #1: 4-(trans-4'-propylcyclohexyl)-benzoic acid With sodium hydroxide; hydrogen In water at 140 - 150℃; under 22502.3 - 30003 Torr; for 1h; Stage #2: With sodium hydroxide In water at 260 - 280℃; under 22502.3 - 30003 Torr; for 2h; Further stages.;	80%
With pentan-1-ol; sodium Heating;	74%

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

115914-43-7

bis{1,9-(4-hydroxyphenyl)nonane}

nonane-1,9-diylbis(4,1-phenylene) bis(4-(trans 4-propylcyclohexyl)benzoate)

Conditions

Conditions	Yield
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane for 2h;	72%

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

73163-49-2

4-(trans-4-propylcyclohexyl)benzamide

Conditions

Conditions	Yield
With ammonium hydroxide; thionyl chloride 1) DMF, reflux, 2.5 h; 2) DMF, dioxane; Multistep reaction;
Multi-step reaction with 2 steps 1: SOCl2 / 1 h / Heating 2: 25percent aq. NH4OH View Scheme

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

81005-00-7

4-n-propyl-(4-trans-cyclohexyl)benzoyl chloride

Conditions

Conditions	Yield
With thionyl chloride for 1h; Heating;
With thionyl chloride
With thionyl chloride In benzene for 6h; Heating;

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

93205-73-3

[4-(4-Propyl-cyclohexyl)-phenyl]-methanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride
With lithium aluminium tetrahydride In tetrahydrofuran Heating;
With lithium aluminium tetrahydride In tetrahydrofuran Ambient temperature;

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

61203-99-4

trans-4-propyl-(4'-cyanophenyl)cyclohexane

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: SOCl2 / 1 h / Heating 2: 25percent aq. NH4OH 3: 56 percent / SOCl2, dimethylformamide / 1.5 h / Ambient temperature View Scheme
Multi-step reaction with 2 steps 1: 1) SOCl2; 2) 25 percent aq. NH3 / 1) DMF, reflux, 2.5 h; 2) DMF, dioxane 2: SOCl2 / dimethylformamide / 3 h / 80 °C View Scheme

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

81930-17-8

4-(4-Propyl-cyclohexyl)-benzoic acid 4-cyano-phenyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: SOCl2 / 1 h / Heating 2: 63 percent / pyridine / dimethyl ether / overnight View Scheme

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

81945-43-9

trans-4'-propylbi(cyclohexane)-trans-4-carboxylic acid chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: aq. NaOH; H2; RNC-5 / H2O / 1 h / 140 - 150 °C / 22502.3 - 30003 Torr 1.2: 80 percent / aq. NaOH / H2O / 2 h / 260 - 280 °C / 22502.3 - 30003 Torr 2.1: SOCl2 / benzene View Scheme

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

3-methyl-2S-[trans-4-(trans-4-propylcyclohexyl)-cyclohexylcarboxamido]butanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: aq. NaOH; H2; RNC-5 / H2O / 1 h / 140 - 150 °C / 22502.3 - 30003 Torr 1.2: 80 percent / aq. NaOH / H2O / 2 h / 260 - 280 °C / 22502.3 - 30003 Torr 2.1: SOCl2 / benzene 3.1: aq. NaOH / H2O; dioxane View Scheme

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

5--2-(p-cyanophenyl)pyrimidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: SOCl2 / benzene / 6 h / Heating 2: pyridine / 16 h / 70 °C View Scheme

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

65355-35-3

trans,trans-4'-propyl-[1,1'-bicyclohexyl]-4-carbonitrile

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 74 percent / amyl alcohol, sodium / Heating 2: 35 percent View Scheme

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

93205-81-3

1-Chloromethyl-4-(4-propyl-cyclohexyl)-benzene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: LiAlH4 2: SOCl2, pyridine / Ambient temperature View Scheme

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

C24H27F3

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: lithium aluminum hydride / tetrahydrofuran / Ambient temperature 2: 48 percent hydrobromic acid / 10 h / Heating 3: toluene / 6 h / Heating 4: 1.) butyllithium / 1.) hexan/ether, 2 h, room temperature, 2.) hexane/ether, 4 h, room temperature View Scheme

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

C24H29F3

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: lithium aluminum hydride / tetrahydrofuran / Ambient temperature 2: 48 percent hydrobromic acid / 10 h / Heating 3: toluene / 6 h / Heating 4: 1.) butyllithium / 1.) hexan/ether, 2 h, room temperature, 2.) hexane/ether, 4 h, room temperature 5: hydrogen / 10 percent Pd/C / tetrahydrofuran; ethanol / 48 h / 2844.3 Torr View Scheme

65355-29-5

4-(trans-4'-propylcyclohexyl)-benzoic acid

4-cyano-3-fluorophenyl 4-(trans-4-propylcyclohexyl)-benzyl ether

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: LiAlH4 / tetrahydrofuran / Heating 2: 1.) Br2, Ph3P / 1.) MeCN, 0-10 deg C; rt, 1 h; 2.) MeCN, rt, 30 min; 3.) 120 deg C, 15 min 3: K2CO3 / butan-2-one / Heating View Scheme

4-(trans-4-Propylcyclohexyl)benzoic acid Chemical Properties

4-(trans-4-Propylcyclohexyl)benzoic acid Uses

4-(trans-4-Propylcyclohexyl)benzoic acid Specification