Product Name

  • Name

    4-Chloro-3-methylpyridine

  • EINECS -0
  • CAS No. 1681-36-3
  • Article Data17
  • CAS DataBase
  • Density 1.15 g/cm3
  • Solubility
  • Melting Point 165-169 °C(lit.)
  • Formula C6H6ClN
  • Boiling Point 176.208 °C at 760 mmHg
  • Molecular Weight 127.573
  • Flash Point 75.31 °C
  • Transport Information
  • Appearance Light yellow liquid
  • Safety 1681-36-3
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 1681-36-3 (4-Chloro-3-methylpyridine)
  • Hazard Symbols IrritantXi
  • Synonyms 3-Picoline,4-chloro- (6CI,7CI,8CI);3-Methyl-4-chloropyridine;4-Chloro-3-picoline;
  • PSA 12.89000
  • LogP 2.04340

4-Chloro-3-methylpyridine Specification

The 4-Chloro-3-methylpyridine, with the CAS registry number 1681-36-3, is also known as 4-Chloro-3-picoline. It belongs to the product categories of Pyridine; Pyridines; Chiral Chemicals; Pyridine Series. This chemical's molecular formula is C6H6ClN and molecular weight is 127.57. What's more, its IUPAC name is the same with its product name. It should be stored in a cool, dry and well-ventilated place.

Physical properties about 4-Chloro-3-methylpyridine are: (1)ACD/LogP: 1.633; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.63; (4)ACD/LogD (pH 7.4): 1.63; (5)ACD/BCF (pH 5.5): 10.16; (6)ACD/BCF (pH 7.4): 10.25; (7)ACD/KOC (pH 5.5): 182.54; (8)ACD/KOC (pH 7.4): 184.10; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 12.89 Å2; (13)Index of Refraction: 1.527; (14)Molar Refractivity: 34.064 cm3; (15)Molar Volume: 110.883 cm3; (16)Polarizability: 13.504×10-24cm3; (17)Surface Tension: 37.80 dyne/cm; (18)Density: 1.15 g/cm3; (19)Flash Point: 75.31 °C; (20)Enthalpy of Vaporization: 39.559 kJ/mol; (21)Boiling Point: 176.208 °C at 760 mmHg; (22)Vapour Pressure: 1.49 mmHg at 25 °C.

Preparation of 4-Chloro-3-methylpyridine: this chemical can be prepared by 3-methyl-4-nitro-pyridine 1-oxide. This reaction needs reagents HCl, PCl3 and other condition of heating for 20 min. The yield is 97 %.

4-Chloro-3-methylpyridine can be prepared by 3-methyl-4-nitro-pyridine 1-oxide.

Uses of 4-Chloro-3-methylpyridine: it is used to produce other chemicals. For example, it can react with 1-formyl-piperazine to get 4-(3-methyl-pyridin-4-yl)-piperazine-1-carbaldehyde. The reaction occurs with various solvent at temperature of 90 °C. The reaction time is 16 hours. The yield is 46 %.

4-Chloro-3-methylpyridine can react with 1-formyl-piperazine to get 4-(3-methyl-pyridin-4-yl)-piperazine-1-carbaldehyde.

When you are dealing with this chemical, you should be very careful. This chemical is inflammation to the skin, eyes and respiratory system or other mucous membranes. Therefore, you should wear suitable protective clothing and gloves. In case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: Clc1ccncc1C
(2) InChI: InChI=1S/C6H6ClN/c1-5-4-8-3-2-6(5)7/h2-4H,1H3
(3) InChIKey: DZNXMHJMXLSNIR-UHFFFAOYSA-N

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