4-Chloro-3-nitrobenzaldehyde supplier

Name
4-Chloro-3-nitrobenzaldehyde
EINECS 240-645-7
CAS No. 16588-34-4
Article Data28
CAS DataBase
Density 1.485 g/cm³
Solubility 4 g/L (98 ºC)
Melting Point 61-63 °C(lit.)
Formula C₇H₄ClNO₃
Boiling Point 299.8 °C at 760 mmHg
Molecular Weight 185.567
Flash Point 135.1 °C
Transport Information
Appearance Light yellow powder
Safety 26-36/37-36/37/39-22-36
Risk Codes 36/37/38-43
Molecular Structure
Hazard Symbols Xi
Synonyms 2-Chloro-5-formylnitrobenzene;3-Nitro-4-chlorobenzaldehyde;NSC 68097;
PSA 62.89000
LogP 2.58390

Synthetic route

: 55912-20-4
4-chloro-3-nitrobenzyl alcohol

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

Conditions

Conditions	Yield
With 4-methyl-morpholine; chromium(VI) oxide; hydrogenchloride In diethyl ether; chloroform at 65℃; for 0.116667h; microwave irradiation;	98%
With oxygen; sodium carbonate In water for 1.5h; Reflux;	91%
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene; oxygen; potassium nitrite at 80℃; for 15h;	60 % Spectr.
With galactose oxidase M3-5 from Fusarium; dihydrogen peroxide; copper(II) sulfate; catalase; horseradish peroxidase In aq. phosphate buffer; dimethyl sulfoxide at 20℃; under 2068.65 Torr; pH=7.4; Flow reactor; Enzymatic reaction;

: 104-88-1
4-chlorobenzaldehyde

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

Conditions

Conditions	Yield
With sulfuric acid; nitric acid for 2h; Cooling;	97%
With sulfuric acid; nitric acid at 0 - 20℃; for 0.5h; Inert atmosphere;	94%
With magnesium(II) nitrate hexahydrate; AMA at 20℃; for 4h; Neat (no solvent);	87%

: 66399-01-7
2-chloro-5-hydroxyiminomethylnitrobenzene

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

Conditions

Conditions	Yield
With water; 2-nitro-4,5-dichloropyridazin-3(2H)-one In methanol at 130℃; under 10336 Torr; for 0.166667h; Microwave irradiation;	94%

: 662165-72-2
2-(4'-chloro-3'-nitrophenyl)-1,3-oxathiolane

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

Conditions

Conditions	Yield
With Montmorillonite K10 In benzene for 5h; Heating;	76%

: 85152-60-9
4-chloro-3-nitrobenzaldehyde hydrate

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

Conditions

Conditions	Yield
In water at 25℃; Rate constant; base and acid catalysis;

diazotized 3-nitro-4-amino-benzaldehyde: diazotized 3-nitro-4-amino-benzaldehyde

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

Conditions

Conditions	Yield
With hydrogenchloride; copper(l) chloride
With hydrogenchloride; copper chloride

: 54-85-3
isoniazid

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: 99513-84-5
isonicotinic acid N2-(4-chloro-3-nitrobenzylidene)hydrazide

Conditions

Conditions	Yield
In ethanol Reflux;	100%
With ethanol

: 75-61-6
dibromodifluoromethane

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: 102844-90-6
3-nitro-4-(trifluoromethyl)benzaldehyde

Conditions

Conditions	Yield
With ISOPROPYLAMIDE; copper at 100℃; for 8h;	100%
With copper In N,N-dimethyl acetamide at 100℃; for 7h;	60%

: 60-24-2
2-hydroxyethanethiol

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: 662165-72-2
2-(4'-chloro-3'-nitrophenyl)-1,3-oxathiolane

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In diethyl ether for 3h; Heating;	100%

: 106-44-5
p-cresol

: 1634-04-4
tert-butyl methyl ether

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: 6,6-((4-chloro-3-nitrophenyl)methylene)bis(2-(tert-butyl)4-methylphenol)

Conditions

Conditions	Yield
With sulfonated multi-walled carbon nanotubes In neat (no solvent) at 100℃; for 3.5h; Catalytic behavior; regiospecific reaction;	100%

...Expand

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: 19155-93-2
4-azido-3-nitrobenzaldehyde

Conditions

Conditions	Yield
With sodium azide In dimethyl sulfoxide at 75℃; for 1h;	99%
With sodium azide In dimethyl sulfoxide at 75℃; for 1h;	99%
With sodium azide; benzyl tri-n-butylammonium bromide In 1,2-dichloro-ethane at 29℃; for 6h;	96%

: 79296-92-7
triphenyl-(pyridin-3-yl-methyl)-phosphonium chloride

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: 388594-38-5
3-[2-(4-chloro-3-nitrophenyl)vinyl]pyridine

Conditions

Conditions	Yield
Stage #1: triphenyl-(pyridin-3-yl-methyl)-phosphonium chloride With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: 4-chloro-3-nitro-benzaldehyde In N,N-dimethyl-formamide at 0 - 20℃; for 2h;	99%

: 3530-15-2
3,5-dimethyl-4H-1,2,4-triazol-4-amine

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: (N-(4-chloro-3-nitrobenzylidene)-4H-3,5-Dimethyl-1,2,4-triazole-4-amine) hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In acetonitrile for 3h; Reflux;	98%

: 504-17-6
4,6-dihydroxy-2-mercaptopyrimidine

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: 5-(4-chloro-3-nitrophenyl)-2,8-dithioxo-2,3,7,8,9,10-hexahydropyrido[2,3-d:6,5-d′]dipyrimidine-4,6(1H,5H)-dione

Conditions

Conditions	Yield
With copper(II) ferrite; ammonium acetate In water for 0.2h; Sonication; Green chemistry;	98%
With copper(II) ferrite; ammonium acetate In water at 20℃; for 0.416667h; Hantzsch Dihydropyridine Synthesis; Green chemistry;	98%
With copper(II) ferrite; ammonium acetate In water for 0.0166667h; Microwave irradiation;	97%
With 1-methyl-2-oxopyrrolidinium hydrogen sulfate; ammonium acetate In water at 20℃; for 0.166667h; Irradiation; Green chemistry;	95%

: 1076-38-6
4-hydroxy[1]benzopyran-2-one

: 6642-31-5
6-Amino-1,3-dimethylbarbituric acid

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: 6-Amino-5-((4-chloro-3-nitrophenyl)(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione

Conditions

Conditions	Yield
With 2-(3-phenylthioureido)ethylprolinamide In water for 0.333333h; Reflux;	98%

...Expand

: 83-72-7
2-Hydroxy-1,4-naphthoquinone

: 109-77-3
malononitrile

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: 2-amino-4-(4-chloro-3-nitrophenyl)-5,10-dihydro-5,10-dioxo-4H-benzo[g]chromene-3-carbonitrile

Conditions

Conditions	Yield
In neat (no solvent) at 80℃; for 0.133333h; Green chemistry;	98%

...Expand

: 22105-09-5
4‐hydroxycoumarin

: 6642-31-5
6-Amino-1,3-dimethylbarbituric acid

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: R-6-amino-5-((4-chloro-3-nitrophenyl)(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In ethanol at 20℃; for 1.5h; Sonication;	98%

...Expand

: 122-51-0
orthoformic acid triethyl ester

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: 129011-62-7
4-chloro-3-nitrobenzaldehyde diethyl acetal

Conditions

Conditions	Yield
With ammonium chloride In ethanol for 30h; Ambient temperature;	97%

: 107-13-1
acrylonitrile

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: 3-hydroxy-2-methylene-3-(4-chloro-3-nitrophenyl)propanenitrile

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane; choline chloride; glycerol In water at 20℃; for 0.833333h; Morita-Baylis-Hillman Alkylation; Green chemistry;	97%
N-methylcyclohexylamine In 1,4-dioxane; water at 20℃; for 20h; Morita-Baylis-Hillman reaction;	83%
With hexamethylenetetramine; N-butylpyridinium tetrafluoroborate at 20℃; for 8h; Baylis-Hillman reaction;	82%

: 1076-38-6
4-hydroxy[1]benzopyran-2-one

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: 3,3'-((4-chloro-3-nitrophenyl)methylene)bis(2-hydroxy-4H-chromen-4-one)

Conditions

Conditions	Yield
With 2-(3-phenylthioureido)ethylprolinamide In water for 0.25h; Reflux;	97%
With copper chromite nanoparticles In water at 20℃; for 0.0333333h; Green chemistry;	96%
With nanoparticles of the immobilized Ni(II) species on thiourea functionalized copper ferrite (CuFe2O4SiO2PTMSTuNi(II)) In neat (no solvent) at 70℃; for 0.416667h;	95%

: 21204-67-1
methyl (triphenylphosphoranylidene)acetate

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: 877065-30-0
3-(4-chloro-3-nitrophenyl)acrylic acid methyl ester

Conditions

Conditions	Yield
Stage #1: methyl (triphenylphosphoranylidene)acetate; 4-chloro-3-nitro-benzaldehyde In toluene for 1.5h; Wittig Reaction; Heating / reflux; Stage #2: With water In toluene	97%

: 135-19-3
β-naphthol

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: 68828-13-7
14-(4-chloro-3-nitrophenly)-14H-dibenxo[a,j]xanthene

Conditions

Conditions	Yield
With polyethylene glycol-supported sulfonic acid catalyst at 60 - 65℃; for 0.333333h; Neat (no solvent);	97%
With sulfonic acid functionalized diatomite In neat (no solvent) at 90℃; for 0.05h; Catalytic behavior; Green chemistry;	96%
With 1-methyl-2-oxopyrrolidinium hydrogen sulfate In ethanol for 0.0583333h; Microwave irradiation; Green chemistry;	95%

: 1275601-94-9
3-aminoethyl-2-[(p-trifluoromethoxy)anilino]quinazolin-4(3H)-one

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: 1461736-79-7
C24H17ClF3N5O4

Conditions

Conditions	Yield
In ethanol at 75℃; for 1.5h;	97%

: 126-81-8
dimedone

: 109-77-3
malononitrile

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: 303012-46-6
2-amino-4-(4-chloro-3-nitrophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile

Conditions

Conditions	Yield
With 1-carboxymethyl-3-methyl-3H-imidazolium bromide at 110℃; for 0.0166667h;	97%
With Fe3O4 supported on SiO2-imidazole-H3PMo12O40 magnetic nanoparticles In water at 20℃; for 0.0833333h; Temperature; Sonication; Green chemistry;	96%
With magnetic core shell titanium dioxide nanoparticle In neat (no solvent) at 95℃; for 0.0666667h; Knoevenagel Condensation;	96%

...Expand

: 85-44-9
phthalic anhydride

: 105-56-6
ethyl 2-cyanoacetate

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: C20H15ClN4O6

Conditions

Conditions	Yield
With hydrazine hydrate In neat (no solvent) at 80℃; for 0.333333h;	97%

...Expand

: 621-84-1
O-benzyl carbamate

: 135-19-3
β-naphthol

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: C25H19ClN2O5

Conditions

Conditions	Yield
With {Fe3O4(at)SiO2(at)(CH2)3-NHNHC(O)NH-SO3H*HCl} In neat (no solvent) at 70℃; for 0.0833333h; Green chemistry;	97%

...Expand

4-Chloro-3-nitrobenzaldehyde Chemical Properties

IUPAC Name: 4-chloro-3-nitrobenzaldehyde
The MF of 4-Chloro-3-nitrobenzaldehyde(16588-34-4): C₇H₄ClNO₃The MW of 4-Chloro-3-nitrobenzaldehyde(16588-34-4): 185.56
EINECS: 240-645-7
mp: 61-63 °C(lit.)
Water Solubility: 4 g/L (98 °C)
Sensitive: Air Sensitive
Appearance: Light yellow powder.
Categories: Aromatic Aldehydes & Derivatives (substituted);Aldehydes;C7;Carbonyl Compounds
Synonyms: 4-chloro-3-nitro-benzaldehyd;Benzaldehyde, 4-chloro-3-nitro-;TIMTEC-BB SBB007674;ASISCHEM R36965;AKOS BBS-00003244;3-NITRO-4-CHLOROBENZALDEHYDE;4-CHLORO-3-NITROBENZALDEHYDE;4-Chloro-3-Nitrobenzaldehyde 3-Nitro-4-Chlorobenzaldehyde
The Structure of 4-Chloro-3-nitrobenzaldehyde(16588-34-4):

4-Chloro-3-nitrobenzaldehyde Safety Profile

Hazard Codes: Xi
Risk Statements: 36/37/38-43
36/37/38: Irritating to eyes, respiratory system and skin
43: May cause sensitization by skin contact
Safety Statements: 26-36/37-36/37/39-22-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37: Wear suitable protective clothing and gloves
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
22: Do not breathe dust
36: Wear suitable protective clothing
WGK Germany: 3
F: 10: Keep under argon.
Hazard Note: Irritant
HS Code: 29130000

4-Chloro-3-nitrobenzaldehyde Specification

1. First Aid Measures
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
2. Handling and Storage
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Product Name

4-Chloro-3-nitrobenzaldehyde

Synthetic route

4-Chloro-3-nitrobenzaldehyde Chemical Properties

4-Chloro-3-nitrobenzaldehyde Safety Profile

4-Chloro-3-nitrobenzaldehyde Specification

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