Product Name

  • Name

    4-Chlorotestosterone acetate

  • EINECS 212-720-4
  • CAS No. 855-19-6
  • Article Data19
  • CAS DataBase
  • Density 1.19 g/cm3
  • Solubility
  • Melting Point 112-116°C(lit.)
  • Formula C21H29ClO3
  • Boiling Point 457.2 °C at 760 mmHg
  • Molecular Weight 364.912
  • Flash Point 155.7 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes R22; R43
  • Molecular Structure Molecular Structure of 855-19-6 (4-Chlorotestosterone acetate)
  • Hazard Symbols Xn
  • Synonyms Androst-4-en-3-one,4-chloro-17b-hydroxy-, acetate (8CI);Testosterone, 4-chloro-, acetate (6CI);17b-Acetoxy-4-chloroandrost-4-en-3-one;4-Chloro-17b-hydroxyandrost-4-en-3-one17-acetate;4-Chlorotestosterone 17-acetate;Anabolit;Chlorotestosterone acetate;Clostebol acetate;Macrobin;Megagrisevit;NSC 72159;Stearanabol;Sterabol;Steranabol;Test-anabol;Testomed;Turinabol;
  • PSA 43.37000
  • LogP 5.01650

Synthetic route

testosterone acetate
1045-69-8

testosterone acetate

clostebol acetate
855-19-6

clostebol acetate

Conditions
ConditionsYield
Stage #1: testosterone acetate With 3,3-dimethyldioxirane In acetone at 20℃; for 8h; Epoxidation;
Stage #2: With Amberlyst 15; sodium chloride In acetone at 20℃; for 12h; Chlorination;		89%
With pyridine; sulfuryl dichloride for 1h; Product distribution; Ambient temperature; other steroids;
With pyridine; sulfuryl dichloride for 1h; Ambient temperature;
Multi-step reaction with 2 steps
1: N-chloro-succinimide, HN3 / CHCl3; 2-methyl-propan-2-ol
2: SiO2 / benzene
View Scheme
Multi-step reaction with 2 steps
1: N-chloro-succinimide, HN3 / CHCl3; 2-methyl-propan-2-ol
2: SiO2 / benzene
View Scheme
17β-acetoxy-4β,5β-epoxyandrostan-3-one
5012-85-1

17β-acetoxy-4β,5β-epoxyandrostan-3-one

clostebol acetate
855-19-6

clostebol acetate

Conditions
ConditionsYield
With hydrogenchloride; acetic acid
acetic anhydride
108-24-7

acetic anhydride

4-Cloro-3-(2'-cloro-etossi)-Δ3,5-androstadien-17β-olo-acetato

4-Cloro-3-(2'-cloro-etossi)-Δ3,5-androstadien-17β-olo-acetato

clostebol acetate
855-19-6

clostebol acetate

Conditions
ConditionsYield
(i) H2SO4, MeOH, (ii) /BRN= 385737/, Py; Multistep reaction;
4β-Chlor-5β-azido-androstanol-17β-on-3-acetat
18586-71-5

4β-Chlor-5β-azido-androstanol-17β-on-3-acetat

clostebol acetate
855-19-6

clostebol acetate

Conditions
ConditionsYield
With silica gel In benzene
4β-Chlor-5α-azido-androstanol-17β-on-3-acetat

4β-Chlor-5α-azido-androstanol-17β-on-3-acetat

clostebol acetate
855-19-6

clostebol acetate

Conditions
ConditionsYield
With silica gel In benzene
2α,4-Dichlor-testosteron-acetat
857-14-7

2α,4-Dichlor-testosteron-acetat

clostebol acetate
855-19-6

clostebol acetate

Conditions
ConditionsYield
With acetic acid; zinc In methanol
4-Cloro-Δ4-androsten-17β-ol-3-one acetato etilenchetale

4-Cloro-Δ4-androsten-17β-ol-3-one acetato etilenchetale

clostebol acetate
855-19-6

clostebol acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (i) POCl3, DMF, trichloroethene, (ii) NaOAc
2: (i) H2SO4, MeOH, (ii) /BRN= 385737/, Py
View Scheme
17β-acetoxy-2α-chloro-androst-4-en-3-one
855-60-7

17β-acetoxy-2α-chloro-androst-4-en-3-one

clostebol acetate
855-19-6

clostebol acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: SO2Cl2, Py
2: Zn, AcOH / methanol
View Scheme
clostebol acetate
855-19-6

clostebol acetate

acetic anhydride
108-24-7

acetic anhydride

3,17β-diacetoxy-4-chloro-androsta-3,5-diene
112551-54-9

3,17β-diacetoxy-4-chloro-androsta-3,5-diene

Conditions
ConditionsYield
With pyridine hydrochloride
clostebol acetate
855-19-6

clostebol acetate

propionic acid anhydride
123-62-6

propionic acid anhydride

17β-acetoxy-4-chloro-3-propionyloxy-androsta-3,5-diene
114694-63-2

17β-acetoxy-4-chloro-3-propionyloxy-androsta-3,5-diene

Conditions
ConditionsYield
With pyridine hydrochloride
clostebol acetate
855-19-6

clostebol acetate

A

C42H60Cl2O6
131400-48-1

C42H60Cl2O6

B

17β-acetoxy-4-chloro-androst-3-ene
131400-47-0, 131400-52-7

17β-acetoxy-4-chloro-androst-3-ene

Conditions
ConditionsYield
With acetic acid; zinc for 5.5h; Ambient temperature;A 233 mg
B 3.1 g
clostebol acetate
855-19-6

clostebol acetate

17β-acetoxy-4-chloro-androst-3-ene
131400-47-0, 131400-52-7

17β-acetoxy-4-chloro-androst-3-ene

Conditions
ConditionsYield
With acetic acid; zinc In water at 15℃; for 0.25h; ultrasonic irradiation; Yield given;
clostebol acetate
855-19-6

clostebol acetate

A

17β-acetoxy-4-chloroandrosta-4,6-diene-3-one
21589-92-4

17β-acetoxy-4-chloroandrosta-4,6-diene-3-one

B

17β-acetoxy-4-chloroandrosta-1,4-diene-3-one
62799-78-4

17β-acetoxy-4-chloroandrosta-1,4-diene-3-one

Conditions
ConditionsYield
With toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone In benzene for 24h; Heating;A 350 mg
B 500 mg
clostebol acetate
855-19-6

clostebol acetate

A

17β-acetoxy-3α-hydroxy-4-chloroandrost-4-ene
117993-39-2

17β-acetoxy-3α-hydroxy-4-chloroandrost-4-ene

B

17β-acetoxy-3β-hydroxy-4-chloroandrost-4-ene
117993-40-5

17β-acetoxy-3β-hydroxy-4-chloroandrost-4-ene

Conditions
ConditionsYield
With lithium tri-t-butoxyaluminum hydride In tetrahydrofuran for 3h;A 250 mg
B 6.7 g
clostebol acetate
855-19-6

clostebol acetate

A

17β-acetoxy-4β-chloro-4,5-epoxy-5α-androstan-3-one
113324-62-2

17β-acetoxy-4β-chloro-4,5-epoxy-5α-androstan-3-one

B

17β-acetoxy-4α-chloro-4,5-epoxy-5β-androstan-3-one
118100-03-1

17β-acetoxy-4α-chloro-4,5-epoxy-5β-androstan-3-one

Conditions
ConditionsYield
With sodium hydroxide; dihydrogen peroxide In methanol at 5℃; for 18h;A n/a
B 230 mg
clostebol acetate
855-19-6

clostebol acetate

3,4-Dicloro-Δ3,5-androstadien-17β-olo acetato

3,4-Dicloro-Δ3,5-androstadien-17β-olo acetato

Conditions
ConditionsYield
With N,N-dimethyl-formamide; trichlorophosphate
clostebol acetate
855-19-6

clostebol acetate

6-dehydrotestosterone
3591-23-9, 3593-33-7, 4030-88-0, 4223-57-8, 2484-30-2

6-dehydrotestosterone

Conditions
ConditionsYield
With sulfuric acid; dimethyl sulfoxide
Multi-step reaction with 2 steps
1: LiCl / dimethylformamide
2: aq. K2CO3 / methanol
View Scheme
clostebol acetate
855-19-6

clostebol acetate

17β-acetoxy-5α-androstan-3,6-dione
25469-53-8

17β-acetoxy-5α-androstan-3,6-dione

Conditions
ConditionsYield
With sulfuric acid; dimethyl sulfoxide
clostebol acetate
855-19-6

clostebol acetate

androsta-4,6-dien-17β-ol-3-one acetate
2352-19-4

androsta-4,6-dien-17β-ol-3-one acetate

Conditions
ConditionsYield
With sulfuric acid; dimethyl sulfoxide
With lithium chloride In N,N-dimethyl-formamide
clostebol acetate
855-19-6

clostebol acetate

17beta-Acetoxyandrost-4-ene-3,6-dione
4594-27-8, 6726-17-6

17beta-Acetoxyandrost-4-ene-3,6-dione

Conditions
ConditionsYield
With dimethyl sulfoxide at 150℃;
clostebol acetate
855-19-6

clostebol acetate

17β-acetoxy-4-chloroandrosta-1,4-diene-3-one
62799-78-4

17β-acetoxy-4-chloroandrosta-1,4-diene-3-one

Conditions
ConditionsYield
With acetic anhydride; selenious acid In tert-Amyl alcohol
clostebol acetate
855-19-6

clostebol acetate

2α-Brom-4-chlor-testosteronacetat

2α-Brom-4-chlor-testosteronacetat

Conditions
ConditionsYield
(i) (CO2Et)2, NaH, benzene, (ii) NBS, Py; Multistep reaction;
clostebol acetate
855-19-6

clostebol acetate

acetic anhydride
108-24-7

acetic anhydride

2α,4-Dichlor-testosteron-acetat
857-14-7

2α,4-Dichlor-testosteron-acetat

Conditions
ConditionsYield
(i) (CO2Et)2, NaH, benzene, (ii) N-chloro-succinimide, Py, (iii) /BRN= 385737/, Py; Multistep reaction;
clostebol acetate
855-19-6

clostebol acetate

4,17β-dihydroxy-4,6-androstadien-3-one
4721-70-4

4,17β-dihydroxy-4,6-androstadien-3-one

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol
clostebol acetate
855-19-6

clostebol acetate

17β-acetoxy-3β-hydroxy-4-chloroandrost-4-ene
117993-40-5

17β-acetoxy-3β-hydroxy-4-chloroandrost-4-ene

Conditions
ConditionsYield
With chromium chloride; sodium tetrahydroborate In methanol at 0℃; for 0.333333h;910 mg
clostebol acetate
855-19-6

clostebol acetate

(aminooxy)acetic acid hemihydrochloride
2921-14-4, 7776-18-3, 20295-82-3

(aminooxy)acetic acid hemihydrochloride

3-carboxymethyl-oxime-clostebol acetate

3-carboxymethyl-oxime-clostebol acetate

Conditions
ConditionsYield
With pyridine In ethanol at 20℃;
clostebol acetate
855-19-6

clostebol acetate

clostebol
1093-58-9

clostebol

Conditions
ConditionsYield
With hydrogenchloride In acetone at 75℃; for 15h;
clostebol acetate
855-19-6

clostebol acetate

clostebol-17-hemisuccinate
3038-80-0

clostebol-17-hemisuccinate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1 N aq. HCl / acetone / 15 h / 75 °C
2: pyridine / 120 h / 20 °C
View Scheme
clostebol acetate
855-19-6

clostebol acetate

3-carboxymethyl-oxime-4-chloro-androstenedione

3-carboxymethyl-oxime-4-chloro-androstenedione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine / ethanol / 20 °C
2: 2 N aq. HCl / 3 h / 80 °C
3: aq. CrO3; H2SO4 / acetone / 0.08 h / 0 °C
View Scheme
clostebol acetate
855-19-6

clostebol acetate

[(8R,9S,10R,13S,14S,17S)-4-Chloro-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-(3E)-ylideneaminooxy]-acetic acid

[(8R,9S,10R,13S,14S,17S)-4-Chloro-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-(3E)-ylideneaminooxy]-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine / ethanol / 20 °C
2: 2 N aq. HCl / 3 h / 80 °C
View Scheme

4-Chlorotestosterone acetate Chemical Properties

IUPAC Name: [(8R,9S,10R,13S,14S,17S)-4-Chloro-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate
Synonyms of 4-Chlorotestosterone 17-acetate (CAS NO.855-19-6): 17beta-Acetoxy-4-chloroandrost-4-en-3-one ;  4-Chlorotestosterone acetate ; 4-Chlortestosterone acetate ; Alfa-Trofodermin ; Anabolit ; Chlorotestosterone acetate ; Clostebol acetate ; Clostebolacetate ; Clostene ; EINECS 212-720-4 ; Macrobin ; Megagrisevit ; NSC 72159 ; Stearanabol ; Sterabol ; Steranabol ; Test-anabol ; Testomed ; Turinabol ; Androst-4-en-3-one, 17-(acetyloxy)-4-chloro-, (17beta)- ; Androst-4-en-3-one, 4-chloro-17-beta-hydroxy-, acetate ; Testosterone, 4-chloro-, acetate ; DEA No. 4000
CAS NO: 855-19-6
Classification Code: Hormone ; Reproductive Effect
Molecular Formula of 4-Chlorotestosterone 17-acetate (CAS NO.855-19-6): C21H29ClO3
Molecular Weight: 364.9062
Molecular Structure:

Polar Surface Area: 43.37 Å2
Index of Refraction: 1.548
Molar Refractivity: 97.3 cm3
Molar Volume: 306.2 cm3
Surface Tension: 43.7 dyne/cm
Density of 4-Chlorotestosterone 17-acetate (CAS NO.855-19-6): 1.19 g/cm3
Flash Point: 155.7 °C
Enthalpy of Vaporization: 71.73 kJ/mol
Boiling Point: 457.2 °C at 760 mmHg
Vapour Pressure: 1.52E-08 mmHg at 25°C

4-Chlorotestosterone acetate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 2780ug/kg (2.78mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.

4-Chlorotestosterone acetate Safety Profile

A poison by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic vapors of Cl−.

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