Product Name

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  • Name

    5,5-Diethylbarbituric acid sodium salt

  • EINECS 205-613-9
  • CAS No. 144-02-5
  • Density 1.418[at 20℃]
  • Solubility Soluble in water
  • Melting Point 190℃
  • Formula C8H11N2O3Na
  • Boiling Point
  • Molecular Weight 206.177
  • Flash Point
  • Transport Information UN 3288
  • Appearance white solid.
  • Safety 36
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 144-02-5 (5,5-Diethylbarbituric acid sodium salt)
  • Hazard Symbols HarmfulXn
  • Synonyms 2,4,6(1H,3H,5H)-Pyrimidinetrione,5,5-diethyl-, monosodium salt (9CI);Barbituric acid, 5,5-diethyl-, sodium salt(8CI);Barbital sodium;Barbital soluble;Barbitone sodium;Diethylmalonylureasodium;Embinal;Medinal;Natrinal;Nervoseton;Sodium5,5-diethylbarbiturate;Sodium Veronal;Sodium barbital;Sodium barbitone;Sodium diethylbarbiturate;Soluble barbital;Soprinal;Thyalone;Veronal sodium;4,6(1H,5H)-pyrimidinedione, 5,5-diethyl-2-hydroxy-, sodium salt (1:1);5,5-Diethyl-2,4,6(1H,3H,5H)-pyrimidinetrione Monosodium Salt;sodium 5,5-diethyl-4,6-dioxo-1,4,5,6-tetrahydropyrimidin-2-olate;
  • PSA 81.59000
  • LogP 0.00010

5,5-Diethylbarbituric acid sodium salt Specification

The Barbital sodium, with the CAS registry number 144-02-5 and EINECS registry number 205-613-9, has the IUPAC name of sodium 5,5-diethyl-4,6-dioxo-1,4,5,6-tetrahydropyrimidin-2-olate. A long-acting Barbital sodium that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. And the molecular formula of this chemical is C8H11N2O3Na. What's more, it is usually used in serum protein electrophoresis, hepatic function test and so on.  

The physical properties of Barbital sodium are as followings: (1)ACD/LogP: 0.37; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.21; (4)ACD/LogD (pH 7.4): -3.09; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 5; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 69.97 Å2.

You should be cautious while dealing with this chemical. It is harmful if swallowed. Therefore, you had better wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)SMILES: [Na+].O=C1/N=C(/[O-])NC(=O)C1(CC)CC
(2)InChI: InChI=1/C8H12N2O3.Na/c1-3-8(4-2)5(11)9-7(13)10-6(8)12;/h3-4H2,1-2H3,(H2,9,10,11,12,13);/q;+1/p-1
(3)InChIKey: RGHFKWPGWBFQLN-REWHXWOFAJ

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 400mg/kg (400mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: GENERAL ANESTHETIC		 Journal of Pharmacology and Experimental Therapeutics. Vol. 39, Pg. 177, 1930.
cat LDLo subcutaneous 300mg/kg (300mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 52, 1973.
dog LDLo intravenous 300mg/kg (300mg/kg) BEHAVIORAL: GENERAL ANESTHETIC Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 125, 1937.
guinea pig LDLo subcutaneous 200mg/kg (200mg/kg) BEHAVIORAL: SLEEP Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 128, Pg. 678, 1938.
mouse LD50 intraperitoneal 620mg/kg (620mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 265, 1946.
mouse LD50 intravenous 830mg/kg (830mg/kg)   Toxicology and Applied Pharmacology. Vol. 27, Pg. 70, 1974.
mouse LD50 oral 800mg/kg (800mg/kg)   Toxicology and Applied Pharmacology. Vol. 27, Pg. 70, 1974.
mouse LD50 subcutaneous 700mg/kg (700mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 268, 1953.
rabbit LD50 intraperitoneal 250mg/kg (250mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 42, Pg. 253, 1931.
rabbit LDLo intravenous 400mg/kg (400mg/kg) BEHAVIORAL: GENERAL ANESTHETIC Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 125, 1937.
rabbit LDLo oral 275mg/kg (275mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 42, Pg. 253, 1931.
rabbit LDLo subcutaneous 290mg/kg (290mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 31, Pg. 1, 1927.
rat LD50 intraperitoneal 300mg/kg (300mg/kg)   Anesthesiology. Vol. 17, Pg. 43, 1956.
rat LD50 intravenous 280mg/kg (280mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 135, Pg. 213, 1962.
rat LD50 oral 600mg/kg (600mg/kg)   Archives of Toxicology. Vol. 54, Pg. 275, 1983.
rat LDLo subcutaneous 300mg/kg (300mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 31, Pg. 1, 1927.

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