5-Acetylamido-2-chloroaniline

The systematic name of 5-Acetylamido-2-chloroaniline is N-(3-amino-4-chlorophenyl)acetamide. With the CAS registry number 51867-83-5 and EINECS 257-485-9, it is also named as acetamide, N-(3-amino-4-chlorophenyl)-. The product's category is Intermediates of Dyes and Pigments. It is brown crystalline powder which should be sealed in the container and stored in the cool and dry place.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 1.29; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.29; (4)ACD/LogD (pH 7.4): 1.29; (5)ACD/BCF (pH 5.5): 5.59; (6)ACD/BCF (pH 7.4): 5.59; (7)ACD/KOC (pH 5.5): 119.2; (8)ACD/KOC (pH 7.4): 119.31; (9)#H bond acceptors: 3; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 23.55 Å²; (13)Index of Refraction: 1.646; (14)Molar Refractivity: 49.65 cm³; (15)Molar Volume: 136.7 cm³; (16)Polarizability: 19.68×10^-24 cm³; (17)Surface Tension: 55.1 dyne/cm; (18)Density: 1.35 g/cm3; (19)Flash Point: 190.7 °C; (20)Enthalpy of Vaporization: 64.13 kJ/mol; (21)Boiling Point: 391.7 °C at 760 mmHg; (22)Vapour Pressure: 2.42E-06 mmHg at 25°C.

Preparation of 5-Acetylamido-2-chloroaniline: It can be obtained by acetic acid-(4-chloro-3-nitro-anilide). This reaction needs reagents Fe, 37percent aq. HCl and solvent ethanol, H₂O by heating. The reaction time is 3 hours. The yield is 75%.

Uses of 5-Acetylamido-2-chloroaniline: It is used as intermediate of color former and as developer of colour film. It also can be used to produce 3-azido-4-chloroacetanilide. This reaction needs reagents 37percent aq. HCl, NaNO₂, NaN₃ and solvent H₂O. The yield is 78%.

When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes, respiratory system and skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection.

People can use the following data to convert to the molecule structure.
1. SMILES:Clc1ccc(NC(=O)C)cc1N
2. InChI:InChI=1/C8H9ClN2O/c1-5(12)11-6-2-3-7(9)8(10)4-6/h2-4H,10H2,1H3,(H,11,12)
3. InChIKey:MIIPQGGYCFVDAI-UHFFFAOYAR