5-Chloro-2-nitropyridine supplier

Name
5-Chloro-2-nitropyridine
EINECS
CAS No. 52092-47-4
Article Data11
CAS DataBase
Density 1.489 g/cm³
Solubility
Melting Point 119-123oC
Formula C₅H₃ClN₂O₂
Boiling Point 275.3 °C at 760 mmHg
Molecular Weight 158.544
Flash Point 120.3 °C
Transport Information
Appearance
Safety 26-36/37/39-36
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 2-Nitro-5-chloropyridine;NSC 90388;
PSA 58.71000
LogP 2.16640

Synthetic route

: 1072-98-6
5-chloro-2-pyridylamine

: 52092-47-4
5-chloro-2-nitropyridine

Conditions

Conditions	Yield
With sulfuric acid; dihydrogen peroxide at 20℃; for 48h;	71%
With caro's acid
Multi-step reaction with 2 steps 1: 94 percent / trifluoroacetic anhydride / CH2Cl2 / -60 °C 2: 62 percent / trifluoroacetic acid, H2O2 / CH2Cl2 / 1.5 h / 0 °C View Scheme

: 134251-85-7
2-dimethylsulfilimino-5-chloropyridine

A: 52092-47-4
5-chloro-2-nitropyridine

B: 134251-87-9
5-Chloro-2-nitro-pyridine 1-oxide

Conditions

Conditions	Yield
With dihydrogen peroxide; trifluoroacetic acid In dichloromethane at 0℃; for 1.5h;	A 62% B 38%

: 99848-04-1
(3-chloro-6-nitro-[2]pyridyl)-hydrazine

: 52092-47-4
5-chloro-2-nitropyridine

Conditions

Conditions	Yield
With water; silver(I) acetate

: 15128-82-2
3-hydroxy-2-nitropyridine

: 52092-47-4
5-chloro-2-nitropyridine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: acetic acid anhydride; nitric acid 2: phosphorus (V)-chloride / 130 °C 3: methanol; N2H4 4: silver acetate; water View Scheme
Multi-step reaction with 4 steps 1: acetic acid; acetic acid anhydride; nitric acid 2: phosphorus (V)-chloride / 130 °C 3: methanol; N2H4 4: silver acetate; water View Scheme

: 15128-91-3
3-hydroxy-2,6-dinitropyridine

: 52092-47-4
5-chloro-2-nitropyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: phosphorus (V)-chloride / 130 °C 2: methanol; N2H4 3: silver acetate; water View Scheme

: 101079-67-8
3-chloro-2,6-dinitro-pyridine

: 52092-47-4
5-chloro-2-nitropyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol; N2H4 2: silver acetate; water View Scheme

: 1072-98-6
5-chloro-2-pyridylamine

concentrated H2 SO4: concentrated H2 SO4

: 7722-84-1
dihydrogen peroxide

: 52092-47-4
5-chloro-2-nitropyridine

Conditions

Conditions	Yield
In ethyl acetate; toluene

...Expand

: 67-56-1
methanol

: 52092-47-4
5-chloro-2-nitropyridine

: 124-41-4
sodium methylate

: 126739-64-8
3-methoxy-6-nitropyridine

Conditions

Conditions	Yield
at 20℃;	100%

...Expand

: 52092-47-4
5-chloro-2-nitropyridine

: 106-44-5
p-cresol

: 2-nitro-5-(p-tolyloxy)pyridine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 12h;	94%

: 110-85-0
piperazine

: 52092-47-4
5-chloro-2-nitropyridine

: 775288-71-6
1-(6-nitropyridin-3-yl)piperazine

Conditions

Conditions	Yield
In butan-1-ol at 22 - 100℃;	89.5%
In isopropyl alcohol at 80 - 85℃; for 24h; Time;	102.2 g

: 52092-47-4
5-chloro-2-nitropyridine

: 20194-18-7
sodium phenyl-methanolate

: 2-nitro-5-phenylmethoxypyridine

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	89.1%

: 52092-47-4
5-chloro-2-nitropyridine

: 371-41-5
4-Fluorophenol

: 5-(4-fluorophenoxy)-2-nitropyridine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 12h;	86%

: 52092-47-4
5-chloro-2-nitropyridine

: 1195781-15-7
benzyl (3-fluoro-4-hydroxyphenyl)carbamate

: 1195781-16-8
benzyl {3-fluoro-4-[(6-nitropyridin-3-yl)oxy]phenyl}carbamate

Conditions

Conditions	Yield
With caesium carbonate In dimethyl sulfoxide at 20℃; for 3h;	83%

: 110-85-0
piperazine

: 52092-47-4
5-chloro-2-nitropyridine

: 1221726-34-6
1-(6-nitropyridin-3-yl)piperazine hydrochloride

Conditions

Conditions	Yield
In butan-1-ol at 95℃; for 24h; Inert atmosphere;	82.3%

: 52092-47-4
5-chloro-2-nitropyridine

: 1072-98-6
5-chloro-2-pyridylamine

Conditions

Conditions	Yield
With sulfuric acid; hydrogen In ethanol at 25℃; Electrochemical reaction;	82%
With boron dimethyl-trifluoro sulphide In dichloromethane at 60℃; for 0.5h; Sealed tube;	72%
With hydrogenchloride; sodium hydrogensulfide
With hydrogenchloride; tin(ll) chloride
With ammonium hydroxide; iron(II) sulfate

: 52092-47-4
5-chloro-2-nitropyridine

: 147081-29-6
(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

: 1433849-53-6
(3S)-tert-butyl 3-methyl-4-(6-nitropyridin-3-yl)piperazine-1-carboxylate

Conditions

Conditions	Yield
With potassium phosphate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,4-dioxane at 95 - 105℃; Inert atmosphere;	80.5%
With potassium phosphate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 80 - 90℃; for 20h; Inert atmosphere; Industrial scale;

: 52092-47-4
5-chloro-2-nitropyridine

: 1005788-04-4
N-(2-fluoro-5-hydroxyphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide

: 1092394-02-9
N-{2-fluoro-5-[(6-nitropyridin-3-yl)oxy]phenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide

Conditions

Conditions	Yield
With potassium carbonate In water; dimethyl sulfoxide at 75 - 85℃; for 6h; Large scale;	78%

: 52092-47-4
5-chloro-2-nitropyridine

: 1195781-24-8
benzyl (2-fluoro-4-hydroxyphenyl)carbamate

: 1195781-25-9
benzyl {2-fluoro-4-[(6-nitropyridin-3-yl)oxy]phenyl}carbamate

Conditions

Conditions	Yield
With caesium carbonate In dimethyl sulfoxide at 20℃; for 6h;	77%

: 52092-47-4
5-chloro-2-nitropyridine

: 106-41-2
4-bromo-phenol

: 5-(4-bromophenoxy)-2-nitropyridine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 12h;	77%

: 4318-42-7
1-(1-methylethyl)piperazine

: 52092-47-4
5-chloro-2-nitropyridine

: 943758-04-1
1-isopropyl-4-(6-nitropyridin-3-yl)piperazine

Conditions

Conditions	Yield
In acetonitrile for 5h; Reflux;	76%

: 52092-47-4
5-chloro-2-nitropyridine

: 62257-16-3
5-hydroxy-2-fluoroaniline

: 1020173-38-9
2-fluoro-5-(6-nitropyridin-3-yloxy)benzenamine

Conditions

Conditions	Yield
With potassium phosphate In water; dimethyl sulfoxide at 75 - 80℃; for 9h;	76%

: 109-00-2
3-HYDROXYPYRIDINE

: 52092-47-4
5-chloro-2-nitropyridine

: 2-nitro-5-(pyridine-3-yloxy)pyridine

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 5h;	76%

: 52092-47-4
5-chloro-2-nitropyridine

: 108-43-0
3-monochlorophenol

: 5-(3-chlorophenoxy)-2-nitropyridine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 12h;	75%

: 109-01-3
1-methyl-piperazine

: 52092-47-4
5-chloro-2-nitropyridine

: 657410-79-2
1-methyl-4-(6-nitro-pyridin-3-yl)-piperazine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 3h;	75%

: 52092-47-4
5-chloro-2-nitropyridine

: 2554-06-5
2,4,6,8-tetramethyl-2,4,6,8-tetravinyl-cyclotetrasiloxane

: 125889-39-6
2-nitro-5-vinylpyridine

Conditions

Conditions	Yield
With XPhos; tetrabutyl ammonium fluoride; palladium diacetate In tetrahydrofuran at 67℃; for 24h; Inert atmosphere; Schlenk technique;	74%

: 52092-47-4
5-chloro-2-nitropyridine

: 5203-77-0
1,3-dimethyl-1H-pyrazol-5-ol

: 5-((1,3-dimethyl-1H-pyrazol-5-yl)oxy)-2-nitropyridine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 12h; Inert atmosphere;	71%

: 52092-47-4
5-chloro-2-nitropyridine

: 201733-56-4
2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane

: C10H15BN2O2

Conditions

Conditions	Yield
Stage #1: 5-chloro-2-nitropyridine; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 80 - 90℃; Suzuki Coupling; Inert atmosphere; Stage #2: With hydrogen In 1,4-dioxane at 20℃; under 2280.15 Torr;	68%

: 5382-16-1
4-HYDROXYPIPERIDINE

: 52092-47-4
5-chloro-2-nitropyridine

: 1-(6-nitropyridin-3-yl)piperidin-4-ol

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 90℃;	65%
With potassium carbonate In dimethyl sulfoxide at 90℃; Sealed tube;	65%

: 52092-47-4
5-chloro-2-nitropyridine

: 100-53-8
phenylmethanethiol

: 5-(benzylthio)-2-nitropyridine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 12h;	65%

: 52092-47-4
5-chloro-2-nitropyridine

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 571189-16-7
4-(6-nitropyridin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 100 - 110℃; Microwave irradiation;	63.81%
With cesium fluoride In dimethyl sulfoxide at 80℃; for 16h;	30.15%

: 52092-47-4
5-chloro-2-nitropyridine

: 105-53-3
diethyl malonate

: diethyl 2-(6-nitro-3-pyridinyl)malonate

Conditions

Conditions	Yield
Stage #1: diethyl malonate With sodium hydride In N,N-dimethyl-formamide at 10 - 20℃; for 0.5h; Inert atmosphere; Stage #2: 5-chloro-2-nitropyridine In N,N-dimethyl-formamide at 80℃; for 12h;	60.66%
Stage #1: diethyl malonate With sodium hydride In N,N-dimethyl-formamide at 10 - 20℃; for 0.5h; Inert atmosphere; Stage #2: 5-chloro-2-nitropyridine In N,N-dimethyl-formamide at 80℃; for 12h; Inert atmosphere;	60.66%

5-Chloro-2-nitropyridine Chemical Properties

Molecular Structure of 5-Chloro-2-nitropyridine(52092-47-4)

IUPAC Name:5-chloro-2-nitropyridine
Molecular Formula:C₅H₃ClN₂O₂
Molecular Weight:158.542520 g/mol
Density:1.489 g/cm³
Flash Point:120.3 °C
Enthalpy of Vaporization:49.3 kJ/mol
Boiling Point:275.3 °C at 760 mmHg
Vapour Pressure:0.00865 mmHg at 25 °C
Water Solubility:2345 mg/L at 25 °C
Synonyms of 5-Chloro-2-nitropyridine(52092-47-4):
5-CHLORO-2-NITROPYRIDINE;3-Chloro-6-nitropyridine;5-CHLORO-2-NITROPYRIDINE/2-NITRO-5-CHLOROPYRIDINE
Categories of 5-Chloro-2-nitropyridine(52092-47-4):
Pyridine;Pyridines

5-Chloro-2-nitropyridine Safety Profile

Safety Information of 5-Chloro-2-nitropyridine(52092-47-4):
Hazard Codes:Xi

Risk Statements:20/21/22-36/37/38
20/21/22:Harmful by inhalation, in contact with skin and if swallowed
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:26-36/37/39-36
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
36:Wear suitable protective clothing
Hazard Note:Irritant

Product Name

5-Chloro-2-nitropyridine

Synthetic route

5-Chloro-2-nitropyridine Chemical Properties

5-Chloro-2-nitropyridine Safety Profile

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