6-METHOXYGRAMINE

The 1H-Indole-3-methanamine,6-methoxy-N,N-dimethyl-, with the CAS registry number 62467-65-6, is also known as 6-Methoxygramine. It belongs to the product category of Indoles and Derivatives. This chemical's molecular formula is C₁₂H₁₆N₂O and molecular weight is 204.27. What's more, its systematic name is 1-(6-methoxy-1H-indol-3-yl)-N,N-dimethylmethanamine.

Physical properties of 1H-Indole-3-methanamine,6-methoxy-N,N-dimethyl- are: (1)ACD/LogP: 1.76; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.17; (4)ACD/LogD (pH 7.4): 0.23; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 6.41; (9)#H bond acceptors: 3; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 17.4 Å²; (13)Index of Refraction: 1.608; (14)Molar Refractivity: 63.11 cm³; (15)Molar Volume: 182.4 cm³; (16)Polarizability: 25.01×10^-24cm³; (17)Surface Tension: 43.8 dyne/cm; (18)Density: 1.119 g/cm³; (19)Flash Point: 156.2 °C; (20)Enthalpy of Vaporization: 57.77 kJ/mol; (21)Boiling Point: 334.7 °C at 760 mmHg; (22)Vapour Pressure: 0.000126 mmHg at 25°C.

Preparation: this chemical can be prepared by 6-methoxy-indole, dimethylamine and formaldehyde at the ambient temperature. It will need solvent aq. acetic acid with the reaction time of 15 hours. The yield is about 96%.

Uses of 1H-Indole-3-methanamine,6-methoxy-N,N-dimethyl-: it can be used to produce (6-methoxy-1-triisopropylsilanyl-1H-indol-3-ylmethyl)-dimethyl-amine at the temperature of 0°C . It will need reagent NaH and solvent tetrahydrofuran. The yield is about 97%.

You can still convert the following datas into molecular structure:
(1)SMILES: O(c1ccc2c(c1)ncc2CN(C)C)C
(2)Std. InChI: InChI=1S/C12H16N2O/c1-14(2)8-9-7-13-12-6-10(15-3)4-5-11(9)12/h4-7,13H,8H2,1-3H3
(3)Std. InChIKey: MGXIQKFKOYJROW-UHFFFAOYSA-N