Product Name

  • Name

    7-(2-HYDROXYETHYL)THEOPHYLLINE

  • EINECS 208-269-8
  • CAS No. 519-37-9
  • Article Data15
  • CAS DataBase
  • Density 1.51 g/cm3
  • Solubility 2.991g/L(temperature not stated)
  • Melting Point 163 °C
  • Formula C9H12N4O3
  • Boiling Point 495.5 °C at 760 mmHg
  • Molecular Weight 224.219
  • Flash Point 253.5 °C
  • Transport Information
  • Appearance
  • Safety 36-36/37-26
  • Risk Codes 22-36/37/38
  • Molecular Structure Molecular Structure of 519-37-9 (7-(2-HYDROXYETHYL)THEOPHYLLINE)
  • Hazard Symbols IrritantXi,HarmfulXn
  • Synonyms Theophylline,7-(2-hydroxyethyl)- (7CI,8CI);7-(2-Hydroxyethyl)-1,3-dimethylxanthine;7-(2-Hydroxyethyl)theophylline;7-(Hydroxyethyl)theophylline;7-(b-Hydroxyethyl)theophylline;7-Theophyllineethanol;Aethophyllinum;Ascorphylline;Bio-phylline;Cordalin;Corophyllin-N;Dilaphyllin;Etofylline;Etophyllin;Etophylline;Frekaphyllin;Hydroxyethyltheophylline;KT 200G;NSC 113373;Oxphylline;Oxyethophylline;Oxyethyltheophylline;Oxyphyllin;Oxyphylline;Oxytheonyl;Phyllocormin N;Soluphylline;
  • PSA 82.05000
  • LogP -1.57400

7-(2-Hydroxyethyl)theophylline Chemical Properties

Chemistry informtion about Hydroxyethyltheophylline (CAS NO.519-37-9) is:
IUPAC Name: 7-(2-hydroxyethyl)-1,3-dimethylpurine-2,6-dione
Synonyms: Etofylline ; Beta-Hydroxyethyltheophylline ; Biophylline ; 7-(A-Hydroxyethyl)Theophylline ; 7-(Beta-Hydroxyethyl)Theophylline ; 7-(2-Hydroxyethyl)Theophylline ; 1,3-Dimethyl-7-(Beta-Hydroxyethyl)Xanthine ; 1,3-Dimethyl-7-[2-Hydroxyethyl]-Xanthine
MF: C9H12N4O3
MW: 224.22
EINECS: 208-269-8
Melting Point: 163°C
Density: 1.51 g/cm3
Flash Point: 253.5 °C Boiling Point: 495.5 °C at 760 mmHg
Vapour Pressure: 1.23E-10 mmHg at 25°C 
Enthalpy of Vaporization: 80.36 kJ/mol
Merck: 3878
Following is the molecular structure of  Hydroxyethyltheophylline (CAS NO.519-37-9) is:

7-(2-Hydroxyethyl)theophylline Uses

Hydroxyethyltheophylline (CAS NO.519-37-9) is useful synthetic intermediate in the preparation of 7-substituted xanthines.

7-(2-Hydroxyethyl)theophylline Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 400mg/kg (400mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 190, 1958.
mouse LD50 intravenous 344mg/kg (344mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957.
mouse LD50 oral 400mg/kg (400mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1173, 1977.
mouse LD50 subcutaneous 400mg/kg (400mg/kg)

Behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: respiratory stimulation skin and appendages (skin): sweating: other

 Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 649, 1954.
rat LD50 intravenous 486mg/kg (486mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957.
rat LD50 oral 710mg/kg (710mg/kg)

Liver: other changes

 Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 2023, 1980.
rat LD50 subcutaneous 176mg/kg (176mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957.

7-(2-Hydroxyethyl)theophylline Safety Profile

Poison by ingestion, subcutaneous, intravenous and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also THEOPHYLLINE.
Hazard Codes:
Xn: Harmful 
Xi: Irritant
Risk Statements:
R22: Harmful if swallowed. 
R36/37/38: Irritating to eyes, respiratory system and skin. 
Safety Statements:
S36: Wear suitable protective clothing. 
S36/37: Wear suitable protective clothing and gloves.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: XH5850000

7-(2-Hydroxyethyl)theophylline Specification

 Hydroxyethyltheophylline (CAS NO.519-37-9) is a white solid.

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