Product Name

  • Name

    7,12-DIMETHYLBENZ[A]ANTHRACENE

  • EINECS 200-359-5
  • CAS No. 57-97-6
  • Article Data19
  • CAS DataBase
  • Density 1.142 g/cm3
  • Solubility
  • Melting Point 122-123 °C(lit.)
  • Formula C20H16
  • Boiling Point 463.5 °C at 760 mmHg
  • Molecular Weight 256.347
  • Flash Point 227.3 °C
  • Transport Information
  • Appearance Yellow powder
  • Safety 45-53-36/37
  • Risk Codes 22-45
  • Molecular Structure Molecular Structure of 57-97-6 (7,12-DIMETHYLBENZ[A]ANTHRACENE)
  • Hazard Symbols ToxicT;HarmfulXn
  • Synonyms 7,12-Dimethylbenz[a]anthracene;9,10-Dimethyl-1,2-benz[a]anthracene;9,10-Dimethyl-1,2-benzanthracene;DMBA;DMBAn;NSC408823;
  • PSA 0.00000
  • LogP 5.76300

Synthetic route

7,12-dihydro-7,12-dimethylbenzanthracene-7,12-diol
2518-00-5

7,12-dihydro-7,12-dimethylbenzanthracene-7,12-diol

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

Conditions
ConditionsYield
With hydrogenchloride; acetic acid; tin(ll) chloride
With 2TiCl2*LiAlH4 In tetrahydrofuran for 3h; Heating; Yield given;
Multi-step reaction with 2 steps
1: 57 percent aq. HI
2: 1 percent bisulfite solution / Heating
View Scheme
Multi-step reaction with 2 steps
1: methanol; sulfuric acid
2: potassium; benzene
View Scheme
benz[a]anthracene-7,12-dione
2498-66-0

benz[a]anthracene-7,12-dione

methylmagnesium bromide
75-16-1

methylmagnesium bromide

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

Conditions
ConditionsYield
Reaktion ueber mehrere Stufen;
7,12-dimethyl-7,12-dihydro-benz[a]anthracene
35281-31-3

7,12-dimethyl-7,12-dihydro-benz[a]anthracene

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

Conditions
ConditionsYield
With sulfur at 200℃;
With sulfur at 210 - 220℃;
7-iodomethyl-12-methylbenz[a]anthracene
27018-50-4

7-iodomethyl-12-methylbenz[a]anthracene

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

Conditions
ConditionsYield
With 1,4-dioxane; hydrogenchloride; tin(ll) chloride
With bisulfite solution Heating; Yield given;
7-(12-Methylbenzanthryl)acetic acid
63020-22-4

7-(12-Methylbenzanthryl)acetic acid

(E)-3-Ureido-but-2-enoic acid ethyl ester
5435-44-9, 22243-66-9

(E)-3-Ureido-but-2-enoic acid ethyl ester

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

Conditions
ConditionsYield
at 180 - 185℃;
7-(12-Methylbenzanthryl)acetic acid
63020-22-4

7-(12-Methylbenzanthryl)acetic acid

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

Conditions
ConditionsYield
With tin(IV) chloride at 110 - 120℃;
With zinc(II) chloride at 180 - 185℃;
7,12-dimethoxy-7,12-dimethyl-7,12-dihydro-benz[a]anthracene
63018-76-8

7,12-dimethoxy-7,12-dimethyl-7,12-dihydro-benz[a]anthracene

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

Conditions
ConditionsYield
With sodium; benzene
With potassium; benzene
7-bromo-12-methyl-benz[a]anthracene
81830-40-2

7-bromo-12-methyl-benz[a]anthracene

methyl iodide
74-88-4

methyl iodide

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

Conditions
ConditionsYield
With n-butyllithium; diethyl ether; benzene
diethyl ether
60-29-7

diethyl ether

acetic acid-(12-methyl-benz[a]anthracen-7-yl ester)
17526-35-1

acetic acid-(12-methyl-benz[a]anthracen-7-yl ester)

methylmagnesium bromide
75-16-1

methylmagnesium bromide

benzene
71-43-2

benzene

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

Conditions
ConditionsYield
Reaktion ueber mehrere Stufen;
...Expand
7,12-epidioxy-7,12-dihydro-7,12-dimethylbenzanthracene
2518-01-6

7,12-epidioxy-7,12-dihydro-7,12-dimethylbenzanthracene

A

8,13-epoxy-8,13-dihydro-8,13-dimethyl-1a,7a-naphtho-8a,12a-benzoxepin
65273-21-4

8,13-epoxy-8,13-dihydro-8,13-dimethyl-1a,7a-naphtho-8a,12a-benzoxepin

B

7,12-dihydro-7,12-dimethylbenzanthracene-7,12-diol
2518-00-5

7,12-dihydro-7,12-dimethylbenzanthracene-7,12-diol

C

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

Conditions
ConditionsYield
In chlorobenzene for 10h; Product distribution; Heating; other time, other solvent;
...Expand
hydrogenchloride
7647-01-0

hydrogenchloride

methanol
67-56-1

methanol

7,12-dimethyl-7,12-dihydro-benz[a]anthracen-7-ol
77318-30-0

7,12-dimethyl-7,12-dihydro-benz[a]anthracen-7-ol

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

...Expand
(+-)-7.12-dimethyl-7.12-dihydro-7.12-epoxy-benz<a>anthracene

(+-)-7.12-dimethyl-7.12-dihydro-7.12-epoxy-benz<a>anthracene

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

Conditions
ConditionsYield
With hydrogen iodide; acetic acid
acetic acid-(12-methyl-benz[a]anthracen-7-yl ester)
17526-35-1

acetic acid-(12-methyl-benz[a]anthracen-7-yl ester)

excessive methyl magnesium bromide

excessive methyl magnesium bromide

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

Conditions
ConditionsYield
With diethyl ether; benzene Reaktion ueber mehrere Stufen;
12-methyltetraphen-7(12H)-one
73038-40-1

12-methyltetraphen-7(12H)-one

methyl magnesium halide

methyl magnesium halide

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

Conditions
ConditionsYield
With diethyl ether; benzene anschliessend mit wss. NH4Cl behandeln;
7-(12-Methylbenzanthryl)acetic acid
63020-22-4

7-(12-Methylbenzanthryl)acetic acid

tin(IV) chloride
7646-78-8

tin(IV) chloride

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

Conditions
ConditionsYield
at 110 - 120℃;
diethyl ether
60-29-7

diethyl ether

7,12-dimethoxy-7,12-dimethyl-7,12-dihydro-benz[a]anthracene
63018-76-8

7,12-dimethoxy-7,12-dimethyl-7,12-dihydro-benz[a]anthracene

benzene
71-43-2

benzene

potassium

potassium

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

...Expand
diethyl ether
60-29-7

diethyl ether

7,12-dimethoxy-7,12-dimethyl-7,12-dihydro-benz[a]anthracene
63018-76-8

7,12-dimethoxy-7,12-dimethyl-7,12-dihydro-benz[a]anthracene

benzene
71-43-2

benzene

sodium

sodium

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

...Expand
diethyl ether
60-29-7

diethyl ether

7,12-diethoxy-7,12-dimethyl-7,12-dihydro-benz[a]anthracene

7,12-diethoxy-7,12-dimethyl-7,12-dihydro-benz[a]anthracene

benzene
71-43-2

benzene

sodium

sodium

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

...Expand
benz[a]anthracene-7,12-dione
2498-66-0

benz[a]anthracene-7,12-dione

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: benzene; diethyl ether / Ambient temperature
2: 2TiCl2*LiAlH4 / tetrahydrofuran / 3 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: benzene; diethyl ether / 24 h / Ambient temperature
2: 57 percent aq. HI
3: 1 percent bisulfite solution / Heating
View Scheme
Multi-step reaction with 2 steps
1: diethyl ether; benzene / Behandlung des nach der Hydrolyse erhaltenen Reaktionsprodukts mit wss. HI in Methanol
2: SnCl2; concentrated aqueous HCl; dioxane
View Scheme
12-methylbenzo[a]anthracene
2422-79-9

12-methylbenzo[a]anthracene

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous HI
2: SnCl2; concentrated aqueous HCl; dioxane
View Scheme
Multi-step reaction with 2 steps
1: aqueous HI
2: SnCl2; concentrated aqueous HCl; dioxane
View Scheme
7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

7,12-bis(bromomethyl)benz[a]anthracene
34331-98-1

7,12-bis(bromomethyl)benz[a]anthracene

Conditions
ConditionsYield
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane for 3h; Inert atmosphere; Reflux;65.2%
With carbon disulfide; bromine unter Kuehlung;
7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

2'-Deoxyguanosine
961-07-9

2'-Deoxyguanosine

A

2-Amino-7-(7-methyl-benzo[a]anthracen-12-ylmethyl)-1,7-dihydro-purin-6-one
138606-34-5

2-Amino-7-(7-methyl-benzo[a]anthracen-12-ylmethyl)-1,7-dihydro-purin-6-one

B

2-Amino-8-(7-methyl-benzo[a]anthracen-12-ylmethyl)-1,7-dihydro-purin-6-one
138877-58-4

2-Amino-8-(7-methyl-benzo[a]anthracen-12-ylmethyl)-1,7-dihydro-purin-6-one

C

2-Amino-7-(12-methyl-benzo[a]anthracen-7-ylmethyl)-1,7-dihydro-purin-6-one
138877-59-5

2-Amino-7-(12-methyl-benzo[a]anthracen-7-ylmethyl)-1,7-dihydro-purin-6-one

D

2-Amino-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-8-(7-methyl-benzo[a]anthracen-12-ylmethyl)-1,9-dihydro-purin-6-one
138898-82-5

2-Amino-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-8-(7-methyl-benzo[a]anthracen-12-ylmethyl)-1,9-dihydro-purin-6-one

Conditions
ConditionsYield
With potassium perchlorate In N,N-dimethyl-formamide electrolysis; Further byproducts given;A 55%
B 10%
C 12%
D 13%
...Expand
7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

2'-deoxy-D-adenosine
958-09-8

2'-deoxy-D-adenosine

A

7-(7-Methyl-benzo[a]anthracen-12-ylmethyl)-7H-purin-6-ylamine
138606-33-4

7-(7-Methyl-benzo[a]anthracen-12-ylmethyl)-7H-purin-6-ylamine

B

3-(12-Methyl-benzo[a]anthracen-7-ylmethyl)-3H-purin-6-ylamine
138877-60-8

3-(12-Methyl-benzo[a]anthracen-7-ylmethyl)-3H-purin-6-ylamine

Conditions
ConditionsYield
With potassium perchlorate In N,N-dimethyl-formamide electrolysis;A 45%
B 55%
...Expand
7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

trans-7,12-dihydro-7,12-dimethylbenzanthracene
23660-33-5

trans-7,12-dihydro-7,12-dimethylbenzanthracene

cis-7,12-dihydro-7,12-dimethylbenzanthracene
24316-23-2

cis-7,12-dihydro-7,12-dimethylbenzanthracene

Conditions
ConditionsYield
With hydrogen iodide In acetic acid for 0.25h; Heating; Title compound not separated from byproducts;A 50%
B 25%
para-xylene
106-42-3

para-xylene

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

silver perchlorate

silver perchlorate

[Ag2(7,12-dimethylbenz[a]anthracene)2(perchlorato)2](p-xylene)

[Ag2(7,12-dimethylbenz[a]anthracene)2(perchlorato)2](p-xylene)

Conditions
ConditionsYield
In xylene under Ar; 7,12-dimethylbenz(a)anthracene added to p-xylene soln. of AgClO4 (molar ratio 1:1); stirred for 10 min; filtered; filtrate layered with n-hexane; sealed under Ar and wrapped with Al foil; stored at room temp. for 2 weeks; elem. anal.;49%
...Expand
7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

chromium(0) hexacarbonyl
199620-14-9, 13007-92-6

chromium(0) hexacarbonyl

(η6-7,12-dimethylbenz{a}anthracene)tricarbonylchromium
146596-56-7

(η6-7,12-dimethylbenz{a}anthracene)tricarbonylchromium

Conditions
ConditionsYield
In tetrahydrofuran; dibutyl ether refluxing under nitrogen for 7 h;; filtration; recrystn. from toluene-hexane at -78°C; purifn. by sublimation; elem. anal.;32%
maleic anhydride
108-31-6

maleic anhydride

7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

7,12-dimethyl-7,12-dihydro-7,12-ethano-benz[a]anthracene-13,14-dicarboxylic acid-anhydride
6632-71-9

7,12-dimethyl-7,12-dihydro-7,12-ethano-benz[a]anthracene-13,14-dicarboxylic acid-anhydride

Conditions
ConditionsYield
With benzene
7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

7,12-bis-acetoxymethyl-benz[a]anthracene
63018-62-2

7,12-bis-acetoxymethyl-benz[a]anthracene

Conditions
ConditionsYield
With lead(IV) acetate; acetic acid
Multi-step reaction with 2 steps
1: carbon disulfide; bromine / unter Kuehlung
2: potassium acetate
View Scheme
7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

7,12-epidioxy-7,12-dihydro-7,12-dimethylbenzanthracene
2518-01-6

7,12-epidioxy-7,12-dihydro-7,12-dimethylbenzanthracene

Conditions
ConditionsYield
With carbon disulfide mit Sauerstoff unter Belichtung;
With oxygen for 4h; Irradiation;
7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

(+/-)-7,12-dimethylbenzanthracene-cis-5S,6R-dihydrodiol
16644-15-8, 28622-94-8, 64265-59-4, 75262-88-3, 92693-64-6, 92693-65-7, 92693-66-8, 92693-67-9, 2518-02-7

(+/-)-7,12-dimethylbenzanthracene-cis-5S,6R-dihydrodiol

Conditions
ConditionsYield
With pyridine; osmium(VIII) oxide; benzene Behandeln des Reaktionsprodukts in Dichlormethan mit wss. KOH und Mannit;
(i) OsO4, Py, benzene, (ii) mannitol, aq. NaOH, CH2Cl2; Multistep reaction;
With pyridine; osmium(VIII) oxide
7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

A

7,12-dimethyl-5,6-dihydrobenzanthracene
35281-29-9

7,12-dimethyl-5,6-dihydrobenzanthracene

B

8,9,10,11-tetrahydro-7,12-dimethylbenzanthracene
25486-91-3

8,9,10,11-tetrahydro-7,12-dimethylbenzanthracene

cis-7,12-dihydro-7,12-dimethylbenzanthracene
24316-23-2

cis-7,12-dihydro-7,12-dimethylbenzanthracene

D

5,6,8,9,10,11-hexahydro-7,12-dimethylbenzanthracene
73712-72-8

5,6,8,9,10,11-hexahydro-7,12-dimethylbenzanthracene

Conditions
ConditionsYield
With hydrogen; platinum(IV) oxide In ethyl acetate under 2585.7 Torr; for 22h; Ambient temperature; Title compound not separated from byproducts;A 12 % Chromat.
B 64 % Chromat.
C 18 % Chromat.
D 6 % Chromat.
With hydrogen; platinum(IV) oxide In ethyl acetate under 2585.7 Torr; for 22h; Ambient temperature;A 12 % Chromat.
B 64 % Chromat.
C 18 % Chromat.
D 6 % Chromat.
With hydrogen; platinum(IV) oxide; iron(II) chloride In hydrogenchloride under 1034.3 Torr; for 24h; Ambient temperature; Further byproducts given. Title compound not separated from byproducts;A 11 % Chromat.
B 6 % Chromat.
C 15 % Chromat.
D 62 % Chromat.
With hydrogen; platinum(IV) oxide; iron(II) chloride In hydrogenchloride under 1034.3 Torr; for 24h; Ambient temperature; Further byproducts given;A 11 % Chromat.
B 6 % Chromat.
C 15 % Chromat.
D 62 % Chromat.
...Expand
7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

A

7,12-dimethyl-5,6-dihydrobenzanthracene
35281-29-9

7,12-dimethyl-5,6-dihydrobenzanthracene

trans-7,12-dihydro-7,12-dimethylbenzanthracene
23660-33-5

trans-7,12-dihydro-7,12-dimethylbenzanthracene

cis-7,12-dihydro-7,12-dimethylbenzanthracene
24316-23-2

cis-7,12-dihydro-7,12-dimethylbenzanthracene

D

5,6,8,9,10,11-hexahydro-7,12-dimethylbenzanthracene
73712-72-8

5,6,8,9,10,11-hexahydro-7,12-dimethylbenzanthracene

Conditions
ConditionsYield
With hydrogen; platinum(IV) oxide; iron(II) chloride In hydrogenchloride under 1034.3 Torr; for 24h; Ambient temperature; Further byproducts given;A 11 % Chromat.
B 6 % Chromat.
C 15 % Chromat.
D 62 % Chromat.
...Expand
7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

A

7,12-dimethyl-5,6-dihydrobenzanthracene
35281-29-9

7,12-dimethyl-5,6-dihydrobenzanthracene

cis-7,12-dihydro-7,12-dimethylbenzanthracene
24316-23-2

cis-7,12-dihydro-7,12-dimethylbenzanthracene

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethyl acetate under 1034.3 Torr; for 8h; Ambient temperature;A 80 % Spectr.
B 20 % Spectr.
7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

A

8,9,10,11-tetrahydro-7,12-dimethylbenzanthracene
25486-91-3

8,9,10,11-tetrahydro-7,12-dimethylbenzanthracene

trans-7,12-dihydro-7,12-dimethylbenzanthracene
23660-33-5

trans-7,12-dihydro-7,12-dimethylbenzanthracene

cis-7,12-dihydro-7,12-dimethylbenzanthracene
24316-23-2

cis-7,12-dihydro-7,12-dimethylbenzanthracene

D

5,6,8,9,10,11-hexahydro-7,12-dimethylbenzanthracene
73712-72-8

5,6,8,9,10,11-hexahydro-7,12-dimethylbenzanthracene

Conditions
ConditionsYield
With hydrogen; platinum(IV) oxide In acetic acid; ethyl acetate under 1551.4 Torr; for 22h; Further byproducts given;A 10 % Chromat.
B 10 % Chromat.
C 19 % Chromat.
D 55 % Chromat.
...Expand
7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

A

[3H]-7-Hydroxymethyl-12-methylbenz[a]anthracene
568-75-2

[3H]-7-Hydroxymethyl-12-methylbenz[a]anthracene

B

7,12-epidioxy-7,12-dihydro-7,12-dimethylbenzanthracene
2518-01-6

7,12-epidioxy-7,12-dihydro-7,12-dimethylbenzanthracene

Conditions
ConditionsYield
With oxygen In octane Product distribution; Irradiation; Oxidative degradation,initiated Co60 source(1-5 W/kg) ;other solvents;relative values k/ko (ko = benzo<a>pyrene)</a>;
7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

cis-7,12-dihydro-7,12-dimethylbenzanthracene
24316-23-2

cis-7,12-dihydro-7,12-dimethylbenzanthracene

Conditions
ConditionsYield
With hydrogen iodide In acetic acid for 1h; Heating;85 % Turnov.
Multi-step reaction with 2 steps
1: 50 percent / HI / acetic acid / 0.25 h / Heating
2: HI / acetic acid / 1 h / Heating
View Scheme
7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

2'-Deoxyguanosine
961-07-9

2'-Deoxyguanosine

A

7,12-dihydroxymethylbenz[a]anthracene
2564-65-0

7,12-dihydroxymethylbenz[a]anthracene

B

2-Amino-7-(7-methyl-benzo[a]anthracen-12-ylmethyl)-1,7-dihydro-purin-6-one
138606-34-5

2-Amino-7-(7-methyl-benzo[a]anthracen-12-ylmethyl)-1,7-dihydro-purin-6-one

C

2-Amino-8-(7-methyl-benzo[a]anthracen-12-ylmethyl)-1,7-dihydro-purin-6-one
138877-58-4

2-Amino-8-(7-methyl-benzo[a]anthracen-12-ylmethyl)-1,7-dihydro-purin-6-one

D

2-Amino-7-(12-methyl-benzo[a]anthracen-7-ylmethyl)-1,7-dihydro-purin-6-one
138877-59-5

2-Amino-7-(12-methyl-benzo[a]anthracen-7-ylmethyl)-1,7-dihydro-purin-6-one

E

2-Amino-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-8-(7-methyl-benzo[a]anthracen-12-ylmethyl)-1,9-dihydro-purin-6-one
138898-82-5

2-Amino-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-8-(7-methyl-benzo[a]anthracen-12-ylmethyl)-1,9-dihydro-purin-6-one

Conditions
ConditionsYield
With potassium perchlorate In N,N-dimethyl-formamide Mechanism; other nucleosides; electrolysis;
...Expand
7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

trans-7,12-dihydro-7,12-dimethylbenzanthracene
23660-33-5

trans-7,12-dihydro-7,12-dimethylbenzanthracene

Conditions
ConditionsYield
With ammonia; lithium
7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

[3H]-12-Hydroxymethyl-7-methylbenz[a]anthracene
568-70-7

[3H]-12-Hydroxymethyl-7-methylbenz[a]anthracene

Conditions
ConditionsYield
(i) NBS, (ii) aq. NaOH; Multistep reaction;
7,12-dimethyl-1,2-benzanthracene
57-97-6

7,12-dimethyl-1,2-benzanthracene

7,12-dimethyl-5,6-dihydrobenzanthracene
35281-29-9

7,12-dimethyl-5,6-dihydrobenzanthracene

Conditions
ConditionsYield
With hydrogen; Pd/SrCO3

7,12-Dimethylbenz[a]anthracene Chemical Properties

IUPAC Name: 7,12-dimethylbenzo[b]phenanthrene
Molecular Formula: C20H16
Molecular Weight: 256.36g/mol
Chemical Properties: yellow powder
Density: 1.142 g/cm3
EINECS: 200-359-5
Liansport Information: UN 3077 9/PG 3
Melting Point: 122-123°C(lit.)
Boiling Point: 463.5 °C at 760 mmHg 
Flash Point: 227.3 °C 
storage temperature: 2-8°C
Freely Rotating Bonds: 0 
Polar Surface Area: 0 Å2 
Index of Refraction: 1.728 
Molar Refractivity: 89.43 cm3 
Molar Volume: 224.3 cm3 
Polarizability: 35.45× 10-24cm3 
Surface Tension: 49.1 dyne/cm  
Enthalpy of Vaporization: 69.69 kJ/mol 
Vapour Pressure: 2.51E-08 mmHg at 25°C
Solubility: insoluble in water
Sensitivity: incompatible with strong oxidizing agents  
   The chemical synonyms of Dimethylbenzanthracene (57-97-6) are DMBA ; 7,12-Dimethylbenzanthracene ; Dimethylbenz[a]anthracene ; Dimethylbenzanthrene ; Dimethylbenzanthracene ; 7,12-Dimethyltetraphene ; ETHYL ACETATE ; 9,10-Dimethyl-1,2-benzanthracene .Product categories of  Dimethylbenzanthracene (57-97-6) are Organics ; Aromatics Compounds ; Aromatics ; Mutagenesis Research Chemicals ; Alpha Sort ; D ; DAlphabetic ; DID - DIN ; Volatiles/ Semivolatiles .The molecular structure of Dimethylbenzanthracene (57-97-6) is.

7,12-Dimethylbenz[a]anthracene Uses

It is a highly potent carcinogen that is activated by microsomal enzymes to a diol epoxide metabolite that binds covalently to DNA in mammalian cells, leading ultimately to tumor induction .

7,12-Dimethylbenz[a]anthracene Toxicity Data With Reference

1.    

skn-mus 64 µg MLD

     CALEDQ    Cancer Letters (Shannon, Ireland). 4 (1978),333.
2.    

dnd-hmn:emb 220 nmol/L

     MUREAV    Mutation Research. 89 (1981),95.
3.    

dni-hmn:lvr 1 mmol/L

     VOONAW    Voprosy Onkologii. Problems of Onkology. 28 (11)(1982),53.
4.    

otr-mus:emb 300 µg/L

     PMRSDJ    Progress in Mutation Research. 5 (1985),659.
5.    

orl-rat TDLo:37,500 µg/kg (female 14-20D post):ETA,TER

     CRNGDP    Carcinogenesis. 3 (1978),413.
6.    

ipr-rat TDLo:24 mg/kg (20D preg):ETA,TER

     CCSUDL    Carcinogenesis-A Comprehensive Survey 3 (1978),413.
7.    

ivn-rat TDLo:15 mg/kg (21D preg):ETA,TER

     JNCIAM    Journal of the National Cancer Institute. 52 (1974),1365.
8.    

ivn-rat TDLo:15 mg/kg (21D preg):ETA,TER

     NEOLA4    Neoplasma. 23 (1976),285.
9.    

imp-rat TDLo:11 µg/kg:ETA,TER

     NISFAY    Nippon Sanka Fujinka Gakkai Zasshi. Journal of Japanese Obstetrics and Gynecology. 34 (1982),1853.
10.    

ipc-rat TDLo:1250 µg/kg:ETA,TER

     GANNA2    Gann. Japanese Journal of Cancer Research. 62 (

7,12-Dimethylbenz[a]anthracene Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

7,12-Dimethylbenz[a]anthracene Safety Profile

Suspected carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. A transplacental carcinogen. Poison by ingestion, intravenous, subcutaneous, intraperitoneal, and intratracheal routes. Other experimental reproductive effects. Human mutation data reported. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

 

Hazard Codes:  C,T,N,Xn,F
C:  Corrosive
T:  Toxic
N:  Dangerous for the environment
Xn: Harmful
F:  Highly Flammable  
Risk Statements:  45-22-67-65-50/53-38-11-39/23/24/25-23/24/25
45:  May cause cancer
22:  Harmful if swallowed
65:  Harmful: May cause lung damage if swallowed 
67:  Vapors may cause drowsiness and dizziness 
11:  Highly Flammable 
23/24/25:  Toxic by inhalation, in contact with skin and if swallowed
39/23/24/25:  Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 
50/53:  Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment 
38:  Irritating to the skin 
Safety Statements:  53-36/37-45-62-61-60
45:  In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
53:  Avoid exposure - obtain special instructions before use
60:  This material and/or its container must be disposed of as hazardous waste 
61:  Avoid release to the environment. Refer to special instructions safety data sheet 
62:  If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label 
36/37:  Wear suitable protective clothing and gloves 
F  10-13-23
F 10:  Keep under argon
F 13:  Malodorous
F 23:  Sensitive to air
HazardClass: 6.1(b)

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