• Name

  Pyrimido[4,5-d]pyrimidine, 1,5-dihydro-2-methyl- (6CI,8CI,9CI)

• EINECS
• CAS No. 31375-19-6
• Article Data4
• CAS DataBase
• Density 1.397g/cm3
• Solubility
• Melting Point 173 °C (decomp)
• Formula C7H8 N4
• Boiling Point 277.008°C at 760 mmHg
• Molecular Weight 148.167
• Flash Point 121.33°C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Pyrimido[4,5-d]pyrimidine,1,5-dihydro-2-methyl- (6CI,8CI,9CI);
• PSA 50.17000
• LogP 0.31240

Synthetic route

95-02-3

5-(aminomethyl)-2-methylpyrimidin-4-amine

4637-24-5

N,N-dimethyl-formamide dimethyl acetal

31375-19-6

3,4-Dihydro-7-methylpyrimido<4,5-d>pyrimidine

Conditions

Conditions	Yield
1.) 80 to 85 deg C, 2.) 90 deg C, 30 min;	88.5%

95-02-3

5-(aminomethyl)-2-methylpyrimidin-4-amine

122-51-0

orthoformic acid triethyl ester

31375-19-6

3,4-Dihydro-7-methylpyrimido<4,5-d>pyrimidine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid Heating;	71%

110-86-1

pyridine

31375-20-9

4-Amino-2-methyl-5-thioformamidomethylpyrimidin

31375-19-6

3,4-Dihydro-7-methylpyrimido<4,5-d>pyrimidine

31375-20-9

4-Amino-2-methyl-5-thioformamidomethylpyrimidin

31375-19-6

3,4-Dihydro-7-methylpyrimido<4,5-d>pyrimidine

Conditions

Conditions	Yield
With pyridine

95-02-3

5-(aminomethyl)-2-methylpyrimidin-4-amine

31375-19-6

3,4-Dihydro-7-methylpyrimido<4,5-d>pyrimidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: H2O 2: pyridine View Scheme

31375-19-6

3,4-Dihydro-7-methylpyrimido<4,5-d>pyrimidine

55289-66-2

3-Mercapto-4-oxopentyl Acetate

130967-53-2

Thiamine formate

Conditions

Conditions	Yield
With formic acid for 0.5h; Ambient temperature;	89.3%

31375-19-6

3,4-Dihydro-7-methylpyrimido<4,5-d>pyrimidine

1886-34-6

2-methyl-4-amino-5-formylaminomethylpyrimidine

Conditions

Conditions	Yield
an der Luft erfolgt;

31375-19-6

3,4-Dihydro-7-methylpyrimido<4,5-d>pyrimidine

55289-66-2

3-Mercapto-4-oxopentyl Acetate

67-03-8

Thiamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; formic acid 1.) 30 min, RT, 2.) EtOH, 30 min, RT; Yield given. Multistep reaction;