-
Name
7-N-[2-[[2-(gamma-L-Glutamylamino)ethyl]dithio]ethyl]mitomycin C
- EINECS
- CAS No. 118359-59-4
- Density 1.52g/cm3
- Solubility
- Melting Point
- Formula C24H34 N6 O8 S2
- Boiling Point 909°Cat760mmHg
- Molecular Weight 598.76
- Flash Point 503.5°C
- Transport Information
- Appearance
- Safety A poison by intraperitoneal and intravenous routes. When heated to decomposition it emits toxic vapors of NOx and SOx.
- Risk Codes
-
Molecular Structure
- Hazard Symbols A poison.
- Synonyms L-Glutamine,N-[2-[[2-[[8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,4,7,8,8a,8b-octahydro-8a-methoxy-5-methyl-4,7-dioxoazirino[2',3':3,4]pyrrolo[1,2-a]indol-6-yl]amino]ethyl]dithio]ethyl]-,[1aS-(1aa,8b,8aa,8ba)]-; Azirino[2',3':3,4]pyrrolo[1,2-a]indole,L-glutamine deriv.; KT 6149; KW 2149
- PSA 280.40000
- LogP 1.38140
7-N-((2-((2-(r-l-glutamylamino)ethyl)-dithio)ethyl))mitomycin c Chemical Properties
Molecular Structure of 7-N-((2-((2-(r-l-glutamylamino)ethyl)-dithio)ethyl))mitomycin c (CAS NO.118359-59-4):
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Empirical Formula: C24H34N6O8S2
Molecular Weight: 598.6922
Surface Tension: 81.8 dyne/cm
Density: 1.52 g/cm3
Flash Point: 503.5 °C
Enthalpy of Vaporization: 143.35 kJ/mol
Boiling Point: 909 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C
Index of Refraction: 1.675
Classification Code: Agricultural Chemical;Herbicide;Skin / Eye Irritant
7-N-((2-((2-(r-l-glutamylamino)ethyl)-dithio)ethyl))mitomycin c Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | oral | 125mg/kg (125mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 31(8), Pg. 33, 1966. |
| guinea pig | LD50 | oral | 250mg/kg (250mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 31(8), Pg. 33, 1966. |
| mouse | LD50 | oral | 50mg/kg (50mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 31(8), Pg. 33, 1966. |
| rabbit | LD50 | oral | 200mg/kg (200mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 31(8), Pg. 33, 1966. |
| rat | LD50 | oral | 250mg/kg (250mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 31(8), Pg. 33, 1966. |
| rat | LD50 | unreported | 35mg/kg (35mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 31(8), Pg. 33, 1966. |
7-N-((2-((2-(r-l-glutamylamino)ethyl)-dithio)ethyl))mitomycin c Safety Profile
A poison by intraperitoneal and intravenous routes. When heated to decomposition it emits toxic vapors of NOx and SOx.
7-N-((2-((2-(r-l-glutamylamino)ethyl)-dithio)ethyl))mitomycin c Specification
7-N-((2-((2-(r-l-glutamylamino)ethyl)-dithio)ethyl))mitomycin c ,with CAS number of 118359-59-4,can be called 7-Oxabicyclo(2.2.1)heptane-2,3-dicarboxylic acid, disodium salt, mixt. with 1-methylethyl phenylcarbamate .
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